AR055074A1 - Derivados de heteroaril benzamidas como activadores de glk en el tratamiento de diabetes. procesos de obtencion y composiciones farmaceuticas. - Google Patents
Derivados de heteroaril benzamidas como activadores de glk en el tratamiento de diabetes. procesos de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR055074A1 AR055074A1 ARP060102937A ARP060102937A AR055074A1 AR 055074 A1 AR055074 A1 AR 055074A1 AR P060102937 A ARP060102937 A AR P060102937A AR P060102937 A ARP060102937 A AR P060102937A AR 055074 A1 AR055074 A1 AR 055074A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- atom
- ring
- available
- independently selected
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procesos de preparacion y composiciones farmacéuticas que los comprenden. Reivindicacion 1: Un compuesto de formula (1) donde: R1 se selecciona de isopropilo, but-2-ilo, ciclopentilo, 1,1,1-trifluorprop-2-ilo, 1,3- difluorprop-2-ilo, but-1-in-3-ilo, 1-hidroxiprop-2-ilo, 2-hidroxibut-3-ilo, 1-hidroxibut-2-ilo, tetrahidrofurilo, tetrahidropiranilo, 1-metoxiprop-2-ilo, 1-metoxibut-2-ilo, 2-hidroxiprop-1-ilo, 2-metoxiprop-1-ilo, 2-hidroxibut-1-ilo, 2-metoxibut-1-ilo, 1-fluormetoxiprop-2-ilo, 1,1- difluormetoxiprop-2-ilo y 1-trifluormetoxiprop-2-ilo; HET-1 es un anillo heteroarilo unido a C de 5 o 6 miembros que contiene un átomo de N en la posicion 2 y opcionalmente 1 o 2 heteroátomos adicionales en el anillo independientemente seleccionados de O, N y S; anillo que está opcionalmente sustituido en cualquier átomo de N (siempre que no esté de este modo cuaternizado) con un sustituyente seleccionado de R7 y/o en 1 o 2 átomos de C disponibles con un sustituyente independientemente seleccionado de R6; HET-2 es un anillo heteroarilo de 5 o 6 miembros, que contiene 1, 2 o 3 heteroátomos en el anillo independientemente seleccionados de O, S y N; anillo que está sustituido en un átomo de C disponible con un sustituyente seleccionado de R2, y está opcionalmente además sustituido en 1 o 2 átomos de C disponibles con un sustituyente independientemente seleccionado de R3 y/o en un átomo de N disponible (siempre que no esté de este modo cuaternizado) con un sustituyente seleccionado de R10; R2 se selecciona de -C(O)NR4R5 y -SO2NR4R5; R3 se selecciona de metilo, trifluormetilo y halo; R4 y R5 junto con el átomo de N al cual están unidos forman un anillo heterociclilo saturado o parcialmente insaturado de 4 a 7 miembros, que contiene opcionalmente 1 o 2 heteroátomos adicionales (además del átomo de N conector) independientemente seleccionados de O, N y S, donde un grupo -CH2- puede estar opcionalmente reemplazado por un -C(O)- y donde un átomo de S del anillo puede estar opcionalmente oxidado a un grupo S(O) o S(O)2; anillo que está opcionalmente sustituido en un átomo de C disponible con 1 o 2 sustituyentes independientemente seleccionados de R8 y/o en un átomo de N disponible con un sustituyente seleccionado de R9; o R4 y R5 junto con el átomo de N al cual están unidos forman un anillo heterociclilo saturado o parcialmente insaturado bicíclico de 6 a 10 miembros, que contiene opcionalmente otro átomo de N (además del átomo de N conector), donde un grupo -CH2- puede estar opcionalmente reemplazado por un -C(O)-; anillo que está opcionalmente sustituido en un C disponible con 1 sustituyente seleccionado de hidroxi y R3 o en un átomo de N disponible con metilo; R6 se selecciona independientemente de alquilo C1-4, halo, hidroxialquilo C1-4, alcoxi C1-4-alquilo C1-4, alquil C1-4-S(O)palquilo C1-4, aminoalquilo C1-4, alquilamino C1-4-alquilo C1-4 y dialquilamino C1-4-alquilo C1-4; R7 se selecciona independientemente de alquilo C1-4, haloalquilo C1-4, dihaloalquilo C1-4, trihaloalquilo C1-4, hidroxialquilo C1-4, alcoxi C1-4-alquilo C1-4, alquil C1-4S(O)p-alquilo C1-4, aminoalquilo C1-4, alquilamino C1-4-alquilo C1-4 y di-alquilamino C1-4-alquilo C1-4; R8 se selecciona de hidroxi, alcoxi C1-4, alquilo C1-4, aminocarbonilo, alquilamino C1-4-carbonilo, dialquilamino C1-4-carbonilo, alquilamino C1-4, dialquilamino C1-4, alcoxi C1-4-alquilo C1-4, hidroxialquilo C1-4 y - S(O)p-alquilo C1-4; R9 se selecciona de alquilo C1-4, -C(O)alquilo C1-4, aminocarbonilo, alquilaminocarbonilo C1-4, dialquilaminocarbonilo C1-4, alcoxi C1-4-alquilo C1-4, hidroxialquilo C1-4 y -S(O)p-alquilo C1-4; R10 se selecciona de alquilo C1-4, cicloalquilo C3-6, hidroxialquilo C1- 4, alcoxi C1-4-alquilo C1-4, -C(O)-alquilo C1-4, bencilo y alquilsulfonilo C1-4, p es (independientemente en cada aparicion) 0, 1 o 2; o su sal.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0514173A GB0514173D0 (en) | 2005-07-09 | 2005-07-09 | Chemical compounds |
