AR077396A2 - EXPRESIoN OPTIMIZADA DE LA PROTEíNA DE LA CÁPSIDE L1 DEL VIRUS DE PAPILOMA HUMANO VPH45 EN LEVADURAS - Google Patents

EXPRESIoN OPTIMIZADA DE LA PROTEíNA DE LA CÁPSIDE L1 DEL VIRUS DE PAPILOMA HUMANO VPH45 EN LEVADURAS

Info

Publication number
AR077396A2
AR077396A2 ARP100102440A ARP100102440A AR077396A2 AR 077396 A2 AR077396 A2 AR 077396A2 AR P100102440 A ARP100102440 A AR P100102440A AR P100102440 A ARP100102440 A AR P100102440A AR 077396 A2 AR077396 A2 AR 077396A2
Authority
AR
Argentina
Prior art keywords
hpv45
protein
produce
vph45
leaves
Prior art date
Application number
ARP100102440A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR077396A2 publication Critical patent/AR077396A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan moléculas sintéticas de ADN que codifican la proteína L1 del VPH45. De manera específica, la presente proporciona polinucleotidos que codifican la proteína L1 del VPH45, en la que dichos polinucleotidos se han optimizado para los codones para un nivel elevado de expresion en una célula de levadura. Las moléculas sintéticas se pueden usar para producir partículas pseudovíricas (VLP) del VPH45, y para producir vacunas y composiciones farmacéuticas que comprenden las VLP del VPH45. Las vacunas de la presente solicitud proporcionan una inmunoprofilaxis eficaz frente a la infeccion por el virus del papiloma mediante anticuerpos neutralizantes e inmunidad celular. Vector y célula huésped que comprenden las moléculas de ADN. Procedimiento para producir las VLP.
ARP100102440A 2003-09-29 2010-07-07 EXPRESIoN OPTIMIZADA DE LA PROTEíNA DE LA CÁPSIDE L1 DEL VIRUS DE PAPILOMA HUMANO VPH45 EN LEVADURAS AR077396A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29

Publications (1)

Publication Number Publication Date
AR077396A2 true AR077396A2 (es) 2011-08-24

Family

ID=34421558

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP040103420A AR045804A1 (es) 2003-09-29 2004-09-22 Expresion optimizada de l1 del vph45 en levaduras
ARP100102440A AR077396A2 (es) 2003-09-29 2010-07-07 EXPRESIoN OPTIMIZADA DE LA PROTEíNA DE LA CÁPSIDE L1 DEL VIRUS DE PAPILOMA HUMANO VPH45 EN LEVADURAS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP040103420A AR045804A1 (es) 2003-09-29 2004-09-22 Expresion optimizada de l1 del vph45 en levaduras

Country Status (33)

Country Link
US (2) US7250170B2 (es)
EP (1) EP1673106B1 (es)
JP (4) JP5451960B2 (es)
KR (1) KR101165278B1 (es)
CN (1) CN1859923B (es)
AR (2) AR045804A1 (es)
AT (1) ATE435029T1 (es)
AU (1) AU2004277934B2 (es)
BE (1) BE2015C072I2 (es)
BR (1) BRPI0414845B8 (es)
CA (1) CA2539168C (es)
CY (2) CY1110525T1 (es)
DE (1) DE602004021828D1 (es)
DK (1) DK1673106T3 (es)
ES (1) ES2327530T3 (es)
FR (1) FR15C0083I2 (es)
HU (1) HUS1500063I1 (es)
IL (1) IL174458A (es)
IS (1) IS2694B (es)
LT (2) LTPA2015049I1 (es)
LU (1) LU92902I2 (es)
MX (1) MXPA06003457A (es)
MY (1) MY140664A (es)
NL (1) NL300776I1 (es)
NO (2) NO339932B1 (es)
NZ (1) NZ545834A (es)
PL (1) PL1673106T3 (es)
PT (1) PT1673106E (es)
RU (1) RU2360001C2 (es)
SI (1) SI1673106T1 (es)
TW (1) TWI350853B (es)
WO (1) WO2005032586A1 (es)
ZA (1) ZA200601961B (es)

