AR076875A1 - Anticuerpo contra receptor de la tirosina quinasa (anti-axl) - Google Patents

Anticuerpo contra receptor de la tirosina quinasa (anti-axl)

Info

Publication number
AR076875A1
AR076875A1 ARP100101702A ARP100101702A AR076875A1 AR 076875 A1 AR076875 A1 AR 076875A1 AR P100101702 A ARP100101702 A AR P100101702A AR P100101702 A ARP100101702 A AR P100101702A AR 076875 A1 AR076875 A1 AR 076875A1
Authority
AR
Argentina
Prior art keywords
axl
antibodies
typeosin
antibody against
agents
Prior art date
Application number
ARP100101702A
Other languages
English (en)
Inventor
Tatsuhiko Tachibana
Hirotake Shiraiwa
Atsushi Matsuo
Hajime Miyamoto
Hiroyuki Tsunoda
Tomoyuki Igawa
Taichi Kuramochi
Atsuhiki Maeda
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR076875A1 publication Critical patent/AR076875A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un objetivo de la presente es disminuir la inmunogenicidad de los anticuerpos anti-AXL derivados de raton en los seres humanos por medio de la humanizacion de dichos anticuerpos. En la presente se proveen anticuerpos que se unen a una region específica en Anexelekto (AXL) y anticuerpos humanizados que se producen sobre la base de dichos anticuerpos. Los anticuerpos anti-AXL de la presente solicitud presentan una actividad antitumoral elevada y son utiles como agentes para disminuir el nivel de expresion de AXL, como agentes antitumorales y como agentes de diagnostico para el cáncer.
ARP100101702A 2009-05-15 2010-05-14 Anticuerpo contra receptor de la tirosina quinasa (anti-axl) AR076875A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009118725 2009-05-15

Publications (1)

Publication Number Publication Date
AR076875A1 true AR076875A1 (es) 2011-07-13

Family

ID=43085106

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101702A AR076875A1 (es) 2009-05-15 2010-05-14 Anticuerpo contra receptor de la tirosina quinasa (anti-axl)

Country Status (22)

Country Link
US (1) US9340615B2 (es)
EP (1) EP2431393B1 (es)
JP (1) JP5669732B2 (es)
KR (1) KR20120024763A (es)
CN (1) CN102459344A (es)
AR (1) AR076875A1 (es)
AU (1) AU2010248365A1 (es)
BR (1) BRPI1011145A2 (es)
CA (1) CA2761891A1 (es)
CL (1) CL2011002877A1 (es)
CO (1) CO6460749A2 (es)
CR (1) CR20110646A (es)
EC (1) ECSP11011538A (es)
IL (1) IL216097A0 (es)
MA (1) MA33405B1 (es)
MX (1) MX2011012136A (es)
PE (1) PE20120562A1 (es)
RU (1) RU2011151069A (es)
SG (1) SG176074A1 (es)
TW (1) TW201041595A (es)
WO (1) WO2010131733A1 (es)
ZA (1) ZA201108526B (es)

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EP2431393A1 (en) 2012-03-21
CL2011002877A1 (es) 2012-05-25
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RU2011151069A (ru) 2013-06-20
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