AR066799A1 - Antagonistas para el receptor ccr2 y sus usos - Google Patents
Antagonistas para el receptor ccr2 y sus usosInfo
- Publication number
- AR066799A1 AR066799A1 ARP080102302A ARP080102302A AR066799A1 AR 066799 A1 AR066799 A1 AR 066799A1 AR P080102302 A ARP080102302 A AR P080102302A AR P080102302 A ARP080102302 A AR P080102302A AR 066799 A1 AR066799 A1 AR 066799A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- optionally substituted
- cycloalkyl
- optionally
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Su uso para proporcionar medicamentos para tratar afecciones y enfermedades, en especial enfermedades pulmonares tales como asma y EPOC. Reivindicacion 1: Compuestos caracterizado porque tiene la formula general (1), A-L-D-L'-E-G en la que A es un grupo seleccionado de una cadena de carbonos C1-6 saturada o insaturada, ramificada o lineal, que opcionalmente comprende uno o más heteroátomos seleccionados de N, O y S y que opcionalmente está sustituida con uno o más grupos seleccionados de halogeno, -CF3, -OCF3, =O, -OH, -O-alquilo C1-6, -C(O)-alquilo C1-6, -alquilen C1-4-C(O)-alquileno C1-4-, -alquilen C1-4-O-alquilo C1-4, -C(O)-N(R1,R1') y -N(R2,R2'), con R1 y R1' y R2 y R2' independientemente seleccionados de -H o alquilo C1-6, -alquenilo C2-6, -alquinilo C2-6 sustituidos o no sustituidos, o en los que R1 y R1' y R2 y R2', respectivamente, están unidos por un puente por un alquileno C2-8 sustituido o no sustituido formando un anillo, o -N(R3,R3') con R3 y R3' independientemente seleccionados de -H y -alquilo C1-4, -alquilen C0-4-cicloalquilo C3-8, -alquil C1-6-N(R4,R4') con R4 y R4' independientemente seleccionados de H y -alquilo C1-6, o R4 y R4' están unidos por un puente por un -alquileno C2-8, formando así un anillo, o un anillo aromático o alifático de 4-8 miembros que opcionalmente comprende uno o más heteroátomos seleccionados de N, O y S y que está opcionalmente sustituido con uno o más R5 que se selecciona de -alquilo C1-6, -cicloalquilo C3-8, -alquilen C0-4-arilo C5-10, -alquilen C0-4-heteroarilo C5-10, -alquilen C0-4-cicloalquilo C5-10-, -alquilen C0-4-heterociclilo C5-10, -alquilen C1-4)-O-alquilo C1-4, -cicloalquil C3-8-arilo C5-10, -cicIoalquil C3-8-heteroarilo C5-10, y anillos de 3-10 miembros saturados, insaturados o aromáticos, que opcionalmente comprenden uno o más heteroátomos seleccionados de N, O y S, en el que R5 está opcionalmente sustituido con uno o más de -halogeno, -CF3, -OCF3, =O, -OH, O-alquilo C1-4, -alquilo C1-4, -arilo C5-10, -heteroarilo C5-10, o - alquil C0-4-N(R6,R6') con R6 y R6' seleccionados independientemente de -H y -alquilo C1-4, L es un conector seleccionado de un enlace sencillo, -NH-, -SO2, o M, con M seleccionado de -alquileno C1-8, -alquenileno C2-8, -alquinileno C2-8, y M opcionalmente comprende uno o más grupos -NH-, -N-alquileno C1-4-, -alquilen C1-4-O-alquileno C1-4-, y M está opcionalmente sustituido con uno o más grupos =O; D es un anillo de 4-8 miembros que opcionalmente comprende 1 a 3 heteroátomos seleccionados de N, O y S, D además comprende átomos Z y Z', en el que Z y Z' se seleccionan independientemente de C y N, y en el que D está unido a L por Z y a L' por Z' respectivamente, en el que D está opcionalmente sustituido con uno o más grupos seleccionados de -alquilo C1-4, =O, -OH, -F, -CF3, L' es un grupo seleccionado de un enlace sencillo, -alquileno C1-4, -NH-, -N-alquilo C1-4-, -N-cicloalquilo C3-6-, -N-alquilen C1-3-cicloalquiIo C3-6-, -O-, -S-; E es un heterociclo de 4 a 8 miembros insaturado o