ZA946507B - Ortho-substituted benzoylguanidines process for their preparation their use as pharmaceutical of diagnostic and pharmaceutical containing them - Google Patents
Ortho-substituted benzoylguanidines process for their preparation their use as pharmaceutical of diagnostic and pharmaceutical containing themInfo
- Publication number
- ZA946507B ZA946507B ZA946507A ZA946507A ZA946507B ZA 946507 B ZA946507 B ZA 946507B ZA 946507 A ZA946507 A ZA 946507A ZA 946507 A ZA946507 A ZA 946507A ZA 946507 B ZA946507 B ZA 946507B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- cyclo
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4328869A DE4328869A1 (de) | 1993-08-27 | 1993-08-27 | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA946507B true ZA946507B (en) | 1995-03-28 |
Family
ID=6496184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA946507A ZA946507B (en) | 1993-08-27 | 1994-08-26 | Ortho-substituted benzoylguanidines process for their preparation their use as pharmaceutical of diagnostic and pharmaceutical containing them |
Country Status (18)
Country | Link |
---|---|
US (1) | US5965744A (xx) |
EP (1) | EP0640588B1 (xx) |
JP (1) | JP3655650B2 (xx) |
CN (1) | CN1064954C (xx) |
AT (1) | ATE184273T1 (xx) |
AU (1) | AU685137B2 (xx) |
CA (1) | CA2130944C (xx) |
DE (2) | DE4328869A1 (xx) |
DK (1) | DK0640588T3 (xx) |
ES (1) | ES2135514T3 (xx) |
FI (1) | FI120341B (xx) |
GR (1) | GR3031851T3 (xx) |
HU (1) | HU217635B (xx) |
IL (1) | IL110772A (xx) |
NO (1) | NO301975B1 (xx) |
NZ (1) | NZ264307A (xx) |
TW (1) | TW400318B (xx) |
ZA (1) | ZA946507B (xx) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
IL114670A0 (en) * | 1994-08-05 | 1995-11-27 | Fujisawa Pharmaceutical Co | Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
DE4430916A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl-benzoylguanidin-Derivate |
DE19502644A1 (de) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | 4-Amino-benzoylguanidin-Derivate |
DE19502895A1 (de) * | 1995-01-31 | 1996-08-01 | Merck Patent Gmbh | 4-Mercapto-benzoylguanidin-Derivate |
DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
DE19518073A1 (de) * | 1995-05-17 | 1996-11-21 | Hoechst Ag | Substituierte Benzyloxycarbonylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19518796A1 (de) * | 1995-05-22 | 1996-11-28 | Hoechst Ag | Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19526381A1 (de) * | 1995-07-19 | 1997-01-23 | Hoechst Ag | 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19531138A1 (de) * | 1995-08-24 | 1997-02-27 | Merck Patent Gmbh | Alkenyl-benzoylguanidin-Derivate |
DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
CA2195697A1 (en) | 1996-02-02 | 1997-08-03 | Masahumi Kitano | Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof |
DE19606509A1 (de) * | 1996-02-22 | 1997-08-28 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
WO1997031900A1 (fr) * | 1996-02-29 | 1997-09-04 | Kissei Pharmaceutical Co., Ltd. | Derives d'imidazole et inhibiteur d'epaississement de la paroi vasculaire |
DE19608162A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19608161A1 (de) | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19621319A1 (de) * | 1996-05-28 | 1997-12-04 | Hoechst Ag | Bis-ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19624178A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US6262229B1 (en) | 1996-12-04 | 2001-07-17 | Biomeasure Incorporated | Somatostatin antagonists |
DE19713427A1 (de) * | 1997-04-01 | 1998-10-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19737224A1 (de) | 1997-08-27 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen |
DE19950898A1 (de) | 1999-10-22 | 2001-04-26 | Aventis Pharma Gmbh | Heterocyclisch substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10001879A1 (de) | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10060292A1 (de) | 2000-12-05 | 2002-06-20 | Aventis Pharma Gmbh | Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament |
DE10163239A1 (de) * | 2001-12-21 | 2003-07-10 | Aventis Pharma Gmbh | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
US6953465B2 (en) * | 2002-03-25 | 2005-10-11 | Concentric Medical, Inc. | Containers and methods for delivering vaso-occluding filaments and particles |
DK1902017T3 (da) | 2005-06-24 | 2014-06-30 | Biotron Ltd | Antivirale acylguanidinforbindelser |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
DE59302959D1 (de) * | 1992-02-15 | 1996-07-25 | Hoechst Ag | 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen |
EP0556673B1 (de) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
ATE151071T1 (de) * | 1992-12-16 | 1997-04-15 | Hoechst Ag | 3,5-substituierte aminobenzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
-
1993
- 1993-08-27 DE DE4328869A patent/DE4328869A1/de not_active Withdrawn
- 1993-12-17 TW TW082110699A patent/TW400318B/zh not_active IP Right Cessation
-
1994
- 1994-08-22 DK DK94113047T patent/DK0640588T3/da active
- 1994-08-22 DE DE59408722T patent/DE59408722D1/de not_active Expired - Lifetime
- 1994-08-22 AT AT94113047T patent/ATE184273T1/de active
- 1994-08-22 EP EP94113047A patent/EP0640588B1/de not_active Expired - Lifetime
- 1994-08-22 ES ES94113047T patent/ES2135514T3/es not_active Expired - Lifetime
- 1994-08-25 HU HU9402454A patent/HU217635B/hu not_active IP Right Cessation
- 1994-08-25 NZ NZ264307A patent/NZ264307A/en not_active IP Right Cessation
- 1994-08-25 CN CN941091902A patent/CN1064954C/zh not_active Expired - Fee Related
- 1994-08-25 IL IL11077294A patent/IL110772A/xx not_active IP Right Cessation
- 1994-08-25 FI FI943901A patent/FI120341B/fi not_active IP Right Cessation
- 1994-08-26 NO NO943175A patent/NO301975B1/no not_active IP Right Cessation
- 1994-08-26 AU AU71507/94A patent/AU685137B2/en not_active Ceased
- 1994-08-26 JP JP20158594A patent/JP3655650B2/ja not_active Expired - Fee Related
- 1994-08-26 CA CA002130944A patent/CA2130944C/en not_active Expired - Fee Related
- 1994-08-26 ZA ZA946507A patent/ZA946507B/xx unknown
-
1997
- 1997-02-24 US US08/805,321 patent/US5965744A/en not_active Expired - Lifetime
-
1999
- 1999-11-17 GR GR990402945T patent/GR3031851T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3031851T3 (en) | 2000-02-29 |
JP3655650B2 (ja) | 2005-06-02 |
DE59408722D1 (de) | 1999-10-14 |
CN1106381A (zh) | 1995-08-09 |
TW400318B (en) | 2000-08-01 |
IL110772A (en) | 2000-06-29 |
FI120341B (fi) | 2009-09-30 |
NO943175D0 (no) | 1994-08-26 |
EP0640588B1 (de) | 1999-09-08 |
ES2135514T3 (es) | 1999-11-01 |
NO943175L (no) | 1995-02-28 |
FI943901A0 (fi) | 1994-08-25 |
HU217635B (hu) | 2000-03-28 |
US5965744A (en) | 1999-10-12 |
JPH07109251A (ja) | 1995-04-25 |
HUT70538A (en) | 1995-10-30 |
DE4328869A1 (de) | 1995-03-02 |
ATE184273T1 (de) | 1999-09-15 |
CA2130944A1 (en) | 1995-02-28 |
EP0640588A1 (de) | 1995-03-01 |
FI943901A (fi) | 1995-02-28 |
DK0640588T3 (da) | 2000-03-27 |
AU685137B2 (en) | 1998-01-15 |
CA2130944C (en) | 2005-11-15 |
CN1064954C (zh) | 2001-04-25 |
AU7150794A (en) | 1995-03-09 |
NO301975B1 (no) | 1998-01-05 |
HU9402454D0 (en) | 1994-10-28 |
NZ264307A (en) | 1995-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU685137B2 (en) | Ortho-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them | |
IL104713A0 (en) | 3,5-substituted benzoylguanidines,process for their preparation,their use as a medicament or diagnostic and medicament containing them | |
CA2125104A1 (en) | Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them | |
GR3021397T3 (en) | 3,4,5 substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them. | |
TW250479B (xx) | ||
FI943548A0 (fi) | Substituoidut bentsoyyliguanidiinit, menetelmä niiden valmistamiseksi, niiden käyttö lääkeaineena tai diagnostisena aineena sekä niitä sisältävä lääkeaine | |
GR3024927T3 (en) | Substituted benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them. | |
ZA946074B (en) | Urea-substituted benzoylguanidines process for their preparation their use as pharmaceutical or diagnostic and pharmaceutical containing them | |
NZ264282A (en) | Diacyl substituted guanidine derivatives, preparation and pharmaceutical compositions thereof |