AR080027A1 - Proteinas de union a cd127 - Google Patents

Proteinas de union a cd127

Info

Publication number
AR080027A1
AR080027A1 ARP110100251A ARP110100251A AR080027A1 AR 080027 A1 AR080027 A1 AR 080027A1 AR P110100251 A ARP110100251 A AR P110100251A AR P110100251 A ARP110100251 A AR P110100251A AR 080027 A1 AR080027 A1 AR 080027A1
Authority
AR
Argentina
Prior art keywords
antigen binding
diseases
receptor
nucleic acid
human
Prior art date
Application number
ARP110100251A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR080027A1 publication Critical patent/AR080027A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporcionan proteínas de union a antígeno que se unen al receptor de IL-7 humano (CD127) y específicamente a la cadena alfa. Las proteínas de union a antígeno típicamente son anticuerpo, y son utiles en el tratamiento de enfermedades o trastornos en seres humanos, particularmente enfermedades autoinmunes tales como la esclerosis multiple. Además un anticuerpo humanizado comprendiendo al menos uno de un resto de lisina en la posicion 66, un resto de leucina en la posicion 69 o una valina en la posicion 71 de la region variable de la cadena pesada. Se proporciona además una molécula de ácido nucleico que codifica la proteína de union a antígeno que se une al receptor de IL-7 humano (CD127), un vector de expresion que comprende el ácido nucleico, una célula huésped recombinante que contiene al vector, una composicion farmacéutica y su uso en el tratamiento de enfermedades autoinmunes o inflamatorias.
ARP110100251A 2010-01-28 2011-01-26 Proteinas de union a cd127 AR080027A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29901010P 2010-01-28 2010-01-28

Publications (1)

Publication Number Publication Date
AR080027A1 true AR080027A1 (es) 2012-03-07

Family

ID=44320081

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100251A AR080027A1 (es) 2010-01-28 2011-01-26 Proteinas de union a cd127

Country Status (25)

Country Link
US (2) US9150653B2 (es)
EP (1) EP2528947A4 (es)
JP (1) JP5850860B2 (es)
KR (1) KR20130028055A (es)
CN (1) CN102812046B (es)
AR (1) AR080027A1 (es)
AU (1) AU2011209713B2 (es)
BR (1) BR112012018914A2 (es)
CA (1) CA2787070A1 (es)
CL (1) CL2012002081A1 (es)
CO (1) CO6592067A2 (es)
CR (1) CR20120404A (es)
EA (1) EA023700B1 (es)
IL (1) IL220899A (es)
MA (1) MA34004B1 (es)
MX (1) MX339083B (es)
MY (1) MY160590A (es)
NZ (1) NZ601271A (es)
PE (2) PE20170687A1 (es)
SG (1) SG182590A1 (es)
TW (1) TWI489996B (es)
UA (1) UA104663C2 (es)
UY (1) UY33202A (es)
WO (1) WO2011094259A2 (es)
ZA (1) ZA201205624B (es)

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US9217040B2 (en) 2011-01-14 2015-12-22 The Regents Of The University Of California Therapeutic antibodies against ROR-1 protein and methods for use of same
EP2583980A1 (en) * 2011-10-19 2013-04-24 Effimune Antibodies directed against the alpha chain of IL7 receptor - their use for the preparation of drug candidates
EP2955196A1 (en) * 2014-06-10 2015-12-16 Effimune Antibodies directed against CD127
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WO2017055966A1 (en) 2015-10-01 2017-04-06 Pfizer Inc. Low viscosity antibody compositions
WO2017120479A1 (en) * 2016-01-07 2017-07-13 The Schepens Eye Research Institute, Inc. Therapeutics for ocular immunoinflammatory diseases
ES2737307T3 (es) 2016-02-29 2020-01-13 Ose Immunotherapeutics Anticuerpos no antagonistas dirigidos contra la cadena alfa del dominio extracelular del receptor de IL7 y uso del mismo en el tratamiento del cáncer
NZ753213A (en) * 2016-12-09 2022-05-27 Ose Immunotherapeutics Antibodies and polypeptides directed against cd127
WO2019136180A2 (en) * 2018-01-04 2019-07-11 Avidity Biosciences Llc Heteroduplex nucleic acid molecules and uses thereof
SG11202107951YA (en) * 2019-01-22 2021-08-30 Bristol Myers Squibb Co Antibodies against il-7r alpha subunit and uses thereof
CN114466864A (zh) 2019-06-21 2022-05-10 索瑞索制药公司 多肽
CN114514243A (zh) 2019-06-21 2022-05-17 索瑞索制药公司 多肽
MX2021015762A (es) 2019-06-21 2022-04-18 Sorriso Pharmaceuticals Inc Composiciones.
CN110894237B (zh) * 2019-12-05 2021-08-03 山东省分析测试中心 抗cd127的抗体、分泌该抗体的细胞株及其制备方法和应用
US20220389104A1 (en) * 2021-05-28 2022-12-08 Ose Immunotherapeutics Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent
WO2023232826A1 (en) 2022-05-30 2023-12-07 Ose Immunotherapeutics Biomarkers of il7r modulator activity
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

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Also Published As

Publication number Publication date
EP2528947A4 (en) 2013-09-18
MA34004B1 (fr) 2013-02-01
US9150653B2 (en) 2015-10-06
SG182590A1 (en) 2012-08-30
CL2012002081A1 (es) 2012-12-14
CN102812046A (zh) 2012-12-05
CA2787070A1 (en) 2011-08-04
BR112012018914A2 (pt) 2017-07-25
MY160590A (en) 2017-03-15
US20110200585A1 (en) 2011-08-18
EP2528947A2 (en) 2012-12-05
AU2011209713A1 (en) 2012-09-13
UY33202A (es) 2011-08-31
US20120282254A1 (en) 2012-11-08
MX2012008765A (es) 2012-09-07
UA104663C2 (en) 2014-02-25
KR20130028055A (ko) 2013-03-18
CN102812046B (zh) 2015-02-25
IL220899A (en) 2017-08-31
WO2011094259A2 (en) 2011-08-04
MX339083B (es) 2016-04-01
TW201136607A (en) 2011-11-01
EA201290589A1 (ru) 2013-05-30
CO6592067A2 (es) 2013-01-02
PE20170687A1 (es) 2017-06-13
PE20121702A1 (es) 2012-12-14
EA023700B1 (ru) 2016-07-29
TWI489996B (zh) 2015-07-01
JP2013517799A (ja) 2013-05-20
NZ601271A (en) 2014-09-26
JP5850860B2 (ja) 2016-02-03
US8940303B2 (en) 2015-01-27
WO2011094259A3 (en) 2011-09-29
AU2011209713B2 (en) 2014-04-03
ZA201205624B (en) 2014-01-29
CR20120404A (es) 2012-10-04
IL220899A0 (en) 2012-09-24

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