AR038781A1 - Compuesto de pirazinoisoquinolina o naftaleno, composicion farmaceutica e inhibidor de pde4 que lo comprenden y sal famaceuticamente aceptable de un compuesto de pirazinoisoquinolina - Google Patents
Compuesto de pirazinoisoquinolina o naftaleno, composicion farmaceutica e inhibidor de pde4 que lo comprenden y sal famaceuticamente aceptable de un compuesto de pirazinoisoquinolinaInfo
- Publication number
- AR038781A1 AR038781A1 ARP020103001A ARP020103001A AR038781A1 AR 038781 A1 AR038781 A1 AR 038781A1 AR P020103001 A ARP020103001 A AR P020103001A AR P020103001 A ARP020103001 A AR P020103001A AR 038781 A1 AR038781 A1 AR 038781A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- ring
- formula
- compound
- pirazinoisoquinolina
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Un compuesto de pirazinoisoquinolina o naftaleno de la fórmula (1), en donde R1 y R2 son iguales o diferentes y cada uno es un grupo seleccionado de un grupo hidroxilo y un grupo alcoxilo inferior, el anillo A0 es un grupo de las fórmulas (2) ó (3), el anillo A es (a) un anillo de benceno sustituido o sin sustituir o un anillo heterocíclico aromático sustituido o sin sustituir, cuando el anillo A0 es un grupo de la fórmula (2) o (b) un grupo de la fórmula (4) en donde n es un entero de 1 a 6, cuando el anillo A0 es un grupo de la fórmula (3), R3 es (a) un átomo de H, un grupo de la fórmula -(CH2)m-R31 o un grupo de la fórmula -CO-R32, cuando el anillo A es un anillo de benceno sustituido o un grupo heterocíclico aromático sustituido o sin sustituir, o (b) un grupo de la fórmula -(CH2)m-R31 o un grupo de la fórmula -CO-R32, cuando el anillo A es un anillo de benceno sin sustituir; R31 es un átomo de H, un grupo arilo, un grupo hidroxilo, un grupo amino, un grupo carboxilo, un grupo alcoxicarbonilo inferior o un grupo alquiltio inferior, R32 es un grupo arilo, un grupo alquilo inferior, un grupo hidroxialquilo inferior o un grupo aminoalquilo inferior; m es un entero de 1 a 6; Q es un enlace simple enlazado al anillo A; y Ra y Rb son iguales o diferentes y cada uno es un grupo seleccionado de un átomo de H, un y grupo acilo, o una sal farmacéuticamente aceptable del mismo. Una composición farmacéutica que comprende como ingrediente activo un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo. La composición farmacéutica es usada para profilaxis o tratamiento de una enfermedad asociada a PDE4, tal como enfermedad inflamatoria o alérgica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001241502 | 2001-08-09 | ||
JP2001241521 | 2001-08-09 | ||
JP2001241517 | 2001-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR038781A1 true AR038781A1 (es) | 2005-01-26 |
Family
ID=27347300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020103001A AR038781A1 (es) | 2001-08-09 | 2002-08-08 | Compuesto de pirazinoisoquinolina o naftaleno, composicion farmaceutica e inhibidor de pde4 que lo comprenden y sal famaceuticamente aceptable de un compuesto de pirazinoisoquinolina |
Country Status (15)
Country | Link |
---|---|
US (4) | US7153859B2 (es) |
EP (1) | EP1424326B1 (es) |
KR (1) | KR100622879B1 (es) |
CN (1) | CN1266134C (es) |
AR (1) | AR038781A1 (es) |
AT (1) | ATE396972T1 (es) |
AU (1) | AU2002325493B2 (es) |
CA (1) | CA2455298C (es) |
DE (1) | DE60226878D1 (es) |
ES (1) | ES2305278T3 (es) |
HK (1) | HK1064673A1 (es) |
MX (1) | MXPA04001171A (es) |
MY (1) | MY129094A (es) |
TW (1) | TWI221838B (es) |
WO (1) | WO2003016279A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060205749A1 (en) * | 2003-03-13 | 2006-09-14 | Yuzuru Abe | Remedy and/or preventive for lung diseases |
US20060173028A1 (en) * | 2003-03-17 | 2006-08-03 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic and/or preventive agent for chronic skin disease |
JPWO2004087147A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 肺疾患の治療および/または予防剤 |
WO2004096274A1 (ja) * | 2003-03-31 | 2004-11-11 | Kyowa Hakko Kogyo Co., Ltd. | 気道内投与剤 |
JPWO2005056009A1 (ja) * | 2003-12-12 | 2007-07-05 | 協和醗酵工業株式会社 | 肺疾患治療剤 |
TWI339578B (en) * | 2004-10-29 | 2011-04-01 | Mitsubishi Tanabe Pharma Corp | Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions |
MD20150071A2 (ro) | 2013-02-19 | 2016-02-29 | Pfizer Inc. | Compuşi azabenzimidazolici ca inhibitori ai PDE4 izoenzimelor pentru tratamentul tulburărilor SNC şi altor afecţiuni |
JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
JP6506833B2 (ja) | 2014-08-06 | 2019-04-24 | ファイザー・インク | イミダゾピリダジン化合物 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4678501A (en) * | 1981-07-30 | 1987-07-07 | Union Carbide Corporation | Certain pyrazinyl 1,3 cycloalkanedione derivatives having herbicidal activity |
JP3042156B2 (ja) * | 1992-02-20 | 2000-05-15 | 田辺製薬株式会社 | ナフタレン誘導体、その製法及びその合成中間体 |
IL118469A (en) * | 1995-06-15 | 2000-08-13 | Tanabe Seiyaku Co | Naphthalene derivatives their preparation and intermediates thereof |
US5728844A (en) | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic agents |
GB9603723D0 (en) | 1996-02-22 | 1996-04-24 | Merck & Co Inc | Diphenyl pyridyl derivatives as pde iv inhibitors |
DE19617864A1 (de) | 1996-04-23 | 1997-10-30 | Schering Ag | Neue chirale Phenyldihydrofuranone |
GB9614718D0 (en) | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
AU724549B2 (en) | 1996-09-04 | 2000-09-28 | Pfizer Inc. | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) |
SI0934280T1 (en) | 1996-10-02 | 2003-12-31 | Janssen Pharmaceutica N.V. | Pde iv inhibiting 2-cyanoiminoimidazole derivatives |
JP2000063275A (ja) | 1998-06-12 | 2000-02-29 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
WO2000012503A1 (fr) | 1998-08-26 | 2000-03-09 | Tanabe Seiyaku Co., Ltd. | Derives de naphthyridine et leur procede de preparation |
ATE300543T1 (de) * | 2000-06-26 | 2005-08-15 | Lilly Icos Llc | Kondensierte pyrazindionderivate als pde5 inhibitore |
MXPA03004023A (es) | 2000-11-08 | 2004-02-12 | Lilly Icos Llc | Compuestos quimicos. |
CN1520313A (zh) | 2001-05-23 | 2004-08-11 | ������ҩ��ʽ���� | 一种加速骨折愈合的组合物 |
CA2447618A1 (en) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | A composition for regenerative treatment of cartilage disease |
-
2002
- 2002-07-30 TW TW091116963A patent/TWI221838B/zh not_active IP Right Cessation
- 2002-07-31 WO PCT/JP2002/007783 patent/WO2003016279A1/ja active IP Right Grant
- 2002-07-31 CA CA002455298A patent/CA2455298C/en not_active Expired - Fee Related
- 2002-07-31 AT AT02758780T patent/ATE396972T1/de not_active IP Right Cessation
- 2002-07-31 KR KR1020047002009A patent/KR100622879B1/ko not_active IP Right Cessation
- 2002-07-31 AU AU2002325493A patent/AU2002325493B2/en not_active Ceased
- 2002-07-31 US US10/486,088 patent/US7153859B2/en not_active Expired - Fee Related
- 2002-07-31 CN CNB028155378A patent/CN1266134C/zh not_active Expired - Fee Related
- 2002-07-31 EP EP02758780A patent/EP1424326B1/en not_active Expired - Lifetime
- 2002-07-31 ES ES02758780T patent/ES2305278T3/es not_active Expired - Lifetime
- 2002-07-31 MX MXPA04001171A patent/MXPA04001171A/es active IP Right Grant
- 2002-07-31 DE DE60226878T patent/DE60226878D1/de not_active Expired - Lifetime
- 2002-08-06 MY MYPI20022928A patent/MY129094A/en unknown
- 2002-08-08 AR ARP020103001A patent/AR038781A1/es not_active Application Discontinuation
-
2004
- 2004-10-05 HK HK04107642.3A patent/HK1064673A1/xx not_active IP Right Cessation
-
2006
- 2006-09-06 US US11/515,737 patent/US7550464B2/en not_active Expired - Fee Related
- 2006-09-06 US US11/515,928 patent/US7550476B2/en not_active Expired - Fee Related
- 2006-09-06 US US11/515,907 patent/US7550475B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2002325493B2 (en) | 2005-06-09 |
US7550464B2 (en) | 2009-06-23 |
US20070004739A1 (en) | 2007-01-04 |
US7153859B2 (en) | 2006-12-26 |
US20040204418A1 (en) | 2004-10-14 |
CN1266134C (zh) | 2006-07-26 |
DE60226878D1 (de) | 2008-07-10 |
US7550475B2 (en) | 2009-06-23 |
US7550476B2 (en) | 2009-06-23 |
ES2305278T3 (es) | 2008-11-01 |
US20070010521A1 (en) | 2007-01-11 |
HK1064673A1 (en) | 2005-04-08 |
CA2455298C (en) | 2009-10-13 |
KR100622879B1 (ko) | 2006-09-14 |
US20070004740A1 (en) | 2007-01-04 |
CA2455298A1 (en) | 2003-02-27 |
CN1538959A (zh) | 2004-10-20 |
ATE396972T1 (de) | 2008-06-15 |
TWI221838B (en) | 2004-10-11 |
EP1424326A4 (en) | 2005-08-17 |
WO2003016279A1 (fr) | 2003-02-27 |
KR20040023742A (ko) | 2004-03-18 |
EP1424326B1 (en) | 2008-05-28 |
EP1424326A1 (en) | 2004-06-02 |
MXPA04001171A (es) | 2004-05-20 |
MY129094A (en) | 2007-03-30 |
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