AR062207A1 - Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer. - Google Patents
Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer.Info
- Publication number
- AR062207A1 AR062207A1 ARP070103435A ARP070103435A AR062207A1 AR 062207 A1 AR062207 A1 AR 062207A1 AR P070103435 A ARP070103435 A AR P070103435A AR P070103435 A ARP070103435 A AR P070103435A AR 062207 A1 AR062207 A1 AR 062207A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyridazin
- imidazo
- benzamide
- substituent
- hydrogen atom
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Un agente farmacéutico que contiene el compuesto que es un inhibidor de quinasa (VEGFR, VEGFR2, PDGFR, Raf), un inhibidor de angiogénesis, un agente para la prevencion o el tratamiento del cáncer, un inhibidor del crecimiento del cáncer o un supresor de la metástasis cancerosa. Reivindicacion 1: Un compuesto caracterizado por la formula (1) en donde anillo Y es un grupo cíclico opcionalmente sustituido; X es -O-, -S-, -S(O)-, -S(O)2- o -NR- (en donde R es un átomo de hidrogeno o un sustituyente); R1 es un átomo de hidrogeno o un sustituyente; R2 es un átomo de hidrogeno o un sustituyente; R3 es un átomo de hidrogeno o un sustituyente; R4 es un átomo de hidrogeno o un sustituyente; con la condicion de que cuando R1 es distinto de un amino opcionalmente sustituido, anillo Y sea un grupo cíclico sustituido con un amino opcionalmente sustituido, en donde el grupo cíclico también está opcionalmente sustituido, y que se excluyan [6-(feniltio)imidazo(1,2-b]piridazin-2- il]carbamato de metilo, [6-(fenilsulfinil)imidazo[1,2-b]piridazin-2-il]carbamato de metilo, 6-(4-acetamidofenoxi) imidazo[1,2-b]piridazin-2-carboxilato de etilo, 6-[4-(4-acetilpiperazin-1-il)fenoxi]imidazo[1,2- b]piridazin-2-carboxilato de etilo, N- [1-(imidazo[1,2-b]piridazin-6-ilamino)-2,5-dioxo- 1,2, 5, 6,7, 8-hexahidroquinolin-3-il]benzamida, N-[1-(imidazo[1,2-b]piridazin-6-ilamino)-7,7-dimetil-2,5- dioxo-1,2,5,6,7,8-hexahidroquinolin-3-il]benzamida, N-[1-(imidazo[1,2-b]piridazin-6-ilamino)- 2,5-dioxo-2,5,6,7- tetrahidro-1H-ciclopenta[b]piridin-3-il]benzamida, N-[1-(imidazo[1,2-b]piridazin-6-ilamino)-7-metil-2,5-dioxo- 1,2,5,6,7,8-hexahidroquinolin-3-il]benzamida, N-[(5E)-5-(imidazo[1,2-b]piridazin-6-ilhidrazono)-7-metil-2-oxo-4a,5, 6,7,8,8a-hexahidro-2H-cromen-3-il)benzamida, (6R, 7R)-3- (imidazo[1,2-b]piridazin-6-iltio)-8-oxo-7-[(fenilacetil)amino]-5-tia-1-azabiciclo[4,2,0]oct-2-en-2-carboxilato de 4-metoxibencilo, 4-[(3-metoxi-2-fenilimidazo[1,2-b)piridazin-6-il)tio]-N,N- dimetilanilina, 3-metoxi-6-(3-nitrofenoxi)-2-fenilimidazo[1,2-b]piridazina, 3-[(3-metoxi-2-fenilimidazo[1,2-b]piridazin-6-il)oxi)anilina, y 3-[(3-metoxi-2-fenilimidazo[1,2-b]piridazin-6-il)oxi]-N,N-dimetilanilina, o una de sus sales.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006213981 | 2006-08-04 | ||
JP2006331230 | 2006-12-07 | ||
JP2007144072 | 2007-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR062207A1 true AR062207A1 (es) | 2008-10-22 |
Family
ID=38996616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103435A AR062207A1 (es) | 2006-08-04 | 2007-08-03 | Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer. |
Country Status (18)
Country | Link |
---|---|
US (4) | US8044049B2 (es) |
EP (1) | EP2049541B1 (es) |
JP (1) | JP5238697B2 (es) |
KR (1) | KR20090047509A (es) |
AR (1) | AR062207A1 (es) |
AU (1) | AU2007279595A1 (es) |
BR (1) | BRPI0714665A2 (es) |
CA (1) | CA2659971A1 (es) |
CL (1) | CL2007002261A1 (es) |
CO (1) | CO6150183A2 (es) |
CR (1) | CR10607A (es) |
IL (1) | IL196799A0 (es) |
MA (1) | MA30651B1 (es) |
MX (1) | MX2009001349A (es) |
NO (1) | NO20090986L (es) |
PE (1) | PE20080538A1 (es) |
TW (1) | TW200817409A (es) |
WO (1) | WO2008016192A2 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5352476B2 (ja) | 2007-06-05 | 2013-11-27 | 武田薬品工業株式会社 | キナーゼ阻害剤としての二環式複素環化合物 |
US8431608B2 (en) * | 2007-08-17 | 2013-04-30 | Icagen Inc. | Heterocycles as potassium channel modulators |
CA2696631A1 (en) * | 2007-08-17 | 2009-02-26 | Icagen, Inc. | Heterocycles as potassium channel modulators |
