EA201390095A1 - ИННОВАЦИОННОЕ ОТКРЫТИЕ ТЕРАПЕВТИЧЕСКИХ КОМПОЗИЦИЙ, ДИАГНОСТИЧЕСКИХ КОМПОЗИЦИЙ И КОМПОЗИЦИЙ АНТИТЕЛ, СВЯЗАННЫХ С БЕЛКОВЫМИ ФРАГМЕНТАМИ ГИСТИДИЛ-тРНК-СИНТЕТАЗ - Google Patents
ИННОВАЦИОННОЕ ОТКРЫТИЕ ТЕРАПЕВТИЧЕСКИХ КОМПОЗИЦИЙ, ДИАГНОСТИЧЕСКИХ КОМПОЗИЦИЙ И КОМПОЗИЦИЙ АНТИТЕЛ, СВЯЗАННЫХ С БЕЛКОВЫМИ ФРАГМЕНТАМИ ГИСТИДИЛ-тРНК-СИНТЕТАЗInfo
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- EA201390095A1 EA201390095A1 EA201390095A EA201390095A EA201390095A1 EA 201390095 A1 EA201390095 A1 EA 201390095A1 EA 201390095 A EA201390095 A EA 201390095A EA 201390095 A EA201390095 A EA 201390095A EA 201390095 A1 EA201390095 A1 EA 201390095A1
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- Eurasian Patent Office
- Prior art keywords
- compositions
- trna
- synthethes
- hystidyl
- diagnostic
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
- C12Y601/01021—Histidine-tRNA ligase (6.1.1.21)
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- G01—MEASURING; TESTING
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Abstract
Предложены композиции, содержащие новые идентифицированные белковые фрагменты аминоацил-тРНК-синтетаз, полинуклеотиды, которые их кодируют, и соответствующие комплементарные последовательности и родственные агенты, и способы их применения в диагностических целях, в целях поиска лекарственных средств, научно-исследовательских и терапевтических целях.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36358510P | 2010-07-12 | 2010-07-12 | |
US36358110P | 2010-07-12 | 2010-07-12 | |
US36358710P | 2010-07-12 | 2010-07-12 | |
PCT/US2011/043758 WO2012021249A2 (en) | 2010-07-12 | 2011-07-12 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
Publications (2)
Publication Number | Publication Date |
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EA201390095A1 true EA201390095A1 (ru) | 2013-06-28 |
EA030418B1 EA030418B1 (ru) | 2018-08-31 |
Family
ID=45568116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390095A EA030418B1 (ru) | 2010-07-12 | 2011-07-12 | ТЕРАПЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ, ПОЛИПЕПТИД АМИНОАЦИЛ-тРНК-СИНТЕТАЗЫ (AARS) |
Country Status (11)
Country | Link |
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US (5) | US20130202576A1 (ru) |
EP (1) | EP2593126B1 (ru) |
JP (3) | JP6177129B2 (ru) |
KR (2) | KR20180059953A (ru) |
CN (1) | CN103108649B (ru) |
AU (1) | AU2011289833C1 (ru) |
CA (1) | CA2804424C (ru) |
EA (1) | EA030418B1 (ru) |
ES (1) | ES2653718T3 (ru) |
NZ (1) | NZ603813A (ru) |
WO (1) | WO2012021249A2 (ru) |
Families Citing this family (35)
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ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
DK2408905T3 (en) | 2009-03-16 | 2017-08-28 | Pangu Biopharma Ltd | Compositions and Methods comprising Histidyl-tRNA Synthetase Splicing Variants with Non-Canonical Biological Activities |
JP5819314B2 (ja) | 2009-12-11 | 2015-11-24 | エータイアー ファーマ, インコーポレイテッド | 炎症を調節するためのアミノアシルtRNAシンテターゼ |
CN103118692A (zh) | 2010-04-26 | 2013-05-22 | Atyr医药公司 | 与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
AU2011248521B2 (en) | 2010-04-27 | 2017-03-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl tRNA synthetases |
JP6008837B2 (ja) | 2010-04-28 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | アラニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CN103118693B (zh) | 2010-04-29 | 2017-05-03 | Atyr 医药公司 | 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
EP2566495B1 (en) | 2010-05-03 | 2017-03-01 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
CN103108655B (zh) | 2010-05-03 | 2017-04-05 | Atyr 医药公司 | 与丝氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CA2797978C (en) | 2010-05-03 | 2019-12-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
CN103096909A (zh) | 2010-05-04 | 2013-05-08 | Atyr医药公司 | 与谷氨酰-脯氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
JP6396656B2 (ja) | 2010-05-14 | 2018-09-26 | エータイアー ファーマ, インコーポレイテッド | フェニルアラニルβtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
WO2011146410A2 (en) | 2010-05-17 | 2011-11-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
AU2011258106B2 (en) | 2010-05-27 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
EP2575857B1 (en) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
EA030418B1 (ru) | 2010-07-12 | 2018-08-31 | ЭйТИР ФАРМА, ИНК. | ТЕРАПЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ, ПОЛИПЕПТИД АМИНОАЦИЛ-тРНК-СИНТЕТАЗЫ (AARS) |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
CN103118695B (zh) | 2010-07-12 | 2016-08-03 | Atyr医药公司 | 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
WO2012009289A2 (en) | 2010-07-12 | 2012-01-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
AU2011293294B2 (en) | 2010-08-25 | 2016-03-24 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases |
ES2645019T3 (es) | 2010-10-06 | 2017-12-01 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de triptofanil-ARNt sintetasas |
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AU2011289833A1 (en) | 2013-02-21 |
CN103108649B (zh) | 2016-10-12 |
AU2011289833C1 (en) | 2017-06-15 |
CA2804424C (en) | 2021-03-30 |
KR20180059953A (ko) | 2018-06-05 |
CN103108649A (zh) | 2013-05-15 |
US20150344866A1 (en) | 2015-12-03 |
EA030418B1 (ru) | 2018-08-31 |
US10669533B2 (en) | 2020-06-02 |
WO2012021249A3 (en) | 2012-04-26 |
WO2012021249A2 (en) | 2012-02-16 |
CA2804424A1 (en) | 2012-02-16 |
US20170321206A1 (en) | 2017-11-09 |
EP2593126A4 (en) | 2014-08-06 |
JP6177129B2 (ja) | 2017-08-09 |
US20130202576A1 (en) | 2013-08-08 |
KR20130102534A (ko) | 2013-09-17 |
JP2013533750A (ja) | 2013-08-29 |
US9637730B2 (en) | 2017-05-02 |
JP2017201993A (ja) | 2017-11-16 |
EP2593126A2 (en) | 2013-05-22 |
US9422539B2 (en) | 2016-08-23 |
NZ603813A (en) | 2015-03-27 |
US20170029800A1 (en) | 2017-02-02 |
JP2015227379A (ja) | 2015-12-17 |
ES2653718T3 (es) | 2018-02-08 |
AU2011289833B2 (en) | 2017-02-02 |
EP2593126B1 (en) | 2017-09-20 |
US20190264190A1 (en) | 2019-08-29 |
US10196628B2 (en) | 2019-02-05 |
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