SG10201405568UA - 4-substituted pyridin-3-yl-carboxamide compounds and methods of use - Google Patents
4-substituted pyridin-3-yl-carboxamide compounds and methods of useInfo
- Publication number
- SG10201405568UA SG10201405568UA SG10201405568UA SG10201405568UA SG10201405568UA SG 10201405568U A SG10201405568U A SG 10201405568UA SG 10201405568U A SG10201405568U A SG 10201405568UA SG 10201405568U A SG10201405568U A SG 10201405568UA SG 10201405568U A SG10201405568U A SG 10201405568UA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- carboxamide compounds
- substituted pyridin
- pyridin
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24047409P | 2009-09-08 | 2009-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201405568UA true SG10201405568UA (en) | 2014-11-27 |
Family
ID=43479412
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201405568UA SG10201405568UA (en) | 2009-09-08 | 2010-09-07 | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
| SG2012015350A SG178986A1 (en) | 2009-09-08 | 2010-09-07 | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012015350A SG178986A1 (en) | 2009-09-08 | 2010-09-07 | 4-substituted pyridin-3-yl-carboxamide compounds and methods of use |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP2475659B1 (en) |
| JP (1) | JP5567136B2 (en) |
| CN (1) | CN102625807B (en) |
| CA (1) | CA2770252C (en) |
| ES (1) | ES2557316T3 (en) |
| SG (2) | SG10201405568UA (en) |
| WO (1) | WO2011029802A1 (en) |
Families Citing this family (37)
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|---|---|---|---|---|
| DK2343299T3 (en) | 2005-12-13 | 2016-01-18 | Incyte Holdings Corp | Heteroberl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
| ES2575797T3 (en) | 2007-06-13 | 2016-07-01 | Incyte Holdings Corporation | Salts of the kinase inhibitor Janus (R) -3- (4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanonitrile |
| EP2432555B1 (en) | 2009-05-22 | 2014-04-30 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| DK2432472T3 (en) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3- [4- (7H-PYRROLO [2,3-D] PYRIMIDIN-4-YL) -1H-PYRAZOL-1-YL] OCTAN OR HEPTAN NITRIL AS JAK INHIBITORS |
| US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| MX364636B (en) | 2010-03-10 | 2019-05-03 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors. |
| EP2556066B1 (en) * | 2010-04-07 | 2016-10-19 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| EP3087972A1 (en) | 2010-05-21 | 2016-11-02 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
| CN103080106A (en) * | 2010-07-06 | 2013-05-01 | 诺瓦提斯公司 | Cyclic ether compounds useful as kinase inhibitors |
| AU2011329734B2 (en) | 2010-11-19 | 2015-05-28 | Incyte Holdings Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| JP5917544B2 (en) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Heterocyclic substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
| KR20140040819A (en) | 2011-06-20 | 2014-04-03 | 인사이트 코포레이션 | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| CN102924446B (en) * | 2011-08-11 | 2015-08-26 | 上海吉铠医药科技有限公司 | PIM kinase inhibitor and preparation method thereof and the application in pharmacy |
| TW201313721A (en) | 2011-08-18 | 2013-04-01 | Incyte Corp | Cyclohexyl azetidine derivatives as JAK inhibitors |
| UA111854C2 (en) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS |
| EP2760857A1 (en) * | 2011-09-27 | 2014-08-06 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| TW201406761A (en) | 2012-05-18 | 2014-02-16 | Incyte Corp | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| TW201408641A (en) * | 2012-05-21 | 2014-03-01 | Novartis Ag | Novel ring-substituted N-pyridinyl amides as kinase inhibitors |
| WO2014033630A1 (en) * | 2012-08-31 | 2014-03-06 | Novartis Ag | Novel aminothiazole carboxamides as kinase inhibitors |
| EP3949953A1 (en) | 2012-11-15 | 2022-02-09 | Incyte Holdings Corporation | Sustained-release dosage forms of ruxolitinib |
| CA2897200C (en) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| MX2015009057A (en) | 2013-01-15 | 2015-10-05 | Incyte Corp | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors. |
| EP3489239B1 (en) | 2013-03-06 | 2021-09-15 | Incyte Holdings Corporation | Processes and intermediates for making a jak inhibitor |
| JP6851826B2 (en) * | 2013-07-19 | 2021-03-31 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Peptide Epoxy Ketone Proteasome Inhibitor Combined with PIM Kinase Inhibitor for Cancer Treatment |
| PT3030227T (en) | 2013-08-07 | 2020-06-25 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
