AR094214A1 - Inhibidores de la quinasa que regula la señal de la apoptosis - Google Patents
Inhibidores de la quinasa que regula la señal de la apoptosisInfo
- Publication number
- AR094214A1 AR094214A1 ARP130104949A ARP130104949A AR094214A1 AR 094214 A1 AR094214 A1 AR 094214A1 AR P130104949 A ARP130104949 A AR P130104949A AR P130104949 A ARP130104949 A AR P130104949A AR 094214 A1 AR094214 A1 AR 094214A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- diseases
- hydrogen
- cycloalkyl
- substituted
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Estos compuestos presentan actividad de inhibición sobre la quinasa que regula la señal de la apoptosis (ASK1), por lo que son útiles para tratar las afecciones que están mediadas por la ASK1, lo que abarca los trastornos autoinmunes, las enfermedades inflamatorias, las enfermedades cardiovasculares, la diabetes, la nefropatía diabética, las enfermedades cardiorrenales, que abarcan las enfermedades en los riñones, las enfermedades fibróticas, las enfermedades respiratorias, la EPOC, la fibrosis pulmonar idiopática, las lesiones agudas en los pulmones, las enfermedades hepáticas agudas o crónicas y las enfermedades neurodegenerativas. Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1), donde R¹ es un alquilo C₁₋₃ o un cicloalquilo C₃₋₆, donde el alquilo o el cicloalquilo pueden estar sustituidos con entre uno y tres átomos halógenos; R² es hidrógeno o un alquilo C₁₋₆, donde el alquilo puede estar sustituido con un halógeno; R³ es hidrógeno o un alquilo C₁₋₃; R⁴ es hidrógeno o un alquilo C₁₋₃; R⁵ es hidrógeno, un alquilo C₁₋₃, ORᵃ o NHRᵃ; R⁶ es hidrógeno, un alquilo C₁₋₃, un haloalquilo C₁₋₃ o un cicloalquilo C₃₋₆, donde el cicloalquilo puede estar sustituido con un alquilo C₁₋₃, con un haloalquilo C₁₋₃ o con 1 ó 2 átomos halógenos; Rᵃ y Rᵇ son independientemente hidrógeno o un alquilo C₁₋₃, o Rᵃ y Rᵇ pueden combinarse con el átomo de nitrógeno al que están unidos para formar un anillo heterocíclico de seis miembros, que puede comprender un átomo de oxígeno o de nitrógeno; o una sal o un estereoisómero farmacéuticamente aceptable de dicho compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261740777P | 2012-12-21 | 2012-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094214A1 true AR094214A1 (es) | 2015-07-15 |
Family
ID=49943575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130104949A AR094214A1 (es) | 2012-12-21 | 2013-12-20 | Inhibidores de la quinasa que regula la señal de la apoptosis |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US9051313B2 (es) |
| EP (2) | EP2935258B1 (es) |
| JP (2) | JP6086633B2 (es) |
| KR (1) | KR101712758B1 (es) |
| CN (1) | CN104918936B (es) |
| AR (1) | AR094214A1 (es) |
| AU (2) | AU2013361140B2 (es) |
| BR (1) | BR112015014567A2 (es) |
| CA (1) | CA2896060C (es) |
| CY (1) | CY1118574T1 (es) |
| DK (1) | DK2935258T3 (es) |
| EA (1) | EA027645B1 (es) |
| ES (1) | ES2612979T3 (es) |
| HK (1) | HK1214247A1 (es) |
| HR (1) | HRP20170112T8 (es) |
| HU (1) | HUE032988T2 (es) |
| IL (2) | IL239322A (es) |
| LT (1) | LT2935258T (es) |
| MX (1) | MX2015008090A (es) |
| NZ (1) | NZ709248A (es) |
| PL (1) | PL2935258T3 (es) |
| PT (1) | PT2935258T (es) |
| RS (1) | RS55676B1 (es) |
| SG (1) | SG11201504865YA (es) |
| SI (1) | SI2935258T1 (es) |
| SM (1) | SMT201700051B (es) |
| TW (1) | TWI622589B (es) |
| UY (1) | UY35212A (es) |
| WO (1) | WO2014100541A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| JP5705314B2 (ja) * | 2010-07-02 | 2015-04-22 | ギリアード サイエンシーズ， インコーポレイテッド | アポトーシスシグナル調節キナーゼ阻害剤 |