GB0516297A GB0516297D0 (en) | 2005-08-09 | 2005-08-09 | Chemical compounds |
GB0523862A GB0523862D0 (en) | 2005-11-24 | 2005-11-24 | Chemical compounds |
GB0524589A GB0524589D0 (en) | 2005-12-02 | 2005-12-02 | Chemical compounds |
GB0607977A GB0607977D0 (en) | 2006-04-22 | 2006-04-22 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
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AR055074A1 true AR055074A1 (es) | 2007-08-01 |
Family
ID=36809156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060102937A AR055074A1 (es) | 2005-07-09 | 2006-07-07 | Derivados de heteroaril benzamidas como activadores de glk en el tratamiento de diabetes. procesos de obtencion y composiciones farmaceuticas. |
Country Status (20)
Country | Link |
---|---|
US (4) | US7642259B2 (es) |
EP (4) | EP2301929A1 (es) |
JP (4) | JP4651714B2 (es) |
KR (2) | KR20110084339A (es) |
AR (1) | AR055074A1 (es) |
AU (2) | AU2006268406C1 (es) |
BR (3) | BRPI0613570B8 (es) |
CA (1) | CA2614746C (es) |
EC (1) | ECSP088164A (es) |
ES (1) | ES2397648T3 (es) |
HK (1) | HK1116769A1 (es) |
IL (2) | IL188059A0 (es) |
MX (1) | MX2008000172A (es) |
MY (1) | MY147749A (es) |
NO (1) | NO20076658L (es) |
NZ (4) | NZ564608A (es) |
SA (1) | SA06270215B1 (es) |
TW (1) | TW200730174A (es) |
UY (1) | UY29656A1 (es) |
WO (1) | WO2007007041A1 (es) |
Families Citing this family (33)
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AU2005214132B9 (en) * | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
EP2301929A1 (en) * | 2005-07-09 | 2011-03-30 | AstraZeneca AB (Publ) | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
RU2009105818A (ru) | 2006-07-24 | 2010-08-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Пиразолы в качестве активаторов глюкокиназы |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
TW200825060A (en) * | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
UY30822A1 (es) * | 2006-12-21 | 2008-07-31 | Astrazeneca Ab | Fnueva forma cristalina de 3-{[5-azetidin-1-ylcabonyl)pyrazin-2-yl]oxy}-5-[1-methylethyloxy]-n-1h-pyrazol-3-ylbenzamida, composiciones conteniéndola, procesos de preparacion y aplicaciones |
TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
EP2170852A1 (en) | 2007-06-11 | 2010-04-07 | Bristol-Myers Squibb Company | 1, 3 - dihydroxy substituted phenylamide glucokinase activators |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
SI2195312T1 (sl) * | 2007-10-09 | 2013-01-31 | Merck Patent Gmbh | Derivati piridina, uporabni kot aktivatorji glukokinaze |
KR20100066580A (ko) | 2007-10-09 | 2010-06-17 | 메르크 파텐트 게엠베하 | 글루코키나아제 활성인자로서의 n-(피라졸-3-일)-벤즈아미드 유도체 |
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US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
KR20110052676A (ko) | 2008-08-04 | 2011-05-18 | 아스트라제네카 아베 | 피라졸로[3,4]피리미딘-4-일 유도체 및 당뇨병 및 비만을 치료하기 위한 이의 용도 |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
WO2010116176A1 (en) * | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
WO2011095997A1 (en) | 2010-02-08 | 2011-08-11 | Advinus Therapeutics Private Limited | Benzamide compounds as glucokinase activators and their pharmaceutical application |
WO2011135355A1 (en) | 2010-04-29 | 2011-11-03 | Astrazeneca Ab | 3-{ [5 -(azetidin-1-ylcarbonyl)pyrazin-2 -yl] oxy} -5-{ [(1s) -2 -hydroxy- 1 -methylethyl]oxy} -n- (5 -methylpyrazin-2-) benzamid monohydrate |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
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KR20240063930A (ko) | 2021-09-02 | 2024-05-10 | 콘두이트 유케이 매니지먼트 엘티디 | 3-{[5-(아제티딘-1-일카르보닐)피라진-2-일]옥시}-5-{[(1s)-1-메틸-2-(메틸옥시)에틸]옥시)-n-(5-메틸피라진-2-일)벤즈아미드의치료 공결정 |
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