AR059908A1 - Derivados de 4-(pirrolopiridinil)-pirimidinil-2-amina - Google Patents
Derivados de 4-(pirrolopiridinil)-pirimidinil-2-aminaInfo
- Publication number
- AR059908A1 AR059908A1 ARP070101066A ARP070101066A AR059908A1 AR 059908 A1 AR059908 A1 AR 059908A1 AR P070101066 A ARP070101066 A AR P070101066A AR P070101066 A ARP070101066 A AR P070101066A AR 059908 A1 AR059908 A1 AR 059908A1
- Authority
- AR
- Argentina
- Prior art keywords
- ncycloalkyl
- nhet
- nar
- hal
- atoms
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la formula (1) en donde R1 es A, -[C(R6)2]nAr, -[C(R6)2]nHet, -[C(R6)2]ncicloalquilo, COR7, COOR7, CON(R7)2 o SO2R7, en donde Het (distinto) 2,2,6,6-tetrametil-piperidin-4-ilo, R2 es H o A, R3, R4 son cada uno, de modo independiente entre sí, H, A, Hal, CN, -[C(R6)2]nAr, -[C(R6)2]nHet o -[C(R6)2]ncicloalquilo, R5 es H, A, -[C(R6)2]nAr, -[C(R6)2]nHet o -[C(R6)2]ncicloalquilo; R6 es H o alquilo C1-6, R7 es H, A, -[C(R6)2]nAr, -[C(R6)2]nHet o -[C(R6)2]ncicloalquilo; A, A' son cada uno, de modo independiente entre sí, alquilo no ramificado o ramificado C1-10, en donde uno o dos grupos CH2 pueden estar reemplazados por átomos de O o S y/o por grupos -CH=CH- y/o también 1-7 átomos de H pueden estar reemplazados por F, Hal es F, Cl, Br o I, Ar es un carbociclo saturado, insaturado o aromático no sustituido o mono-, di-, tri-, tetra- o pentasustituido con OH, OA, SH, SA, SOA, SO2A, Hal, NO2, NH2, NHA, NAA', A, SO2NH2, SO2NHA, SO2NAA', CONH2, CONHA, CONAA', NACOA', NASO2A', COOH, COOA, COA, CHO o CN C5-14; Het es un heterociclo saturado, insaturado o aromático mono-, di- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con OH, OA, SH, SA, SOA, SO2A, Hal, NO2, NH2, NHA, NAA', A, SO2NH2, SO2NHA, SO2NAA', CONH2, CONHA, CONAA', NACOA', NASO2A', COOH, COOA, CHO, COA, CN, =S, =NH, =NA y/u =O (oxígeno del carbonilo), n es 0, 1 o 2, así como sus derivados, solvatos, sales, tautomeros y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones, son inhibidores de la proliferacion celular / vitalidad celular y se pueden emplear para el tratamiento de tumores.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006012617A DE102006012617A1 (de) | 2006-03-20 | 2006-03-20 | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059908A1 true AR059908A1 (es) | 2008-05-07 |
Family
ID=38157884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101066A AR059908A1 (es) | 2006-03-20 | 2007-03-16 | Derivados de 4-(pirrolopiridinil)-pirimidinil-2-amina |
Country Status (8)
Country | Link |
---|---|
US (1) | US20100173923A1 (es) |
EP (1) | EP1996586A1 (es) |
JP (1) | JP2009530321A (es) |
AR (1) | AR059908A1 (es) |
AU (1) | AU2007229070A1 (es) |
CA (1) | CA2646463A1 (es) |
DE (1) | DE102006012617A1 (es) |
WO (1) | WO2007107221A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007328981B2 (en) | 2006-12-08 | 2013-07-11 | F. Hoffmann-La Roche Ag | Substituted pyrimidines and their use as JNK modulators |
TW200838517A (en) | 2006-12-21 | 2008-10-01 | Vertex Pharma | Compounds useful as protein kinases inhibitors |
DE102007028515A1 (de) * | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | 6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
DE102008005493A1 (de) * | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
DE102008031517A1 (de) * | 2008-07-03 | 2010-01-07 | Merck Patent Gmbh | Pyrrolopyridinyl-pyrimidin-2-yl-amin-derivate |
CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
JP5721706B2 (ja) | 2009-06-17 | 2015-05-20 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルス複製の阻害剤 |
EP2454262B1 (en) | 2009-07-15 | 2014-05-14 | Abbott Laboratories | Pyrrolopyrazine inhibitors of kinases |
CN102471339A (zh) | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
DE102009060175A1 (de) * | 2009-12-23 | 2011-06-30 | Merck Patent GmbH, 64293 | Pyrrolo[2,3-d] pyrazin-7-yl-pyrimidin-Verbindungen |
DE102010050558A1 (de) * | 2010-11-05 | 2012-05-10 | Merck Patent Gmbh | 1H-Pyrrolo[2,3-b]pyridinderivate |
CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
DE102011009961A1 (de) * | 2011-02-01 | 2012-08-02 | Merck Patent Gmbh | 7-Azaindolderivate |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
SI3421468T1 (sl) | 2013-11-13 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Postopki za pripravo inhibitorjev replikacije virusov influence |
CN105849100B (zh) | 2013-11-13 | 2019-07-16 | 沃泰克斯药物股份有限公司 | 流感病毒复制抑制剂 |
MX2017009571A (es) * | 2015-01-23 | 2018-09-27 | Aclaris Therapeutics Inc | Inhibidores heterociclicos de itk para el tratamiento de la inflamacion y cancer. |
EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤 |
AU2021406650A1 (en) * | 2020-12-24 | 2023-06-29 | Exscientia Ai Limited | Aromatic heterocyclic compound, and pharmaceutical composition and application thereof |
CN115785134B (zh) * | 2022-10-28 | 2023-08-29 | 浙大城市学院 | 一种含氮杂环的硼酸化合物及制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001506980A (ja) * | 1996-11-19 | 2001-05-29 | アムジエン・インコーポレーテツド | アリールおよびヘテロアリール置換縮合ピロール抗炎症剤 |
GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
TWI465437B (zh) * | 2004-03-30 | 2014-12-21 | Vertex Pharma | 適合作為jak及其它蛋白質激酶抑制劑之氮雜吲哚 |
US20080153869A1 (en) * | 2004-06-14 | 2008-06-26 | Bressi Jerome C | Kinase Inhibitors |
CA2573362A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
CA2583428A1 (en) * | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
WO2006038001A1 (en) * | 2004-10-06 | 2006-04-13 | Celltech R & D Limited | Aminopyrimidine derivatives as jnk inhibitors |
US7855205B2 (en) * | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
CA2608333A1 (en) * | 2005-05-16 | 2006-11-23 | Irm Llc | Pyrrolopyridine derivatives as protein kinase inhibitors |
-
2006
- 2006-03-20 DE DE102006012617A patent/DE102006012617A1/de not_active Withdrawn
-
2007
- 2007-02-21 EP EP07703534A patent/EP1996586A1/de not_active Withdrawn
- 2007-02-21 JP JP2009500722A patent/JP2009530321A/ja active Pending
- 2007-02-21 CA CA002646463A patent/CA2646463A1/en not_active Abandoned
- 2007-02-21 US US12/293,691 patent/US20100173923A1/en not_active Abandoned
- 2007-02-21 AU AU2007229070A patent/AU2007229070A1/en not_active Abandoned
- 2007-02-21 WO PCT/EP2007/001494 patent/WO2007107221A1/de active Application Filing
- 2007-03-16 AR ARP070101066A patent/AR059908A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20100173923A1 (en) | 2010-07-08 |
AU2007229070A1 (en) | 2007-09-27 |
WO2007107221A1 (de) | 2007-09-27 |
CA2646463A1 (en) | 2007-09-27 |
EP1996586A1 (de) | 2008-12-03 |
DE102006012617A1 (de) | 2007-09-27 |
JP2009530321A (ja) | 2009-08-27 |
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Legal Events
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FB | Suspension of granting procedure |