ES8402585A1 - Procedimiento para la preparacion de nuevas benzoxazin-2-onas. - Google Patents
Procedimiento para la preparacion de nuevas benzoxazin-2-onas.Info
- Publication number
- ES8402585A1 ES8402585A1 ES522104A ES522104A ES8402585A1 ES 8402585 A1 ES8402585 A1 ES 8402585A1 ES 522104 A ES522104 A ES 522104A ES 522104 A ES522104 A ES 522104A ES 8402585 A1 ES8402585 A1 ES 8402585A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- group
- benzoxazin
- ones
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS BENZOXAZIN-2-ONAS.CONSISTE EN HACER REACCIONAR UN COMPUESTO HIDROXILICO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN PRESENCIA DE UN DISOLVENTE COMO METANOL, O DE UN AGENTE ANHIDRO COMO ACETONA O DE UNA BASE ALCALINA COMO HIDROXIDO SODIDO, A TEMPERATURA ENTRE 0J Y 100J, PARA OBTENER UN COMPUESTO DE FORMULA (I); R2 Y R3 PUEDEN SER IGUALES O DIFERENTES, SIGNIFICAN ATOMOS DE HIDROGENO, GRUPO FENILO, GRUPO ALCOHILO DE C1 A 6; R4 SIGNIFICA UN ATOMO DE HIDROGENO; R6 SIGNIFICA, UN ATOMO DE HIDROGENO O HALOGENO, O UNGRUPO ALCOHILO DE C1 A 3; R1 SIGNIFICA UN GRUPO ALCOHILO DE C1 A 3, O GRUPO FENILO; A SIGNIFICA UN ATOMO DE AZUFRE, UN GRUPO DE SO2; D SIGNIFICA UN GRUPO ALCOHILENO DE CADENA RECTA DE C2 A 6.SE UTILIZAN COMO MEDICAMENTOS POR SUS PROPIEDADES ANTITROMBOTICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823217012 DE3217012A1 (de) | 1982-05-06 | 1982-05-06 | Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8402585A1 true ES8402585A1 (es) | 1984-02-01 |
| ES522104A0 ES522104A0 (es) | 1984-02-01 |
Family
ID=6162917
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES522104A Granted ES522104A0 (es) | 1982-05-06 | 1983-05-05 | Procedimiento para la preparacion de nuevas benzoxazin-2-onas. |
| ES526723A Expired ES8406453A1 (es) | 1982-05-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas benzoxazin-2-onas |
| ES526724A Granted ES526724A0 (es) | 1982-05-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas benzoxazin-2-onas |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526723A Expired ES8406453A1 (es) | 1982-05-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas benzoxazin-2-onas |
| ES526724A Granted ES526724A0 (es) | 1982-05-06 | 1983-10-25 | Procedimiento para la preparacion de nuevas benzoxazin-2-onas |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4518597A (es) |
| EP (1) | EP0093922B1 (es) |
| JP (1) | JPS58203979A (es) |
| KR (1) | KR900006546B1 (es) |
| AT (1) | ATE24501T1 (es) |
| AU (1) | AU563453B2 (es) |
| CA (1) | CA1204744A (es) |
| CS (1) | CS236876B2 (es) |
| DD (1) | DD210453A5 (es) |
| DE (2) | DE3217012A1 (es) |
| DK (1) | DK164860C (es) |
| ES (3) | ES522104A0 (es) |
| FI (1) | FI79704C (es) |
| GB (1) | GB2119382B (es) |
| GR (1) | GR79255B (es) |
| HU (1) | HU194842B (es) |
| IE (1) | IE55481B1 (es) |
| IL (1) | IL68573A (es) |
| NO (1) | NO158738C (es) |
| NZ (1) | NZ204143A (es) |
| PL (1) | PL139119B1 (es) |
| PT (1) | PT76627B (es) |
| SU (1) | SU1138025A3 (es) |
| YU (1) | YU42854B (es) |
| ZA (1) | ZA833190B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3439281A1 (de) * | 1984-10-26 | 1986-04-30 | Bayer Ag, 5090 Leverkusen | Chromogene 4,4-diaryl-2-oxo-benzo-3,1-oxazine, ihre herstellung und verwendung |
| US5519021A (en) * | 1992-08-07 | 1996-05-21 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
