CO6592067A2 - Proteinas de elance a cd 127 - Google Patents

Proteinas de elance a cd 127

Info

Publication number
CO6592067A2
CO6592067A2 CO12124175A CO12124175A CO6592067A2 CO 6592067 A2 CO6592067 A2 CO 6592067A2 CO 12124175 A CO12124175 A CO 12124175A CO 12124175 A CO12124175 A CO 12124175A CO 6592067 A2 CO6592067 A2 CO 6592067A2
Authority
CO
Colombia
Prior art keywords
elance
protein
antigen binding
binding proteins
diseases
Prior art date
Application number
CO12124175A
Other languages
English (en)
Inventor
Ian Kirby
Alexander H Taylor
Thomas Webb
Yu Xue
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO6592067A2 publication Critical patent/CO6592067A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporcionan proteínas de enlace a antígeno que se enlazan al receptor de IL-7 humano (CD127). Las proteínas de enlace a antígeno típicamente son anticuerpos, y son útiles en el tratamiento de enfermedades o trastornos en seres humanos, particularmente enfermedades autoinmunes, tales como la esclerosis múltiple.
CO12124175A 2010-01-28 2012-07-24 Proteinas de elance a cd 127 CO6592067A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29901010P 2010-01-28 2010-01-28

Publications (1)

Publication Number Publication Date
CO6592067A2 true CO6592067A2 (es) 2013-01-02

Family

ID=44320081

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12124175A CO6592067A2 (es) 2010-01-28 2012-07-24 Proteinas de elance a cd 127

Country Status (25)

