ZA924109B - ((arylalkylpiperidin-4-yl)methyl)-2a,3,4,5-tetrahydro-1(2h)-acenaphthylen-1-ones and related compounds - Google Patents

((arylalkylpiperidin-4-yl)methyl)-2a,3,4,5-tetrahydro-1(2h)-acenaphthylen-1-ones and related compounds

Info

Publication number: ZA924109B
Authority: ZA; South Africa
Prior art keywords: loweralkoxy; hydrogen; arylalkylpiperidin; acenaphthylen; tetrahydro
Prior art date: 1991-06-07

Application number

ZA924109A

Other languages

English (en)

Inventor

Raymond W Kosley Jr

W Kosley Raymond Jr

Bettina Spahl

Spahl Bettina

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-07

Filing date

1992-06-05

Publication date

1993-02-24

1992-06-05 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1993-02-24 Publication of ZA924109B publication Critical patent/ZA924109B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Lubricants (AREA)
Pyridine Compounds (AREA)

ZA924109A 1991-06-07 1992-06-05 ((arylalkylpiperidin-4-yl)methyl)-2a,3,4,5-tetrahydro-1(2h)-acenaphthylen-1-ones and related compounds ZA924109B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/713,249 US5106856A (en)	1991-06-07	1991-06-07	[(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds

Publications (1)

Publication Number	Publication Date
ZA924109B true ZA924109B (en)	1993-02-24

Family

ID=24865395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA924109A ZA924109B (en)	1991-06-07	1992-06-05	((arylalkylpiperidin-4-yl)methyl)-2a,3,4,5-tetrahydro-1(2h)-acenaphthylen-1-ones and related compounds

Country Status (23)

Country	Link
US (1)	US5106856A (ja)
EP (1)	EP0517221B1 (ja)
JP (1)	JP2961013B2 (ja)
KR (1)	KR100234445B1 (ja)
AT (1)	ATE131814T1 (ja)
AU (1)	AU646784B2 (ja)
CA (1)	CA2070714A1 (ja)
CZ (1)	CZ284591B6 (ja)
DE (1)	DE69206889T2 (ja)
DK (1)	DK0517221T3 (ja)
ES (1)	ES2081517T3 (ja)
FI (1)	FI101297B1 (ja)
GR (1)	GR3018558T3 (ja)
HU (1)	HU217967B (ja)
IE (1)	IE72199B1 (ja)
IL (1)	IL102118A (ja)
MX (1)	MX9202736A (ja)
NO (1)	NO178889C (ja)
NZ (1)	NZ243013A (ja)
PL (1)	PL169423B1 (ja)
RU (1)	RU2043989C1 (ja)
TW (1)	TW206214B (ja)
ZA (1)	ZA924109B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW248556B (ja) *	1993-01-18	1995-06-01	Takeda Pharm Industry Co
US6939879B2 (en) *	1998-08-28	2005-09-06	Aventis Pharmaceuticals Inc.	Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia
EP1891954A3 (en)	1998-09-30	2009-01-14	Takeda Pharmaceutical Company Limited	Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
EA037187B1 (ru)	2010-02-09	2021-02-17	Дзе Джонс Хопкинс Юниверсити	Способ и композиция для лечения когнитивного расстройства
AU2011328993B2 (en)	2010-11-15	2017-03-02	Agenebio, Inc.	Pyridazine derivatives, compositions and methods for treating cognitive impairment
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
WO2014144801A1 (en)	2013-03-15	2014-09-18	Agenebio Inc.	Methods and compositions for improving cognitive function
WO2014144663A1 (en)	2013-03-15	2014-09-18	The Johns Hopkins University	Methods and compositions for improving cognitive function
JP6883988B2 (ja)	2013-12-20	2021-06-09	エージンバイオ，インコーポレイテッド	ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
US10925834B2 (en)	2015-05-22	2021-02-23	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
EA036844B1 (ru)	2015-06-19	2020-12-28	Эйджинбайо, Инк.	Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения
US20180170941A1 (en)	2016-12-19	2018-06-21	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
BR112019012821A2 (pt)	2016-12-19	2019-11-26	Agenebio Inc	derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
JP7514534B2 (ja)	2018-06-19	2024-07-11	エージンバイオ，インコーポレイテッド	認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
US20240132513A1 (en)	2022-08-19	2024-04-25	Agenebio, Inc.	Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2589934A (en) *	1950-08-24	1952-03-18	Abbott Lab	2-aminomethyl-tetrahydroacenapthones-1 and their preparation
US3391178A (en) *	1964-12-30	1968-07-02	Ernest E. Campaigne	Dialkylaminoalkyl 1-oxo-2alpha, 3, 4, 5-tetrahydroacenaphthen-2alpha-carboxylates
FI95572C (fi) *	1987-06-22	1996-02-26	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JP2969359B2 (ja) *	1989-01-13	1999-11-02	武田薬品工業株式会社	環状アミン化合物

1991
- 1991-06-07 US US07/713,249 patent/US5106856A/en not_active Expired - Fee Related
1992
- 1992-05-23 TW TW081104034A patent/TW206214B/zh active
- 1992-06-04 EP EP92109467A patent/EP0517221B1/en not_active Expired - Lifetime
- 1992-06-04 NZ NZ243013A patent/NZ243013A/en unknown
- 1992-06-04 ES ES92109467T patent/ES2081517T3/es not_active Expired - Lifetime
- 1992-06-04 DK DK92109467.8T patent/DK0517221T3/da active
- 1992-06-04 AT AT92109467T patent/ATE131814T1/de not_active IP Right Cessation
- 1992-06-04 DE DE69206889T patent/DE69206889T2/de not_active Expired - Fee Related
- 1992-06-04 FI FI922592A patent/FI101297B1/fi not_active IP Right Cessation
- 1992-06-05 NO NO922223A patent/NO178889C/no not_active IP Right Cessation
- 1992-06-05 ZA ZA924109A patent/ZA924109B/xx unknown
- 1992-06-05 CZ CS921713A patent/CZ284591B6/cs not_active IP Right Cessation
- 1992-06-05 AU AU18015/92A patent/AU646784B2/en not_active Ceased
- 1992-06-05 JP JP4144694A patent/JP2961013B2/ja not_active Expired - Fee Related
- 1992-06-05 IL IL10211892A patent/IL102118A/en not_active IP Right Cessation
- 1992-06-05 PL PL92294803A patent/PL169423B1/pl unknown
- 1992-06-05 KR KR1019920009765A patent/KR100234445B1/ko not_active IP Right Cessation
- 1992-06-05 HU HU9201887A patent/HU217967B/hu not_active IP Right Cessation
- 1992-06-06 RU SU925052251A patent/RU2043989C1/ru active
- 1992-06-08 MX MX9202736A patent/MX9202736A/es not_active IP Right Cessation
- 1992-06-08 CA CA002070714A patent/CA2070714A1/en not_active Abandoned
- 1992-07-01 IE IE921840A patent/IE72199B1/en not_active IP Right Cessation
1995
- 1995-12-28 GR GR950403690T patent/GR3018558T3/el unknown

Also Published As

Publication number	Publication date
EP0517221A1 (en)	1992-12-09
ATE131814T1 (de)	1996-01-15
DE69206889D1 (de)	1996-02-01
CA2070714A1 (en)	1992-12-08
DE69206889T2 (de)	1996-05-30
AU646784B2 (en)	1994-03-03
US5106856A (en)	1992-04-21
HU217967B (hu)	2000-05-28
DK0517221T3 (da)	1996-04-22
ES2081517T3 (es)	1996-03-16
KR100234445B1 (ko)	1999-12-15
PL169423B1 (pl)	1996-07-31
HU9201887D0 (en)	1992-08-28
IL102118A (en)	1996-05-14
CZ284591B6 (cs)	1999-01-13
GR3018558T3 (en)	1996-03-31
AU1801592A (en)	1992-12-10
FI922592A0 (fi)	1992-06-04
CS171392A3 (en)	1992-12-16
MX9202736A (es)	1993-01-01
EP0517221B1 (en)	1995-12-20
RU2043989C1 (ru)	1995-09-20
JP2961013B2 (ja)	1999-10-12
NO922223D0 (no)	1992-06-05
IE921840A1 (en)	1992-12-16
NO178889B (no)	1996-03-18
NZ243013A (en)	1995-04-27
FI101297B (fi)	1998-05-29
HUT65605A (en)	1994-07-28
PL294803A1 (en)	1993-07-26
KR930000483A (ko)	1993-01-15
NO922223L (no)	1992-12-08
NO178889C (no)	1996-06-26
TW206214B (ja)	1993-05-21
IL102118A0 (en)	1993-01-14
IE72199B1 (en)	1997-04-09
FI922592A (fi)	1992-12-08
JPH06116237A (ja)	1994-04-26
FI101297B1 (fi)	1998-05-29

Publication	Publication Date	Title
ZA924109B (en)	1993-02-24	((arylalkylpiperidin-4-yl)methyl)-2a,3,4,5-tetrahydro-1(2h)-acenaphthylen-1-ones and related compounds
IL116122A0 (en)	1996-01-31	Intermediates to heterocyclic-cyclic amine derivatives
NZ221543A (en)	1990-09-26	4-aminoquinoline derivatives and pharmaceutical compositions containing such
PL294221A1 (en)	1993-08-09	Method of obtaining novel 1-pyrido (3,4-b)-1,4-oxazinyl-4-ilo)-1h-indoles
NZ222640A (en)	1990-10-26	Quinolinol derivatives and pharmaceutical compositions
IL107001A0 (en)	1993-12-28	Tetrahydroacridine amino compounds and pharmaceutical compositions containing them
DK0570850T3 (da)	1997-06-16	Benzo(b)thiophen-3-yl-piperaziner, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
IL111404A (en)	2000-02-17	Pharmaceutical compositions for the enhancement ofmemory and cognition comprising 3-aryl-4-alkyl and 4,5-dialkyl-4H-1,2,4-triazoles and some such novel compounds
NO902556L (no)	1990-12-10	4,5,5a,6-tetrahydro-3h-isoksazol(5,4,3-kl)akridinderivater og fremgangsmaate for fremstilling derav.