| IL106507A (en) * | 1992-08-07 | 1997-11-20 | Merck & Co Inc | Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type |
| US5874430A (en) * | 1996-10-02 | 1999-02-23 | Dupont Pharmaceuticals Company | 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same |
| US5965729A (en) | 1997-02-05 | 1999-10-12 | Merck & Co., Inc. | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| EP2247579B1 (en) * | 2008-01-17 | 2012-04-18 | Bayer Pharma Aktiengesellschaft | Sulphoximine-substituted quinazoline derivatives as immunomodulators, their preparation and use as medicaments |
| EP3102567B1 (en) | 2014-02-04 | 2019-07-17 | University of Tennessee Research Foundation | Inhibitors of paxillin function and related compositions and methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3526621A (en) * | 1966-08-03 | 1970-09-01 | Farmaceutical Italia Soc | Substituted 3,1-benzoxazin-2-one |
| US3542774A (en) * | 1968-07-05 | 1970-11-24 | Warner Lambert Pharmaceutical | 3,4-dihydrobenzoxazinones |
| CH624395A5 (es) * | 1976-01-08 | 1981-07-31 | Ciba Geigy Ag | |
| SU843739A3 (ru) * | 1978-02-17 | 1981-06-30 | Карл Томэ Гмбх (Фирма) | Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ |
| US4442111A (en) * | 1981-07-25 | 1984-04-10 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Antithrombotic sulfimino and sulfoximino indolinones-2 |
-
1982
- 1982-05-06 DE DE19823217012 patent/DE3217012A1/de not_active Withdrawn
-
1983
- 1983-04-22 AT AT83103980T patent/ATE24501T1/de not_active IP Right Cessation
- 1983-04-22 DE DE8383103980T patent/DE3368621D1/de not_active Expired
- 1983-04-22 EP EP83103980A patent/EP0093922B1/de not_active Expired
- 1983-04-26 FI FI831412A patent/FI79704C/fi not_active IP Right Cessation
- 1983-04-26 SU SU833583668A patent/SU1138025A3/ru active
- 1983-04-27 YU YU957/83A patent/YU42854B/xx unknown
- 1983-05-02 DD DD83250508A patent/DD210453A5/de not_active IP Right Cessation
- 1983-05-02 PT PT76627A patent/PT76627B/pt unknown
- 1983-05-03 DK DK195583A patent/DK164860C/da not_active IP Right Cessation
- 1983-05-04 IL IL68573A patent/IL68573A/xx unknown
- 1983-05-04 KR KR1019830001917A patent/KR900006546B1/ko not_active IP Right Cessation
- 1983-05-04 GR GR71308A patent/GR79255B/el unknown
- 1983-05-04 HU HU831540A patent/HU194842B/hu not_active IP Right Cessation
- 1983-05-04 CS CS833145A patent/CS236876B2/cs unknown
- 1983-05-05 NZ NZ204143A patent/NZ204143A/en unknown
- 1983-05-05 IE IE1032/83A patent/IE55481B1/en not_active IP Right Cessation
- 1983-05-05 GB GB08312344A patent/GB2119382B/en not_active Expired
- 1983-05-05 NO NO831599A patent/NO158738C/no unknown
- 1983-05-05 AU AU14265/83A patent/AU563453B2/en not_active Ceased
- 1983-05-05 ES ES522104A patent/ES522104A0/es active Granted
- 1983-05-05 ZA ZA833190A patent/ZA833190B/xx unknown
- 1983-05-05 PL PL1983241806A patent/PL139119B1/pl unknown
- 1983-05-05 CA CA000427530A patent/CA1204744A/en not_active Expired
- 1983-05-06 JP JP58079222A patent/JPS58203979A/ja active Pending
- 1983-10-25 ES ES526723A patent/ES8406453A1/es not_active Expired
- 1983-10-25 ES ES526724A patent/ES526724A0/es active Granted
-
1984
- 1984-06-06 US US06/617,797 patent/US4518597A/en not_active Expired - Fee Related
Also Published As
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