AR035258A1 - Procedimiento para la preparacion de compuestos que contienen uno o mas enlaces amida, y un compuesto que contiene uno o mas enlaces amida preparado con dicho procedimiento - Google Patents
Procedimiento para la preparacion de compuestos que contienen uno o mas enlaces amida, y un compuesto que contiene uno o mas enlaces amida preparado con dicho procedimientoInfo
- Publication number
- AR035258A1 AR035258A1 ARP020102686A ARP020102686A AR035258A1 AR 035258 A1 AR035258 A1 AR 035258A1 AR P020102686 A ARP020102686 A AR P020102686A AR P020102686 A ARP020102686 A AR P020102686A AR 035258 A1 AR035258 A1 AR 035258A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- preparation
- amida
- links
- compounds containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un procedimiento para la preparación de péptidos usando un exceso de un componente carboxílico activado para acilar un componente amino, donde después de la acilación una amina que comprende un anión libre o un anión latente es usada como agente barredor de las funciones carboxílicas activadas residuales. Este procedimiento es útil para la producción de oligo - y polipéptidos y, más generalmente, para la preparación de compuestos que contienen uno o más enlaces amida. La amida comprende un anión latente que lleva un grupo protector temporal tipo bencilo y más específicamente un derivado amino ácido protegido en el c-terminal tal como la Beta-alanina. El agente barredor es Beta-adenilato de bencilo. Este procedimiento es útil para la producción de oligo- y polipéptidos y, más generalmente para la preparación de compuestos que contienen uno o más enlaces amida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01202751 | 2001-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR035258A1 true AR035258A1 (es) | 2004-05-05 |
Family
ID=8180655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102686A AR035258A1 (es) | 2001-07-19 | 2002-07-18 | Procedimiento para la preparacion de compuestos que contienen uno o mas enlaces amida, y un compuesto que contiene uno o mas enlaces amida preparado con dicho procedimiento |
Country Status (25)
Country | Link |
---|---|
US (2) | US6864357B2 (es) |
EP (1) | EP1277761B1 (es) |
JP (1) | JP3579038B2 (es) |
KR (1) | KR100869520B1 (es) |
CN (1) | CN1254482C (es) |
AR (1) | AR035258A1 (es) |
AT (1) | ATE531724T1 (es) |
AU (1) | AU2002300166C1 (es) |
BR (1) | BRPI0202779B1 (es) |
CA (1) | CA2394216C (es) |
DK (1) | DK1277761T3 (es) |
EC (1) | ECSP024292A (es) |
ES (1) | ES2374389T3 (es) |
HK (1) | HK1050905A1 (es) |
HR (1) | HRP20020608A2 (es) |
HU (1) | HUP0202370A2 (es) |
IL (1) | IL150600A (es) |
MX (1) | MXPA02006997A (es) |
NO (1) | NO326377B1 (es) |
PE (1) | PE20030215A1 (es) |
PL (1) | PL355126A1 (es) |
RU (1) | RU2242457C2 (es) |
SG (1) | SG120874A1 (es) |
TW (1) | TWI243826B (es) |
ZA (1) | ZA200205408B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
US7393277B2 (en) * | 2003-08-25 | 2008-07-01 | Igt | Horseshoe payline system and games using that system |
EP1790656A1 (en) * | 2005-11-25 | 2007-05-30 | Nanokem S.A. | Solution-phase synthesis of leuprolide |
DE602007005349D1 (de) * | 2006-01-17 | 2010-04-29 | Organon Nv | SELEKTIVE ENZYMATISCHE HYDROLYSE VON C-TERMINALEN tert-BUTYL-PEPTIDESTERN |
JP4684124B2 (ja) * | 2006-02-16 | 2011-05-18 | 富士通株式会社 | 移動局装置及び同装置における送信電力制御方法 |
US8716439B2 (en) | 2006-03-01 | 2014-05-06 | Kaneka Corporation | Method of producing peptide |
US7601062B2 (en) * | 2006-11-06 | 2009-10-13 | Igt | Gaming device and method including moving paylines |
US8124372B2 (en) * | 2007-06-25 | 2012-02-28 | N.V. Organon | Selective enzymatic amidation of C-terminal esters or acids of peptides |
EP2755690B1 (en) | 2011-08-04 | 2020-04-01 | Merck Sharp & Dohme B.V. | Kisspeptide-pentasaccharide conjugates |
US9177447B2 (en) | 2012-09-25 | 2015-11-03 | Igt | Gaming system and method for providing a symbol matrix with a moveable symbol display window |
