AR076875A1 - Anticuerpo contra receptor de la tirosina quinasa (anti-axl) - Google Patents
Anticuerpo contra receptor de la tirosina quinasa (anti-axl)Info
- Publication number
- AR076875A1 AR076875A1 ARP100101702A ARP100101702A AR076875A1 AR 076875 A1 AR076875 A1 AR 076875A1 AR P100101702 A ARP100101702 A AR P100101702A AR P100101702 A ARP100101702 A AR P100101702A AR 076875 A1 AR076875 A1 AR 076875A1
- Authority
- AR
- Argentina
- Prior art keywords
- axl
- antibodies
- typeosin
- antibody against
- agents
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un objetivo de la presente es disminuir la inmunogenicidad de los anticuerpos anti-AXL derivados de raton en los seres humanos por medio de la humanizacion de dichos anticuerpos. En la presente se proveen anticuerpos que se unen a una region específica en Anexelekto (AXL) y anticuerpos humanizados que se producen sobre la base de dichos anticuerpos. Los anticuerpos anti-AXL de la presente solicitud presentan una actividad antitumoral elevada y son utiles como agentes para disminuir el nivel de expresion de AXL, como agentes antitumorales y como agentes de diagnostico para el cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009118725 | 2009-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR076875A1 true AR076875A1 (es) | 2011-07-13 |
Family
ID=43085106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101702A AR076875A1 (es) | 2009-05-15 | 2010-05-14 | Anticuerpo contra receptor de la tirosina quinasa (anti-axl) |
Country Status (22)
Country | Link |
---|---|
US (1) | US9340615B2 (es) |
EP (1) | EP2431393B1 (es) |
JP (1) | JP5669732B2 (es) |
KR (1) | KR20120024763A (es) |
CN (1) | CN102459344A (es) |
AR (1) | AR076875A1 (es) |
AU (1) | AU2010248365A1 (es) |
BR (1) | BRPI1011145A2 (es) |
CA (1) | CA2761891A1 (es) |
CL (1) | CL2011002877A1 (es) |
CO (1) | CO6460749A2 (es) |
CR (1) | CR20110646A (es) |
EC (1) | ECSP11011538A (es) |
IL (1) | IL216097A0 (es) |
MA (1) | MA33405B1 (es) |
MX (1) | MX2011012136A (es) |
PE (1) | PE20120562A1 (es) |
RU (1) | RU2011151069A (es) |
SG (1) | SG176074A1 (es) |
TW (1) | TW201041595A (es) |
WO (1) | WO2010131733A1 (es) |
ZA (1) | ZA201108526B (es) |
Families Citing this family (56)
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EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
PL2202245T3 (pl) | 2007-09-26 | 2017-02-28 | Chugai Seiyaku Kabushiki Kaisha | Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr |
SG193868A1 (en) | 2007-09-26 | 2013-10-30 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
AU2008321835B2 (en) * | 2007-11-15 | 2014-11-20 | Chugai Seiyaku Kabushiki Kaisha | Monoclonal antibody capable of binding to anexelekto, and use thereof |
ES2563483T3 (es) | 2008-04-11 | 2016-03-15 | Chugai Seiyaku Kabushiki Kaisha | Molécula de unión a antígeno capaz de unirse repetidamente a dos o más moléculas de antígeno |
EP2826789A1 (en) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
US20140234340A1 (en) | 2010-11-30 | 2014-08-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
ES2677367T3 (es) * | 2011-06-22 | 2018-08-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticuerpos anti-Axl y usos de los mismos |
KR20140104944A (ko) * | 2011-06-22 | 2014-08-29 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 항-axl 항체 및 그의 용도 |
WO2013033008A2 (en) | 2011-08-26 | 2013-03-07 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
