AR090456A1 - Combinaciones farmaceuticas que comprenden un analogo de tionucleotidos - Google Patents

Combinaciones farmaceuticas que comprenden un analogo de tionucleotidos

Info

Publication number
AR090456A1
AR090456A1 ARP130100925A ARP130100925A AR090456A1 AR 090456 A1 AR090456 A1 AR 090456A1 AR P130100925 A ARP130100925 A AR P130100925A AR P130100925 A ARP130100925 A AR P130100925A AR 090456 A1 AR090456 A1 AR 090456A1
Authority
AR
Argentina
Prior art keywords
compound
formula
solvate
hydrate
pharmaceutically acceptable
Prior art date
Application number
ARP130100925A
Other languages
English (en)
Original Assignee
Alios Biopharma Inc
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc, Vertex Pharma filed Critical Alios Biopharma Inc
Publication of AR090456A1 publication Critical patent/AR090456A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

Reivindicación 1: Una composición farmacéutica que comprende una cantidad efectiva de lo siguiente: un compuesto de la fórmula (A), o una sal farmacéuticamente aceptable, hidrato o solvato del mismo y dos compuestos diferentes de la fórmula (C), o una sal farmacéuticamente aceptable, hidrato o solvato de lo que antecede. Reivindicación 2: La composición farmacéutica de acuerdo con la reivindicación 1, caracterizada porque el compuesto de la fórmula (A) es el compuesto 1002, o una sal farmacéuticamente aceptable, hidrato o solvato del mismo; en la cual el compuesto de la fórmula (C) es el compuesto 3001 y donde el compuesto de la fórmula (C) es el compuesto 3031. Reivindicación 3: La composición farmacéutica de acuerdo con la reivindicación 1, caracterizada porque el compuesto de la fórmula (A) es el compuesto 1004, o una sal farmacéuticamente aceptable, hidrato o solvato del mismo, en la cual el compuesto de la fórmula (C) es el compuesto 3001 y en la cual el compuesto de la fórmula (C) es el compuesto 3031. Reivindicación 4: Una composición farmacéutica que comprende una cantidad efectiva de lo siguiente: un compuesto de la fórmula (A), o una sal farmacéuticamente aceptable, hidrato o solvato del mismo y un compuesto de la fórmula (C) seleccionado entre 3015, 3016, 3025, 3026, 3027, 3028, 3037, 3038, 3039, 3040, 3041, 3042, 3048, 3049, 3050, 3051, 3052, 3053, 3054, 3057, 3058, 3059, 3060, 3061, 3062, 3063, 3064, 3065 y 3067 o una sal farmacéuticamente aceptable, hidrato o solvato de lo que antecede.
ARP130100925A 2012-03-22 2013-03-21 Combinaciones farmaceuticas que comprenden un analogo de tionucleotidos AR090456A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261614494P 2012-03-22 2012-03-22
US201261613854P 2012-04-19 2012-04-19
US13/797,511 US9012427B2 (en) 2012-03-22 2013-03-12 Pharmaceutical combinations comprising a thionucleotide analog

Publications (1)

Publication Number Publication Date
AR090456A1 true AR090456A1 (es) 2014-11-12

Family

ID=49212364

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130100925A AR090456A1 (es) 2012-03-22 2013-03-21 Combinaciones farmaceuticas que comprenden un analogo de tionucleotidos

Country Status (8)

Country Link
US (1) US9012427B2 (es)
EP (1) EP2827876A4 (es)
AR (1) AR090456A1 (es)
HK (1) HK1203356A1 (es)
NZ (1) NZ630805A (es)
TW (1) TW201343170A (es)
UY (1) UY34698A (es)
WO (1) WO2013142157A1 (es)

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