ES2700973T3 (es) * | 2014-02-14 | 2019-02-20 | Corden Pharma Int Gmbh | Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol |
WO2021192488A1 (ja) * | 2020-03-27 | 2021-09-30 | 株式会社カネカ | アミド結合含有化合物の製造方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5221754A (en) * | 1989-06-09 | 1993-06-22 | Research Corporation Technologies, Inc. | Reagents for rapid peptide synthesis |
US5101059A (en) * | 1989-12-05 | 1992-03-31 | Research Corporation Technologies, Inc. | Amino acid protecting groups |
US5516892A (en) * | 1992-12-28 | 1996-05-14 | Indiana University Foundation | Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids |
US6310180B1 (en) * | 1993-06-21 | 2001-10-30 | Vanderbilt University | Method for synthesis of proteins |
US5516639A (en) * | 1993-07-22 | 1996-05-14 | Mayo Foundation For Medical Education And Research | Antibodies specific for human prostate glandular kallkrein |
US5849954A (en) * | 1996-01-18 | 1998-12-15 | Research Corporation Technologies, Inc. | Method of peptide synthesis |
CA2251700A1 (en) * | 1996-05-03 | 1997-11-13 | Warner-Lambert Company | Rapid purification by polymer supported quench |
US6121488A (en) * | 1997-09-24 | 2000-09-19 | Warner-Lambert Company | Quenching reagents for solution phase synthesis |
JPH11217397A (ja) * | 1997-11-27 | 1999-08-10 | Saburo Aimoto | ペプチドチオールエステルの製造方法 |
FR2780061B1 (fr) * | 1998-06-22 | 2001-09-07 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
WO2000071567A2 (en) * | 1999-05-06 | 2000-11-30 | Human Genome Sciences, Inc. | Fibroblast growth factor 13 |
WO2000071569A1 (en) * | 1999-05-26 | 2000-11-30 | Abbott Laboratories | Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents |
US20020127219A1 (en) * | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
WO2002006306A2 (en) * | 2000-07-19 | 2002-01-24 | Pharmacia & Upjohn Company | SUBSTRATES AND ASSAYS FOR β-SECRETASE ACTIVITY |
-
2002
- 2002-07-04 IL IL15060002A patent/IL150600A/xx unknown
- 2002-07-04 TW TW091114833A patent/TWI243826B/zh active
- 2002-07-05 JP JP2002197549A patent/JP3579038B2/ja not_active Expired - Lifetime
- 2002-07-05 ZA ZA200205408A patent/ZA200205408B/xx unknown
- 2002-07-15 EP EP02077875A patent/EP1277761B1/en not_active Expired - Lifetime
- 2002-07-15 SG SG200204299A patent/SG120874A1/en unknown
- 2002-07-15 AT AT02077875T patent/ATE531724T1/de active
- 2002-07-15 DK DK02077875.9T patent/DK1277761T3/da active
- 2002-07-15 ES ES02077875T patent/ES2374389T3/es not_active Expired - Lifetime
- 2002-07-17 MX MXPA02006997A patent/MXPA02006997A/es active IP Right Grant
- 2002-07-18 HU HU0202370A patent/HUP0202370A2/hu unknown
- 2002-07-18 CN CNB021261903A patent/CN1254482C/zh not_active Expired - Lifetime
- 2002-07-18 RU RU2002119631/04A patent/RU2242457C2/ru not_active IP Right Cessation
- 2002-07-18 PE PE2002000640A patent/PE20030215A1/es not_active Application Discontinuation
- 2002-07-18 AR ARP020102686A patent/AR035258A1/es active IP Right Grant
- 2002-07-18 CA CA002394216A patent/CA2394216C/en not_active Expired - Lifetime
- 2002-07-18 BR BRPI0202779A patent/BRPI0202779B1/pt active IP Right Grant
- 2002-07-18 NO NO20023445A patent/NO326377B1/no not_active IP Right Cessation
- 2002-07-18 KR KR1020020041897A patent/KR100869520B1/ko not_active IP Right Cessation
- 2002-07-18 AU AU2002300166A patent/AU2002300166C1/en not_active Expired
- 2002-07-19 EC EC2002004292A patent/ECSP024292A/es unknown
- 2002-07-19 PL PL02355126A patent/PL355126A1/xx not_active IP Right Cessation
- 2002-07-19 US US10/199,785 patent/US6864357B2/en not_active Expired - Lifetime
- 2002-07-19 HR HR20020608A patent/HRP20020608A2/hr not_active Application Discontinuation
-
2003
- 2003-04-29 HK HK03103038.5A patent/HK1050905A1/xx not_active IP Right Cessation
-
2004
- 2004-12-14 US US11/012,439 patent/US20050101764A1/en not_active Abandoned
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Legal Events
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FG | Grant, registration |