AR038235A1 - Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1 - Google Patents
Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1Info
- Publication number
- AR038235A1 AR038235A1 ARP030100227A ARP030100227A AR038235A1 AR 038235 A1 AR038235 A1 AR 038235A1 AR P030100227 A ARP030100227 A AR P030100227A AR P030100227 A ARP030100227 A AR P030100227A AR 038235 A1 AR038235 A1 AR 038235A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- independently selected
- hydroxy
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
Estos compuestos son ligandos para el receptor ORL-1 y especialmente son antagonistas del citado receptor. Reivindicación 1: Un compuesto de la siguiente fórmula (1): o una sal o solvato farmacéuticamente aceptable del mismo, caracterizado porque R1 a R12 se seleccionan independientemente del grupo constituido por hidrógeno; halo; hidroxi; alquilo C1-6; alquilo C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alquilo C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6]NHC(=O)-, [alquil C1-6]2NC(=O)-, alcoxi C1-6 y un heterociclilo de cinco a seis miembros totalmente saturado que contiene de uno a dos heteroátomos independientemente seleccionados de nitrógeno y oxígeno; alcoxi C1-6; alcoxi C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alcoxi C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6]NHC(=O)- y [alquil C1-6]2NC(=O)-; amino; carboxi; [alcoxi C1-6]C(=O)-; H2NC(=O)-; [alquil C1-6]NHC(=O)-; [alquil C1-6]NHC(=O)- en el que el citado alquilo C1-6 está sustituido con un hidroxi; [alquil C1-6]2NC(=O)-, [alquil C1-6]2NC(=O)-, en el que uno o ambos de los alquilo C1-6 están sustituidos con un hidroxilo; arilo seleccionados de fenilo y naftilo; y un heterociclilo de cuatro a ocho miembros que contiene de uno a cuatro heteroátomos en el anillo independientemente seleccionados de nitrógeno, oxígeno y azufre; o de los grupos R1, R2, R3 y R4 tomados conjuntamente forman -CH2- o -(CH2)2-, y los dos grupos restantes se definen como anteriormente; X1 y X2 se seleccionan independientemente de CH2; CH-hidroxi; O; NH; S; C(=O); SO2 y [alquil C1-6]N; o X1 y X2 tomados conjuntamente forman CH=CH; R13 se selecciona del grupo constituido por hidrógeno; hidroxi; alquilo C1-6; alquilo C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; y alquilo C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6]NHC(=O)-, [alquil C1-6]2NC(=O)-, alcoxi C1-6 y un heterociclilo de cinco a seis miembros totalmente saturado que contiene de uno a dos heteroátomos independientemente seleccionados de nitrógeno y oxígeno; o R12 y R13 tomados conjuntamente con los tres átomos de anillo del anillo de dihidroquinolina o tetrahidroquinolina que separa los citados sustituyentes forman un anillo de cinco a siete miembros que está parcial o totalmente insaturado, en el que el átomo de anillo no compartido con el anillo de dihidroquinolina o tetrahidroquinolina y adyacente al átomo de nitrógeno en el anillo de dihidroquinolina o tetrahidroquinolina es un átomo de carbono; los restantes uno a tres átomos de anillo no compartidos con el anillo de dihidroquinolina o tetrahidroquinolina son átomos de carbono, estando opcionalmente reemplazado uno de los citados átomos de carbono por un átomo de nitrógeno, oxígeno o azufre; y uno o dos de los átomos de carbono y nitrógeno no compartidos con el anillo de dihidroquinolina o tetrahidroquinolina están opcionalmente sustituidos con sustituyentes independientemente seleccionados de oxo; hidroxi; alquilo C1-6; alquilo C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alquilo