EA200700489A1 - Новые бензоконденсированные гетероарилсульфамидные производные, полезные в качестве противоконвульсивных средств - Google Patents

Новые бензоконденсированные гетероарилсульфамидные производные, полезные в качестве противоконвульсивных средств

Info

Publication number
EA200700489A1
EA200700489A1 EA200700489A EA200700489A EA200700489A1 EA 200700489 A1 EA200700489 A1 EA 200700489A1 EA 200700489 A EA200700489 A EA 200700489A EA 200700489 A EA200700489 A EA 200700489A EA 200700489 A1 EA200700489 A1 EA 200700489A1
Authority
EA
Eurasian Patent Office
Prior art keywords
convoltive
useful
agent
condensed heteroaryl
sulfamide derivatives
Prior art date
Application number
EA200700489A
Other languages
English (en)
Other versions
EA010977B1 (ru
Inventor
Майкл Х. Паркер
Аллен Б. Рейтц
Брюс Э. Марьянофф
Original Assignee
Янссен Фармацевтика Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н. В. filed Critical Янссен Фармацевтика Н. В.
Publication of EA200700489A1 publication Critical patent/EA200700489A1/ru
Publication of EA010977B1 publication Critical patent/EA010977B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Настоящее изобретение касается новых бензоконденсированных гетероарилсульфамидных производных, фармацевтических композиций, содержащих указанные производные, и применения этих производных для лечения эпилепсии и связанных с эпилепсией нарушений.
EA200700489A 2004-08-24 2005-08-22 Бензоконденсированные гетероарилсульфамидные производные, полезные в качестве противоконвульсивных средств EA010977B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60413404P 2004-08-24 2004-08-24
PCT/US2005/029814 WO2006023861A1 (en) 2004-08-24 2005-08-22 Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents

Publications (2)

Publication Number Publication Date
EA200700489A1 true EA200700489A1 (ru) 2007-10-26
EA010977B1 EA010977B1 (ru) 2008-12-30

Family

ID=35134694

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700489A EA010977B1 (ru) 2004-08-24 2005-08-22 Бензоконденсированные гетероарилсульфамидные производные, полезные в качестве противоконвульсивных средств

Country Status (25)

Country Link
US (1) US20060047001A1 (ru)
EP (1) EP1794143B8 (ru)
JP (1) JP4912312B2 (ru)
KR (1) KR20070057848A (ru)
CN (1) CN101090896B (ru)
AR (1) AR050530A1 (ru)
AT (1) ATE400565T1 (ru)
AU (1) AU2005277134A1 (ru)
BR (1) BRPI0514278A (ru)
CA (1) CA2578407A1 (ru)
CR (1) CR9014A (ru)
DE (1) DE602005008084D1 (ru)
EA (1) EA010977B1 (ru)
EC (1) ECSP077275A (ru)
ES (1) ES2310366T3 (ru)
HK (1) HK1105411A1 (ru)
IL (1) IL181518A0 (ru)
MX (1) MX2007002309A (ru)
MY (1) MY142329A (ru)
NI (1) NI200700056A (ru)
NO (1) NO20071549L (ru)
PE (1) PE20060500A1 (ru)
TW (1) TW200621745A (ru)
WO (1) WO2006023861A1 (ru)
ZA (1) ZA200702440B (ru)

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US20070191450A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder
US20070191460A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Disease Modification / Epileptogenesis
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ATE400565T1 (de) 2008-07-15
TW200621745A (en) 2006-07-01
CN101090896A (zh) 2007-12-19
NO20071549L (no) 2007-05-15
NI200700056A (es) 2008-02-04
DE602005008084D1 (de) 2008-08-21
ECSP077275A (es) 2007-03-29
EA010977B1 (ru) 2008-12-30
AR050530A1 (es) 2006-11-01
EP1794143A1 (en) 2007-06-13
PE20060500A1 (es) 2006-07-13
CN101090896B (zh) 2011-10-26
BRPI0514278A (pt) 2008-06-10
CA2578407A1 (en) 2006-03-02
AU2005277134A1 (en) 2006-03-02
IL181518A0 (en) 2007-07-04
WO2006023861A1 (en) 2006-03-02
JP2008510813A (ja) 2008-04-10
ZA200702440B (en) 2009-01-28
US20060047001A1 (en) 2006-03-02
MX2007002309A (es) 2007-10-08
JP4912312B2 (ja) 2012-04-11
EP1794143B8 (en) 2008-12-24
KR20070057848A (ko) 2007-06-07
ES2310366T3 (es) 2009-01-01
MY142329A (en) 2010-11-15

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