AR032139A1 - Derivados de adamantano, proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de la composicion farmaceutica, y usos de estos derivados para la fabricacion de medicamentos - Google Patents
Derivados de adamantano, proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de la composicion farmaceutica, y usos de estos derivados para la fabricacion de medicamentosInfo
- Publication number
- AR032139A1 AR032139A1 ARP000106417A ARP000106417A AR032139A1 AR 032139 A1 AR032139 A1 AR 032139A1 AR P000106417 A ARP000106417 A AR P000106417A AR P000106417 A ARP000106417 A AR P000106417A AR 032139 A1 AR032139 A1 AR 032139A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- preparation
- pharmaceutical composition
- alkyl group
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Abstract
Un derivado de adamantano que tiene la formula general (1), donde: D representa CH2 o CH2CH2; E representa C(O)NH o NHC(O); R1 y R2 cada uno independientemente representa un átomo de hidrogeno o halogeno o un grupo amino, nitro, alquilo C1-6 o trifluormetilo; R3 representa un grupo de formula (2); X representa un átomo de oxígeno o azufre o un grupo NH, SO o SO2; Y representa un átomo de oxígeno o azufre o un grupo NR11, SO o SO2; Z representa un grupo -OH, -SH, -CO2H, alcoxi C1-6, alquiltio C1-6, alquilsulfinilo C1-6, alquilsulfonilo C1-6, -NR6R7, -C(O)NR8R9, imidazolilo, 1-metilimidazolilo, -N(R10)C(O)-alquilo C1-6, alquilcarboniloxi C1-6, alcoxicarboniloxi C1-6, -OC(O)NR12R13, -OCH2OC(O)R14, -OCH2OC(O)OR15 o -OC(O)OCH2OR16; R4 representa un grupo alquilo C2-6; R5 representa un grupo alquilo C1-6; R6, R7, R8, R9, R10, R12 y R13 cada uno independientemente representan un átomo de hidrogeno, o un grupo alquilo C1-6 opcionalmente sustituido con al menos un grupo hidroxilo; R11 representa un átomo de hidrogeno, o un grupo alquilo C1-6 opcionalmente sustituido con al menos un sustituyente independientemente seleccionados de hidroxilo y alcoxi C1-6; y R14, R15 y R16 cada uno, independientemente, un grupo alquilo C1-6; con las condiciones de que (i) cuando E representa NHC(O), X representa O, S o NH e Y representa O, entonces Z representa NR6R7 donde R6 representa un átomo de hidrogeno y R7 representa un átomo de hidrogeno o un grupo alquilo C1-6 sustituido con al menos un grupo hidroxilo, y (ii) cuando E representa NHC(O), X representa O, S o NH, Y representa NH y R5 representa CH2CH2, entonces Z no es -OH o imidazolilo; o una sal o solvato farmacéuticamente aceptable del mismo; proceso para su preparacion, composicion farmacéutica, proceso para la preparacion de la composicion farmacéutica, y usos de estos derivados para la fabricacion de medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9904505A SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032139A1 true AR032139A1 (es) | 2003-10-29 |
Family
ID=20418060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000106417A AR032139A1 (es) | 1999-12-09 | 2000-12-04 | Derivados de adamantano, proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de la composicion farmaceutica, y usos de estos derivados para la fabricacion de medicamentos |
Country Status (27)
Country | Link |
---|---|
US (1) | US6720452B2 (es) |
EP (1) | EP1240132B1 (es) |
JP (1) | JP2003516382A (es) |
KR (1) | KR20020060991A (es) |
CN (1) | CN1407968A (es) |
AR (1) | AR032139A1 (es) |
AT (1) | ATE263748T1 (es) |
AU (1) | AU2036301A (es) |
BR (1) | BR0016227A (es) |
CA (1) | CA2394236A1 (es) |
CO (1) | CO5261526A1 (es) |
CZ (1) | CZ20021982A3 (es) |
DE (1) | DE60009747T2 (es) |
EE (1) | EE200200295A (es) |
HK (1) | HK1046527A1 (es) |
HU (1) | HUP0300618A3 (es) |
IL (1) | IL149762A0 (es) |
IS (1) | IS6405A (es) |
MX (1) | MXPA02005668A (es) |
NO (1) | NO20022727L (es) |
NZ (1) | NZ518985A (es) |
PL (1) | PL357103A1 (es) |
RU (1) | RU2002118213A (es) |
SE (1) | SE9904505D0 (es) |
SK (1) | SK7622002A3 (es) |
WO (1) | WO2001042194A1 (es) |
ZA (1) | ZA200203834B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI258462B (en) * | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
SE0300445D0 (sv) * | 2003-02-18 | 2003-02-18 | Astrazeneca Ab | New combination |
SE0300480D0 (sv) * | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
ATE355273T1 (de) * | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
TW200507829A (en) * | 2003-05-29 | 2005-03-01 | Astrazeneca Ab | New combination |
EP1644041A1 (en) * | 2003-05-29 | 2006-04-12 | AstraZeneca AB | A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine |
US20070281931A1 (en) * | 2003-05-29 | 2007-12-06 | Nigel Boughton-Smith | Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate |
SE0302192D0 (sv) * | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
AU2005258924A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
JP2008504360A (ja) * | 2004-06-29 | 2008-02-14 | ファイザー・プロダクツ・インク | ヒドロキシル保護された前駆体を脱保護することによる5−[4−(2−ヒドロキシ−プロピル)−3,5−ジオキソ−4,5−ジヒドロ−3h−1,2,4−トリアジン−2−イル]−ベンズアミド誘導体の製造方法 |
SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
US20060063834A1 (en) * | 2004-09-09 | 2006-03-23 | Frangioni John V | Substituted adamantanes, and methods of making the same |
SE0402925D0 (sv) * | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
KR100643514B1 (ko) * | 2005-05-17 | 2006-11-23 | (주)아모레퍼시픽 | 히드록시벤조산 아미드 화합물과 그 제조방법 및 이를함유하는 미백화장료 조성물 |
WO2007008157A1 (en) * | 2005-07-11 | 2007-01-18 | Astrazeneca Ab | New combination 2 |
US20080207577A1 (en) * | 2005-07-11 | 2008-08-28 | Astrazeneca Ab | Combination I |
ZA200904477B (en) | 2006-11-27 | 2010-09-29 | Lundbeck & Co As H | Heteroaryl amide derivatives |
RU2010121763A (ru) | 2007-10-31 | 2011-12-10 | Ниссан Кемикал Индастриз, Лтд. (Jp) | Производные пиридазинона и ингибиторы р2х7 рецептора |
US8232290B2 (en) | 2008-03-25 | 2012-07-31 | Affectis Pharmaceuticals Ag | P2X7R antagonists and their use |
KR20100053150A (ko) * | 2008-11-12 | 2010-05-20 | 한국생명공학연구원 | 아릴옥시아세틸계 유도체를 유효성분으로 포함하는 dna 메틸트렌스퍼레이즈 억제용 약학적 조성물 |
PT2243772E (pt) | 2009-04-14 | 2012-03-28 | Affectis Pharmaceuticals Ag | Novos antagonistas de p2x7r e sua utilização |
EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
CN102858741A (zh) | 2010-05-14 | 2013-01-02 | 阿费克蒂斯制药股份公司 | 制备p2x7r拮抗剂的新方法 |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
MX2014000894A (es) | 2011-07-22 | 2014-02-27 | Actelion Pharmaceuticals Ltd | Derivados de amidas heterociclicas como antagonistas de receptores p2x7. |
KR101957843B1 (ko) * | 2011-10-06 | 2019-03-14 | (주)아모레퍼시픽 | 신규 아다만탄 유도체 화합물 |
AR089753A1 (es) | 2012-01-20 | 2014-09-17 | Actelion Pharmaceuticals Ltd | Derivados de amida heterociclicos como antagonistas del receptor p2x7 |
EA029644B1 (ru) | 2012-12-12 | 2018-04-30 | Идорсиа Фармасьютиклз Лтд | Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов |
US9556117B2 (en) | 2012-12-18 | 2017-01-31 | Actelion Pharmaceuticals Ltd. | Indole carboxamide derivatives as P2X7 receptor antagonists |
EP2956457B1 (en) | 2013-01-22 | 2016-11-23 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
CA2896790C (en) | 2013-01-22 | 2022-05-10 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
EP4098650A4 (en) | 2020-01-31 | 2024-03-13 | Kumiai Chemical Industry Co | 3-ALKOXYBENZOIC ACID AMIDE DERIVATIVE AND PEST CONTROL AGENT |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3464998A (en) | 1968-03-04 | 1969-09-02 | Searle & Co | Adamantyl esters and amides of pyridinecarboxylic acids |
US3732305A (en) | 1970-03-03 | 1973-05-08 | Us Army | S-substituted thiosulfuric acid derivatives and preparation thereof |
US3789072A (en) | 1970-04-22 | 1974-01-29 | Squibb & Sons Inc | Carboxamides |
