AR105643A1 - COMPUESTOS ANTIVIRALES DE FOSFODIAMIDA DE ÉSTER DE b-AMINOÁCIDO - Google Patents
COMPUESTOS ANTIVIRALES DE FOSFODIAMIDA DE ÉSTER DE b-AMINOÁCIDOInfo
- Publication number
- AR105643A1 AR105643A1 ARP160102427A ARP160102427A AR105643A1 AR 105643 A1 AR105643 A1 AR 105643A1 AR P160102427 A ARP160102427 A AR P160102427A AR P160102427 A ARP160102427 A AR P160102427A AR 105643 A1 AR105643 A1 AR 105643A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently selected
- substituted
- bromine
- chlorine
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000002131 composite material Substances 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 12
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 12
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 12
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 12
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 12
- 229910052794 bromium Inorganic materials 0.000 abstract 12
- 229910052801 chlorine Inorganic materials 0.000 abstract 12
- 239000000460 chlorine Substances 0.000 abstract 12
- 229910052731 fluorine Inorganic materials 0.000 abstract 12
- 239000011737 fluorine Substances 0.000 abstract 12
- 125000001424 substituent group Chemical group 0.000 abstract 12
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 4
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 4
- 125000001624 naphthyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
- 229940024606 amino acid Drugs 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 125000006529 (C3-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 229930182821 L-proline Natural products 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Los compuestos y sus sales farmacéuticamente aceptables revelados por la presente solicitud son útiles para la inhibición de la transcriptasa inversa del VIH. Los compuestos también pueden ser útiles para la profilaxis o el tratamiento de la infección por VIH, y en la profilaxis, el retraso de la aparición o la progresión y el tratamiento del SIDA. Los compuestos y sus sales se pueden emplear como ingredientes en composiciones farmacéuticas, opcionalmente, en combinación con otros agentes antivirales, inmunomoduladores, antibióticos o vacunas. Reivindicación 1: Un compuesto de fórmula estructural (1), o sal farmacéuticamente aceptable del mismo, en la que: R¹ y R² se seleccionan cada uno independientemente entre (a) H, (b) -alquilo C₁₋₄, (c) -alquilo C₁₋₄ sustituido con -OH, -SH, -SCH₃, -NH₂ o -NH-C(=NH)-NH₂, (d) -CH₂-fenilo, (e) -CH₂-fenol, (f) -(CH₂)₁₋₂-COOH, (g) -(CH₂)₁₋₂-CONH₂, (h) -CH₂-1H-indol, (i) -CH₂-imidazol, (j) arilo (por ejemplo, pero sin limitación, fenilo o naftilo) o (k) heteroarilo (por ejemplo, pero sin limitación, piridina); R³ es (a) -alquilo C₁₋₁₀ no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁰ᵃ, -SH, -NR¹¹R¹², -cicloalquilo C₃₋₆ o espiro-cicloalquilo C₃₋₆, (b) -CH₂-fenilo no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵃ, -SH, -NR¹¹R¹² o -alquilo C₁₋₃, (c) -cicloalquilo C₃₋₈ no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵃ, -SH, -NR¹¹R¹² o -alquilo C₁₋₃, (d) arilo no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵃ, -SH, -NR¹¹R¹² o -alquilo C₁₋₃, (e) -alquil C₁₋₅-X-alquilo C₁₋₅, en el que X es O, S o NH, (f) heteroarilo no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵃ, -SH, -NR¹¹R¹² o -alquilo C₁₋₃, o (g) un anillo heterocíclico no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵃ, -SH, -NR¹¹R¹² o -alquilo C₁₋₃; RA es un resto de éster de L-aminoácido