C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino [alquil C1-6]NH-, [alquil C1-6]2N-, -H2NC(=O)-, [alquil C1-6]NHC(=O)-, alcoxi C1-6 y un heterociclilo de cinco a seis miembros totalmente saturado que contiene de uno a dos heteroátomos independientemente seleccionados de nitrógeno y oxígeno; alcoxi C1-6; alcoxi C1-6 sustituido con uno a cinco halos que pueden ser iguales o diferentes; alcoxi C1-6 sustituido con uno a cinco sustituyentes independientemente seleccionados del grupo constituido por hidroxi, amino, [alquil C1-6]NH-, [alquil C1-6]2N-, H2NC(=O)-, [alquil C1-6NHC(=O)- y [alquil C1-6]2NC(=O)-, amino; ambos R14 y R15 son hidrógeno o tomados conjuntamente forman un grupo oxo y la línea de trazos representa un enlace sencillo o doble.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35243702P | 2002-01-28 | 2002-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR038235A1 true AR038235A1 (es) | 2005-01-05 |
Family
ID=27663095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030100227A AR038235A1 (es) | 2002-01-28 | 2003-01-27 | Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1 |
Country Status (13)
Country | Link |
---|---|
US (1) | US6869960B2 (es) |
EP (1) | EP1470126A1 (es) |
JP (1) | JP2005519921A (es) |
AR (1) | AR038235A1 (es) |
BR (1) | BR0307268A (es) |
CA (1) | CA2466915A1 (es) |
GT (1) | GT200300014A (es) |
MX (1) | MXPA04007242A (es) |
PA (1) | PA8564201A1 (es) |
PE (1) | PE20030848A1 (es) |
TW (1) | TW200302725A (es) |
UY (1) | UY27623A1 (es) |
WO (1) | WO2003064425A1 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
KR20050043935A (ko) | 2002-09-09 | 2005-05-11 | 얀센 파마슈티카 엔.브이. | Orl-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체 |
ITMI20031349A1 (it) * | 2003-07-01 | 2005-01-02 | Ufpeptides S R L | Antagonisti del recettore nop e loro usi terapeutici. |
WO2005016913A1 (en) * | 2003-08-19 | 2005-02-24 | Pfizer Japan, Inc. | Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders |
CN1930145B (zh) * | 2004-03-05 | 2011-06-15 | Msdk.K.公司 | 环烷吡啶衍生物 |
CA2563164A1 (en) * | 2004-03-29 | 2005-10-06 | Pfizer Inc. | Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists |
WO2005117862A1 (en) * | 2004-06-03 | 2005-12-15 | Pfizer Limited, | Treatment of urinary conditions including incontinence |
US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
EP1781288A2 (en) * | 2004-08-19 | 2007-05-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
RU2007124373A (ru) * | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
MY158766A (en) | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
AU2006252781A1 (en) * | 2005-06-02 | 2006-12-07 | Janssen Pharmaceutica, N.V. | Novel 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators |
KR20080012976A (ko) * | 2005-06-17 | 2008-02-12 | 화이자 인코포레이티드 | Orl1-수용기 길항제로서의 알파-(아릴- 또는헤테로아릴-메틸)-베타-피페리디노 프로판아마이드 화합물 |
EP1973543A2 (en) * | 2005-12-22 | 2008-10-01 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
US8263605B2 (en) | 2006-02-22 | 2012-09-11 | Vertex Pharmaceutical Incorporated | Modulators of muscarinic receptors |
RU2008137593A (ru) * | 2006-02-22 | 2010-03-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
GB0608452D0 (en) * | 2006-04-27 | 2006-06-07 | Glaxo Group Ltd | Novel compounds |
CN101500565A (zh) * | 2006-06-29 | 2009-08-05 | 弗特克斯药品有限公司 | 毒蕈碱性受体的调节剂 |
CA2660903A1 (en) * | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
AU2007284350A1 (en) * | 2006-08-18 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
BRPI0719210A2 (pt) | 2006-10-12 | 2015-05-05 | Xenon Pharmaceuticals Inc | Uso de compostos espiro-oxindol como agentes terapêuticos |
AU2007325355A1 (en) * | 2006-11-28 | 2008-06-05 | Janssen Pharmaceutica N.V. | Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl) -1,3,8-triaza-spiro[4.5]decan-4-one |
WO2008124209A1 (en) | 2007-04-09 | 2008-10-16 | Janssen Pharmaceutica, N.V. | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
CA2700724A1 (en) * | 2007-10-03 | 2009-04-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
SI2350090T1 (sl) | 2008-10-17 | 2015-10-30 | Xenon Pharmaceuticals Inc. | Spojine spiro-oksindola in njihova uporaba kot terapevtska sredstva |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
KR20120099429A (ko) | 2009-10-14 | 2012-09-10 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물의 합성 방법 |
UA107943C2 (en) * | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Compounds of spiropiperidines as antagonists of the orl-1 receptors |
PE20121699A1 (es) | 2010-02-26 | 2012-12-22 | Xenon Pharmaceuticals Inc | Composiciones farmaceuticas del compuesto espiro-oxindol para administracion topica |
US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
US9855286B2 (en) | 2012-05-18 | 2018-01-02 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-di methyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component |
US20130310435A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N, N-dimethyl-4-phenyl-4,9' -dihydro-3'H-spiro[cyclohexane-1,1' -pyrano[3,4,b]indol]-4-amine and Paracetamol or Propacetamol |
US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
WO2014102592A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
WO2014102590A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
EP3383390A4 (en) * | 2015-12-02 | 2019-11-20 | Astraea Therapeutics, LLC | PIPERIDINYL COMPOUNDS FOR NOCICEPTIN RECEPTOR |
US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
CN106336357A (zh) * | 2016-08-29 | 2017-01-18 | 启东东岳药业有限公司 | 2‑羟甲基丙烯酸甲酯的制备方法 |
CN110143918B (zh) * | 2019-06-19 | 2020-08-04 | 青岛农业大学 | 3,4-二氢-3-(2-羟基苯甲酰)-2(1h)-喹啉酮活性骨架及合成方法和应用 |
CN113264949B (zh) * | 2021-05-31 | 2022-04-05 | 西南大学 | 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4562799A (en) | 1998-06-15 | 2000-01-05 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
ES2316559T3 (es) * | 2001-04-18 | 2009-04-16 | Euro-Celtique S.A. | Compuestos espiroindeno y espiroindano. |
US20030078278A1 (en) * | 2001-06-26 | 2003-04-24 | Pfizer Inc. | Spiropiperidine compounds as ligands for ORL-1 receptor |
-
2003
- 2003-01-16 MX MXPA04007242A patent/MXPA04007242A/es unknown
- 2003-01-16 EP EP20030700412 patent/EP1470126A1/en not_active Withdrawn
- 2003-01-16 BR BR0307268-1A patent/BR0307268A/pt not_active IP Right Cessation
- 2003-01-16 CA CA002466915A patent/CA2466915A1/en not_active Abandoned
- 2003-01-16 WO PCT/IB2003/000203 patent/WO2003064425A1/en not_active Application Discontinuation
- 2003-01-16 JP JP2003564048A patent/JP2005519921A/ja not_active Withdrawn
- 2003-01-23 US US10/349,760 patent/US6869960B2/en not_active Expired - Fee Related
- 2003-01-24 GT GT200300014A patent/GT200300014A/es unknown
- 2003-01-24 PE PE2003000075A patent/PE20030848A1/es not_active Application Discontinuation
- 2003-01-24 UY UY27623A patent/UY27623A1/es not_active Application Discontinuation
- 2003-01-27 AR ARP030100227A patent/AR038235A1/es not_active Application Discontinuation
- 2003-01-27 TW TW092101738A patent/TW200302725A/zh unknown
- 2003-01-28 PA PA20038564201A patent/PA8564201A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US6869960B2 (en) | 2005-03-22 |
TW200302725A (en) | 2003-08-16 |