Country Link
US (2) US9150653B2 (es)
EP (1) EP2528947A4 (es)
JP (1) JP5850860B2 (es)
KR (1) KR20130028055A (es)
CN (1) CN102812046B (es)
AR (1) AR080027A1 (es)
AU (1) AU2011209713B2 (es)
BR (1) BR112012018914A2 (es)
CA (1) CA2787070A1 (es)
CL (1) CL2012002081A1 (es)
CO (1) CO6592067A2 (es)
CR (1) CR20120404A (es)
EA (1) EA023700B1 (es)
IL (1) IL220899A (es)
MA (1) MA34004B1 (es)
MX (1) MX339083B (es)
MY (1) MY160590A (es)
NZ (1) NZ601271A (es)
PE (2) PE20170687A1 (es)
SG (1) SG182590A1 (es)
TW (1) TWI489996B (es)
UA (1) UA104663C2 (es)
UY (1) UY33202A (es)
WO (1) WO2011094259A2 (es)
ZA (1) ZA201205624B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3252076B1 (en) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostic use of antibodies against ror-1 protein
EP2583980A1 (en) * 2011-10-19 2013-04-24 Effimune Antibodies directed against the alpha chain of IL7 receptor - their use for the preparation of drug candidates
EP2955196A1 (en) * 2014-06-10 2015-12-16 Effimune Antibodies directed against CD127
EP3207061A1 (en) 2014-10-18 2017-08-23 Pfizer Inc Anti-il-7r antibody compositions
WO2017055966A1 (en) 2015-10-01 2017-04-06 Pfizer Inc. Low viscosity antibody compositions
EP3399999A4 (en) 2016-01-07 2020-03-11 The Schepens Eye Research Institute, Inc. THERAPEUTICS FOR IMMUNE-INFLAMMATORY DISEASES OF THE EYE
BR112018067479A2 (pt) 2016-02-29 2019-01-15 Ose Immunotherapeutics anticorpo, fragmento de ligação ao antígeno de um anticorpo, molécula quimérica, receptor de antígeno quimérico, polinucleotídeo, célula, métodos para preparação de receptor de antígeno quimérico, para fabricação de um anticorpo e para determinação da presença de células cd127+, composição farmacêutica, meio terapêutico de combinação, método de diagnóstico, e, uso de um anticorpo anti-cd127 ou um fragmento de ligação ao antígeno do mesmo
RU2769352C2 (ru) 2016-12-09 2022-03-30 Осе Иммьюнотерапьютикс Антитела и полипептиды, направленные против cd127
EP3735252A4 (en) * 2018-01-04 2021-10-06 Avidity Biosciences, Inc. HETERODUPLEX NUCLEIC ACID MOLECULES AND THEIR USES
BR112021014106A2 (pt) * 2019-01-22 2021-10-13 Bristol-Myers Squibb Company Anticorpos contra subunidade alfa de il-7r e usos dos mesmos
JP2022538083A (ja) 2019-06-21 2022-08-31 ソリッソ ファーマシューティカルズ，インク． ポリペプチド
JP2022537780A (ja) 2019-06-21 2022-08-29 ソリッソ ファーマシューティカルズ，インク． ポリペプチド
WO2020254828A1 (en) 2019-06-21 2020-12-24 Vhsquared Limited Compositions
CN110894237B (zh) * 2019-12-05 2021-08-03 山东省分析测试中心 抗cd127的抗体、分泌该抗体的细胞株及其制备方法和应用
US20220389104A1 (en) * 2021-05-28 2022-12-08 Ose Immunotherapeutics Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent
WO2023232826A1 (en) 2022-05-30 2023-12-07 Ose Immunotherapeutics Biomarkers of il7r modulator activity
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
DE3883899T3 (de) 1987-03-18 1999-04-22 Sb2 Inc Geänderte antikörper.
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US20040049014A1 (en) * 1988-12-28 2004-03-11 Protein Design Labs, Inc. Humanized immunoglobulins
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
CA2033082A1 (en) 1989-06-15 1990-12-16 Linda S. Park Interleukin-7 receptors
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US6800738B1 (en) * 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
ATE181571T1 (de) 1991-09-23 1999-07-15 Medical Res Council Methoden zur herstellung humanisierter antikörper
GB9122820D0 (en) 1991-10-28 1991-12-11 Wellcome Found Stabilised antibodies
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
GB9203459D0 (en) 1992-02-19 1992-04-08 Scotgen Ltd Antibodies with germ-line variable regions
WO1994004690A1 (en) 1992-08-17 1994-03-03 Genentech, Inc. Bispecific immunoadhesins
DK0701571T3 (da) 1993-06-03 1997-09-15 Therapeutic Antibodies Inc Antistoffragmenter til terapi
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5795737A (en) 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
DE69535319T2 (de) * 1994-12-23 2007-07-19 Smithkline Beecham Corp. Rekombinante il-5 antagonisten für die behandlung von il-5 bedingten krankheiten
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
SK150298A3 (en) * 1996-05-04 1999-04-13 Zeneca Ltd Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system
DE69836206T2 (de) 1997-02-07 2007-08-23 Merck & Co., Inc. Synthetische hiv gag gene
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
ATE403154T1 (de) * 1999-04-13 2008-08-15 Wilex Ag Diagnostischer und therapeutischer einsatz von antikörpern gegen den urokinase-rezeptor
AU7950400A (en) 1999-10-19 2001-04-30 Kyowa Hakko Kogyo Co. Ltd. Process for producing polypeptide
WO2002020565A2 (en) 2000-09-08 2002-03-14 Universität Zürich Collections of repeat proteins comprising repeat modules
EP2298809A3 (en) 2001-07-12 2012-02-15 FOOTE, Jefferson Super humanized antibodies
MXPA04001072A (es) 2001-08-03 2005-02-17 Glycart Biotechnology Ag Variantes de glicosilacion de anticuerpos que tienen citotoxicidad celulares dependiente de anticuerpos incrementada.
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
CN101987871A (zh) 2002-09-27 2011-03-23 赞科股份有限公司 优化的Fc变体及其产生方法
WO2004063351A2 (en) 2003-01-09 2004-07-29 Macrogenics, Inc. IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
EP1641818B1 (en) 2003-07-04 2008-12-03 Affibody AB Polypeptides having binding affinity for her2
AU2003275958A1 (en) 2003-08-25 2005-03-10 Pieris Proteolab Ag Muteins of tear lipocalin
EP1711196A4 (en) 2003-12-05 2011-09-14 Bristol Myers Squibb Co INHIBITORS OF TYPE-2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
AU2005269759A1 (en) 2004-07-21 2006-02-09 Glycofi, Inc. Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
WO2006052660A2 (en) * 2004-11-04 2006-05-18 Childrens Hospital Los Angeles Research Institute Il-7 receptor blockade to suppress immunity
JP5386364B2 (ja) 2006-12-18 2014-01-15 ジェネンテック， インコーポレイテッド 抗Ｎｏｔｃｈ３アンタゴニスト抗体とＮｏｔｃｈ３関連疾患の予防及び治療におけるその使用
EP1958957A1 (en) 2007-02-16 2008-08-20 NascaCell Technologies AG Polypeptide comprising a knottin protein moiety
KR20100106590A (ko) 2008-01-22 2010-10-01 바이오겐 아이덱 엠에이 인코포레이티드 Ｒｏｎ 항체 및 이들의 용도
UY32038A (es) 2008-08-08 2010-03-26 Glaxo Wellcome Mfg Pte Ltd Inmunoblobulinas anti-cd127 y sus usos