| EA201690458A1 (en) | 2013-08-23 | 2016-07-29 | Инсайт Корпорейшн | FURO- AND THYENOPYRIDINCARBOXAMIDES USED AS PIM-KINASE INHIBITORS |
| WO2015160868A1 (en) * | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| AR105967A1 (en) | 2015-09-09 | 2017-11-29 | Incyte Corp | SALTS OF A PIM QUINASA INHIBITOR |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| AR114810A1 (en) | 2018-01-30 | 2020-10-21 | Incyte Corp | PROCESSES AND INTERMEDIATES TO DEVELOP A JAK INHIBITOR |
| MX2022012285A (en) | 2018-03-30 | 2023-08-15 | Incyte Corp | Treatment of hidradenitis suppurativa using jak inhibitors. |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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| GB750155A (en) | 1953-03-17 | 1956-06-13 | Nat Res Dev | Substituted alanines |
| US3032585A (en) | 1954-12-03 | 1962-05-01 | Nat Res Dev | Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine |
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| JPH08336393A (en) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | Production of optically active gamma-substituted-beta-hydroxybutyric ester |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| EE05450B1 (en) | 2000-07-19 | 2011-08-15 | Warner-Lambert Company | Oxygenated esters of 4-iodophen laminobenzh droxamic acids, their crystalline forms and pharmaceutical compositions and their use |
| CA2435146C (en) | 2001-01-25 | 2011-03-29 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Formulation of boronic acid compounds |
| NZ518726A (en) | 2001-05-09 | 2004-06-25 | Warner Lambert Co | Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor |
| MXPA05003431A (en) | 2002-11-15 | 2005-07-05 | Warner Lambert Co | Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer. |
| MXPA06004363A (en) | 2003-10-21 | 2006-06-14 | Warner Lambert Co | Polymorphic form of n-[(r)-2, 3-dihydroxy -propoxy]-3, 4-difluoro-2 -(2-fluoro-4 -iodophenylamino) -benzamide. |
| NZ551017A (en) * | 2004-05-18 | 2010-11-26 | Schering Corp | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors |
| GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| WO2007123269A1 (en) * | 2006-04-19 | 2007-11-01 | Astellas Pharma Inc. | Azolecarboxamide derivative |
| RU2439074C2 (en) * | 2006-04-26 | 2012-01-10 | Ф. Хоффманн-Ля Рош Аг | THIENO[3,2-d]PYRIMIDINE DERIVATIVE AS PHOSPHATIDYL INOSITOL-3-KINASE (PI3K) INHIBITOR |
| AU2007314305B2 (en) * | 2006-10-31 | 2013-01-24 | Merck Sharp & Dohme Corp. | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors |
| US9206142B2 (en) * | 2006-10-31 | 2015-12-08 | Merck Sharp & Dohme Corp. | Anilinopiperazine derivatives and methods of use thereof |
| AR064010A1 (en) | 2006-12-06 | 2009-03-04 | Merck & Co Inc | AKT ACTIVITY INHIBITORS |
| NZ578162A (en) * | 2006-12-07 | 2011-12-22 | Genentech Inc | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| BRPI0816769A2 (en) * | 2007-09-12 | 2016-11-29 | Hoffmann La Roche | combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| WO2009058728A1 (en) * | 2007-10-29 | 2009-05-07 | Schering Corporation | Thiazole derivatives as protein kinase inhibitors |
| MX2010004878A (en) * | 2007-10-29 | 2010-05-19 | Schering Corp | Thiazole carboxamide derivatives and their to treat cancer. |
| JP2011502158A (en) * | 2007-10-29 | 2011-01-20 | シェーリング コーポレイション | Diamide thiazole derivatives as protein kinase inhibitors |
| AR070531A1 (en) * | 2008-03-03 | 2010-04-14 | Novartis Ag | PIM KINASE INHIBITORS AND METHODS FOR USE |
| WO2010051549A1 (en) | 2008-10-31 | 2010-05-06 | Genentech, Inc. | Pyrazolopyrimidine jak inhibitor compounds and methods |
-
2010
- 2010-09-07 SG SG10201405568UA patent/SG10201405568UA/en unknown
- 2010-09-07 SG SG2012015350A patent/SG178986A1/en unknown
- 2010-09-07 ES ES10749864.4T patent/ES2557316T3/en active Active
- 2010-09-07 EP EP10749864.4A patent/EP2475659B1/en not_active Not-in-force
- 2010-09-07 CN CN201080050398.XA patent/CN102625807B/en not_active Expired - Fee Related
- 2010-09-07 WO PCT/EP2010/063069 patent/WO2011029802A1/en active Application Filing
- 2010-09-07 JP JP2012527351A patent/JP5567136B2/en not_active Expired - Fee Related
- 2010-09-07 CA CA2770252A patent/CA2770252C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2770252C (en) | 2018-06-12 |
| WO2011029802A1 (en) | 2011-03-17 |
| JP2013503837A (en) | 2013-02-04 |
| CN102625807B (en) | 2016-03-09 |
| SG178986A1 (en) | 2012-04-27 |
| CN102625807A (en) | 2012-08-01 |
| EP2475659B1 (en) | 2015-10-28 |
| EP2475659A1 (en) | 2012-07-18 |
| JP5567136B2 (en) | 2014-08-06 |
| ES2557316T3 (en) | 2016-01-25 |
| CA2770252A1 (en) | 2011-03-17 |
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