de fórmula (2), un resto de éster de D-aminoácido de fórmula (3), un resto de éster de glicina de fórmula (4), un resto de éster de aminoácido disustituido geminalmente de fórmula (5), un resto de éster de b-aminoácido de fórmula (6) o un residuo de éster de L-prolina de fórmula (7); R⁴ es (a) -alquilo C₁₋₄, (b) -alquilo C₁₋₄ sustituido con -OH, -SH, -SCH₃, -NH₂, -NH-C(=NH)-NH₂, (c) -CH₂-fenilo, (d) -CH₂-fenol, (e) -(CH₂)₁₋₂-COOH, (f) -(CH₂)₁₋₂-CONH₂, (g) -CH₂-1H-indol, (h) -CH₂-imidazol, (i) arilo (por ejemplo, pero sin limitación, fenilo o naftilo) o (j) heteroarilo (por ejemplo, pero sin limitación, piridina); R⁵ y R⁶ se seleccionan cada uno independientemente entre (a) -alquilo C₁₋₄, (b) -alquilo C₁₋₄ sustituido con -OH, -SH, -SCH₃, -NH₂, -NH-C(=NH)-NH₂, (c) -CH₂-fenilo, (d) -CH₂-fenol, (e) -(CH₂)₁₋₂-COOH, (f) -(CH₂)₁₋₂-CONH₂, (g) -CH₂-1H-indol, (h) -CH₂-imidazol, (i) arilo (por ejemplo, pero sin limitación, fenilo o naftilo) o (j) heteroarilo (por ejemplo, pero sin limitación, piridina); o R⁵ y R⁶ están unidos junto con el átomo de carbono al que ambos están unidos para formar -cicloalquilo C₃₋₆ o un anillo heterocíclico de 4 a 6 miembros; R⁷ y R⁸ se seleccionan cada uno independientemente entre (a) H, (b) -alquilo C₁₋₄, (c) -alquilo C₁₋₄ sustituido con -OH, -SH, -SCH₃, -NH₂ o -NH-C(=NH)-NH₂, (d) -CH₂-fenilo, (e) -CH₂-fenol, (f) -(CH₂)₁₋₂-COOH, (g) -(CH₂)₁₋₂-CONH₂, (h) -CH₂-1H-indol, (i) -CH₂-imidazol, (j) arilo (por ejemplo, pero sin limitación, fenilo o naftilo) o (k) heteroarilo (por ejemplo, pero sin limitación, piridina); R⁹ es (a) -alquilo C₁₋₁₀ no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁰ᵇ, -SH, -NR¹³R¹⁴, -cicloalquilo C₃₋₆ o espiro-cicloalquilo C₃₋₆, (b) -CH₂-fenilo no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵇ, -SH, -NR¹³R¹⁴ o -alquilo C₁₋₃, (c) -cicloalquilo C₃₋₈ no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵇ, -SH, -NR¹³R¹⁴ o -alquilo C₁₋₃, (d) arilo no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵇ, -SH, -NR¹³R¹⁴ o -alquilo C₁₋₃, (e) -alquil C₁₋₅-X-alquilo C₁₋₅ en el que X es O, S o NH, (f) heteroarilo no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵇ, -SH, -NR¹³R¹⁴ o -alquilo C₁₋₃, o (g) un anillo heterocíclico no sustituido o sustituido con de uno a tres sustituyentes seleccionados independientemente entre flúor, cloro, bromo, -OR¹⁵ᵇ, -SH, -NR¹³R¹⁴ o -alquilo C₁₋₃; R¹⁰ᵃ y R¹⁰ᵇ se seleccionan cada uno independientemente entre -H o -cicloalquilo C₃₋₆; R¹¹ y R¹² se seleccionan cada uno independientemente entre -H, -alquilo C₁₋₃ o -cicloalquilo C₃₋₆; R¹³ y R¹⁴ se seleccionan cada uno independientemente entre -H, -alquilo C₁₋₃ o -cicloalquilo C₃₋₆; y R¹⁵ᵃ y R¹⁵ᵇ se seleccionan cada uno independientemente entre -H, -alquilo C₁₋₃ o -cicloalquilo C₃₋₆.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562203265P | 2015-08-10 | 2015-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR105643A1 true AR105643A1 (es) | 2017-10-25 |
Family
ID=56852398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102427A AR105643A1 (es) | 2015-08-10 | 2016-08-08 | COMPUESTOS ANTIVIRALES DE FOSFODIAMIDA DE ÉSTER DE b-AMINOÁCIDO |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9822138B2 (es) |
| EP (1) | EP3334743B1 (es) |
| JP (2) | JP6563585B2 (es) |
| KR (1) | KR102163611B1 (es) |
| CN (1) | CN107849071B (es) |
| AR (1) | AR105643A1 (es) |
| AU (1) | AU2016305941B2 (es) |
| CA (1) | CA2994720C (es) |
| CL (1) | CL2018000351A1 (es) |
| CO (1) | CO2018001296A2 (es) |
| CR (1) | CR20180092A (es) |
| EA (1) | EA035028B1 (es) |