Also Published As

Publication number Publication date
IL220899A (en) 2017-08-31
AU2011209713B2 (en) 2014-04-03
WO2011094259A2 (en) 2011-08-04
JP5850860B2 (ja) 2016-02-03
MY160590A (en) 2017-03-15
PE20170687A1 (es) 2017-06-13
US20120282254A1 (en) 2012-11-08
ZA201205624B (en) 2014-01-29
AR080027A1 (es) 2012-03-07
US8940303B2 (en) 2015-01-27
BR112012018914A2 (pt) 2017-07-25
MA34004B1 (fr) 2013-02-01
EP2528947A4 (en) 2013-09-18
MX2012008765A (es) 2012-09-07
CL2012002081A1 (es) 2012-12-14
CR20120404A (es) 2012-10-04
SG182590A1 (en) 2012-08-30
TW201136607A (en) 2011-11-01
TWI489996B (zh) 2015-07-01
UA104663C2 (en) 2014-02-25
EA023700B1 (ru) 2016-07-29
UY33202A (es) 2011-08-31
NZ601271A (en) 2014-09-26
AU2011209713A1 (en) 2012-09-13
CN102812046A (zh) 2012-12-05
US9150653B2 (en) 2015-10-06
PE20121702A1 (es) 2012-12-14
US20110200585A1 (en) 2011-08-18
CN102812046B (zh) 2015-02-25
EA201290589A1 (ru) 2013-05-30
CA2787070A1 (en) 2011-08-04
JP2013517799A (ja) 2013-05-20
IL220899A0 (en) 2012-09-24
EP2528947A2 (en) 2012-12-05
KR20130028055A (ko) 2013-03-18
MX339083B (es) 2016-04-01
WO2011094259A3 (en) 2011-09-29

Similar Documents

Publication Publication Date Title
CO6592067A2 (es) Proteinas de elance a cd 127
PH12018501882A1 (en) Binding proteins and methods of use thereof
CY1121327T1 (el) Τροποποιημενα αντισωματα anti-il-23p19
CO6531481A2 (es) Proteinas de enlace al antigeno il-23 humanas
CO6640254A2 (es) Método para preparar anticuerpos con propiedades mejoradas
EA201370081A1 (ru) Антитела к cd48 и их применение
PH12014502527B1 (en) St2 antigen binding proteins
UY34995A (es) Formulaciones de anticuerpo y proteína
UA118332C2 (uk) Білок, що зв'язує антиген cd27l
MX346500B (es) Metodos y composiciones para inmunoterapia para enfermedad neural.
BR112018068678A2 (pt) anticorpos anti-mica
MY150709A (en) Human cytomegalovirus neutralising antibodies and use thereof
CR20110118A (es) Tratamiento de enfermedades autoinmunes e inflamatorias
EA202090031A3 (ru) Человеческие антитела против gfr3 и способы их применения
PH12014501613A1 (en) Anti-asic1 antibodies and uses thereof
CY1123519T1 (el) Ανθρωπινα μονοκλωνικα αντισωματα εξουδετερωσης il-ß
MX344791B (es) Antígeno sustituto en enfermedades autoinmunes.
UY33043A (es) Proteinas de enlace de antigenos anti-orai 1 y usos de las mismas
TH149802A (th) โปรตีนจับเกาะแอนติเจน

Legal Events

Date Code Title Description
FG Application granted