AR070531A1 - Inhibidores de cinasa pim y metodos para su uso - Google Patents
Inhibidores de cinasa pim y metodos para su usoInfo
- Publication number
- AR070531A1 AR070531A1 ARP090100684A ARP090100684A AR070531A1 AR 070531 A1 AR070531 A1 AR 070531A1 AR P090100684 A ARP090100684 A AR P090100684A AR P090100684 A ARP090100684 A AR P090100684A AR 070531 A1 AR070531 A1 AR 070531A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- compounds
- och3
- pharmaceutically acceptable
- pim kinase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
La presente se refiere a compuestos de Ia formula (1), a sus tautomeros, estereoisomeros y polimorfos, y a las sales farmacéuticamente aceptables, ésteres, metabolitos o pro-fármacos de los mismos, a composiciones de los compuestos junto con vehículos farmacéuticamente aceptables, y al uso de los compuestos, ya sea solos o bien en combinacion con cuando menos un agente terapéutico adicional, en la inhibicion de la actividad de la cinasa Pim y/o en la profilaxis o el tratamiento de cáncer. Reivindicacion 1: Un compuesto de la formula (1), o un estereoisomero, tautomero, o una sal farmacéuticamente aceptable del mismo, en donde: R1 se selecciona a partir de los compuestos del grupo de formulas (2); X representa CH o N; R2a se selecciona a partir de amino, metilo, CH2F, CF3, C2H5, y H; R2b se selecciona a partir de H, y metilo; R3 se selecciona a partir de H, OH, OCH3, CH3, F, y CI; R4a se selecciona a partir de amino, metilo, OH, OCH3, OC2H5, F, CF3, H, y etilo; R4b se selecciona a partir de metilo, H, y F; R21 representa H o F; R22 representa H, CI, o F; R23 representa F, OC2H5, OCH3, CI, H, metilo, OH, u OCH(CH3)2; y R24 representa H u OH.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3335908P | 2008-03-03 | 2008-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070531A1 true AR070531A1 (es) | 2010-04-14 |
Family
ID=41055566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100684A AR070531A1 (es) | 2008-03-03 | 2009-02-27 | Inhibidores de cinasa pim y metodos para su uso |
Country Status (21)
Country | Link |
---|---|
EP (2) | EP2262802B1 (es) |
JP (1) | JP5412448B2 (es) |
KR (1) | KR20100120709A (es) |
CN (2) | CN104098559A (es) |
AR (1) | AR070531A1 (es) |
AU (1) | AU2009221134B2 (es) |
BR (1) | BRPI0909102A2 (es) |
CA (1) | CA2717388A1 (es) |
CL (1) | CL2009000483A1 (es) |
CO (1) | CO6290687A2 (es) |
EA (1) | EA201001412A1 (es) |
EC (1) | ECSP10010447A (es) |
ES (2) | ES2562306T3 (es) |
IL (1) | IL207865A0 (es) |
MA (1) | MA32135B1 (es) |
MX (1) | MX2010009739A (es) |
PE (1) | PE20091577A1 (es) |
TW (1) | TW200942536A (es) |
UY (1) | UY31679A1 (es) |
WO (1) | WO2009109576A1 (es) |
ZA (1) | ZA201006128B (es) |
Families Citing this family (50)
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WO2007070514A1 (en) | 2005-12-13 | 2007-06-21 | Incyte Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
RS58449B1 (sr) | 2007-06-13 | 2019-04-30 | Incyte Holdings Corp | Upotreba soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h- pirazol-1-il)-3-ciklopentilpropionitrila |
GEP20135849B (en) * | 2008-09-02 | 2013-06-10 | Novartis Ag | Picolinamide derivatives as kinase inhibitors |
AU2010249380B2 (en) | 2009-05-22 | 2015-08-20 | Incyte Holdings Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as Janus kinase inhibitors |
EP3643312A1 (en) | 2009-05-22 | 2020-04-29 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
SG10201405568UA (en) * | 2009-09-08 | 2014-11-27 | Hoffmann La Roche | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
US8435976B2 (en) | 2009-09-08 | 2013-05-07 | F. Hoffmann-La Roche | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
