AR042632A1 - Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas - Google Patents
Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticasInfo
- Publication number
- AR042632A1 AR042632A1 ARP030104752A ARP030104752A AR042632A1 AR 042632 A1 AR042632 A1 AR 042632A1 AR P030104752 A ARP030104752 A AR P030104752A AR P030104752 A ARP030104752 A AR P030104752A AR 042632 A1 AR042632 A1 AR 042632A1
- Authority
- AR
- Argentina
- Prior art keywords
- disorders
- pharmaceutical compositions
- oxoetoxi
- etoxipropanoic
- lipids
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Abstract
El enantiómero S de un compuesto de fórmula (1), donde R1 representa cloro, trifluorometilo o trifluorometoxi; R2 representa H o fluoro y R3 representa un grupo alquilo C2-4, así como sales aceptables para uso farmacéutico, solvatos y profármacos del mismo; procesos para preparar dichos compuestos; su utilidad en el tratamiento de trastornos clínicos, por ejemplo de trastornos lipídicos (dislipidemias) relacionados o no relacionados con al resistencia a la insulina; métodos para su uso terapéutico y composiciones farmacéuticas que lo contienen, solo o en combinación con un inhibidor de IBAT.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0229931.1A GB0229931D0 (en) | 2002-12-21 | 2002-12-21 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
AR042632A1 true AR042632A1 (es) | 2005-06-29 |
Family
ID=9950253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104752A AR042632A1 (es) | 2002-12-21 | 2003-12-19 | Compuestos derivados del acido (2s)-3-(4-{2-[amino]-2-oxoetoxi} fenil)-2-etoxipropanoico como agentes terapeuticos para trastornos en el metabolismo de los lipidos y composiciones farmaceuticas |
Country Status (21)
Country | Link |
---|---|
US (1) | US7462644B2 (es) |
EP (1) | EP1572626A1 (es) |
JP (2) | JP3786945B2 (es) |
KR (1) | KR20050089065A (es) |
CN (1) | CN1308291C (es) |
AR (1) | AR042632A1 (es) |
AU (1) | AU2003290309B2 (es) |
BR (1) | BR0317458A (es) |
CA (1) | CA2508851A1 (es) |
CL (1) | CL2003002683A1 (es) |
CO (1) | CO5580820A2 (es) |
GB (1) | GB0229931D0 (es) |
IS (1) | IS7946A (es) |
MX (1) | MXPA05006812A (es) |
NO (1) | NO20052914L (es) |
PL (1) | PL377144A1 (es) |
RU (1) | RU2005117792A (es) |
TW (1) | TW200508180A (es) |
UA (1) | UA80729C2 (es) |
WO (1) | WO2004056748A1 (es) |
ZA (1) | ZA200504730B (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
GB0314079D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
ATE398615T1 (de) | 2002-03-13 | 2008-07-15 | Janssen Pharmaceutica Nv | Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase |
MXPA04007776A (es) | 2002-03-13 | 2004-10-15 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como nuevos inhibidores de histona deacetilasa. |
ES2306858T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de carbonilamino como nuevos inhibidores de las histonadesacetilasas. |
OA12790A (en) | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | New inhibitors of histone deacetylase. |
EP1517883B8 (en) | 2002-06-20 | 2008-05-21 | AstraZeneca AB | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
DK1599468T3 (da) | 2003-01-14 | 2008-02-04 | Arena Pharm Inc | 1,2,3-trisubstituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser forbundet dermed såsom diabetes og hyperglykæmi |
EP2287166A3 (en) | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
WO2006010750A1 (en) | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
BRPI0517701A8 (pt) * | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
US8138198B2 (en) | 2005-05-18 | 2012-03-20 | Angibaud Patrick Rene | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
EP1893583B1 (en) | 2005-05-31 | 2012-04-04 | Pfizer Inc. | Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists |
WO2007004957A1 (en) * | 2005-07-05 | 2007-01-11 | Astrazeneca Ab | Novel crystalline form |
AR055073A1 (es) * | 2005-07-11 | 2007-08-01 | Astrazeneca Ab | Agentes terapeuticos |
CN101370789B (zh) | 2006-01-19 | 2012-05-30 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶抑制剂的吡啶和嘧啶衍生物 |
JP5137849B2 (ja) | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体 |
DK1981871T3 (da) | 2006-01-19 | 2012-02-13 | Janssen Pharmaceutica Nv | Heterocyclylalkylderivater som hidtil ukendte inhibitorer af histondeacetylase |
DK1981874T3 (da) | 2006-01-19 | 2009-09-28 | Janssen Pharmactuica N V | Aminophenylderivater som nye inhibitorer af histondeacetylase |
WO2007082874A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
WO2007082880A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
WO2008150486A2 (en) | 2007-05-31 | 2008-12-11 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
WO2009045503A1 (en) | 2007-10-05 | 2009-04-09 | Genzyme Corporation | Method of treating polycystic kidney diseases with ceramide derivatives |
US8389517B2 (en) | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
EP2349255B1 (en) | 2008-10-03 | 2016-03-30 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
WO2010062861A2 (en) * | 2008-11-26 | 2010-06-03 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
EP2575821B1 (en) | 2010-05-26 | 2015-08-12 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
SG188548A1 (en) | 2010-09-22 | 2013-04-30 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
SI2637668T1 (sl) | 2010-11-08 | 2016-11-30 | Albiero Ab | IBAT inhibitorji za zdravljenje jetrnih bolezni |
JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
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EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
EP3242666A1 (en) | 2015-01-06 | 2017-11-15 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
JP6838744B2 (ja) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ, インコーポレイテッド | S1P1レセプター関連障害における使用のための(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸(化合物1)の結晶性L−アルギニン塩 |
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US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
KR20190116416A (ko) | 2017-02-16 | 2019-10-14 | 아레나 파마슈티칼스, 인크. | 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법 |
CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
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US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
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CA3158181A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
JP2023504644A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
CR20220315A (es) | 2019-12-04 | 2022-10-26 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar |
JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
EP4255565A1 (en) | 2020-12-04 | 2023-10-11 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE266121C (es) | ||||
BE489216A (es) | 1948-06-05 | 1900-01-01 | ||
US2928840A (en) | 1958-11-26 | 1960-03-15 | Us Vitamin Pharm Corp | 3-(o-substituted phenyl) oxazolidinediones and process therefor |
GB1081471A (en) | 1963-09-13 | 1967-08-31 | Stauffer Chemical Co | Glycol amide derivatives and use thereof in controlling weed growth |
US3244398A (en) | 1963-10-28 | 1966-04-05 | Scaramucci Domer | Composite seat ball valve |
AT307640B (de) | 1970-06-18 | 1973-05-25 | Richter Gedeon Vegyeszet | Verfahren zur Herstellung von neuen 17-Aza-steroiden und deren Salzen |
BE792364A (fr) | 1971-12-06 | 1973-06-06 | Basf Ag | Derives de substitution du sulfonylglycolanilide |
DE2349256C2 (de) | 1973-10-01 | 1985-08-01 | Basf Ag, 6700 Ludwigshafen | 0-Alkylsulfonyl-glykolsäureanilide und diese enthaltende Herbizide |
DE2828222A1 (de) | 1978-06-28 | 1980-01-10 | Bayer Ag | Gegenmittel zum schutz von kulturpflanzen vor schaedigungen durch herbizide |
US4735959A (en) | 1981-01-10 | 1988-04-05 | Dr. Karl Thomae Gmbh | Carboxylic acid amides and pharmaceutical compositions containing them |
US5216167A (en) | 1983-12-30 | 1993-06-01 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
US5312924A (en) | 1983-12-30 | 1994-05-17 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
US5210208A (en) | 1990-09-24 | 1993-05-11 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Disubstituted aryl compounds exhibiting selective leukotriene b4 antagonist activity |
US5958792A (en) | 1995-06-07 | 1999-09-28 | Chiron Corporation | Combinatorial libraries of substrate-bound cyclic organic compounds |
ATE268750T1 (de) | 1997-08-28 | 2004-06-15 | Biovitrum Ab | Proteintyrosinphosphatase inhibitoren |
US6410585B1 (en) | 1997-08-28 | 2002-06-25 | Scott D. Larsen | Inhibitors of protein tyrosine phosphatase |
EP1026149A4 (en) * | 1997-10-02 | 2004-12-01 | Sankyo Co | AMIDOCARBONSÄUREDERIVATE |
CA2309792A1 (en) | 1997-11-12 | 1999-05-20 | William C. Shakespeare | Novel signal transduction inhibitors, compositions containing them |
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
IL145732A0 (en) | 1999-04-06 | 2002-07-25 | Sankyo Co | α-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
WO2000061582A1 (fr) | 1999-04-08 | 2000-10-19 | Sankyo Company, Limited | Derives imidazole condenses substitues |
JP2000351777A (ja) * | 1999-04-08 | 2000-12-19 | Sankyo Co Ltd | 置換縮合イミダゾール誘導体 |
US6620929B1 (en) | 1999-04-14 | 2003-09-16 | University Of British Columbia | 1,3-Dipolar cycloadditions to polypyrrolic macrocycles |
WO2000063196A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
EP1177187B1 (en) | 1999-04-28 | 2007-07-25 | Sanofi-Aventis Deutschland GmbH | Di-aryl acid derivatives as ppar receptor ligands |
JP4618845B2 (ja) | 1999-06-09 | 2011-01-26 | 杏林製薬株式会社 | ヒトペルオキシゾーム増殖薬活性化受容体(PPAR)αアゴニストとしての置換フェニルプロピオン酸誘導体 |
TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
JP2001261612A (ja) | 2000-03-22 | 2001-09-26 | Mitsui Chemicals Inc | カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬 |
WO2002044130A1 (fr) | 2000-11-29 | 2002-06-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivés d'acide carboxylique substitués |
WO2002044127A1 (fr) | 2000-11-29 | 2002-06-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivés d'acide carboxylique substitué |
EP1360172A1 (en) | 2001-02-15 | 2003-11-12 | Pfizer Products Inc. | Ppar agonists |
WO2002083616A1 (fr) | 2001-04-10 | 2002-10-24 | Sankyo Company, Limited | DERIVE D'ACIDE GRAS φomega;-ARYLE α-SUBSTITUE |
GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
SE0104334D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
GB0314079D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
CN1662487A (zh) | 2002-06-19 | 2005-08-31 | 伊莱利利公司 | 酰胺连接基过氧化物酶体增殖物激活受体调节剂 |
GB0314136D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
GB0314129D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
GB0314134D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
-
2002
- 2002-12-21 GB GBGB0229931.1A patent/GB0229931D0/en not_active Ceased
-
2003
- 2003-12-10 TW TW092134839A patent/TW200508180A/zh unknown
- 2003-12-18 CL CL200302683A patent/CL2003002683A1/es unknown
- 2003-12-19 US US10/499,893 patent/US7462644B2/en not_active Expired - Fee Related
- 2003-12-19 AR ARP030104752A patent/AR042632A1/es unknown
- 2003-12-19 MX MXPA05006812A patent/MXPA05006812A/es unknown
- 2003-12-19 WO PCT/GB2003/005602 patent/WO2004056748A1/en active Application Filing
- 2003-12-19 EP EP03782668A patent/EP1572626A1/en not_active Withdrawn
- 2003-12-19 PL PL377144A patent/PL377144A1/pl not_active Application Discontinuation
- 2003-12-19 KR KR1020057011714A patent/KR20050089065A/ko not_active Application Discontinuation
- 2003-12-19 CN CNB2003801098952A patent/CN1308291C/zh not_active Expired - Fee Related
- 2003-12-19 AU AU2003290309A patent/AU2003290309B2/en not_active Ceased
- 2003-12-19 JP JP2004561668A patent/JP3786945B2/ja not_active Expired - Fee Related
- 2003-12-19 BR BR0317458-1A patent/BR0317458A/pt not_active IP Right Cessation
- 2003-12-19 RU RU2005117792/04A patent/RU2005117792A/ru not_active Application Discontinuation
- 2003-12-19 UA UAA200505596A patent/UA80729C2/uk unknown
- 2003-12-19 CA CA002508851A patent/CA2508851A1/en not_active Abandoned
-
2005
- 2005-06-15 NO NO20052914A patent/NO20052914L/no not_active Application Discontinuation
- 2005-06-22 ZA ZA200504730A patent/ZA200504730B/en unknown
- 2005-07-19 IS IS7946A patent/IS7946A/is unknown
- 2005-07-19 CO CO05071340A patent/CO5580820A2/es not_active Application Discontinuation
- 2005-09-01 JP JP2005253346A patent/JP2006045240A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1308291C (zh) | 2007-04-04 |
NO20052914D0 (no) | 2005-06-15 |
AU2003290309B2 (en) | 2007-01-18 |
US7462644B2 (en) | 2008-12-09 |
IS7946A (is) | 2005-07-19 |
MXPA05006812A (es) | 2005-09-08 |
AU2003290309A1 (en) | 2004-07-14 |
WO2004056748A1 (en) | 2004-07-08 |
RU2005117792A (ru) | 2006-01-27 |
GB0229931D0 (en) | 2003-01-29 |
CL2003002683A1 (es) | 2005-04-08 |
BR0317458A (pt) | 2005-11-16 |
US20050131068A1 (en) | 2005-06-16 |
UA80729C2 (en) | 2007-10-25 |
JP3786945B2 (ja) | 2006-06-21 |
EP1572626A1 (en) | 2005-09-14 |
TW200508180A (en) | 2005-03-01 |
JP2006045240A (ja) | 2006-02-16 |
CA2508851A1 (en) | 2004-07-08 |
PL377144A1 (pl) | 2006-01-23 |
ZA200504730B (en) | 2006-09-27 |
JP2006511572A (ja) | 2006-04-06 |
CN1753862A (zh) | 2006-03-29 |
KR20050089065A (ko) | 2005-09-07 |
CO5580820A2 (es) | 2005-11-30 |
NO20052914L (no) | 2005-07-19 |
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