DE60317889D1 - Antivirale bicyclo-4.4.0-derivate - Google Patents
Antivirale bicyclo-4.4.0-derivateInfo
- Publication number
- DE60317889D1 DE60317889D1 DE60317889T DE60317889T DE60317889D1 DE 60317889 D1 DE60317889 D1 DE 60317889D1 DE 60317889 T DE60317889 T DE 60317889T DE 60317889 T DE60317889 T DE 60317889T DE 60317889 D1 DE60317889 D1 DE 60317889D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- sub
- heteroaryl
- group
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37673102P | 2002-05-01 | 2002-05-01 | |
US376731P | 2002-05-01 | ||
PCT/US2003/008893 WO2003092695A1 (en) | 2002-05-01 | 2003-03-21 | Bicyclo 4.4.0 antiviral derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60317889D1 true DE60317889D1 (de) | 2008-01-17 |
DE60317889T2 DE60317889T2 (de) | 2008-11-27 |
Family
ID=29401396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60317889T Expired - Lifetime DE60317889T2 (de) | 2002-05-01 | 2003-03-21 | Antivirale bicyclo-4.4.0-derivate |
Country Status (7)
Country | Link |
---|---|
US (1) | US7037913B2 (de) |
EP (1) | EP1499319B1 (de) |
AT (1) | ATE380030T1 (de) |
AU (1) | AU2003220480A1 (de) |
DE (1) | DE60317889T2 (de) |
ES (1) | ES2297146T3 (de) |
WO (1) | WO2003092695A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
US20050075364A1 (en) | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
US20050124623A1 (en) | 2003-11-26 | 2005-06-09 | Bender John A. | Diazaindole-dicarbonyl-piperazinyl antiviral agents |
US7087610B2 (en) | 2004-06-03 | 2006-08-08 | Bristol-Myers Squibb Company | Benzothiazole antiviral agents |
PT2489659T (pt) | 2004-06-24 | 2018-03-07 | Vertex Pharma | Moduladores de transportadores de cassete de ligação a atp |
US8354427B2 (en) * | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US7183284B2 (en) | 2004-12-29 | 2007-02-27 | Bristol-Myers Squibb Company | Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents |
US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
ES2395386T3 (es) * | 2005-12-21 | 2013-02-12 | Abbott Laboratories | Compuestos antivirales |
DE602006015861D1 (de) | 2005-12-21 | 2010-09-09 | Abbott Lab | Antivirale verbindungen |
JP2009521479A (ja) * | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
CA2634113A1 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of abc transporters |
BRPI0620960A2 (pt) | 2005-12-28 | 2011-11-29 | Vertex Pharmaceuticals Incorporated | formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-didro-4- oxiquinolina-3- carboxamida |
US20070259879A1 (en) * | 2006-03-06 | 2007-11-08 | Trimeris, Inc. | Piperazine and piperidine biaryl derivatives |
US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
WO2008133753A2 (en) * | 2006-12-20 | 2008-11-06 | Abbott Laboratories | Anti-viral compounds |
KR101955863B1 (ko) | 2009-03-20 | 2019-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 |
US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
IL311180A (en) | 2012-02-27 | 2024-04-01 | Vertex Pharma | Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof |
CN105229006A (zh) * | 2013-03-27 | 2016-01-06 | 百时美施贵宝公司 | 作为hiv吸附抑制剂的哌嗪和高哌嗪衍生物 |
US9586957B2 (en) * | 2013-03-27 | 2017-03-07 | VIIV Healthcare UK (No.5) Limited | 2-keto amide derivatives as HIV attachment inhibitors |
RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
CN110256342B (zh) * | 2019-07-16 | 2022-06-07 | 河南省科学院化学研究所有限公司 | 一种2-氰基喹啉衍生物的合成方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3277085A (en) * | 1966-10-04 | Nx c cha-chjx o oh | ||
BE791501A (fr) * | 1971-11-19 | 1973-05-17 | Albert Ag Chem Werke | Diamines cycliques n,n'-disubstituees et leur procede de preparation |
US4695121A (en) * | 1985-01-28 | 1987-09-22 | Polaroid Corporation | Integrated optic resonant structres and fabrication method |
GB8615562D0 (en) | 1986-06-25 | 1986-07-30 | Maggioni Farma | Aminoalcohols |
US5023265A (en) | 1990-06-01 | 1991-06-11 | Schering Corporation | Substituted 1-H-pyrrolopyridine-3-carboxamides |
WO1993001181A1 (en) | 1991-07-03 | 1993-01-21 | The Upjohn Company | Substituted indoles as anti-aids pharmaceuticals |
WO1993005020A1 (en) | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
US5124327A (en) | 1991-09-06 | 1992-06-23 | Merck & Co., Inc. | HIV reverse transcriptase |
CA2195027C (en) * | 1991-11-08 | 2000-01-11 | Joseph P. Vacca | Hiv protease inhibitors useful for the treatment of aids |
RU2097815C1 (ru) * | 1993-02-12 | 1997-11-27 | Фирма "Самсунг Электроникс Ко., Лтд." | Оптический процессор |
AU675145B2 (en) * | 1993-06-18 | 1997-01-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
IT1265057B1 (it) | 1993-08-05 | 1996-10-28 | Dompe Spa | Tropil 7-azaindolil-3-carbossiamidi |
US5424329A (en) | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
GB9420521D0 (en) | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
FR2744449B1 (fr) | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
US6172085B1 (en) | 1996-08-29 | 2001-01-09 | Takeda Chemical Industries, Ltd. | Cyclic ether compounds as sodium channel modulators |
US6078605A (en) * | 1998-02-20 | 2000-06-20 | Massachusetts Institute Of Technology | Track-changing utilizing phase response of resonators |
CN1261098C (zh) | 1998-08-28 | 2006-06-28 | 西奥斯股份有限公司 | p38-α激酶的抑制剂 |
US6633696B1 (en) * | 1998-12-07 | 2003-10-14 | California Institute Of Technology | Resonant optical wave power control devices and methods |
WO2000050938A1 (en) * | 1999-02-22 | 2000-08-31 | Massachusetts Institute Of Technology | Vertically coupled optical resonator devices over a cross-grid waveguide architecture |
GB9905010D0 (en) | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
US6573262B2 (en) * | 2000-07-10 | 2003-06-03 | Bristol-Myers Sqibb Company | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives |
US7092590B2 (en) * | 2000-09-22 | 2006-08-15 | Massachusetts Institute Of Technology | Methods of altering the resonance of waveguide micro-resonators |
-
2003
- 2003-03-20 US US10/393,030 patent/US7037913B2/en not_active Expired - Lifetime
- 2003-03-21 EP EP03716789A patent/EP1499319B1/de not_active Expired - Lifetime
- 2003-03-21 DE DE60317889T patent/DE60317889T2/de not_active Expired - Lifetime
- 2003-03-21 ES ES03716789T patent/ES2297146T3/es not_active Expired - Lifetime
- 2003-03-21 AU AU2003220480A patent/AU2003220480A1/en not_active Abandoned
- 2003-03-21 AT AT03716789T patent/ATE380030T1/de not_active IP Right Cessation
- 2003-03-21 WO PCT/US2003/008893 patent/WO2003092695A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE60317889T2 (de) | 2008-11-27 |
EP1499319A1 (de) | 2005-01-26 |
US7037913B2 (en) | 2006-05-02 |
ES2297146T3 (es) | 2008-05-01 |
US20040009985A1 (en) | 2004-01-15 |
ATE380030T1 (de) | 2007-12-15 |
WO2003092695A1 (en) | 2003-11-13 |
EP1499319A4 (de) | 2006-02-08 |
EP1499319B1 (de) | 2007-12-05 |
AU2003220480A1 (en) | 2003-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE380030T1 (de) | Antivirale bicyclo-4.4.0-derivate | |
RS101304A (sr) | Indolni, azaindolni i srodni heterociklični 4-alkenil piperidinski amidi | |
HUP0402313A2 (hu) | Szerotonin újrafelvételt gátló fenilpiperazin-származékok, az ezeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
ATE304853T1 (de) | Zusammensetzung und antivirale wirkung von substituierten indol-oxo-aceto-piperidin- derivaten | |
HUP0300544A2 (hu) | Integrin expresszálás inhibitorokat tartalmazó gyógyszerkészítmények | |
HUP0300203A2 (en) | Novel cyclic amide derivatives, and pharmaceutical compositions containing same | |
HUP0301195A2 (hu) | Alfa-4 integrin antagonista hatású aza-hidas biciklusos aminosav-származékok és ilyen vegyületeket tartalmazó gyógyszerkészítmények | |
HUP0105414A2 (hu) | Pirrolo-izokinolin-, azepino- és diazepino-indol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
HUP0201935A2 (hu) | A SYK tirozin-protein-kináz inhibitoraiként alkalmazható purinszármazékok | |
HUP0101204A2 (hu) | HIV-gátló pirimidinszármazékok és a vegyületeket tartalmazó gyógyászati készítmények | |
WO2002085301A3 (en) | Indole, azaindole and related heterocyclic amidopiperazine derivatives | |
EA200800924A1 (ru) | Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера | |
HUP0401740A2 (hu) | N-szubsztituált hidroxipirimidinon-karboxamid HIV-integráz inhibitorok és ezeket tartalmazó gyógyszerkészítmények | |
ATE402174T1 (de) | Imidazopyridinderivate als kinaseinhibitoren | |
HUP0301005A2 (hu) | Pirrolotriazin kináz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
YU60903A (sh) | Kompozicija i antivirusna aktivnost derivata supstituisanog azaindoloksoacetat piperazina | |
ATE534626T1 (de) | Piperazinamidine als antivirale mittel | |
EA200400466A1 (ru) | Производные пиперазина с антагонистической активностью к рецептору ccr1 | |
HRP20070286T3 (en) | Substituted diketopiperazines and their use as oxytocyn antagonists | |
DK1725536T3 (da) | Imidazolin-derivater med CB1-antagonistisk aktivitet | |
HUP0400246A2 (hu) | 1,2,4-Trioxolánt tartalmazó maláriaellenes gyógyszerkészítmények és eljárás az előállításukra és az alkalmazásukra | |
GEP20084284B (en) | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives | |
WO2004011425A3 (en) | Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives | |
BRPI0417007A (pt) | agentes antivirais de diazaindol-dicarbonil-piperazinila | |
ATE384714T1 (de) | Pyrazolderivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |