AR077111A1 - Proteinas biespecificas tetravalentes de union a antigeno - Google Patents

Proteinas biespecificas tetravalentes de union a antigeno

Info

Publication number
AR077111A1
AR077111A1 ARP100102127A ARP100102127A AR077111A1 AR 077111 A1 AR077111 A1 AR 077111A1 AR P100102127 A ARP100102127 A AR P100102127A AR P100102127 A ARP100102127 A AR P100102127A AR 077111 A1 AR077111 A1 AR 077111A1
Authority
AR
Argentina
Prior art keywords
antibody
antigen
domain
heavy chain
terminal end
Prior art date
Application number
ARP100102127A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR077111A1 publication Critical patent/AR077111A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Proteínas biespecíficas tetravalente de union a antígeno, métodos para la produccion de las mismas, composiciones farmacéuticas que contienen dichos anticuerpos y usos de las mismas. Reivindicacion 1: Proteína biespecífica tetravalente de union a antígeno, que comprende a) cadena pesada modificada de un primer anticuerpo, que se une específicamente a un primer antígeno, y al que se fusiona el extremo C-terminal de dicha cadena pesada, adicionalmente los dominios VH-CH1 de dicho primer anticuerpo, mediante su extremo N-terminal, b) dos cadenas ligeras de dicho primer anticuerpo en a), c) una cadena pesada modificada de un segundo anticuerpo, que se une específicamente a un segundo antígeno, en el que el dominio CH1 se sustituye por el dominio CL de dicho segundo anticuerpo y al que se fusiona el extremo C-terminal de dicha cadena pesada, adicionalmente los dominios VH-CL de dicho segundo anticuerpo, mediante su extremo N-terminal, y d) dos cadenas ligeras modificadas de dicho segundo anticuerpo en c), en el que el dominio CL se sustituye por el dominio CH1 de dicho segundo anticuerpo.
ARP100102127A 2009-06-18 2010-06-16 Proteinas biespecificas tetravalentes de union a antigeno AR077111A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09007966 2009-06-18

Publications (1)

Publication Number Publication Date
AR077111A1 true AR077111A1 (es) 2011-08-03

Family

ID=41168686

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102127A AR077111A1 (es) 2009-06-18 2010-06-16 Proteinas biespecificas tetravalentes de union a antigeno

Country Status (20)

Country Link
US (2) US8703132B2 (es)
EP (1) EP2443153B1 (es)
JP (1) JP5689118B2 (es)
KR (1) KR101431344B1 (es)
CN (1) CN102803295B (es)
AR (1) AR077111A1 (es)
AU (1) AU2010262130A1 (es)
BR (1) BRPI1010109A2 (es)
CA (1) CA2764393C (es)
CL (1) CL2011003149A1 (es)
ES (1) ES2442917T3 (es)
HK (1) HK1174645A1 (es)
IL (1) IL216620A0 (es)
MX (1) MX2011013616A (es)
PE (1) PE20120414A1 (es)
RU (1) RU2604189C2 (es)
SG (1) SG177272A1 (es)
TW (1) TW201111394A (es)
WO (1) WO2010145793A1 (es)
ZA (1) ZA201108922B (es)

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