AR008531A1 - Análogos a heptapeptidos antagonistas de la oxitocina - Google Patents

Análogos a heptapeptidos antagonistas de la oxitocina

Info

Publication number
AR008531A1
AR008531A1 ARP970105543A ARP970105543A AR008531A1 AR 008531 A1 AR008531 A1 AR 008531A1 AR P970105543 A ARP970105543 A AR P970105543A AR P970105543 A ARP970105543 A AR P970105543A AR 008531 A1 AR008531 A1 AR 008531A1
Authority
AR
Argentina
Prior art keywords
heptapeptides
nucleus
oxytocine
antagonist
analogs
Prior art date
Application number
ARP970105543A
Other languages
English (en)
Inventor
Per Melin
Anders Nilsson
Carl-Johan Aurell
Jerzy Trojnar
Pierre Reviere
Robert Haigh
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of AR008531A1 publication Critical patent/AR008531A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Los heptapéptidos análogos o sales farmacéuticamente aceptables de los mismos consisten en un nucleo hexapeptídico con un nitrogeno terminal S y unbeta-aminoalcohol con un carbono terminal Z unido al nucleo S por medio de una union amida, en el queel beta-aminoalcohol Z es -NR-CH(Q)-CH2-OH, donde Qrepresenta -(CH2)n-NH-A, donde n es 1-6 y A representa un H o -C(=NH)NH2, y R representa CH3 o C2H5, y el nucleo S es como se ve en la formula (1), donde X representa un D-alfa-aminoácido aromáticoe Y representa un alfa-aminoácido alifático, y posee una actividad antagonista a la oxitocina. También serevela: un método para su síntesis; composiciones farmacéuticas conteniendo estos análogos; la síntesis de dichas composiciones; un método decontrol decontracciones uterinas.
ARP970105543A 1996-11-26 1997-11-26 Análogos a heptapeptidos antagonistas de la oxitocina AR008531A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9604341A SE9604341D0 (sv) 1996-11-26 1996-11-26 Hepta-peptide oxytocin analogue

Publications (1)

Publication Number Publication Date
AR008531A1 true AR008531A1 (es) 2000-01-19

Family

ID=20404757

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105543A AR008531A1 (es) 1996-11-26 1997-11-26 Análogos a heptapeptidos antagonistas de la oxitocina

Country Status (35)

Country Link
US (1) US6143722A (es)
EP (1) EP0938496B1 (es)
JP (1) JP3405460B2 (es)
KR (1) KR100463132B1 (es)
CN (1) CN1129606C (es)
AR (1) AR008531A1 (es)
AT (1) ATE242264T1 (es)
AU (1) AU713424B2 (es)
BR (1) BR9713366B1 (es)
CA (1) CA2272990C (es)
CZ (1) CZ299532B6 (es)
DE (1) DE69722651T2 (es)
DK (1) DK0938496T3 (es)
EE (1) EE03832B1 (es)
ES (1) ES2203823T3 (es)
HK (1) HK1022481A1 (es)
HR (1) HRP970630B1 (es)
HU (1) HU228568B1 (es)
IL (1) IL129519A (es)
LT (1) LT4650B (es)
LV (1) LV12350B (es)
MY (1) MY125555A (es)
NO (1) NO321380B1 (es)
NZ (1) NZ336445A (es)
PL (1) PL189292B1 (es)
PT (1) PT938496E (es)
RO (1) RO120772B1 (es)
RU (1) RU2180668C2 (es)
SE (1) SE9604341D0 (es)
SI (1) SI20026B (es)
SK (1) SK283800B6 (es)
TR (1) TR199901028T2 (es)
UA (1) UA54459C2 (es)
WO (1) WO1998023636A1 (es)
ZA (1) ZA9710518B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2181297C2 (ru) 2000-06-20 2002-04-20 Эпштейн Олег Ильич Способ лечения патологического синдрома и лекарственное средство
US6476072B1 (en) * 2000-11-21 2002-11-05 Arthur Vanmoor Method of treating menstrual pain by enhancing the effectiveness of the human immune system
DE60309847T2 (de) * 2002-02-27 2007-10-18 Ferring B.V. Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga
EP1504268A2 (en) * 2002-05-02 2005-02-09 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with oxytocin receptor (oxtr)
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
UA76639C2 (uk) * 2002-08-02 2006-08-15 Олєг Ільіч Епштєйн Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій
EP1530967B1 (en) * 2003-11-13 2006-05-03 Ferring B.V. Blister pack and solid dosage form comprising desmopressin
EP1555029A1 (en) 2004-01-19 2005-07-20 Ferring B.V. Use of substances having oxytocin antagonistic properties for the preparation of a medicament for treating hypertension
US20060171909A1 (en) * 2005-02-03 2006-08-03 The Procter & Gamble Company Cosmetic compositions comprising colorants with low free dye
SE528446C2 (sv) * 2006-03-02 2006-11-14 Ferring Int Ct Sa Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
KR101522747B1 (ko) 2007-08-06 2015-05-26 알레간 인코포레이티드 데스모프레신 약물 전달을 위한 방법 및 장치
NZ587817A (en) * 2008-03-31 2012-05-25 Ferring Bv Oxytocin analogues
LT2712622T (lt) 2008-05-21 2016-09-26 Ferring B.V. Burnoje disperguojamas desmopresinas, skirtas nikturijos netrikdomo miego pirminio periodo pailginimui
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
TWI463990B (zh) * 2009-09-21 2014-12-11 Ferring Bv 催產素受體促進劑
AU2011278038B2 (en) 2010-07-15 2017-02-02 Oleg Iliich Epshtein A method of increasing the effect of an activated-potentiated form of an antibody
JO3400B1 (ar) * 2010-09-30 2019-10-20 Ferring Bv مركب صيدلاني من كاربيتوسين
ES2742299T3 (es) 2011-03-09 2020-02-13 Jitsubo Co Ltd Nuevos péptidos entrecruzados que contienen una estructura entrecruzada no peptídica, método para sintetizar péptidos entrecruzados y nuevo compuesto orgánico utilizado en el método
CN102875650B (zh) * 2012-09-26 2014-06-11 深圳翰宇药业股份有限公司 巴卢西班的制备方法
US9365615B2 (en) 2013-09-09 2016-06-14 Jitsubo Co., Ltd. Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method
EP3037101B1 (en) 2014-12-22 2019-03-06 Ferring B.V. Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
EP3359557A1 (en) 2015-10-06 2018-08-15 Ferring B.V. New methods for making barusiban and its intermediates
RS63286B1 (sr) 2016-01-04 2022-06-30 ObsEva SA Istovremeno davanje alfa-amino estra hidroksipropiltiazolidin karboksamidnog derivata i tokolitičkog agensa
MX2019000498A (es) 2016-07-21 2019-09-16 ObsEva SA Regímenes de dosis de antagonista de oxitocina para promover la implantación embrionaria y prevenir abortos espontaneos.
WO2021043726A1 (en) 2019-09-03 2021-03-11 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
EP4103750A1 (en) 2020-02-10 2022-12-21 ObsEva S.A. Biomarkers for oxytocin receptor antagonist therapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2036973A1 (en) * 1990-02-27 1991-08-28 Mark G. Bock Cyclic hexapeptide oxytocin antagonists
SE9002384D0 (sv) * 1990-07-09 1990-07-09 Ferring Ab Derivat av baklobshormoner
SE501678C2 (sv) * 1993-07-13 1995-04-10 Ferring Bv Peptid med oxytocinantagonistaktivitet samt farmaceutisk komposition innehållande nämnda peptid
SE523819C2 (sv) 1994-01-27 2004-05-18 Per-Ingvar Nilsson Accelerationsmunstycke samt metod för dess användning
SE9400918L (sv) 1994-03-18 1995-09-19 Anne Fjellstad Paulsen Stabiliserad komposition för oral administrering av peptider
SE9500249L (sv) 1995-01-25 1996-03-25 Valeo Engine Cooling Ab Värmeväxlartank med ändstycken, förfarande för framställning av en sådan tank, samt värmeväxlare försedd med en sådan

Also Published As

Publication number Publication date
NO992532D0 (no) 1999-05-26
LT4650B (lt) 2000-04-25
NO321380B1 (no) 2006-05-02
ZA9710518B (en) 1998-06-10
CZ183299A3 (cs) 2000-05-17
RO120772B1 (ro) 2006-07-28
ATE242264T1 (de) 2003-06-15
CZ299532B6 (cs) 2008-08-27
PT938496E (pt) 2003-10-31
AU5142998A (en) 1998-06-22
HU228568B1 (en) 2013-04-29
HUP0000577A3 (en) 2001-02-28
SK283800B6 (sk) 2004-02-03
BR9713366B1 (pt) 2010-05-18
CN1129606C (zh) 2003-12-03
HK1022481A1 (en) 2000-08-11
CN1238781A (zh) 1999-12-15
IL129519A0 (en) 2000-02-29
RU2180668C2 (ru) 2002-03-20
JP2000507617A (ja) 2000-06-20
DE69722651T2 (de) 2004-04-08
SI20026A (sl) 2000-02-29
EP0938496B1 (en) 2003-06-04
KR100463132B1 (ko) 2004-12-23
LV12350A (lv) 1999-09-20
NZ336445A (en) 2000-06-23
KR20000069045A (ko) 2000-11-25
EE9900210A (et) 1999-12-15
CA2272990A1 (en) 1998-06-04
AU713424B2 (en) 1999-12-02
ES2203823T3 (es) 2004-04-16
DE69722651D1 (en) 2003-07-10
PL189292B1 (pl) 2005-07-29
MY125555A (en) 2006-08-30
HUP0000577A2 (hu) 2000-11-28
DK0938496T3 (da) 2003-10-06
LV12350B (en) 1999-11-20
BR9713366A (pt) 2000-01-25
LT99052A (en) 2000-01-25
IL129519A (en) 2004-09-27
SE9604341D0 (sv) 1996-11-26
NO992532L (no) 1999-05-26
HRP970630A2 (en) 1998-10-31
UA54459C2 (uk) 2003-03-17
EP0938496A1 (en) 1999-09-01
SK70499A3 (en) 2000-10-09
TR199901028T2 (xx) 1999-07-21
JP3405460B2 (ja) 2003-05-12
HRP970630B1 (en) 2002-04-30
US6143722A (en) 2000-11-07
CA2272990C (en) 2002-11-19
WO1998023636A1 (en) 1998-06-04
EE03832B1 (et) 2002-08-15
SI20026B (sl) 2000-06-30

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