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MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
PL1730175T3 (pl) 2004-03-24 2010-09-30 Merck Sharp & Dohme Optymalizowana ekspresja L1 HPV 52 w drożdżach
US7758866B2 (en) 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
AU2006236905B2 (en) 2005-04-15 2010-06-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
CA2606092A1 (en) * 2005-04-26 2006-11-02 Glaxosmithkline Biologicals S.A. Vaccine
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JP2010520874A (ja) * 2007-03-09 2010-06-17 メルク・シャープ・エンド・ドーム・コーポレイション パピローマウイルスワクチン組成物
RU2494106C2 (ru) 2007-11-23 2013-09-27 Шанхай Зеран Биотекнолоджи Ко., Лтд. Гены, кодирующие главный капсидный белок l1 вируса папилломы человека, и их применение
WO2010147268A1 (ko) 2009-06-19 2010-12-23 아이진 주식회사 자궁경부암 백신
AU2011258501B2 (en) 2010-05-25 2016-07-07 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
CN103717741B (zh) * 2011-06-15 2016-04-13 中央大学校产学协力团 用于提高人***瘤病毒l1蛋白产量的方法
EP2723371B1 (en) 2011-06-24 2019-10-23 Merck Sharp & Dohme Corp. Hpv vaccine formulations comprising aluminum adjuvant and methods of producing same
CN103215302B (zh) * 2012-01-21 2019-01-15 北京安百胜生物科技有限公司 用汉逊酵母表达***产生hpv18 l1蛋白的方法
CN108624614A (zh) * 2012-03-28 2018-10-09 北京安百胜生物科技有限公司 用汉逊酵母表达***产生hpv11 l1蛋白的方法
CN110423774A (zh) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 用汉逊酵母表达***产生hpv58 l1蛋白的方法
CN104120089B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达***产生hpv52 l1蛋白的方法
CN110295190A (zh) * 2013-05-17 2019-10-01 北京安百胜生物科技有限公司 用汉逊酵母表达***产生hpv45 l1蛋白的方法
CN112280792B (zh) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 人***瘤病毒基因，及载体，菌株，表达方法
US9782470B2 (en) 2013-10-16 2017-10-10 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
CA2958222A1 (en) * 2014-09-11 2016-03-17 Cadila Healthcare Limited Superior human papilloma virus antigens with superior immunological properties and vaccine containing it
CN106282278B (zh) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 一种人***瘤病毒l1蛋白的发酵方法
CN106701798B (zh) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 45型重组人***瘤病毒病毒样颗粒及其制备方法
CN109750050B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人***瘤病毒45亚型蛋白表达
MX2022009964A (es) 2020-02-14 2022-09-19 Merck Sharp & Dohme Llc Vacuna contra hpv.
CN112680462B (zh) * 2020-12-29 2022-02-22 上海博唯生物科技有限公司 一种人***瘤病毒35型/hpv35型l1/l2及其制备与应用
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
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WO2023023152A1 (en) 2021-08-19 2023-02-23 Merck Sharp & Dohme Llc Thermostable lipid nanoparticle and methods of use thereof

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Also Published As

Publication number Publication date
LTPA2015049I1 (lt) 2016-01-11
BE2015C072I2 (es) 2023-12-14
BRPI0414845B1 (pt) 2020-10-13
EP1673106B1 (en) 2009-07-01
NL300776I2 (es) 2015-12-29
DK1673106T3 (da) 2009-11-09
US20080138361A1 (en) 2008-06-12
AU2004277934B2 (en) 2009-09-17
WO2005032586A1 (en) 2005-04-14
TWI350853B (en) 2011-10-21
CA2539168C (en) 2011-05-31
RU2360001C2 (ru) 2009-06-27
CN1859923A (zh) 2006-11-08
BRPI0414845A (pt) 2006-11-21
US7482015B2 (en) 2009-01-27
NO20061876L (no) 2006-04-28
CY2015050I2 (el) 2016-06-22
US7250170B2 (en) 2007-07-31
IS2694B (is) 2010-11-15
MY140664A (en) 2010-01-15
NO2017012I1 (no) 2017-04-05
IS8362A (is) 2006-03-20
ZA200601961B (en) 2007-05-30
CA2539168A1 (en) 2005-04-14
JP2007507207A (ja) 2007-03-29
NO339932B1 (no) 2017-02-20
JP2016136947A (ja) 2016-08-04
AR045804A1 (es) 2005-11-16
TW200521233A (en) 2005-07-01
PL1673106T3 (pl) 2009-12-31
NL300776I1 (es) 2015-12-29
ATE435029T1 (de) 2009-07-15
ES2327530T3 (es) 2009-10-30
IL174458A0 (en) 2006-08-01
CY1110525T1 (el) 2015-04-29
JP2011152137A (ja) 2011-08-11
MXPA06003457A (es) 2006-06-05
JP2014221052A (ja) 2014-11-27
RU2006114701A (ru) 2007-11-10
JP5451960B2 (ja) 2014-03-26
KR20070029628A (ko) 2007-03-14
LTC1673106I2 (lt) 2017-05-10
KR101165278B1 (ko) 2012-07-23
CY2015050I1 (el) 2016-06-22
CN1859923B (zh) 2012-09-05
AU2004277934A1 (en) 2005-04-14
NZ545834A (en) 2009-02-28
US20060240040A1 (en) 2006-10-26
FR15C0083I2 (fr) 2016-11-25
SI1673106T1 (sl) 2009-12-31
IL174458A (en) 2014-06-30
PT1673106E (pt) 2009-09-22
EP1673106A1 (en) 2006-06-28
DE602004021828D1 (de) 2009-08-13
HUS1500063I1 (hu) 2016-02-29
FR15C0083I1 (fr) 2016-08-01
LU92902I2 (fr) 2016-03-08
BRPI0414845B8 (pt) 2021-06-15

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