AR112788A1 - Compuesto pentacíclico - Google Patents

Compuesto pentacíclico

Info

Publication number
AR112788A1
AR112788A1 ARP180102517A ARP180102517A AR112788A1 AR 112788 A1 AR112788 A1 AR 112788A1 AR P180102517 A ARP180102517 A AR P180102517A AR P180102517 A ARP180102517 A AR P180102517A AR 112788 A1 AR112788 A1 AR 112788A1
Authority
AR
Argentina
Prior art keywords
thieno
diazepino
pyrimido
dione
dimethyl
Prior art date
Application number
ARP180102517A
Other languages
English (en)
Inventor
Koji Hagiwara
Nobuhiro Sato
Yoshihisa Kobayashi
Yu Yoshida
Tamaki HOSHIKAWA
Toshihiko Norimine
Yoshiaki Ohashi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of AR112788A1 publication Critical patent/AR112788A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque está seleccionado del grupo constituido por: 3-fluoro-6,11-dimetil-6,7,10,11,12,13-hexahidrobenzo[f]pirido[4’’,3’’:4’,5’]tieno[2’,3’:4,5]pirimido[1,2-a][1,4]diazepino-5,14-diona de fórmula (1); 5,10-dimetil-5,6,9,10,11,12-hexahidropirido[4’’,3’’:4’,5’]tieno[2’,3’:4,5]pirimido[1,2-a]tieno[2,3-f][1,4]diazepino-4,13-diona de fórmula (2); 5,10-dimetil-5,6,9,10,11,12-hexahidropirido[4’’,3’’:4’,5’]tieno[2’,3’:4,5]pirimido[1,2-a]tieno[3,2-f][1,4]diazepino-4,13-diona de fórmula (3); (3aS,14aR)-5,10-dimetil-3,3a,5,6,9,10,11,12-octahidro-1H-ciclopenta[f]pirido[4’’,3’’:4’,5’]tieno[2’,3’:4,5]pirimido[1,2-a][1,4]diazepino-4,13(2H;14aH)diona de fórmula (4); (3aR,14aR)-5,10-dimetil-3,3a,5,6,9,10,11,12-octahidro-1H-ciclopenta[f]pirido[4’’,3’’:4’,5’]tieno[2’,3’:4,5]pirimido[1,2-a][1,4]diazepino-4,13(2H,14aH)diona de fórmula (5); y (3aS,14aS)-5,10-dimetil-3,3a,5,6,9,10,11,12-octahidro-1H-ciclopenta[f]pirido[4’’,3’’:4’,5’]tieno[2’,3’:4,5]pirimido[1,2-a][1,4]diazepino-4,13(2H,14aH)diona de fórmula (6); o una sal farmacéuticamente aceptable de estas.
ARP180102517A 2017-09-07 2018-09-05 Compuesto pentacíclico AR112788A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2017172169 2017-09-07

Publications (1)

Publication Number Publication Date
AR112788A1 true AR112788A1 (es) 2019-12-11

Family

ID=65517037

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180102517A AR112788A1 (es) 2017-09-07 2018-09-05 Compuesto pentacíclico

Country Status (33)

Country Link
US (1) US10239889B1 (es)
EP (1) EP3680243B1 (es)
JP (1) JP6557441B1 (es)
KR (1) KR102307738B1 (es)
CN (1) CN111051316B (es)
AR (1) AR112788A1 (es)
AU (1) AU2018330578B2 (es)
BR (1) BR112020003197A2 (es)
CA (1) CA3072740A1 (es)
CL (1) CL2020000376A1 (es)
CO (1) CO2020001471A2 (es)
CY (1) CY1125355T1 (es)
DK (1) DK3680243T3 (es)
ES (1) ES2903172T3 (es)
HR (1) HRP20220019T1 (es)
HU (1) HUE056791T2 (es)
IL (1) IL272652B (es)
JO (1) JOP20200030A1 (es)
LT (1) LT3680243T (es)
MA (1) MA50093B1 (es)
MD (1) MD3680243T2 (es)
MX (1) MX2020001786A (es)
PH (1) PH12020500341A1 (es)
PL (1) PL3680243T3 (es)
PT (1) PT3680243T (es)
RS (1) RS62796B1 (es)
RU (1) RU2754557C1 (es)
SG (1) SG11202001240XA (es)
SI (1) SI3680243T1 (es)
TW (1) TWI707859B (es)
UA (1) UA125940C2 (es)
WO (1) WO2019049869A1 (es)
ZA (1) ZA202000970B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109467538A (zh) 2017-09-07 2019-03-15 和记黄埔医药（上海）有限公司 环烯烃取代的杂芳环类化合物及其用途
AU2018329840A1 (en) 2017-09-07 2020-03-19 Augusta University Research Institute, Inc. Specific Akt3 activator and uses thereof
KR20210135224A (ko) * 2019-03-05 2021-11-12 에자이 알앤드디 매니지먼트 가부시키가이샤 펜타사이클릭 헤테로사이클릭 화합물
AU2020233452A1 (en) 2019-03-05 2021-09-02 Eisai R&D Management Co., Ltd. Salt of pentacyclic compound and crystals thereof
US20230101747A1 (en) * 2019-12-06 2023-03-30 Schrödinger, Inc. Cyclic compounds and methods of using same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187306A (en) 1977-07-26 1980-02-05 Bayer Aktiengesellschaft Benzodiazepine-diones, a process for their production and their use as medicaments
DD258234A1 (de) * 1987-03-05 1988-07-13 Univ Leipzig Verfahren zur herstellung von pyrido/3',2':4,5/thieno/2,3-e/imidazo-/1,2-c/pyrimidinen sowie strukturanaloger -pyrimido/1,2-c/pyrimidine bzw. -1,3-diazepino/1,2-c/pyrimidine
RU2117670C1 (ru) * 1988-10-31 1998-08-20 Эйсай Ко., Лтд. Производные триазоло[1,4]диазепина и способы их получения
TW197442B (es) * 1990-02-08 1993-01-01 Pfizer
KR100203456B1 (ko) 1995-06-20 1999-06-15 한승수 디하이드로에보디아민-에이치씨1를 유효성분으로 함유하는 알츠하이머병에 의한 치매 치료제
FR2779652B1 (fr) * 1998-06-15 2001-06-08 Sod Conseils Rech Applic Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
MX2007004640A (es) * 2004-10-20 2007-06-08 Hoffmann La Roche Derivados de benzodiazepina sustituidos con halogeno.
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
US8192080B2 (en) 2007-01-23 2012-06-05 Tsi Technologies Llc Microwire-controlled autoclave and method

Also Published As

Publication number Publication date
MA50093A (fr) 2021-05-05
AU2018330578A1 (en) 2020-02-27
IL272652A (en) 2020-03-31
LT3680243T (lt) 2021-11-25
UA125940C2 (uk) 2022-07-13
PH12020500341A1 (en) 2020-10-05
WO2019049869A1 (ja) 2019-03-14
CO2020001471A2 (es) 2020-05-29
HRP20220019T1 (hr) 2022-04-01
JOP20200030A1 (ar) 2020-02-12
AU2018330578B2 (en) 2022-11-10
KR102307738B1 (ko) 2021-10-05
CA3072740A1 (en) 2019-03-14
MD3680243T2 (ro) 2022-05-31
US20190071452A1 (en) 2019-03-07
SG11202001240XA (en) 2020-03-30
TW201920195A (zh) 2019-06-01
DK3680243T3 (da) 2022-01-10
EP3680243A1 (en) 2020-07-15
CY1125355T1 (el) 2024-02-16
EP3680243B1 (en) 2021-10-27
SI3680243T1 (sl) 2022-01-31
JP6557441B1 (ja) 2019-08-07
CN111051316A (zh) 2020-04-21
IL272652B (en) 2022-09-01
RS62796B1 (sr) 2022-02-28
TWI707859B (zh) 2020-10-21
JPWO2019049869A1 (ja) 2019-11-07
CL2020000376A1 (es) 2020-08-28
EP3680243A4 (en) 2021-01-06
MX2020001786A (es) 2022-09-13
ES2903172T3 (es) 2022-03-31
HUE056791T2 (hu) 2022-03-28
BR112020003197A2 (pt) 2020-09-29
ZA202000970B (en) 2021-07-28
US10239889B1 (en) 2019-03-26
PT3680243T (pt) 2022-01-12
CN111051316B (zh) 2022-05-31
KR20200051585A (ko) 2020-05-13
MA50093B1 (fr) 2022-05-31
PL3680243T3 (pl) 2022-02-14
RU2754557C1 (ru) 2021-09-03

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