| US9045485B2 (en) | 2010-12-16 | 2015-06-02 | Convergence Pharmaceuticals Limited | ASK 1 inhibiting pyrrolopyrimidine derivatives |
| UY35212A (es) | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
| NZ720660A (en) | 2013-12-20 | 2018-01-26 | Gilead Sciences Inc | Apoptosis signal-regulating kinase inhibitors |
| WO2015187499A1 (en) * | 2014-06-03 | 2015-12-10 | Gilead Sciences, Inc. | Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor |
| TW201618781A (zh) | 2014-08-13 | 2016-06-01 | 吉李德科學股份有限公司 | 治療肺高血壓之方法 |
| SG11201701723XA (en) | 2014-09-24 | 2017-04-27 | Gilead Sciences Inc | Methods of treating liver disease |
| CA2972192C (en) | 2014-12-23 | 2021-07-06 | Gilead Sciences, Inc. | Processes for preparing ask1 inhibitors |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| CN110036005B (zh) * | 2016-11-16 | 2022-09-27 | 广东东阳光药业有限公司 | 酰胺衍生物及其在药物中的应用 |
| WO2018094964A1 (zh) * | 2016-11-25 | 2018-05-31 | 武汉大学 | 一种以凋亡信号调节激酶1n端二聚化为靶点筛选用于治疗脂肪性肝炎药物的方法 |
| CN109963570A (zh) | 2017-01-21 | 2019-07-02 | 宁波知明生物科技有限公司 | 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用 |
| AU2018209573B2 (en) | 2017-01-22 | 2020-08-13 | Fujian Akeylink Biotechnology Co., Ltd. | ASK1 inhibitor and preparation method and use thereof |
| CN109983007B (zh) | 2017-03-03 | 2021-11-05 | 江苏豪森药业集团有限公司 | 酰胺类衍生物抑制剂及其制备方法和应用 |
| MX2019013275A (es) | 2017-05-12 | 2020-07-27 | Enanta Pharm Inc | Inhibidores de la quinasa 1 reguladora de la señal de apoptosis y métodos de uso de estos. |
| WO2018218044A2 (en) | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals Inc | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10253018B2 (en) | 2017-05-25 | 2019-04-09 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2018218051A1 (en) | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2019046186A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF |
| WO2019047094A1 (en) * | 2017-09-07 | 2019-03-14 | Eli Lilly And Company | CYCLOBUTYL-IMIDAZOLIDINONE COMPOUNDS |
| US10370352B2 (en) | 2017-09-07 | 2019-08-06 | Eli Lilly And Company | Cyclobutyl-imidazolidinone compounds |
| WO2019099703A1 (en) * | 2017-11-16 | 2019-05-23 | Sidecar Therapeutics, Inc. | Apoptosis signal-regulating kinase 1 (ask 1) inhibitor compounds |
| WO2019099203A1 (en) * | 2017-11-17 | 2019-05-23 | Hepagene Therapeutics, Inc. | Oxazole and thiazole derivatives as inhibitors of ask1 |
| CN110407806B (zh) * | 2018-04-28 | 2021-08-17 | 深圳微芯生物科技股份有限公司 | 甲酰胺类化合物、其制备方法及其应用 |
| KR20210005195A (ko) | 2018-05-02 | 2021-01-13 | 이난타 파마슈티칼스, 인코포레이티드 | 아폽토시스 신호 조절 키나제 1 억제제를 포함하는 테트라졸 및 이의 사용 방법 |
| US10683289B2 (en) | 2018-05-02 | 2020-06-16 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| JP2021528456A (ja) * | 2018-06-27 | 2021-10-21 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | Ａｓｋ１阻害剤 |
| CN111107848B (zh) * | 2018-08-10 | 2023-05-23 | 江苏豪森药业集团有限公司 | 一种含有酰胺类衍生物的药物组合物及其制备方法和应用 |
| WO2020041417A1 (en) | 2018-08-22 | 2020-02-27 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11345699B2 (en) | 2018-11-19 | 2022-05-31 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020198214A1 (en) | 2019-03-25 | 2020-10-01 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| WO2004103996A1 (en) | 2003-05-21 | 2004-12-02 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
| EP1661581A1 (en) | 2003-07-28 | 2006-05-31 | Osaka Industrial Promotion Organization | Remedy for cardiac failure comprising ask1 inhibitor as the active ingredient and method of screening the same |
| US20070276050A1 (en) | 2006-02-27 | 2007-11-29 | Gilead Sciences, Inc. | Methods for identifying ASK1 inhibitors useful for preventing and/or treating cardiovascular diseases |
| US20100144793A1 (en) | 2006-11-24 | 2010-06-10 | Ac Immune Sa | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
| EP2181112A1 (en) * | 2007-08-31 | 2010-05-05 | Merck Serono S.A. | Triazolopyridine compounds and their use as ask inhibitors |
| TWI491606B (zh) * | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| JP5705314B2 (ja) * | 2010-07-02 | 2015-04-22 | ギリアード サイエンシーズ， インコーポレイテッド | アポトーシスシグナル調節キナーゼ阻害剤 |
| US9255072B2 (en) * | 2011-03-04 | 2016-02-09 | National Health Rsearch Institutes | Pyrazole compounds and thiazole compounds as protein kinases inhibitors |
| UY35212A (es) * | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
| NZ720660A (en) * | 2013-12-20 | 2018-01-26 | Gilead Sciences Inc | Apoptosis signal-regulating kinase inhibitors |
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2013
- 2013-12-19 UY UY0001035212A patent/UY35212A/es not_active Application Discontinuation
- 2013-12-20 AU AU2013361140A patent/AU2013361140B2/en active Active
- 2013-12-20 ES ES13818940.2T patent/ES2612979T3/es active Active
- 2013-12-20 RS RS20170126A patent/RS55676B1/sr unknown
- 2013-12-20 LT LTEP13818940.2T patent/LT2935258T/lt unknown
- 2013-12-20 AR ARP130104949A patent/AR094214A1/es unknown
- 2013-12-20 TW TW102147530A patent/TWI622589B/zh active
- 2013-12-20 BR BR112015014567A patent/BR112015014567A2/pt not_active IP Right Cessation
- 2013-12-20 JP JP2015549760A patent/JP6086633B2/ja active Active
- 2013-12-20 EA EA201591018A patent/EA027645B1/ru not_active IP Right Cessation
- 2013-12-20 WO PCT/US2013/076811 patent/WO2014100541A1/en active Application Filing
- 2013-12-20 US US14/135,812 patent/US9051313B2/en active Active
- 2013-12-20 KR KR1020157019179A patent/KR101712758B1/ko active IP Right Grant
- 2013-12-20 EP EP13818940.2A patent/EP2935258B1/en active Active
- 2013-12-20 NZ NZ709248A patent/NZ709248A/en not_active IP Right Cessation
- 2013-12-20 CN CN201380066600.1A patent/CN104918936B/zh active Active
- 2013-12-20 PL PL13818940T patent/PL2935258T3/pl unknown
- 2013-12-20 SI SI201330489A patent/SI2935258T1/sl unknown
- 2013-12-20 MX MX2015008090A patent/MX2015008090A/es unknown
- 2013-12-20 HU HUE13818940A patent/HUE032988T2/hu unknown
- 2013-12-20 CA CA2896060A patent/CA2896060C/en active Active
- 2013-12-20 SG SG11201504865YA patent/SG11201504865YA/en unknown
- 2013-12-20 EP EP16195735.2A patent/EP3150597A1/en not_active Withdrawn
- 2013-12-20 DK DK13818940.2T patent/DK2935258T3/en active
- 2013-12-20 PT PT138189402T patent/PT2935258T/pt unknown
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2015
- 2015-05-13 US US14/711,331 patent/US20150246910A1/en not_active Abandoned
- 2015-06-10 IL IL239322A patent/IL239322A/en not_active IP Right Cessation
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2016
- 2016-02-23 HK HK16102017.7A patent/HK1214247A1/zh unknown
- 2016-09-29 JP JP2016191437A patent/JP2016222721A/ja not_active Withdrawn
- 2016-10-21 AU AU2016247182A patent/AU2016247182B2/en active Active
- 2016-11-21 US US15/357,878 patent/US9943521B2/en active Active
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2017
- 2017-01-24 SM SM201700051T patent/SMT201700051B/it unknown
- 2017-01-24 HR HRP20170112TT patent/HRP20170112T8/hr unknown
- 2017-01-31 CY CY20171100143T patent/CY1118574T1/el unknown
- 2017-11-21 IL IL255799A patent/IL255799B/en not_active IP Right Cessation
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2018
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