KR102398736B1 (ko) | 2011-10-31 | 2022-05-16 | 추가이 세이야쿠 가부시키가이샤 | 중쇄와 경쇄의 회합이 제어된 항원 결합 분자 |
US9717803B2 (en) * | 2011-12-23 | 2017-08-01 | Innate Pharma | Enzymatic conjugation of polypeptides |
US10132799B2 (en) | 2012-07-13 | 2018-11-20 | Innate Pharma | Screening of conjugated antibodies |
CA2882272C (en) | 2012-08-24 | 2023-08-29 | Chugai Seiyaku Kabushiki Kaisha | Fc.gamma.riib-specific fc region variant |
WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
BR112015010046B1 (pt) * | 2012-11-05 | 2023-05-02 | Pierre Fabre Medicament | Proteínas de ligação a antígeno ou um fragmento de ligação a antígeno da mesma e seu método de produção, vetor, célula hospedeira de microrganismo transgênico, imunoconjugado e seu uso, composição farmacêutica e hibridoma murino |
WO2014072482A1 (en) | 2012-11-09 | 2014-05-15 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
TW201444872A (zh) | 2013-03-06 | 2014-12-01 | Merrimack Pharmaceuticals Inc | 抗C-MET串聯Fc雙特異性抗體 |
WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
EP2982689B1 (en) | 2013-04-02 | 2020-08-26 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
WO2014202773A1 (en) | 2013-06-20 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
JP6744212B2 (ja) | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | ポリペプチドの酵素的結合 |
CN104341505A (zh) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | 对蒙古人种和高加索人种低免疫原性的、抗egfr的人鼠嵌合抗体 |
TWI522099B (zh) * | 2014-06-04 | 2016-02-21 | 中國醫藥大學 | 治療胰臟癌之醫藥配方及其應用 |
GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
GB201410825D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
AU2015286569B2 (en) * | 2014-07-11 | 2021-04-15 | Genmab A/S | Antibodies binding AXL |
JP6864953B2 (ja) * | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Axlに対するヒトモノクローナル抗体 |
SG11201700841QA (en) * | 2014-12-19 | 2017-03-30 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
CN107108729A (zh) | 2015-02-05 | 2017-08-29 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il‑8‑结合抗体,及其应用 |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
DK3319993T3 (da) | 2015-07-10 | 2020-04-20 | Genmab As | AXL-SPECIFIKKE antistof-lægemiddelkonjugater til kræftbehandling |
JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
BR112018014277A2 (pt) | 2016-01-13 | 2018-12-18 | Genmab As | formulação, e, método de preparação de uma solução injetável de um axl-adc |
GB201610902D0 (en) | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
CA3026050A1 (en) | 2016-08-05 | 2018-02-08 | Chugai Seiyaku Kabushiki Kaisha | Composition for prophylaxis or treatment of il-8 related diseases |
KR101909955B1 (ko) * | 2016-11-28 | 2018-10-19 | 재단법인 목암생명과학연구소 | 신규 항-에이엑스엘 항체 및 이를 포함하는 약학적 조성물 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
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US20210070869A1 (en) | 2018-04-10 | 2021-03-11 | Genmab A/S | Axl-specific antibodies for cancer treatment |
CN110483639A (zh) * | 2018-05-15 | 2019-11-22 | 复旦大学 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
CN110540592B (zh) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | 结合axl蛋白的抗体及其应用 |
CN109160941B (zh) * | 2018-09-29 | 2020-09-04 | 未名生物医药有限公司 | 蛋白序列17e11及其用途 |
WO2020138487A1 (ja) * | 2018-12-28 | 2020-07-02 | 協和キリン株式会社 | TfRに結合するバイスペシフィック抗体 |
WO2020205576A1 (en) * | 2019-03-29 | 2020-10-08 | Celldex Therapeutics, Inc. | Anti-axl antibodies and methods of use thereof |
