ZA917008B - An enzymatic process for the conversion of preproinsulins into insulins - Google Patents

An enzymatic process for the conversion of preproinsulins into insulins

Info

Publication number: ZA917008B
Authority: ZA; South Africa
Prior art keywords: preproinsulins; insulins; conversion; enzymatic process; intermediates
Prior art date: 1990-09-05

Application number

ZA917008A

Other languages

English (en)

Inventor

Michael Doerschug

Doerschug Michael

Klaus-Peter Koller

Koller Klaus-Peter

Ruediger Marquardt

Marquardt Ruediger

Johannes Meiwes

Meiwes Johannes

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-05

Filing date

1991-09-04

Publication date

1992-04-29

1991-09-04 Application filed by Hoechst Ag filed Critical Hoechst Ag

1992-04-29 Publication of ZA917008B publication Critical patent/ZA917008B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

ZA917008A 1990-09-05 1991-09-04 An enzymatic process for the conversion of preproinsulins into insulins ZA917008B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4028118		1990-09-05

Publications (1)

Publication Number	Publication Date
ZA917008B true ZA917008B (en)	1992-04-29

Family

ID=6413629

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA917008A ZA917008B (en)	1990-09-05	1991-09-04	An enzymatic process for the conversion of preproinsulins into insulins

Country Status (26)

Country	Link
US (1)	US5728543A (ja)
EP (1)	EP0474212B1 (ja)
JP (1)	JP3005335B2 (ja)
KR (1)	KR100188800B1 (ja)
AT (1)	ATE145922T1 (ja)
AU (1)	AU637254B2 (ja)
CA (1)	CA2050606C (ja)
CZ (1)	CZ283234B6 (ja)
DE (1)	DE59108392D1 (ja)
DK (1)	DK0474212T3 (ja)
ES (1)	ES2095891T3 (ja)
FI (1)	FI103805B1 (ja)
GR (1)	GR3021909T3 (ja)
HR (1)	HRP940766A2 (ja)
HU (1)	HU214676B (ja)
IE (1)	IE75723B1 (ja)
IL (1)	IL99383A (ja)
LT (1)	LT3328B (ja)
LV (1)	LV10508B (ja)
NO (1)	NO300980B1 (ja)
NZ (1)	NZ239652A (ja)
PL (1)	PL167810B1 (ja)
RU (1)	RU2062301C1 (ja)
SK (1)	SK279686B6 (ja)
YU (1)	YU147491A (ja)
ZA (1)	ZA917008B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6461834B1 (en)	1998-11-06	2002-10-08	Bionebraska, Inc.	Clostripain catalyzed amidation of peptides
DE19915938A1 (de) *	1999-04-09	2000-10-19	Aventis Pharma Gmbh	Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
WO2003099847A2 (en) *	2002-05-24	2003-12-04	Restoragen, Inc.	Method for enzymatic production of glp-1 (7-36) amide peptides
CA2485695A1 (en) *	2002-05-24	2003-12-04	Fred W. Wagner	Method for universal enzymatic production of bioactive peptides
AU2003243316A1 (en) *	2002-05-24	2003-12-12	Nps Allelix Corp.	Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
ES2380765T3 (es) *	2003-11-21	2012-05-18	Nps Pharmaceuticals, Inc.	Producción del péptido 2 de tipo glucagón y análogos
WO2013015697A1 (en) *	2011-07-28	2013-01-31	Mabion S.A.	A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
KR102646845B1 (ko) *	2018-08-08	2024-03-14	주식회사 대웅제약	클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU81606A1 (de)	1979-08-14	1981-03-24	Arbed	Verfahren und einrichtung zur wiederverwertung von kohlenstoffreichen abfallprodukten
DE3209184A1 (de) *	1982-03-13	1983-09-15	Hoechst Ag, 6230 Frankfurt	Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
US4581909A (en)	1982-05-27	1986-04-15	Neiman S.A.	Cylinder lock, particularly a steering-wheel lock for a motor vehicle
JPS60217894A (ja) *	1984-04-14	1985-10-31	Suntory Ltd	新規プロテア−ゼ及びその製造方法
DE3440988A1 (de)	1984-11-09	1986-07-10	Hoechst Ag, 6230 Frankfurt	Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
CA1339955C (en)	1986-10-14	1998-07-14	Richard Eugene Heiney	Process for transforming a human insulin precursor to human insulin
DE4012818A1 (de) *	1990-04-21	1991-10-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3919852A1 (de) *	1988-06-23	1989-12-28	Hoechst Ag	Mini-proinsulin, seine herstellung und verwendung
DE58906966D1 (de)	1988-06-23	1994-03-24	Hoechst Ag	Mini-Proinsulin, seine Herstellung und Verwendung.
ES2081826T3 (es)	1988-11-03	1996-03-16	Hoechst Ag	Procedimiento para la preparacion de un producto previo de insulina en estreptomicetos.
US5617606A (en)	1996-02-29	1997-04-08	Baracuda International Corp.	Fluted swimming pool cleaner discs

1991
- 1991-09-03 KR KR1019910015314A patent/KR100188800B1/ko not_active IP Right Cessation
- 1991-09-03 IL IL9938391A patent/IL99383A/en not_active IP Right Cessation
- 1991-09-03 CZ CS912711A patent/CZ283234B6/cs not_active IP Right Cessation
- 1991-09-03 SK SK2711-91A patent/SK279686B6/sk not_active IP Right Cessation
- 1991-09-03 FI FI914151A patent/FI103805B1/fi not_active IP Right Cessation
- 1991-09-03 NZ NZ239652A patent/NZ239652A/xx not_active IP Right Cessation
- 1991-09-04 PL PL91291617A patent/PL167810B1/pl unknown
- 1991-09-04 ZA ZA917008A patent/ZA917008B/xx unknown
- 1991-09-04 AT AT91114934T patent/ATE145922T1/de not_active IP Right Cessation
- 1991-09-04 DK DK91114934.2T patent/DK0474212T3/da active
- 1991-09-04 CA CA002050606A patent/CA2050606C/en not_active Expired - Lifetime
- 1991-09-04 RU SU915001486A patent/RU2062301C1/ru active
- 1991-09-04 ES ES91114934T patent/ES2095891T3/es not_active Expired - Lifetime
- 1991-09-04 NO NO913474A patent/NO300980B1/no not_active IP Right Cessation
- 1991-09-04 DE DE59108392T patent/DE59108392D1/de not_active Expired - Lifetime
- 1991-09-04 YU YU147491A patent/YU147491A/sh unknown
- 1991-09-04 IE IE311791A patent/IE75723B1/en not_active IP Right Cessation
- 1991-09-04 AU AU83567/91A patent/AU637254B2/en not_active Expired
- 1991-09-04 EP EP91114934A patent/EP0474212B1/de not_active Expired - Lifetime
- 1991-09-04 JP JP3223243A patent/JP3005335B2/ja not_active Expired - Lifetime
- 1991-09-05 HU HU912875A patent/HU214676B/hu unknown
1993
- 1993-05-05 LV LVP-93-288A patent/LV10508B/xx unknown
- 1993-06-25 LT LTIP712A patent/LT3328B/lt not_active IP Right Cessation
1994
- 1994-08-08 US US08/291,060 patent/US5728543A/en not_active Expired - Lifetime
- 1994-10-25 HR HRP-1474/91A patent/HRP940766A2/hr not_active Application Discontinuation
1996
- 1996-12-05 GR GR960403067T patent/GR3021909T3/el unknown

Also Published As

Publication number	Publication date
GR3021909T3 (en)	1997-03-31
HU912875D0 (en)	1992-01-28
NO300980B1 (no)	1997-08-25
DK0474212T3 (da)	1997-05-12
CA2050606C (en)	2002-08-13
SK279686B6 (sk)	1999-02-11
HRP940766A2 (en)	1997-08-31
IE75723B1 (en)	1997-09-24
IE913117A1 (en)	1992-03-11
LV10508A (lv)	1995-02-20
KR920006504A (ko)	1992-04-27
AU8356791A (en)	1992-03-12
US5728543A (en)	1998-03-17
CA2050606A1 (en)	1992-03-06
FI103805B (fi)	1999-09-30
HU214676B (hu)	1998-04-28
LTIP712A (en)	1995-01-31
NO913474D0 (no)	1991-09-04
CS271191A3 (en)	1992-03-18
FI914151A0 (fi)	1991-09-03
NZ239652A (en)	1992-09-25
NO913474L (no)	1992-03-06
EP0474212B1 (de)	1996-12-04
EP0474212A2 (de)	1992-03-11
PL291617A1 (en)	1992-03-09
FI103805B1 (fi)	1999-09-30
JPH04258296A (ja)	1992-09-14
PL167810B1 (pl)	1995-11-30
FI914151A (fi)	1992-03-06
IL99383A (en)	1996-01-31
ATE145922T1 (de)	1996-12-15
IL99383A0 (en)	1992-08-18
KR100188800B1 (ko)	1999-06-01
EP0474212A3 (de)	1992-04-08
RU2062301C1 (ru)	1996-06-20
AU637254B2 (en)	1993-05-20
YU147491A (sh)	1995-10-24
LV10508B (en)	1996-02-20
CZ283234B6 (cs)	1998-02-18
LT3328B (en)	1995-07-25
ES2095891T3 (es)	1997-03-01
JP3005335B2 (ja)	2000-01-31
DE59108392D1 (de)	1997-01-16
HUT58823A (en)	1992-03-30

Publication	Publication Date	Title
EP0196042A3 (en)	1988-01-27	Antibiotic prepared from lysobacter sp. sc 14,067
DE68915692D1 (de)	1994-07-07	Fermentationsverfahren zur Herstellung von 2-Keto-L-Gulonsäure.
ZA917008B (en)	1992-04-29	An enzymatic process for the conversion of preproinsulins into insulins
AU556104B2 (en)	1986-10-23	Preparation of 2-exo-hydroxy-7-oxabicyclo(2,2,1)heptanes, and intermediated in their syntheses
EP0287123A3 (en)	1989-10-04	L-valine producing microorganism and a process for producing l-valine by fermentation
AU563288B2 (en)	1987-07-02	Preparing high-dextrose starch hydrolysates
EP0246605A3 (en)	1989-04-26	Conversion of aristeromycin into cyclaradine
TW237480B (ja)	1995-01-01
ATE52258T1 (de)	1990-05-15	Verfahren zur herstellung von 2-beta-dribofuranosylselenazol-4-carboxamid.
ES2038601T3 (es)	1993-08-01	Procedimiento para preparar 4-androsten-3,17-diona y 1,4-androstadien-3,17-diona.
JPS645487A (en)	1989-01-10	Novel microorganism
IE871708L (en)	1987-12-27	Transformation of yeast with a 2 -based recombinant¹plasmid.