CO5640152A2 - Composiciones farmaceuticas para inhibidores de la proteasa del virus de la hepatitis c - Google Patents

Composiciones farmaceuticas para inhibidores de la proteasa del virus de la hepatitis c

Info

Publication number
CO5640152A2
CO5640152A2 CO05110321A CO05110321A CO5640152A2 CO 5640152 A2 CO5640152 A2 CO 5640152A2 CO 05110321 A CO05110321 A CO 05110321A CO 05110321 A CO05110321 A CO 05110321A CO 5640152 A2 CO5640152 A2 CO 5640152A2
Authority
CO
Colombia
Prior art keywords
alkyl
cycloalkyl
halogen
alkoxy
cycloalkoxy
Prior art date
Application number
CO05110321A
Other languages
English (en)
Inventor
Shirlynn Chen
Xiaohui Mei
Zeren Wang
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33310709&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5640152(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO5640152A2 publication Critical patent/CO5640152A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Abstract

1.- Una composición farmacéutica que comprende:(a) un compuesto de fórmula (I): en la que:------ indica un enlace opcional que forma un doble enlace entre las posiciones 13 y 14;R1 es H, halógeno, alquilo C1-6, cicloalquilo C3-6, halógenoalquilo C1-6, alcoxi C1-6, cicloalcoxi C3-6, hidroxi, o N(R5)2, en el que cada R5 es independientemente H, alquilo C1-6 o cicloalquilo C3-6;R2 es H, halógeno, alquilo C1-6, cicloalquilo C3-6, halógenoalquilo C1-6, tioalquilo C1-6, alcoxi C1-6, cicloalcoxi C3-6, alcoxialquilo C2-7, arilo o Het C6 ó 10, en el que Het es un heterociclo saturado o insaturado, de cinco, seis o siete miembros que contiene de uno a cuatro heteroátomos en el anillo seleccionados de nitrógeno, oxigeno y azufre;estando dicho cicloalquilo, arilo o Het opcionalmente sustituido con R6, en el que R6 es H, halógeno, alquilo C1-6, cicloalquilo C3-6, alcoxi C1-6, cicloalcoxi C3-6, NO2, N(R7)2, NH-C(O)-R7; o NH-C(O)-NH-R7, en los que cada R7 es independientemente:H, alquilo C1-6 o cicloalquilo C3-6;o R6 es NH-C(O)-OR8, en el que R8 es alquilo C1-6 o cicloalquilo C3-6;R3 es R9O- o R9NH-, en los que R9 es alquilo C1-6 o cicloalquilo C3-6;R4 es H o de uno a tres sustituyentes en cualquier átomo de carbono disponible en las posiciones 8, 9, 10, 11, 12, 13 ó 14, seleccionado dicho sustituyente independientemente del grupo que consta de: alquilo C1-6, halógenoalquilo C1-6, alcoxi C1-6, hidroxi, halógeno, amino, oxo, tio o tioalquilo C1-6.o uno de sus tautómeros;(b) aproximadamente 0,1 a 10% en peso de una amina farmacéuticamente aceptable o una mezcla de aminas farmacéuticamente aceptables; ...
CO05110321A 2003-04-02 2005-10-28 Composiciones farmaceuticas para inhibidores de la proteasa del virus de la hepatitis c CO5640152A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45976503P 2003-04-02 2003-04-02

Publications (1)

Publication Number Publication Date
CO5640152A2 true CO5640152A2 (es) 2006-05-31

Family

ID=33310709

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05110321A CO5640152A2 (es) 2003-04-02 2005-10-28 Composiciones farmaceuticas para inhibidores de la proteasa del virus de la hepatitis c

Country Status (24)

Country Link
US (1) US7157424B2 (es)
EP (1) EP1613353A1 (es)
JP (1) JP2006522017A (es)
KR (1) KR20050108420A (es)
CN (1) CN100363055C (es)
AR (1) AR043795A1 (es)
AU (1) AU2004231538A1 (es)
BR (1) BRPI0409068A (es)
CA (1) CA2520886A1 (es)
CO (1) CO5640152A2 (es)
EA (1) EA010013B1 (es)
EC (1) ECSP056065A (es)
HK (1) HK1091130A1 (es)
HR (1) HRP20050871A2 (es)
MX (1) MXPA05010338A (es)
NO (1) NO20055057L (es)
NZ (1) NZ543250A (es)
PE (1) PE20050013A1 (es)
RS (1) RS20050741A (es)
TW (1) TW200505484A (es)
UA (1) UA81028C2 (es)
UY (1) UY28250A1 (es)
WO (1) WO2004093915A1 (es)
ZA (1) ZA200506019B (es)

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Also Published As

Publication number Publication date
ECSP056065A (es) 2006-01-27
TW200505484A (en) 2005-02-16
EA010013B1 (ru) 2008-06-30
HK1091130A1 (en) 2007-01-12
EA200501532A1 (ru) 2006-06-30
AR043795A1 (es) 2005-08-10
US7157424B2 (en) 2007-01-02
NO20055057L (no) 2005-10-31
PE20050013A1 (es) 2005-03-01
CN100363055C (zh) 2008-01-23
KR20050108420A (ko) 2005-11-16
ZA200506019B (en) 2006-07-26
NZ543250A (en) 2008-12-24
UA81028C2 (en) 2007-11-26
UY28250A1 (es) 2004-11-30
BRPI0409068A (pt) 2006-03-28
CN1767856A (zh) 2006-05-03
RS20050741A (en) 2007-06-04
EP1613353A1 (en) 2006-01-11
WO2004093915A1 (en) 2004-11-04
JP2006522017A (ja) 2006-09-28
MXPA05010338A (es) 2005-11-17
US20040229776A1 (en) 2004-11-18
CA2520886A1 (en) 2004-11-04
HRP20050871A2 (en) 2006-10-31
AU2004231538A1 (en) 2004-11-04

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