aromático que comprende dos átomos de N vecinos, que no forman enlaces con L' o G, y E está opcionalmente sustituido con uno o más de -alquilo C1-4, halogeno, -CF3, -CCI3, -CBr3, -CN, OH y -OCF3 o -cicloalquilo C3-8 opcionalmente sustituido con uno o más halogenos; o -cicloalquenilo C3-8 opcionalmente sustituido con uno o más halogenos; o -arilo C5-10, que opcionalmente comprende uno o más heteroátomos seleccionados de N, O, S, y está opcionalmente sustituido con uno o más sustituyentes seleccionados de halogeno; o -alquil C1-4-cicloalquilo C3-8, -alquil C1-4-arilo C5-10 y -alquil C1-4-heteroarilo C5-1), G es un grupo seleccionado de -CF3, -CCI3, -CBr3, halogeno: o -arilo C5-10, que opcionalmente comprende uno o más heteroátomos seleccionados de N, O, S, y opcionalmente sustituido con uno o más grupos seleccionados de -halogeno, -CF3, -CBr3, -CCI3, -alquilo C1-4, -alquenilo C2-4, -alquinilo C2-4, -O-alquilo C1-4, -OH, -S-alquilo C1-4, -CN, -OCF3, o -X-alquilen C1-4-X'-, en el que X y X' están unidos a los átomos vecinos de G para el cierre de anillo, y en el que X y X' se seleccionan independientemente de -CH2, -O-, -N-, -S-, -C(O)-, -C(O)-NH-, -C(O)-O; o -heteroarilo C5-10, -cicloalquenilo C3-8, -cicloalquilo C3-8, opcionalmente en forma de sus isomeros opticos individuales, mezclas de sus isomeros opticos individuales, o racematos, así como en forma de sus sales de adicion de ácido con ácidos farmacologicamente aceptables, así como en forma de sus solvatos y/o hidratos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07109376 | 2007-05-31 |
Publications (1)
Publication Number | Publication Date |
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AR066799A1 true AR066799A1 (es) | 2009-09-16 |
Family
ID=38752546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102302A AR066799A1 (es) | 2007-05-31 | 2008-05-30 | Antagonistas para el receptor ccr2 y sus usos |
Country Status (8)
Country | Link |
---|---|
US (1) | US8653262B2 (es) |
EP (1) | EP2155689B1 (es) |
JP (1) | JP5603770B2 (es) |
AR (1) | AR066799A1 (es) |
CA (1) | CA2687931C (es) |
CL (1) | CL2008001593A1 (es) |
TW (1) | TW200904434A (es) |
WO (1) | WO2008145681A2 (es) |
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DE102006039003A1 (de) | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
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EP2025675A1 (de) | 2007-08-14 | 2009-02-18 | Boehringer Ingelheim International GmbH | Arylsulfonamide mit analgetischer Wirkung |
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-
2008
- 2008-05-29 CA CA2687931A patent/CA2687931C/en active Active
- 2008-05-29 JP JP2010509818A patent/JP5603770B2/ja active Active
- 2008-05-29 US US12/602,274 patent/US8653262B2/en active Active
- 2008-05-29 EP EP08760165.4A patent/EP2155689B1/en active Active
- 2008-05-29 WO PCT/EP2008/056573 patent/WO2008145681A2/en active Application Filing
- 2008-05-30 AR ARP080102302A patent/AR066799A1/es unknown
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Publication number | Publication date |
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CA2687931C (en) | 2016-05-24 |
EP2155689B1 (en) | 2015-07-08 |
JP2010528089A (ja) | 2010-08-19 |
WO2008145681A3 (en) | 2009-03-05 |
WO2008145681A2 (en) | 2008-12-04 |
EP2155689A2 (en) | 2010-02-24 |
TW200904434A (en) | 2009-02-01 |
CA2687931A1 (en) | 2008-12-04 |
US20100204209A1 (en) | 2010-08-12 |
CL2008001593A1 (es) | 2009-09-11 |
JP5603770B2 (ja) | 2014-10-08 |
US8653262B2 (en) | 2014-02-18 |
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