CA2015473C (en) | 1989-04-28 | 1998-04-14 | Iwao Kinoshita | Triphenylmethane derivatives |
CA2091194A1 (en) | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
SG52229A1 (en) | 1993-08-10 | 1998-09-28 | Black James Foundation | Gastrin and cck receptor ligands |
JPH10504525A (ja) | 1994-05-27 | 1998-05-06 | ジェイムズ・ブラック・ファウンデーション・リミテッド | ガストリンとcck拮抗薬 |
DE19608653A1 (de) | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
SE9704546D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
NZ514477A (en) * | 1999-04-09 | 2003-04-29 | Astrazeneca Ab | Adamantane derivatives |
SE9901875D0 (sv) | 1999-05-25 | 1999-05-25 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
SE9904738D0 (sv) | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
-
1999
- 1999-12-09 SE SE9904505A patent/SE9904505D0/xx unknown
-
2000
- 2000-12-01 AT AT00983632T patent/ATE263748T1/de not_active IP Right Cessation
- 2000-12-01 MX MXPA02005668A patent/MXPA02005668A/es unknown
- 2000-12-01 SK SK762-2002A patent/SK7622002A3/sk unknown
- 2000-12-01 DE DE60009747T patent/DE60009747T2/de not_active Expired - Lifetime
- 2000-12-01 JP JP2001543496A patent/JP2003516382A/ja not_active Withdrawn
- 2000-12-01 KR KR1020027007354A patent/KR20020060991A/ko not_active Application Discontinuation
- 2000-12-01 EE EEP200200295A patent/EE200200295A/xx unknown
- 2000-12-01 US US10/149,190 patent/US6720452B2/en not_active Expired - Fee Related
- 2000-12-01 CN CN00816771A patent/CN1407968A/zh active Pending
- 2000-12-01 WO PCT/SE2000/002418 patent/WO2001042194A1/en active IP Right Grant
- 2000-12-01 CA CA002394236A patent/CA2394236A1/en not_active Abandoned
- 2000-12-01 RU RU2002118213/04A patent/RU2002118213A/ru unknown
- 2000-12-01 CZ CZ20021982A patent/CZ20021982A3/cs unknown
- 2000-12-01 EP EP00983632A patent/EP1240132B1/en not_active Expired - Lifetime
- 2000-12-01 IL IL14976200A patent/IL149762A0/xx unknown
- 2000-12-01 PL PL00357103A patent/PL357103A1/xx not_active Application Discontinuation
- 2000-12-01 HU HU0300618A patent/HUP0300618A3/hu unknown
- 2000-12-01 NZ NZ518985A patent/NZ518985A/en unknown
- 2000-12-01 BR BR0016227-2A patent/BR0016227A/pt not_active Application Discontinuation
- 2000-12-01 AU AU20363/01A patent/AU2036301A/en not_active Abandoned
- 2000-12-04 AR ARP000106417A patent/AR032139A1/es unknown
- 2000-12-06 CO CO00093169A patent/CO5261526A1/es not_active Application Discontinuation
-
2002
- 2002-05-14 ZA ZA200203834A patent/ZA200203834B/xx unknown
- 2002-05-31 IS IS6405A patent/IS6405A/is unknown
- 2002-06-07 NO NO20022727A patent/NO20022727L/no not_active Application Discontinuation
- 2002-11-05 HK HK02108042.9A patent/HK1046527A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
SK7622002A3 (en) | 2003-01-09 |
NO20022727D0 (no) | 2002-06-07 |
US20020193414A1 (en) | 2002-12-19 |
EP1240132A1 (en) | 2002-09-18 |
KR20020060991A (ko) | 2002-07-19 |
CO5261526A1 (es) | 2003-03-31 |
HUP0300618A3 (en) | 2003-12-29 |
RU2002118213A (ru) | 2004-01-10 |
ZA200203834B (en) | 2003-08-14 |
US6720452B2 (en) | 2004-04-13 |
DE60009747D1 (de) | 2004-05-13 |
EP1240132B1 (en) | 2004-04-07 |
WO2001042194A1 (en) | 2001-06-14 |
NZ518985A (en) | 2004-02-27 |
IS6405A (is) | 2002-05-31 |
CA2394236A1 (en) | 2001-06-14 |
IL149762A0 (en) | 2002-11-10 |
DE60009747T2 (de) | 2005-04-28 |
BR0016227A (pt) | 2002-10-01 |
NO20022727L (no) | 2002-07-29 |
SE9904505D0 (sv) | 1999-12-09 |
EE200200295A (et) | 2003-08-15 |
ATE263748T1 (de) | 2004-04-15 |
JP2003516382A (ja) | 2003-05-13 |
HK1046527A1 (zh) | 2003-01-17 |
CN1407968A (zh) | 2003-04-02 |
CZ20021982A3 (cs) | 2003-01-15 |
AU2036301A (en) | 2001-06-18 |
MXPA02005668A (es) | 2002-09-02 |
HUP0300618A2 (hu) | 2003-07-28 |
PL357103A1 (en) | 2004-07-12 |
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