AR085955A1 - Proteinas de union al antigeno - Google Patents

Proteinas de union al antigeno

Info

Publication number
AR085955A1
AR085955A1 ARP120101214A ARP120101214A AR085955A1 AR 085955 A1 AR085955 A1 AR 085955A1 AR P120101214 A ARP120101214 A AR P120101214A AR P120101214 A ARP120101214 A AR P120101214A AR 085955 A1 AR085955 A1 AR 085955A1
Authority
AR
Argentina
Prior art keywords
antigen binding
binding protein
antibody
egfr
treating
Prior art date
Application number
ARP120101214A
Other languages
English (en)
Inventor
Amy Guo
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AR085955A1 publication Critical patent/AR085955A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

Que interactúan con el Receptor del Factor de Crecimiento Epidérmico (EGFR). Se describen también métodos para tratar distintos tipos de cáncer y otras enfermedades que comprende administrar una cantidad farmacéuticamente eficaz de una proteína de unión al antígeno al EGFR. Se divulga además insectos, célula huésped, composición farmacéutica, y un método para tratar o prevenir cáncer.Reivindicación 1: Una proteína de unión al antígeno caracterizada porque comprende Seq Id Nº 3. Reivindicación 3: La proteína de unión al antígeno de la reivindicación 1, caracterizada porque dicha proteína de unión al antígeno es un anticuerpo humano, un anticuerpo humanizado, un anticuerpo quimérico, un anticuerpo multiespecífico, o fragmento del mismo. Reivindicación 25: Una molécula de ácido nucleico caracterizada porque codifica para la proteína de unión al antígeno de acuerdo a cualquiera de las reivindicaciones 1, 5, 9, 14, ó 19 a 22.
ARP120101214A 2011-04-07 2012-04-09 Proteinas de union al antigeno AR085955A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161473014P 2011-04-07 2011-04-07

Publications (1)

Publication Number Publication Date
AR085955A1 true AR085955A1 (es) 2013-11-06

Family

ID=46168610

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101214A AR085955A1 (es) 2011-04-07 2012-04-09 Proteinas de union al antigeno

Country Status (12)

Country Link
US (1) US8628773B2 (es)
EP (1) EP2694552B1 (es)
JP (1) JP5908972B2 (es)
KR (1) KR102001686B1 (es)
CN (1) CN103619881B (es)
AR (1) AR085955A1 (es)
AU (1) AU2012239997A1 (es)
CA (1) CA2831957A1 (es)
MX (1) MX2013011706A (es)
SG (1) SG194111A1 (es)
TW (1) TW201305213A (es)
WO (1) WO2012138997A1 (es)

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AU2015266664B2 (en) * 2014-05-30 2020-04-30 Shanghai Henlius Biotech, Inc. Anti-epidermal growth factor receptor (EGFR) antibodies
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CN108472382A (zh) * 2015-10-30 2018-08-31 豪夫迈·罗氏有限公司 抗-因子d抗体变体缀合物及其用途
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CN107987161B (zh) * 2016-10-26 2021-04-16 泰州迈博太科药业有限公司 一种抗egfr单克隆抗体制剂
CN110494452B (zh) * 2017-04-03 2023-08-25 豪夫迈·罗氏有限公司 结合steap-1的抗体
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US20240009318A1 (en) * 2020-11-20 2024-01-11 Bliss Biopharmaceutical (Hangzhou) Co., Ltd. Modified egfr antibody with reduced affinity, drug conjugate, and use thereof
WO2022104692A1 (en) * 2020-11-20 2022-05-27 Bliss Biopharmaceutical (Hangzhou) Co., Ltd. Engineered antibody, antibody-drug conjugate, and use thereof
CN114496063B (zh) * 2022-01-13 2023-05-23 北京博康健基因科技有限公司 基于天然氨基酸序列的信号肽设计与二级结构从头算建模方法和装置

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Also Published As

Publication number Publication date
SG194111A1 (en) 2013-11-29
WO2012138997A1 (en) 2012-10-11
EP2694552A1 (en) 2014-02-12
KR102001686B1 (ko) 2019-07-18
CN103619881B (zh) 2017-07-28
MX2013011706A (es) 2014-04-25
AU2012239997A1 (en) 2013-10-17
CA2831957A1 (en) 2012-10-11
JP5908972B2 (ja) 2016-04-26
JP2014516250A (ja) 2014-07-10
CN103619881A (zh) 2014-03-05
KR20140033038A (ko) 2014-03-17
TW201305213A (zh) 2013-02-01
US8628773B2 (en) 2014-01-14
EP2694552B1 (en) 2017-10-11
US20120328511A1 (en) 2012-12-27

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