AR072807A1 - Formas solidas del compuestos (2r,3r,4r,5s,6r)-2-(4-cloro-3-etoxibencil)fenil)6-(metiltio)tetahidro-2h-piran-3,4,5-triol y metodos para su uso como inhibidor del cotransportador 2 de sodio-glucosa (sglt2) - Google Patents

Formas solidas del compuestos (2r,3r,4r,5s,6r)-2-(4-cloro-3-etoxibencil)fenil)6-(metiltio)tetahidro-2h-piran-3,4,5-triol y metodos para su uso como inhibidor del cotransportador 2 de sodio-glucosa (sglt2)

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Publication number
AR072807A1
AR072807A1 ARP090102685A ARP090102685A AR072807A1 AR 072807 A1 AR072807 A1 AR 072807A1 AR P090102685 A ARP090102685 A AR P090102685A AR P090102685 A ARP090102685 A AR P090102685A AR 072807 A1 AR072807 A1 AR 072807A1
Authority
AR
Argentina
Prior art keywords
triol
chloro
phenyl
etoxibencil
tetahydro
Prior art date
Application number
ARP090102685A
Other languages
English (en)
Inventor
Anett Perlberg
Matthew Mangzhu Zhao
Paul Susan Margaret De
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of AR072807A1 publication Critical patent/AR072807A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion 1: (2S,3R,4R,5S,6R)-2-(4-cloro-3-(4-etoxibencil)fenil)-6-(metiltio) tetrahidro-2H-piran-3,4,5-triol amorfo anhidro. Reivindicacion 2: Un compuesto cristalino, el cual es el (2S,3R,4R,5S,6R)-2-(4-cloro-3-(4-etoxibencil)fenil)-6-(metiltio)tetrahidro-2H-piran-3,4,5-triol anhidro. Reivindicacion 3: El compuesto cristalino de la reivindicacion 2, el cual posee una endoterma de DSC a alrededor de 124°C. Reivindicacion 4: El compuesto cristalino de la reivindicacion 2, que posee un patron de difraccion de rayos X de polvo con picos en uno o más de alrededor de 4,0, 8,1, 9,8, 14,0 y/o 19,3 grados 2 theta. Reivindicacion 5: El compuesto cristalino de la reivindicacion 4, que posee un patron de difraccion de rayos X de polvo con un pico en alrededor de 14.0 grados 2 theta.
ARP090102685A 2008-07-17 2009-07-15 Formas solidas del compuestos (2r,3r,4r,5s,6r)-2-(4-cloro-3-etoxibencil)fenil)6-(metiltio)tetahidro-2h-piran-3,4,5-triol y metodos para su uso como inhibidor del cotransportador 2 de sodio-glucosa (sglt2) AR072807A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8142308P 2008-07-17 2008-07-17

Publications (1)

Publication Number Publication Date
AR072807A1 true AR072807A1 (es) 2010-09-22

Family

ID=41137707

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102685A AR072807A1 (es) 2008-07-17 2009-07-15 Formas solidas del compuestos (2r,3r,4r,5s,6r)-2-(4-cloro-3-etoxibencil)fenil)6-(metiltio)tetahidro-2h-piran-3,4,5-triol y metodos para su uso como inhibidor del cotransportador 2 de sodio-glucosa (sglt2)

Country Status (29)

Country Link
US (2) US8217156B2 (es)
EP (1) EP2332947B1 (es)
JP (2) JP2011528366A (es)
KR (2) KR101707246B1 (es)
CN (2) CN102112483A (es)
AR (1) AR072807A1 (es)
AU (1) AU2009270973B2 (es)
BR (1) BRPI0916191A2 (es)
CA (1) CA2730931A1 (es)
CL (1) CL2009001595A1 (es)
CO (1) CO6351797A2 (es)
DK (1) DK2332947T3 (es)
ES (1) ES2656357T3 (es)
HK (1) HK1243713A1 (es)
HU (1) HUE035400T2 (es)
IL (1) IL210269A (es)
MX (1) MX2011000503A (es)
NO (1) NO2332947T3 (es)
NZ (1) NZ590184A (es)
PE (1) PE20100260A1 (es)
PL (1) PL2332947T3 (es)
PT (1) PT2332947T (es)
RU (1) RU2505543C2 (es)
SG (1) SG185317A1 (es)
TW (1) TWI472521B (es)
UA (1) UA106048C2 (es)
UY (1) UY31992A (es)
WO (1) WO2010009197A1 (es)
ZA (1) ZA201100175B (es)

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CL2009001595A1 (es) 2010-07-19
CA2730931A1 (en) 2010-01-21
WO2010009197A1 (en) 2010-01-21
TWI472521B (zh) 2015-02-11
AU2009270973A1 (en) 2010-01-21
EP2332947A1 (en) 2011-06-15
JP2011528366A (ja) 2011-11-17
KR20170010069A (ko) 2017-01-25
US9067962B2 (en) 2015-06-30
KR20110031196A (ko) 2011-03-24
JP2016041701A (ja) 2016-03-31
HK1243713A1 (zh) 2018-07-20
IL210269A0 (en) 2011-03-31
NZ590184A (en) 2012-09-28
PE20100260A1 (es) 2010-04-16
MX2011000503A (es) 2011-03-01
CN107629097A (zh) 2018-01-26
EP2332947B1 (en) 2017-11-01
TW201006808A (en) 2010-02-16
US20130165395A1 (en) 2013-06-27
DK2332947T3 (da) 2018-01-29
BRPI0916191A2 (pt) 2017-08-29
RU2505543C2 (ru) 2014-01-27
ZA201100175B (en) 2012-03-28
US8217156B2 (en) 2012-07-10
ES2656357T3 (es) 2018-02-26
PT2332947T (pt) 2018-02-06
UY31992A (es) 2010-02-26
CN102112483A (zh) 2011-06-29
KR101707246B1 (ko) 2017-02-15
NO2332947T3 (es) 2018-03-31
JP6283337B2 (ja) 2018-02-21
SG185317A1 (en) 2012-11-29
PL2332947T3 (pl) 2018-04-30
IL210269A (en) 2015-06-30
AU2009270973B2 (en) 2014-01-30
CO6351797A2 (es) 2011-12-20
UA106048C2 (uk) 2014-07-25
RU2011105797A (ru) 2012-08-27
HUE035400T2 (en) 2018-05-02
US20100016422A1 (en) 2010-01-21

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