AR051197A1 - Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones - Google Patents

Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones

Info

Publication number
AR051197A1
AR051197A1 ARP050103641A ARP050103641A AR051197A1 AR 051197 A1 AR051197 A1 AR 051197A1 AR P050103641 A ARP050103641 A AR P050103641A AR P050103641 A ARP050103641 A AR P050103641A AR 051197 A1 AR051197 A1 AR 051197A1
Authority
AR
Argentina
Prior art keywords
microemulsion
surfactant
water
temperature
submicron emulsion
Prior art date
Application number
ARP050103641A
Other languages
English (en)
Inventor
Maria Graziella Larm
Ronald Harding
Original Assignee
Connetics Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35999634&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR051197(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Connetics Australia Pty Ltd filed Critical Connetics Australia Pty Ltd
Publication of AR051197A1 publication Critical patent/AR051197A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/068—Microemulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

Se provee un procedimiento para la preparacion de una composicion de microemulsion o emulsion submicrométrica de aceite en agua (aceite/agua) para el suministro dérmico de por lo menos un ingrediente farmacéuticamente activo, el método incluye los pasos de: a) mezclar una primera parte que incluye por lo menos uno del grupo que consiste en aceites animales, minerales o vegetales, silanos, siloxanos, ésteres, ácidos grasos, grasas, compuestos de halogeno o alcoholes alcoxilados; y uno o más de tensioactivos lipofilos; y una segunda parte que incluye agua y por lo menos un tensioactivo hidrofilo para lograr la homogeneidad; b) calentar la mezcla del paso a) a una temperatura de combinacion de fases en el rango de 40-99sC, preferentemente 45-95sC, más preferentemente 65-85sC, con mezclado continuo par obtener una microemulsion o emulsion submicrométrica; c) dejar enfriar a dicha microemulsion o emulsion submicrométrica; y d) agregar una tercera parte a dicha microemulsion o emulsion submicrométrica a una temperatura entre 2sC y dicha temperatura de combinacion de fases, premezclándose y calentándose dicha tercera parte, si es necesario, hasta la disolucion de los componentes, e incluyendo por lo menos un componente seleccionado entre el grupo que consiste en un compuesto tipo anfifílico, no tensioactivo, un tensioactivo y agua, con la condicion de que cuando la tercera parte incluye agua, también incluye un compuesto tipo anfifílico no tensioactivo y/o un tensioactivo. La temperatura de la combinacion de fases puede ser determinada visualmente porque se logra la translucidez en la composicion o por medidas tales como la conductividad que llega a un máximo y luego se mantiene en una meseta mientras se produce la combinacion de fases. Se ha hallado que mientras que si se logra un compuesto tipo anfifílico no tensioactivo tal como el poliol junto con la segunda parte, como seria el caso convencionalmente, no se forma una microemulsion o emulsion submicrométrica, agregando la así llamada tercera parte, se produce la combinacion de fases a una temperatura más baja que la que se esperaría y además, esta fase parece ayudar a mantener las características de la microemulsion o emulsion submicrométrica de la formulacion durante el almacenamiento a temperaturas normales.
ARP050103641A 2004-08-31 2005-08-31 Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones AR051197A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60627804P 2004-08-31 2004-08-31
US67072205P 2005-04-12 2005-04-12

Publications (1)

Publication Number Publication Date
AR051197A1 true AR051197A1 (es) 2006-12-27

Family

ID=35999634

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103641A AR051197A1 (es) 2004-08-31 2005-08-31 Un procedimiento para obtener una microemulsion y sub-micron emulsion y composiciones

Country Status (15)

Country Link
US (1) US8460641B2 (es)
EP (2) EP2438910A1 (es)
JP (1) JP4972553B2 (es)
KR (1) KR101243526B1 (es)
AR (1) AR051197A1 (es)
AU (1) AU2005279704B2 (es)
BR (1) BRPI0514806A (es)
CA (1) CA2578594C (es)
ES (1) ES2429040T5 (es)
HK (1) HK1110198A1 (es)
IL (1) IL181632A (es)
PL (1) PL1796636T5 (es)
RU (1) RU2381023C2 (es)
TW (1) TWI397427B (es)
WO (1) WO2006024095A1 (es)

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Also Published As

Publication number Publication date
TWI397427B (zh) 2013-06-01
US20060057168A1 (en) 2006-03-16
CA2578594A1 (en) 2006-03-09
WO2006024095A1 (en) 2006-03-09
BRPI0514806A (pt) 2008-06-24
HK1110198A1 (en) 2008-07-11
TW200624124A (en) 2006-07-16
EP1796636A1 (en) 2007-06-20
CA2578594C (en) 2012-04-17
US8460641B2 (en) 2013-06-11
ES2429040T3 (es) 2013-11-12
AU2005279704A1 (en) 2006-03-09
EP1796636A4 (en) 2011-03-02
ES2429040T5 (es) 2017-06-13
WO2006024095A8 (en) 2007-04-19
EP2438910A1 (en) 2012-04-11
RU2007111706A (ru) 2008-10-10
RU2381023C2 (ru) 2010-02-10
EP1796636B1 (en) 2013-08-14
AU2005279704B2 (en) 2010-05-13
PL1796636T5 (pl) 2017-10-31
IL181632A (en) 2015-01-29
JP2008511550A (ja) 2008-04-17
KR101243526B1 (ko) 2013-03-20
EP1796636B2 (en) 2016-12-14
KR20070069155A (ko) 2007-07-02
IL181632A0 (en) 2007-07-04
PL1796636T3 (pl) 2014-01-31
JP4972553B2 (ja) 2012-07-11

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