CN102985417B (zh) | 2010-03-10 | 2015-01-28 | 因塞特公司 | 作为jak1抑制剂的哌啶-4-基氮杂环丁烷衍生物 |
PE20130405A1 (es) | 2010-04-07 | 2013-04-10 | Hoffmann La Roche | Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso |
EP2565192B9 (en) | 2010-04-30 | 2015-11-25 | The University of Tokyo | Anticancer agent |
EA035981B1 (ru) | 2010-05-21 | 2020-09-09 | Инсайт Холдингс Корпорейшн | Композиция ингибитора jak для местного применения |
JP2013530199A (ja) * | 2010-07-06 | 2013-07-25 | ノバルティス アーゲー | キナーゼ阻害剤として有用な環状エーテル化合物 |
EP2640725B1 (en) | 2010-11-19 | 2015-01-07 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
TW201249845A (en) | 2010-11-19 | 2012-12-16 | Incyte Corp | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
UY33930A (es) * | 2011-03-04 | 2012-10-31 | Novartis Ag | Inhibidores novedosos de quinasas |
WO2012120415A1 (en) * | 2011-03-04 | 2012-09-13 | Novartis Ag | Tetrasubstituted cyclohexyl compounds as kinase inhibitors |
CA2834166A1 (en) | 2011-04-29 | 2012-11-01 | Amgen Inc. | Bicyclic pyridazine compounds as pim inhibitors |
WO2012177606A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
PL3409278T3 (pl) | 2011-07-21 | 2021-02-22 | Sumitomo Pharma Oncology, Inc. | Heterocykliczne inhibitory kinazy białkowej |
CN102924446B (zh) * | 2011-08-11 | 2015-08-26 | 上海吉铠医药科技有限公司 | Pim激酶抑制剂及其制备方法与在制药中的应用 |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
AR088061A1 (es) | 2011-09-27 | 2014-05-07 | Hoffmann La Roche | Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso |
TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
AU2013264831B2 (en) * | 2012-05-21 | 2016-04-21 | Novartis Ag | Novel ring-substituted N-pyridinyl amides as kinase inhibitors |
WO2014033631A1 (en) * | 2012-08-31 | 2014-03-06 | Novartis Ag | N-(3-pyridyl) biarylamides as kinase inhibitors |
WO2014033630A1 (en) * | 2012-08-31 | 2014-03-06 | Novartis Ag | Novel aminothiazole carboxamides as kinase inhibitors |
WO2014048939A1 (en) * | 2012-09-26 | 2014-04-03 | F. Hoffmann-La Roche Ag | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
CN113384545A (zh) | 2012-11-15 | 2021-09-14 | 因赛特公司 | 鲁索利替尼的缓释剂型 |
CA2897200C (en) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
US9200004B2 (en) | 2013-01-15 | 2015-12-01 | Incyte Holdings Corporation | Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors |
SI3489239T1 (sl) | 2013-03-06 | 2022-04-29 | Incyte Holdings Corporation | Postopki in intermediati za pripravo zaviralca JAK |
EA201690357A1 (ru) | 2013-08-07 | 2016-07-29 | Инсайт Корпорейшн | Лекарственные формы с замедленным высвобождением для ингибитора jak1 |
SG11201601259YA (en) * | 2013-08-23 | 2016-03-30 | Incyte Corp | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Pim激酶抑制劑之鹽 |
US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
WO2019057821A1 (en) * | 2017-09-20 | 2019-03-28 | Lead Discovery Center Gmbh | COUMARIN DERIVATIVES, PROCESSES FOR PREPARING THEM AND USES THEREOF IN THE TREATMENT OF CANCER |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
SI3746429T1 (sl) | 2018-01-30 | 2023-01-31 | Incyte Corporation | Postopki za pripravo (1-(3-fluoro-2-(trifluorometil)izonikotinil) piperidin-4-ona) |
WO2019191684A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
CA3095580A1 (en) | 2018-04-13 | 2019-10-17 | Sumitomo Dainippon Pharma Oncology, Inc. | Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer |
WO2020167990A1 (en) | 2019-02-12 | 2020-08-20 | Tolero Pharmaceuticals, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
CN110452164B (zh) * | 2019-09-10 | 2022-07-22 | 上海皓鸿生物医药科技有限公司 | Pim447关键中间体的制备方法 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (9)
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US7223759B2 (en) | 2003-09-15 | 2007-05-29 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds |
PE20050444A1 (es) * | 2003-10-31 | 2005-08-09 | Takeda Pharmaceutical | Compuestos de piridina como inhibidores de la peptidasa |
WO2007000582A1 (en) * | 2005-06-28 | 2007-01-04 | Takeda Cambridge Limited | Heterocyclic non-peptide gnrh antagonists |
CA2628455A1 (en) * | 2005-11-10 | 2007-05-24 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
WO2007123269A1 (ja) * | 2006-04-19 | 2007-11-01 | Astellas Pharma Inc. | アゾールカルボキサミド誘導体 |
CA2668255A1 (en) * | 2006-10-31 | 2008-05-08 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
WO2008054702A1 (en) * | 2006-10-31 | 2008-05-08 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
KR20090075869A (ko) * | 2006-10-31 | 2009-07-09 | 쉐링 코포레이션 | 단백질 키나제 억제제로서의 2-아미노티아졸-4-카복실산 아미드 |
JP5330274B2 (ja) * | 2007-03-01 | 2013-10-30 | ノバルティス アーゲー | Pimキナーゼ阻害剤およびその使用方法 |
-
2009
- 2009-02-27 AR ARP090100684A patent/AR070531A1/es not_active Application Discontinuation
- 2009-02-27 PE PE2009000308A patent/PE20091577A1/es not_active Application Discontinuation
- 2009-02-27 UY UY031679A patent/UY31679A1/es not_active Application Discontinuation
- 2009-03-02 TW TW098106739A patent/TW200942536A/zh unknown
- 2009-03-02 CL CL2009000483A patent/CL2009000483A1/es unknown
- 2009-03-03 CN CN201410286911.5A patent/CN104098559A/zh active Pending
- 2009-03-03 EP EP09717066.6A patent/EP2262802B1/en active Active
- 2009-03-03 WO PCT/EP2009/052506 patent/WO2009109576A1/en active Application Filing
- 2009-03-03 BR BRPI0909102A patent/BRPI0909102A2/pt not_active IP Right Cessation
- 2009-03-03 ES ES13154157.5T patent/ES2562306T3/es active Active
- 2009-03-03 JP JP2010549127A patent/JP5412448B2/ja active Active
- 2009-03-03 CN CN200980115821.7A patent/CN102015701B/zh active Active
- 2009-03-03 MX MX2010009739A patent/MX2010009739A/es not_active Application Discontinuation
- 2009-03-03 EA EA201001412A patent/EA201001412A1/ru unknown
- 2009-03-03 CA CA2717388A patent/CA2717388A1/en not_active Abandoned
- 2009-03-03 KR KR1020107022008A patent/KR20100120709A/ko not_active Application Discontinuation
- 2009-03-03 ES ES09717066.6T patent/ES2443496T3/es active Active
- 2009-03-03 EP EP13154157.5A patent/EP2596790B1/en active Active
- 2009-03-03 AU AU2009221134A patent/AU2009221134B2/en not_active Expired - Fee Related
-
2010
- 2010-08-27 ZA ZA2010/06128A patent/ZA201006128B/en unknown
- 2010-08-30 IL IL207865A patent/IL207865A0/en unknown
- 2010-09-02 MA MA33140A patent/MA32135B1/fr unknown
- 2010-09-03 EC EC2010010447A patent/ECSP10010447A/es unknown
- 2010-09-07 CO CO10110544A patent/CO6290687A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN104098559A (zh) | 2014-10-15 |
ECSP10010447A (es) | 2010-10-30 |
PE20091577A1 (es) | 2009-11-05 |
BRPI0909102A2 (pt) | 2019-01-15 |
CA2717388A1 (en) | 2009-09-11 |
EA201001412A1 (ru) | 2011-06-30 |
CN102015701B (zh) | 2014-07-23 |
EP2262802A1 (en) | 2010-12-22 |
CL2009000483A1 (es) | 2010-02-19 |
MX2010009739A (es) | 2010-09-28 |
ES2562306T3 (es) | 2016-03-03 |
EP2596790A1 (en) | 2013-05-29 |
JP5412448B2 (ja) | 2014-02-12 |
KR20100120709A (ko) | 2010-11-16 |
UY31679A1 (es) | 2009-09-30 |
CO6290687A2 (es) | 2011-06-20 |
MA32135B1 (fr) | 2011-03-01 |
ZA201006128B (en) | 2011-10-26 |
ES2443496T3 (es) | 2014-02-19 |
IL207865A0 (en) | 2010-12-30 |
EP2262802B1 (en) | 2013-10-23 |
TW200942536A (en) | 2009-10-16 |
AU2009221134B2 (en) | 2012-02-23 |
JP2011513363A (ja) | 2011-04-28 |
WO2009109576A1 (en) | 2009-09-11 |
AU2009221134A1 (en) | 2009-09-11 |
CN102015701A (zh) | 2011-04-13 |
EP2596790B1 (en) | 2015-12-09 |
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Legal Events
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FA | Abandonment or withdrawal |