US20220273809A1 (en) | 2019-07-19 | 2022-09-01 | Genmab A/S | Axl antibody-drug conjugates for use in treating cancer |
GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
WO2021154156A1 (en) * | 2020-01-31 | 2021-08-05 | Agency For Science, Technology And Research | Anti-axl antibody and uses thereof |
GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
MX2022012576A (es) | 2020-04-08 | 2023-01-19 | Bergenbio Asa | Inhibidores de axl para terapia antiviral. |
GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
IL289525B2 (en) * | 2021-12-30 | 2023-03-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Conjugated antibodies for cancer treatment |
CN117924510B (zh) * | 2024-03-21 | 2024-06-04 | 北京星基贝勤生物科技有限公司 | 靶向egfr和axl的双特异性抗体及其药物偶联物与应用 |
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-
2010
- 2010-05-14 WO PCT/JP2010/058166 patent/WO2010131733A1/ja active Application Filing
- 2010-05-14 EP EP10774990.5A patent/EP2431393B1/en active Active
- 2010-05-14 RU RU2011151069/02A patent/RU2011151069A/ru not_active Application Discontinuation
- 2010-05-14 MA MA34445A patent/MA33405B1/fr unknown
- 2010-05-14 AU AU2010248365A patent/AU2010248365A1/en not_active Abandoned
- 2010-05-14 CN CN2010800324176A patent/CN102459344A/zh not_active Withdrawn
- 2010-05-14 AR ARP100101702A patent/AR076875A1/es unknown
- 2010-05-14 SG SG2011084050A patent/SG176074A1/en unknown
- 2010-05-14 CA CA2761891A patent/CA2761891A1/en not_active Abandoned
- 2010-05-14 TW TW099115414A patent/TW201041595A/zh unknown
- 2010-05-14 KR KR1020117029774A patent/KR20120024763A/ko not_active Application Discontinuation
- 2010-05-14 US US13/320,317 patent/US9340615B2/en active Active
- 2010-05-14 JP JP2011513382A patent/JP5669732B2/ja active Active
- 2010-05-14 MX MX2011012136A patent/MX2011012136A/es unknown
- 2010-05-14 PE PE2011001964A patent/PE20120562A1/es not_active Application Discontinuation
- 2010-05-14 BR BRPI1011145A patent/BRPI1011145A2/pt not_active Application Discontinuation
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2011
- 2011-11-02 IL IL216097A patent/IL216097A0/en unknown
- 2011-11-11 CO CO11153892A patent/CO6460749A2/es unknown
- 2011-11-15 CL CL2011002877A patent/CL2011002877A1/es unknown
- 2011-11-21 ZA ZA2011/08526A patent/ZA201108526B/en unknown
- 2011-12-02 CR CR20110646A patent/CR20110646A/es not_active Application Discontinuation
- 2011-12-15 EC ECSP11011538 patent/ECSP11011538A/es unknown
Also Published As
Publication number | Publication date |
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JPWO2010131733A1 (ja) | 2012-11-08 |
BRPI1011145A2 (pt) | 2016-03-15 |
MA33405B1 (fr) | 2012-07-03 |
PE20120562A1 (es) | 2012-06-06 |
EP2431393A1 (en) | 2012-03-21 |
CL2011002877A1 (es) | 2012-05-25 |
MX2011012136A (es) | 2012-04-10 |
KR20120024763A (ko) | 2012-03-14 |
CA2761891A1 (en) | 2010-11-18 |
IL216097A0 (en) | 2012-01-31 |
US9340615B2 (en) | 2016-05-17 |
CO6460749A2 (es) | 2012-06-15 |
WO2010131733A9 (ja) | 2012-01-19 |
SG176074A1 (en) | 2011-12-29 |
TW201041595A (en) | 2010-12-01 |
CR20110646A (es) | 2012-02-09 |
EP2431393B1 (en) | 2018-05-02 |
ECSP11011538A (es) | 2012-03-30 |
ZA201108526B (en) | 2012-11-28 |
JP5669732B2 (ja) | 2015-02-12 |
EP2431393A4 (en) | 2013-07-17 |
RU2011151069A (ru) | 2013-06-20 |
WO2010131733A1 (ja) | 2010-11-18 |
US20120121587A1 (en) | 2012-05-17 |
AU2010248365A1 (en) | 2011-12-22 |
CN102459344A (zh) | 2012-05-16 |
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