US8324395B2 (en) | 2007-08-23 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8389527B2 (en) | 2008-02-06 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
EA201001365A1 (ru) | 2008-02-28 | 2011-04-29 | Новартис Аг | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-b]ПИРИДАЗИНА, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДУЕМОГО C-МЕТ ТИРОЗИНКИНАЗОЙ |
CN101372475B (zh) * | 2008-03-19 | 2012-01-04 | 南京工业大学 | 芳杂环取代的二苯脲类衍生物及其用途 |
EP2277881A4 (en) | 2008-04-18 | 2011-09-07 | Shionogi & Co | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K |
US8445509B2 (en) * | 2008-05-08 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivatives and use thereof |
WO2010007099A1 (en) * | 2008-07-15 | 2010-01-21 | Cellzome Limited | 2-aminoimidazo[1,2-b]pyridazine derivatives as pi3k inhibitors |
UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
ES2461496T3 (es) | 2008-10-02 | 2014-05-20 | Respivert Limited | Inhibidores de cinasa MAP p38 |
GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
TWI491610B (zh) * | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
KR101784798B1 (ko) | 2008-10-22 | 2017-10-16 | 어레이 바이오파마 인크. | TRK 키나아제 억제제로서 치환된 피라졸로[1,5a] 피리미딘 화합물 |
JP5579619B2 (ja) * | 2008-12-01 | 2014-08-27 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
CN102333770B (zh) | 2008-12-11 | 2015-01-28 | 瑞斯比维特有限公司 | P38map激酶抑制剂 |
CN102264705A (zh) | 2008-12-24 | 2011-11-30 | 辛根塔有限公司 | 制备芳基酰胺的方法 |
KR20110113755A (ko) | 2009-02-10 | 2011-10-18 | 아스트라제네카 아베 | 트리아졸로 〔4,3-b〕 피리다진 유도체 및 전립샘암에 대한 이의 용도 |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
US9145419B2 (en) | 2010-04-28 | 2015-09-29 | Bristol-Myers Squibb Company | Imidazopyridazinyl compounds |
CA2831935A1 (en) | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use |
RU2586333C1 (ru) | 2011-12-09 | 2016-06-10 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Производные 4-гидрокси-1,2,3,4-тетрагидронафталин-1-ил-мочевины и их применение в лечении, среди прочего, заболеваний дыхательного тракта |
EP2992112B1 (en) | 2013-04-22 | 2020-06-03 | Icahn School of Medicine at Mount Sinai | Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis |
US9988386B2 (en) | 2013-05-30 | 2018-06-05 | Kata Pharmaceuticals, Inc. | Compounds for treatment of diseases of abnormal angiogenesis or aberrant growth factors and uses thereof |
EP3077393A1 (en) * | 2013-12-06 | 2016-10-12 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
CN106068252B (zh) | 2013-12-13 | 2023-02-03 | 欧洲化学农业有限公司 | 含硝化抑制剂的肥料混合物 |
WO2016086026A1 (en) * | 2014-11-26 | 2016-06-02 | Kala Pharmaceuticals, Inc. | Crystalline forms of a therapeutic compound and uses thereof |
EP3231427A4 (en) * | 2014-12-10 | 2018-07-11 | Senju Pharmaceutical Co., Ltd. | Aqueous liquid agent |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
CR20180501A (es) | 2016-04-04 | 2019-04-05 | Loxo Oncology Inc | Formulaciones liquidas de (s)-n-(5-((r)-2(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a] pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
PT3800189T (pt) | 2016-05-18 | 2023-07-27 | Array Biopharma Inc | Preparação de (s)-n-(5-((r)-2-(2,5- difluoropenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3- il)-3-hidroxipirrolidina-1-carboxamida |
JP2019519582A (ja) | 2016-06-29 | 2019-07-11 | オリオン コーポレーション | ベンゾジオキサン誘導体およびその医薬用途 |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
CN110177581B (zh) * | 2016-11-16 | 2023-01-03 | 通用医疗公司 | 髓过氧化物酶显像剂 |
CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
US20220229072A1 (en) | 2019-06-04 | 2022-07-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
JPWO2021075477A1 (es) * | 2019-10-16 | 2021-04-22 | ||
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
US20220389488A1 (en) * | 2021-03-12 | 2022-12-08 | Gt Molecular, Llc | Multiplexed genotyping assays with a single probe using fluorescent amplitude tuning |
WO2023081923A1 (en) | 2021-11-08 | 2023-05-11 | Frequency Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001333A1 (en) | 1987-08-07 | 1989-02-23 | The Australian National University | IMIDAZO[1,2-b]PYRIDAZINES |
WO1989001478A1 (en) | 1987-08-07 | 1989-02-23 | The Australian National University | ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES |
GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
JPH0820584A (ja) | 1994-07-04 | 1996-01-23 | Takeda Chem Ind Ltd | イミダゾール誘導体及びその用途 |
CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
CN1183114C (zh) | 1999-01-22 | 2005-01-05 | 麒麟麦酒株式会社 | 喹啉衍生物及喹唑啉衍生物 |
BR0015203A (pt) | 1999-11-05 | 2002-07-16 | Astrazeneca Ab | Derivado de quinazolina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um composto, e, processo para a produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente |
AR034118A1 (es) | 2000-02-15 | 2004-02-04 | Sugen Inc | Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis |
EP1506962B1 (en) | 2000-10-20 | 2008-07-02 | Eisai R&D Management Co., Ltd. | Nitrogen-containing aromatic heterocycles |
JP2003137785A (ja) * | 2001-08-23 | 2003-05-14 | Takeda Chem Ind Ltd | Jnk活性化阻害剤 |
CA2551867C (en) | 2003-12-31 | 2010-08-17 | Schering-Plough Ltd. | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives |
EP1813613B1 (en) * | 2004-11-08 | 2012-12-19 | Msd K.K. | Novel fused imidazole derivative |
EP1832588A4 (en) * | 2004-12-28 | 2009-09-02 | Takeda Pharmaceutical | IMIDAZOLE CONDENSE DERIVATIVE AND APPLICATIONS THEREOF |
WO2007013673A1 (en) | 2005-07-29 | 2007-02-01 | Astellas Pharma Inc. | Fused heterocycles as lck inhibitors |
WO2007025090A2 (en) * | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase |
DE102005042742A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US7723336B2 (en) * | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
JPWO2008016131A1 (ja) | 2006-08-04 | 2009-12-24 | 武田薬品工業株式会社 | 縮合複素環化合物 |
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2007
- 2007-08-03 AR ARP070103435A patent/AR062207A1/es unknown
- 2007-08-03 US US12/064,903 patent/US8044049B2/en active Active
- 2007-08-03 BR BRPI0714665-5A patent/BRPI0714665A2/pt not_active IP Right Cessation
- 2007-08-03 JP JP2009522492A patent/JP5238697B2/ja active Active
- 2007-08-03 KR KR1020097004527A patent/KR20090047509A/ko not_active Application Discontinuation
- 2007-08-03 EP EP07792327.4A patent/EP2049541B1/en active Active
- 2007-08-03 CL CL200702261A patent/CL2007002261A1/es unknown
- 2007-08-03 MX MX2009001349A patent/MX2009001349A/es unknown
- 2007-08-03 PE PE2007001018A patent/PE20080538A1/es not_active Application Discontinuation
- 2007-08-03 WO PCT/JP2007/065681 patent/WO2008016192A2/en active Application Filing
- 2007-08-03 AU AU2007279595A patent/AU2007279595A1/en not_active Abandoned
- 2007-08-03 CA CA002659971A patent/CA2659971A1/en not_active Abandoned
- 2007-08-03 TW TW096128518A patent/TW200817409A/zh unknown
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2008
- 2008-11-03 US US12/263,949 patent/US8273741B2/en active Active
- 2008-11-03 US US12/263,884 patent/US8034812B2/en active Active
- 2008-11-03 US US12/263,841 patent/US20100168424A1/en not_active Abandoned
-
2009
- 2009-01-29 IL IL196799A patent/IL196799A0/en unknown
- 2009-02-09 CR CR10607A patent/CR10607A/es not_active Application Discontinuation
- 2009-02-17 MA MA31647A patent/MA30651B1/fr unknown
- 2009-03-04 CO CO09022290A patent/CO6150183A2/es unknown
- 2009-03-04 NO NO20090986A patent/NO20090986L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2049541A2 (en) | 2009-04-22 |
BRPI0714665A2 (pt) | 2012-03-13 |
AU2007279595A1 (en) | 2008-02-07 |
US20100168424A1 (en) | 2010-07-01 |
JP5238697B2 (ja) | 2013-07-17 |
MX2009001349A (es) | 2009-04-17 |
IL196799A0 (en) | 2009-11-18 |
US20100273788A1 (en) | 2010-10-28 |
CL2007002261A1 (es) | 2008-05-02 |
US8044049B2 (en) | 2011-10-25 |
US8034812B2 (en) | 2011-10-11 |
WO2008016192A3 (en) | 2008-05-08 |
CO6150183A2 (es) | 2010-04-20 |
CA2659971A1 (en) | 2008-02-07 |
PE20080538A1 (es) | 2008-06-18 |
US20090137595A1 (en) | 2009-05-28 |
CR10607A (es) | 2009-03-12 |
AU2007279595A2 (en) | 2009-03-19 |
WO2008016192A2 (en) | 2008-02-07 |
JP2009545583A (ja) | 2009-12-24 |
NO20090986L (no) | 2009-05-04 |
KR20090047509A (ko) | 2009-05-12 |
US8273741B2 (en) | 2012-09-25 |
MA30651B1 (fr) | 2009-08-03 |
TW200817409A (en) | 2008-04-16 |
EP2049541B1 (en) | 2015-09-23 |
US20090306374A1 (en) | 2009-12-10 |
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