ZA939404B - Pyrazoles and pyrazolopyrimidines - Google Patents
Pyrazoles and pyrazolopyrimidinesInfo
- Publication number
- ZA939404B ZA939404B ZA939404A ZA939404A ZA939404B ZA 939404 B ZA939404 B ZA 939404B ZA 939404 A ZA939404 A ZA 939404A ZA 939404 A ZA939404 A ZA 939404A ZA 939404 B ZA939404 B ZA 939404B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- pyrazoles
- date jun
- sec
- pyrazolopyrimidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99222592A | 1992-12-17 | 1992-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA939404B true ZA939404B (en) | 1995-06-15 |
Family
ID=25538063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA939404A ZA939404B (en) | 1992-12-17 | 1993-12-15 | Pyrazoles and pyrazolopyrimidines |
Country Status (27)
Country | Link |
---|---|
US (1) | US5712303A (ja) |
EP (1) | EP0674624B1 (ja) |
JP (1) | JP2862374B2 (ja) |
KR (1) | KR0170567B1 (ja) |
CN (1) | CN1060768C (ja) |
AT (1) | ATE175961T1 (ja) |
AU (1) | AU690527B2 (ja) |
BR (1) | BR9307659A (ja) |
CA (1) | CA2150483C (ja) |
CZ (1) | CZ284157B6 (ja) |
DE (1) | DE69323212T2 (ja) |
DK (1) | DK0674624T3 (ja) |
EG (1) | EG20397A (ja) |
ES (1) | ES2126661T3 (ja) |
FI (1) | FI113648B (ja) |
GR (1) | GR3029568T3 (ja) |
HU (1) | HUT67457A (ja) |
IL (1) | IL107946A (ja) |
MX (2) | MX9308042A (ja) |
MY (1) | MY131382A (ja) |
NO (2) | NO304831B1 (ja) |
NZ (1) | NZ257770A (ja) |
PL (1) | PL175831B1 (ja) |
RU (1) | RU2142946C1 (ja) |
TW (1) | TW238303B (ja) |
WO (1) | WO1994013643A1 (ja) |
ZA (1) | ZA939404B (ja) |
Families Citing this family (82)
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US6103900A (en) * | 1992-12-17 | 2000-08-15 | Pfizer Inc | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
US6005109A (en) * | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
CA2174080A1 (en) * | 1993-10-12 | 1995-04-20 | Paul Edward Aldrich | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
US5646152A (en) * | 1994-06-15 | 1997-07-08 | Pfizer Inc. | Methods of administering CRF antagonists |
CN1165482A (zh) * | 1994-11-10 | 1997-11-19 | 科西雷佩蒂斯公司 | 用作蛋白激酶抑制剂的吡唑药物组合物 |
EP0729758A3 (en) * | 1995-03-02 | 1997-10-29 | Pfizer | Pyrazolopyrimidines and pyrrolopyrimidines to treat neuronal disorders and other diseases |
US7067664B1 (en) | 1995-06-06 | 2006-06-27 | Pfizer Inc. | Corticotropin releasing factor antagonists |
US6403599B1 (en) | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
US5817688A (en) * | 1995-12-19 | 1998-10-06 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
US5922885A (en) | 1995-12-19 | 1999-07-13 | Rhone-Poulenc Inc. | Pesticidal 1-arylpyrazole derivatives |
US6051578A (en) * | 1996-02-12 | 2000-04-18 | Pfizer Inc. | Pyrazolopyrimidines for treatment of CNS disorders |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
US5760225A (en) | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
ES2203937T3 (es) | 1997-03-26 | 2004-04-16 | Taisho Pharmaceutical Co., Ltd | Derivados de 4-tetrahidropiridilpirimidina. |
SE9701398D0 (sv) * | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
US6613777B1 (en) | 1998-03-06 | 2003-09-02 | Chen Chen | CRF antagonistic pyrazolo[4,3-b]pyridines |
JP2002510686A (ja) | 1998-04-02 | 2002-04-09 | ニューロゲン コーポレイション | アミノアルキルで置換された5,6,7,8−テトラヒドロ−9H−ピリジノ[2,3−b]インドール及び5,6,7,8−テトラヒドロ−9Hピリミジノ[4,5−B]インドール誘導体:CRF1特異的配位子 |
US6472402B1 (en) | 1998-04-02 | 2002-10-29 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives |
US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
CN1147476C (zh) * | 1998-05-05 | 2004-04-28 | 霍夫曼-拉罗奇有限公司 | 作为p-38map激酶抑制剂的吡唑衍生物 |
US6376527B1 (en) | 1998-05-05 | 2002-04-23 | Syntex (U.S.A.) Llc | Pyrazole derivatives-p38 map kinase inhibitors |
US20020156114A1 (en) | 1998-05-05 | 2002-10-24 | Goldstein David Michael | Pyrazole derivatives - p38 MAP kinase inhibitors |
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DE10142665B4 (de) | 2001-08-31 | 2004-05-06 | Aventis Pharma Deutschland Gmbh | C2-Disubstituierte Indan-1-one und ihre Derivate |
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CN100439341C (zh) * | 2002-12-02 | 2008-12-03 | 弗·哈夫曼-拉罗切有限公司 | 作为促肾上腺皮质激素释放因子拮抗剂的吲唑衍生物 |
WO2004054566A1 (en) | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Pregabalin derivatives for the treatment of fibromyalgia and other disorders |
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EP3312172B1 (en) | 2015-06-17 | 2020-05-06 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives useful as src kinase inhibitors |
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EP3563848A1 (en) * | 2018-04-30 | 2019-11-06 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Serpin inhibitors for the treatment of prion and prion-like diseases |
CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
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US3778443A (en) * | 1969-02-13 | 1973-12-11 | Ciba Geigy Ag | 4-tetrahydro pyridyl,hydroxy alkyl pyrazoles |
FR2460299A1 (fr) * | 1979-07-05 | 1981-01-23 | Bellon Labor Sa Roger | Nouveaux derives du pyrazole et leur application therapeutique |
FR2472564A1 (fr) * | 1979-12-31 | 1981-07-03 | Bellon Labor Sa Roger | Nouveaux aryl-1 arylsulfonyl-4 1h-pyrazolols-3, et procede pour les preparer |
DE3602728A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 51373 Leverkusen | Schaedlingsbekaempfungsmittel auf basis von pyrazolderivaten |
US5063245A (en) * | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
-
1993
- 1993-11-03 AU AU54548/94A patent/AU690527B2/en not_active Ceased
- 1993-11-03 EP EP93925103A patent/EP0674624B1/en not_active Expired - Lifetime
- 1993-11-03 AT AT93925103T patent/ATE175961T1/de not_active IP Right Cessation
- 1993-11-03 CZ CZ951585A patent/CZ284157B6/cs not_active IP Right Cessation
- 1993-11-03 WO PCT/US1993/010359 patent/WO1994013643A1/en active IP Right Grant
- 1993-11-03 CA CA002150483A patent/CA2150483C/en not_active Expired - Fee Related
- 1993-11-03 BR BR9307659A patent/BR9307659A/pt not_active Application Discontinuation
- 1993-11-03 DE DE69323212T patent/DE69323212T2/de not_active Expired - Fee Related
- 1993-11-03 JP JP6514147A patent/JP2862374B2/ja not_active Expired - Lifetime
- 1993-11-03 DK DK93925103T patent/DK0674624T3/da active
- 1993-11-03 PL PL93309356A patent/PL175831B1/pl unknown
- 1993-11-03 US US08/448,529 patent/US5712303A/en not_active Expired - Fee Related
- 1993-11-03 KR KR1019950702478A patent/KR0170567B1/ko not_active IP Right Cessation
- 1993-11-03 RU RU95113969/04A patent/RU2142946C1/ru not_active IP Right Cessation
- 1993-11-03 NZ NZ257770A patent/NZ257770A/en unknown
- 1993-11-03 ES ES93925103T patent/ES2126661T3/es not_active Expired - Lifetime
- 1993-11-06 TW TW082109298A patent/TW238303B/zh active
- 1993-12-09 IL IL10794693A patent/IL107946A/en not_active IP Right Cessation
- 1993-12-10 MY MYPI93002669A patent/MY131382A/en unknown
- 1993-12-15 HU HU9303591A patent/HUT67457A/hu not_active Application Discontinuation
- 1993-12-15 MX MX9308042A patent/MX9308042A/es unknown
- 1993-12-15 ZA ZA939404A patent/ZA939404B/xx unknown
- 1993-12-15 EG EG79593A patent/EG20397A/xx active
- 1993-12-16 FI FI935674A patent/FI113648B/fi not_active IP Right Cessation
- 1993-12-16 CN CN93120120A patent/CN1060768C/zh not_active Expired - Fee Related
-
1995
- 1995-06-16 NO NO952395A patent/NO304831B1/no unknown
-
1998
- 1998-06-29 MX MXPA98005325A patent/MXPA98005325A/es unknown
- 1998-11-25 NO NO985494A patent/NO306111B1/no unknown
-
1999
- 1999-03-04 GR GR990400652T patent/GR3029568T3/el unknown
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