BRPI0613570A8 - composto ou um sal do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método para tratar doenças mediadas por glk, e, processo para a preparação de um composto. - Google Patents

composto ou um sal do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método para tratar doenças mediadas por glk, e, processo para a preparação de um composto.

Info

Publication number
BRPI0613570A8
BRPI0613570A8 BRPI0613570A BRPI0613570A BRPI0613570A8 BR PI0613570 A8 BRPI0613570 A8 BR PI0613570A8 BR PI0613570 A BRPI0613570 A BR PI0613570A BR PI0613570 A BRPI0613570 A BR PI0613570A BR PI0613570 A8 BRPI0613570 A8 BR PI0613570A8
Authority
BR
Brazil
Prior art keywords
compound
salt
preparing
pharmaceutically acceptable
pharmaceutical composition
Prior art date
Application number
BRPI0613570A
Other languages
English (en)
Inventor
Mckerrecher Darren
Gordon Pike Kurt
James Waring Michael
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36809156&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0613570(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0514173A external-priority patent/GB0514173D0/en
Priority claimed from GB0516297A external-priority patent/GB0516297D0/en
Priority claimed from GB0523862A external-priority patent/GB0523862D0/en
Priority claimed from GB0524589A external-priority patent/GB0524589D0/en
Priority claimed from GB0607977A external-priority patent/GB0607977D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0613570A2 publication Critical patent/BRPI0613570A2/pt
Publication of BRPI0613570A8 publication Critical patent/BRPI0613570A8/pt
Publication of BRPI0613570B1 publication Critical patent/BRPI0613570B1/pt
Publication of BRPI0613570B8 publication Critical patent/BRPI0613570B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

os compostos da fórmula (i): os compostos da fórmula (i) em que r1, het-1 and het-2 são como descritos no relatório descritivo e seus sais e pró-medicamentos, são ativadores de glicocinase (glk) e são, desse modo úteis no tratamento de, por exemplo, diabete 2. os processos para a preparação de compostos da fórmula (i) também são descritos.
BRPI0613570A 2005-07-09 2006-07-03 composto, composição farmacêutica e uso de um composto ou um sal farmaceuticamente aceitável do mesmo BRPI0613570B8 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
GB0514173A GB0514173D0 (en) 2005-07-09 2005-07-09 Chemical compounds
GB0514173.4 2005-07-09
GB0516297A GB0516297D0 (en) 2005-08-09 2005-08-09 Chemical compounds
GB0516297.9 2005-08-09
GB0523862.1 2005-11-24
GB0523862A GB0523862D0 (en) 2005-11-24 2005-11-24 Chemical compounds
GB0524589A GB0524589D0 (en) 2005-12-02 2005-12-02 Chemical compounds
GB0524589.9 2005-12-02
GB0607977.6 2006-04-22
GB0607977A GB0607977D0 (en) 2006-04-22 2006-04-22 Chemical compounds
PCT/GB2006/002471 WO2007007041A1 (en) 2005-07-09 2006-07-03 Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes

Publications (4)

Publication Number Publication Date
BRPI0613570A2 BRPI0613570A2 (pt) 2010-07-06
BRPI0613570A8 true BRPI0613570A8 (pt) 2017-12-26
BRPI0613570B1 BRPI0613570B1 (pt) 2020-02-18
BRPI0613570B8 BRPI0613570B8 (pt) 2021-05-25

Family

ID=36809156

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0613570A BRPI0613570B8 (pt) 2005-07-09 2006-07-03 composto, composição farmacêutica e uso de um composto ou um sal farmaceuticamente aceitável do mesmo
BRPI0622262-5A BRPI0622262A2 (pt) 2005-07-09 2006-07-03 composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
BRPI0622261-7A BRPI0622261A2 (pt) 2005-07-09 2006-07-03 composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto

Family Applications After (2)

Application Number Title Priority Date Filing Date
BRPI0622262-5A BRPI0622262A2 (pt) 2005-07-09 2006-07-03 composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
BRPI0622261-7A BRPI0622261A2 (pt) 2005-07-09 2006-07-03 composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto

Country Status (20)

Country Link
US (4) US7642259B2 (pt)
EP (4) EP2301929A1 (pt)
JP (4) JP4651714B2 (pt)
KR (2) KR101346902B1 (pt)
AR (1) AR055074A1 (pt)
AU (2) AU2006268406C1 (pt)
BR (3) BRPI0613570B8 (pt)
CA (1) CA2614746C (pt)
EC (1) ECSP088164A (pt)
ES (1) ES2397648T3 (pt)
HK (1) HK1116769A1 (pt)
IL (2) IL188059A0 (pt)
MX (1) MX2008000172A (pt)
MY (1) MY147749A (pt)
NO (1) NO20076658L (pt)
NZ (4) NZ575513A (pt)
SA (1) SA06270215B1 (pt)
TW (1) TW200730174A (pt)
UY (1) UY29656A1 (pt)
WO (1) WO2007007041A1 (pt)

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AU2006268406C1 (en) * 2005-07-09 2011-02-24 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
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TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
CL2007003061A1 (es) * 2006-10-26 2008-08-01 Astrazeneca Ab Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2.
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US20100094009A1 (en) * 2006-12-21 2010-04-15 Mccabe James Novel crystalline compound useful as glk activator
TW200836719A (en) 2007-02-12 2008-09-16 Astrazeneca Ab Chemical compounds
WO2008154563A1 (en) * 2007-06-11 2008-12-18 Bristol-Myers Squibb Company 1, 3 - dihydroxy substituted phenylamide glucokinase activators
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PT2197849E (pt) 2007-10-09 2013-04-23 Merck Patent Gmbh Derivados de n-(pirazole-3-il)-benzamida como ativadores de glucoquinase
EP2195312B1 (en) * 2007-10-09 2012-11-21 Merck Patent GmbH Pyridine derivatives useful as glucokinase activators
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GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
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AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
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NZ575512A (en) 2009-11-27
UY29656A1 (es) 2007-02-28
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AU2006268406B2 (en) 2010-09-16
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NZ575514A (en) 2009-11-27
IL188059A0 (en) 2008-03-20
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US7977328B2 (en) 2011-07-12
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