UY27623A1 (es) | 2003-08-29 |
GT200300014A (es) | 2003-08-22 |
CA2466915A1 (en) | 2003-08-07 |
MXPA04007242A (es) | 2004-10-29 |
EP1470126A1 (en) | 2004-10-27 |
BR0307268A (pt) | 2004-12-14 |
US20030158219A1 (en) | 2003-08-21 |
JP2005519921A (ja) | 2005-07-07 |
PE20030848A1 (es) | 2003-10-11 |
PA8564201A1 (es) | 2003-12-10 |
WO2003064425A1 (en) | 2003-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR038235A1 (es) | Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1 | |
AR054090A1 (es) | Derivados de quinuclidina como antagonistas del receptor muscarinico m3. composiciones farmaceuticas y proceso de obtencion | |
AR015528A1 (es) | Compuestos heterociclicos como inhibidores de enzimas rotamasas, composiciones, su uso para la preparacion de medicinas, proceso para su preparacion ycompuestos intermediarios | |
ECSP056016A (es) | Nuevos derivados de 2-piridinacarboxamida | |
AR055878A1 (es) | Derivados de ciclopropanocarboxamida | |
AR052943A1 (es) | Derivados de 2-(4-oxo-4h-quinazolin-3-il)acetamida | |
AR041303A1 (es) | Compuestos de piperidinil-imidazopiridina n-sustituidos como moduladores del receptor 5-ht4" | |
ATE293101T1 (de) | Piperidine zur verwendung als orexin rezeptor antagonisten | |
AR022303A1 (es) | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion | |
EA199800404A1 (ru) | Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперазина | |
AR045931A1 (es) | Derivados de piperazina | |
PE20091884A1 (es) | Antagonistas de cgrp seleccionados, procedimiento para su preparacion, asi como su uso como medicamento | |
CO5700720A2 (es) | Derivados de n-(quinolin-5l) alquilamida-sustituida; n-alquilquinolin-5-carboxamida-sustituida; n-alquilisoquinolin-5-carboxamida-sustituida; n-(isoquinolin-5-yl) alquilamida-sustituida y procesos para su preparacion | |
PE53097A1 (es) | Nuevos derivados de arilglicinamida, procedimientos para su preparacion, y composiciones farmaceuticas que contienen estos compuestos | |
NO964700L (no) | Nye aminosyrederivater, fremgangsmåte til deres fremstilling og farmasöytiske blandinger som inneholder disse forbindelser | |
AR071763A1 (es) | Pirazoles trisustituidos, composiciones farmaceuticas que los contienen, y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos | |
NO20073729L (no) | Heterocykliske forbindelser som CCR2B-antagonister | |
ES2476422T3 (es) | Compuestos de piperidina 3,5-sustituida como inhibidores de renina | |
PE20001303A1 (es) | Derivados de la 4-aroilpiperidina como antagonistas del receptor ccr-3 | |
ATE524432T1 (de) | Aminverbindung und deren verwendung für medizinische zwecke | |
BR0013498A (pt) | Composto, método para a preparação do mesmo, composição farmacêutica, e, métodos para a preparação da mesma e para o tratamento de distúrbios do snc | |
AR053435A1 (es) | Derivados de 5-amminoindol, un metodo para su preparacion, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un madicamento para el tratamiento de enfermedades asociadas a la modulacion de receptores h3. | |
AR042362A1 (es) | Derivados de 3h-quinazolin-4-ona, proceso de obtencion y composiciones farmaceuticas que los contienen | |
EA200501148A1 (ru) | Пиридилоксиметильные и бензизоксазольные азабициклические производные | |
AR033942A1 (es) | Compuestos de monofluoroalquilo aplicables en la potenciacion de los compuestos intermediarios utilizables en la sintesis de dichos compuestos de monofluoralquilo; composiciones farmaceuticas formuladas con dichos compuestos potenciadores y metodos para la potenciacion de las funciones de dichos rec |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |