AR034869A1 - Procedimiento para la sintesis rapida de un peptido en solucion, metodos para la sintesis combinatoria de bibliotecas de peptidos y para l a sintesis automatizada de peptidos en solucion que aplican dicho procedimiento y un peptido o una mezcla de peptidos asi obtenido(a) - Google Patents
Procedimiento para la sintesis rapida de un peptido en solucion, metodos para la sintesis combinatoria de bibliotecas de peptidos y para l a sintesis automatizada de peptidos en solucion que aplican dicho procedimiento y un peptido o una mezcla de peptidos asi obtenido(a)Info
- Publication number
- AR034869A1 AR034869A1 ARP020102687A ARP020102687A AR034869A1 AR 034869 A1 AR034869 A1 AR 034869A1 AR P020102687 A ARP020102687 A AR P020102687A AR P020102687 A ARP020102687 A AR P020102687A AR 034869 A1 AR034869 A1 AR 034869A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptide
- synthesis
- procedure
- solution
- peptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un procedimiento para la síntesis rápida de un péptido en solución, que comprende ciclos repetidos de las etapas (a) - (d): (a) una etapa de acoplamiento usando un exceso de un componente carboxílico activado para acilar un componente amino, (b) una etapa de extinción en que se usa un agente barredor para remover las funciones carboxílicas activadas residuales, done el agente barredor también puede usarse para la desprotección del péptido en crecimiento. (c) una o más extracciones acuosas y opcionalmente, (d) una etapa de desprotección separada, seguida por una o más extracciones acuosas, en donde el procedimiento comprende al menos una etapa (b), denominada etapa (b'), en que una amina o un tiol que comprende un anión libre o un anión latente se usa como agente barredor de las funciones carboxílicas activadas residuales. El anión latente en la amina barredora lleva un grupo protector temporal, de tipo bencilo, más específicamente un derivado de aminoácido protegido en el c-terminal, tal como la beta-alanina. El agente barredor es beta-alaninato de bencilo, un tiol que comprende un anión libre o latente o una poliamina. El procedimiento comprende extracciones que se efectúan en presencia de cloruro de sodio o nitrato de potasio. Durante el procedimiento el péptido en crecimiento no necesita ser aislado hasta que se haya obtenido la secuencia final del péptido. Este procedimiento altamente eficiente es útil para la producción de oligo- y polipéptidos de alta pureza. También se divulgan métodos para la síntesis combinatoria de bibliotecas de péptidos y para la síntesis automatizada de péptidos en solución que aplican el procedimiento y un péptido o una mezcla de péptidos así obtenido (a).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202753 | 2001-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034869A1 true AR034869A1 (es) | 2004-03-24 |
Family
ID=8180656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102687A AR034869A1 (es) | 2001-07-19 | 2002-07-18 | Procedimiento para la sintesis rapida de un peptido en solucion, metodos para la sintesis combinatoria de bibliotecas de peptidos y para l a sintesis automatizada de peptidos en solucion que aplican dicho procedimiento y un peptido o una mezcla de peptidos asi obtenido(a) |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20030018164A1 (es) |
| EP (1) | EP1291356B1 (es) |
| JP (1) | JP4142907B2 (es) |
| KR (1) | KR100861031B1 (es) |
| CN (1) | CN1254483C (es) |
| AR (1) | AR034869A1 (es) |
| AT (1) | ATE302792T1 (es) |
| BR (1) | BRPI0202783B1 (es) |
| CA (1) | CA2390358C (es) |
| DE (1) | DE60205693T2 (es) |
| DK (1) | DK1291356T3 (es) |
| EC (1) | ECSP024291A (es) |
| ES (1) | ES2248485T3 (es) |
| HK (1) | HK1050904A1 (es) |
| HR (1) | HRP20020609B1 (es) |
| HU (1) | HUP0202369A2 (es) |
| IL (1) | IL150601A (es) |
| MX (1) | MXPA02006998A (es) |
| NO (1) | NO324245B1 (es) |
| PE (1) | PE20030214A1 (es) |
| PL (1) | PL205559B1 (es) |
| PT (1) | PT1291356E (es) |
| RU (1) | RU2237673C2 (es) |
| SG (1) | SG119160A1 (es) |
| TW (1) | TWI247012B (es) |
| ZA (1) | ZA200205409B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
| EP1801086A1 (en) * | 2005-11-25 | 2007-06-27 | Synthacon GmbH | Synthesis of carbon acid amides |
| EP1790656A1 (en) * | 2005-11-25 | 2007-05-30 | Nanokem S.A. | Solution-phase synthesis of leuprolide |
| WO2007082890A1 (en) * | 2006-01-17 | 2007-07-26 | N.V. Organon | SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES |
| ES2729197T3 (es) | 2006-03-01 | 2019-10-30 | Kaneka Corp | Método de producción de péptidos |
| US8124372B2 (en) | 2007-06-25 | 2012-02-28 | N.V. Organon | Selective enzymatic amidation of C-terminal esters or acids of peptides |
| ATE494383T1 (de) * | 2007-06-25 | 2011-01-15 | Organon Nv | Verfahren zur umsetzung von c-terminalen peptidestern oder -säuren zu amiden unter verwendung von subtilisin in gegenwart von ammoniumsalzen |
| WO2010075849A1 (de) * | 2008-12-30 | 2010-07-08 | Gkl-Biotec Ag | Peptidkombination |
| KR101032399B1 (ko) * | 2010-02-11 | 2011-05-03 | 주식회사 이너트론 | 밴드패스필터의 철재하우징 및 그 제조방법 |
| EP2409982A3 (en) * | 2010-02-25 | 2012-02-08 | Corning Incorporated | Chemical processes generating solid(s) carried out continuously within microreactors |
| JP6136934B2 (ja) | 2011-12-15 | 2017-05-31 | 味の素株式会社 | Ｆｍｏｃ基の除去方法 |
| DK3266792T3 (da) | 2015-03-04 | 2021-02-01 | Jitsubo Co Ltd | Fremgangsmåde til peptidsyntese |
| ES2957399T3 (es) | 2018-04-13 | 2024-01-18 | Jitsubo Co Ltd | Método de síntesis de péptidos |
| US12024537B2 (en) | 2018-05-31 | 2024-07-02 | Sederma | Compositions and methods for chemical synthesis |
| FR3090636B1 (fr) * | 2018-12-24 | 2021-01-01 | Strainchem | Procédé de synthèse de peptides |
| US11827660B2 (en) | 2019-02-01 | 2023-11-28 | Sederma | Synthesis strategy for gap protecting group |
| TW202138382A (zh) * | 2019-12-27 | 2021-10-16 | 日商中外製藥股份有限公司 | 胜肽化合物的合成法 |
| WO2021192488A1 (ja) * | 2020-03-27 | 2021-09-30 | 株式会社カネカ | アミド結合含有化合物の製造方法 |
| JP7063408B1 (ja) | 2021-07-02 | 2022-05-09 | ペプチスター株式会社 | 液相ペプチド製造方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1991A (en) * | 1841-02-23 | Manner of fastening bedsteads | ||
| US5221754A (en) * | 1989-06-09 | 1993-06-22 | Research Corporation Technologies, Inc. | Reagents for rapid peptide synthesis |
| US5101059A (en) * | 1989-12-05 | 1992-03-31 | Research Corporation Technologies, Inc. | Amino acid protecting groups |
| US5877278A (en) | 1992-09-24 | 1999-03-02 | Chiron Corporation | Synthesis of N-substituted oligomers |