| EC (1) | ECSP18018823A (es) |
| HK (1) | HK1249107A1 (es) |
| IL (1) | IL257156A (es) |
| MA (1) | MA42615A (es) |
| MX (1) | MX2018001729A (es) |
| MY (1) | MY192607A (es) |
| NI (1) | NI201800023A (es) |
| PE (1) | PE20181016A1 (es) |
| PH (1) | PH12018500292A1 (es) |
| SV (1) | SV2018005629A (es) |
| TN (1) | TN2018000048A1 (es) |
| TW (1) | TWI639598B (es) |
| WO (1) | WO2017027434A1 (es) |
| ZA (1) | ZA201800514B (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3285582B1 (en) * | 2015-03-26 | 2020-11-11 | Merck Sharp & Dohme Corp. | Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors |
| US10745428B2 (en) | 2015-12-10 | 2020-08-18 | Idenix Pharmaceuticals Llc | Antiviral phosphodiamide prodrugs of tenofovir |
| WO2017106069A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Antiviral oxime phosphoramide compounds |
| JP2017182110A (ja) * | 2016-03-28 | 2017-10-05 | セイコーエプソン株式会社 | 表示システム、表示装置、情報処理装置及び情報処理方法 |
| EP3503895B1 (en) | 2016-08-25 | 2021-09-15 | Merck Sharp & Dohme Corp. | Antiviral prodrugs of tenofovir |
| KR102305215B1 (ko) | 2016-10-14 | 2021-09-28 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| EP3532069A4 (en) | 2016-10-26 | 2020-05-13 | Merck Sharp & Dohme Corp. | ARYL-AMIDE PHOSPHODIAMIDE COMPOUNDS ANTIVIRALS |
| WO2018119013A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antiviral aliphatic ester prodrugs of tenofovir |
| BR112019012511A2 (pt) | 2016-12-22 | 2019-11-19 | Idenix Pharmaceuticals Llc | compostos antivirais de benzil-amina fosfodiamida, composição farmacêutica e uso do composto |
| JP7037667B2 (ja) | 2017-12-20 | 2022-03-16 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する３’３’環状ジヌクレオチド |
| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| WO2020018399A1 (en) | 2018-07-19 | 2020-01-23 | Merck Sharp & Dohme Corp. | Phosphinic amide prodrugs of tenofovir |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| EP3833437A1 (en) * | 2018-08-09 | 2021-06-16 | GlaxoSmithKline Intellectual Property (No.2) Limited | Compounds useful in hiv therapy |
| CN108623632A (zh) * | 2018-08-17 | 2018-10-09 | 上海麦步医药科技有限公司 | 一种替诺福韦艾拉酚胺的制备方法 |
| LT3873903T (lt) | 2018-10-31 | 2024-05-10 | Gilead Sciences, Inc. | Pakeistieji 6-azabenzimidazolo junginiai, kaip hpk1 inhibitoriai |
| US11071730B2 (en) | 2018-10-31 | 2021-07-27 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| CA3125991A1 (en) | 2019-01-25 | 2020-07-30 | Brown University | Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders |
| WO2020178769A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| AU2020231115A1 (en) | 2019-03-07 | 2021-08-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| CR20210687A (es) | 2019-06-25 | 2022-03-03 | Gilead Sciences Inc | PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO |
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| US5977061A (en) | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
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| DK2682397T3 (da) | 2000-07-21 | 2017-06-19 | Gilead Sciences Inc | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
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| TWI444384B (zh) * | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| US8680071B2 (en) | 2010-04-01 | 2014-03-25 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
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| WO2017007701A1 (en) | 2015-07-07 | 2017-01-12 | Merck Sharp & Dohme Corp. | Antiviral phosphodiamide compounds |
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