| US5516892A (en) | 1992-12-28 | 1996-05-14 | Indiana University Foundation | Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids |
| US6310180B1 (en) * | 1993-06-21 | 2001-10-30 | Vanderbilt University | Method for synthesis of proteins |
| US5516639A (en) * | 1993-07-22 | 1996-05-14 | Mayo Foundation For Medical Education And Research | Antibodies specific for human prostate glandular kallkrein |
| US6001966A (en) | 1995-10-19 | 1999-12-14 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
| US5698676A (en) | 1995-11-30 | 1997-12-16 | Abbott Laboratories | Use of propylene oxide as an acid scavenger in peptide synthesis |
| US5849954A (en) * | 1996-01-18 | 1998-12-15 | Research Corporation Technologies, Inc. | Method of peptide synthesis |
| EP0896590A1 (en) | 1996-05-03 | 1999-02-17 | Warner-Lambert Company | Rapid purification by polymer supported quench |
| US6121488A (en) * | 1997-09-24 | 2000-09-19 | Warner-Lambert Company | Quenching reagents for solution phase synthesis |
| JPH11217397A (ja) * | 1997-11-27 | 1999-08-10 | Saburo Aimoto | ペプチドチオールエステルの製造方法 |
| FR2780061B1 (fr) | 1998-06-22 | 2001-09-07 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
| EP1180115A1 (en) * | 1999-05-26 | 2002-02-20 | Abbott Laboratories | Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents |
| US20020127219A1 (en) | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| US7205120B2 (en) | 2000-07-19 | 2007-04-17 | Pharmacia & Upjohn Company | Substrates and assays for β-secretase activity |
| IL150600A (en) * | 2001-07-19 | 2005-09-25 | Akzo Nobel Nv | Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component |
| TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
| US8067525B2 (en) * | 2005-06-17 | 2011-11-29 | Eastman Chemical Company | Film(s) and/or sheet(s) comprising polyester compositions which comprise cyclobutanediol and have a certain combination of inherent viscosity and high glass transition temperature |
-
2002
- 2002-07-04 TW TW091114832A patent/TWI247012B/zh not_active IP Right Cessation
- 2002-07-04 IL IL150601A patent/IL150601A/en active IP Right Grant
- 2002-07-05 JP JP2002197550A patent/JP4142907B2/ja not_active Expired - Lifetime
- 2002-07-05 ZA ZA200205409A patent/ZA200205409B/xx unknown
- 2002-07-15 ES ES02077830T patent/ES2248485T3/es not_active Expired - Lifetime
- 2002-07-15 AT AT02077830T patent/ATE302792T1/de active
- 2002-07-15 SG SG200204298A patent/SG119160A1/en unknown
- 2002-07-15 PT PT02077830T patent/PT1291356E/pt unknown
- 2002-07-15 DK DK02077830T patent/DK1291356T3/da active
- 2002-07-15 EP EP02077830A patent/EP1291356B1/en not_active Expired - Lifetime
- 2002-07-15 DE DE60205693T patent/DE60205693T2/de not_active Expired - Lifetime
- 2002-07-17 MX MXPA02006998A patent/MXPA02006998A/es active IP Right Grant
- 2002-07-17 PE PE2002000637A patent/PE20030214A1/es not_active Application Discontinuation
- 2002-07-18 NO NO20023446A patent/NO324245B1/no not_active IP Right Cessation
- 2002-07-18 KR KR1020020041898A patent/KR100861031B1/ko not_active IP Right Cessation
- 2002-07-18 CA CA002390358A patent/CA2390358C/en not_active Expired - Lifetime
- 2002-07-18 AR ARP020102687A patent/AR034869A1/es active IP Right Grant
- 2002-07-18 RU RU2002119630/04A patent/RU2237673C2/ru not_active IP Right Cessation
- 2002-07-18 BR BRPI0202783A patent/BRPI0202783B1/pt active IP Right Grant
- 2002-07-18 HU HU0202369A patent/HUP0202369A2/hu unknown
- 2002-07-18 CN CNB021261911A patent/CN1254483C/zh not_active Expired - Lifetime
- 2002-07-19 EC EC2002004291A patent/ECSP024291A/es unknown
- 2002-07-19 HR HR20020609A patent/HRP20020609B1/xx not_active IP Right Cessation
- 2002-07-19 PL PL355125A patent/PL205559B1/pl not_active IP Right Cessation
- 2002-07-19 US US10/199,805 patent/US20030018164A1/en not_active Abandoned
-
2003
- 2003-04-29 HK HK03103037A patent/HK1050904A1/xx not_active IP Right Cessation
- 2003-10-22 US US10/692,354 patent/US20040082760A1/en not_active Abandoned
- 2003-10-23 US US10/693,802 patent/US7435791B2/en not_active Expired - Lifetime
- 2003-10-23 US US10/693,123 patent/US20060063918A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR034869A1 (es) | Procedimiento para la sintesis rapida de un peptido en solucion, metodos para la sintesis combinatoria de bibliotecas de peptidos y para l a sintesis automatizada de peptidos en solucion que aplican dicho procedimiento y un peptido o una mezcla de peptidos asi obtenido(a) | |
| Albericio | Orthogonal protecting groups for Nα‐amino and C‐terminal carboxyl functions in solid‐phase peptide synthesis | |
| JP2002505672A (ja) | 水溶液中における保護されていないか又はｎ−末端システインで保護されたペプチドの固相での自然化学連結 | |
| JP2011001384A (ja) | ペプチド合成におけるマイクロ波により向上されたｎ−ｆｍｏｃ脱保護 | |
| CN111479819A (zh) | 制备肽的方法和处理碱的方法 | |
| ES2374389T3 (es) | Procedimiento de preparación de péptidos. | |
| DE60123125D1 (de) | Verfahren zur herstellung von 1-(aminomethyl) cyclohexanessigsäure | |
| JP2899430B2 (ja) | 安定化されたヒルディンのスルホネ−ト、サルフェ−ト、ホスホネ−ト、及びホスフェ−ト誘導体 | |
| DE602004023827D1 (de) | Ionenkanalaktivität hemmende niedrigmolekulare peptide | |
| Carpino et al. | Dramatically enhanced N→ O acyl migration during the trifluoroacetic acid-based deprotection step in solid phase peptide synthesis | |
| WEN et al. | A systematic approach to the solid‐phase synthesis of linear and cyclic pseudopeptide libraries containing ψ [CH2NH] amide bond surrogates | |
| Spetzler et al. | Preparation and application of O‐amino‐serine, Ams, a new building block in chemoselective ligation chemistry | |
| Fang et al. | A convenient approach to synthesizing peptide C‐terminal N‐alkyl amides | |
| JPH05508850A (ja) | 抗凝固ペプチド | |
| JP2001505578A (ja) | スルホニル保護基を用いるペプチド合成 | |
| JPS6393796A (ja) | ペプチド合成の脱保護基用薬剤 | |
| EA200400603A1 (ru) | Новые пептиды - аналоги гормона высвобождения гормона роста человека | |
| Johnson et al. | Synthesis, stability and optimized photolytic cleavage of 4-methoxy-2-nitrobenzyl backbone-protected peptides | |
| KR20240004561A (ko) | 포스포릴콜린 접합체를 포함하는 펩티드 및 이의 합성 방법 | |
| Botti et al. | Chemical Synthesis of Proteins and Circular Peptides Using Nα-(1-Phenyl-2-Mercaptoethyl) Auxiliaries | |
| FAUCHERE et al. | and Selective Deprotection in Peptide Synthesis | |
| Tatsu et al. | Caged Compounds and Solid‐Phase Synthesis | |
| JPH05506250A (ja) | エンドテリン形成の阻害 | |
| Ornelas | Photochemical synthesis of amino acid and peptide oxo-esters | |
| FEHRENTZ | SARAH L. MELLOR, DONALD A. WELLINGS, JEAN-ALAIN FEHRENTZ, MARIELLE PARIS, JEAN MARTINEZ, NICHOLAS J. EDE, ANDREW M. BRAY, DAVID J. EVANS and GB BLOOMBERG |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |