ZA91410B - Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine - Google Patents

Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine

Info

Publication number
ZA91410B
ZA91410B ZA91410A ZA91410A ZA91410B ZA 91410 B ZA91410 B ZA 91410B ZA 91410 A ZA91410 A ZA 91410A ZA 91410 A ZA91410 A ZA 91410A ZA 91410 B ZA91410 B ZA 91410B
Authority
ZA
South Africa
Prior art keywords
synthesis
physostigmine
enantioselection
intermediates
preparation
Prior art date
Application number
ZA91410A
Other languages
English (en)
Inventor
Thomas B K Lee
B K Lee Thomas
George S K Wong
S K Wong George
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA91410B publication Critical patent/ZA91410B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA91410A 1990-01-22 1991-01-21 Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine ZA91410B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46988290A 1990-01-22 1990-01-22

Publications (1)

Publication Number Publication Date
ZA91410B true ZA91410B (en) 1991-10-30

Family

ID=23865415

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA91410A ZA91410B (en) 1990-01-22 1991-01-21 Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine

Country Status (23)

Country Link
EP (1) EP0438796B1 (xx)
JP (1) JPH0757747B2 (xx)
KR (1) KR0175933B1 (xx)
AT (1) ATE170173T1 (xx)
AU (1) AU631957B2 (xx)
CA (1) CA2034668A1 (xx)
CZ (1) CZ278815B6 (xx)
DE (1) DE69032595T2 (xx)
DK (1) DK0438796T3 (xx)
ES (1) ES2120407T3 (xx)
HK (1) HK1011993A1 (xx)
HR (1) HRP930321B1 (xx)
HU (2) HU9801313D0 (xx)
IE (1) IE910194A1 (xx)
IL (1) IL97002A (xx)
LT (1) LT3982B (xx)
NZ (1) NZ236837A (xx)
PH (1) PH30059A (xx)
PT (1) PT96534B (xx)
RU (1) RU2072354C1 (xx)
SG (1) SG52631A1 (xx)
YU (1) YU9891A (xx)
ZA (1) ZA91410B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2075102T3 (es) * 1989-09-19 1995-10-01 Hoechst Roussel Pharma Procedimiento para la resolucion quimica de (+/-)-1,3-dimetiloxiindoliletilaminas 5-alcoxi sustituidas.
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5840915A (en) * 1990-01-22 1998-11-24 Hoechst Marion Roussel, Inc. Process for the enatioselective synthesis of intermediates used
US5521320A (en) * 1990-01-22 1996-05-28 Hoechst-Roussel Pharmaceuticals Incorporated Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
US6596870B2 (en) * 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
US9126995B2 (en) * 2011-11-08 2015-09-08 Nissan Chemical Industries, Ltd. Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
JP6140266B2 (ja) 2012-03-14 2017-05-31 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 不斉相間移動触媒としてのビス四級シンコナアルカロイド塩

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578509A (en) 1983-04-01 1986-03-25 Merck & Co., Inc. Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
ES2075102T3 (es) * 1989-09-19 1995-10-01 Hoechst Roussel Pharma Procedimiento para la resolucion quimica de (+/-)-1,3-dimetiloxiindoliletilaminas 5-alcoxi sustituidas.
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
CN1071359C (zh) 1994-11-28 2001-09-19 美国3M公司 具有耐久的色彩和/或荧光性能的制品

Also Published As

Publication number Publication date
JPH0757747B2 (ja) 1995-06-21
LTIP1629A (en) 1995-07-25
IE910194A1 (en) 1991-07-31
IL97002A (en) 1994-10-21
DE69032595T2 (de) 1999-03-25
AU6949691A (en) 1991-07-25
ES2120407T3 (es) 1998-11-01
CA2034668A1 (en) 1991-07-23
KR910014349A (ko) 1991-08-31
EP0438796A2 (en) 1991-07-31
LT3982B (en) 1996-06-25
HU910210D0 (en) 1991-08-28
HRP930321B1 (en) 1999-02-28
HU9801313D0 (en) 1998-08-28
DE69032595D1 (de) 1998-10-01
SG52631A1 (en) 1998-09-28
HUT56539A (en) 1991-09-30
CZ278815B6 (en) 1994-07-13
EP0438796B1 (en) 1998-08-26
HK1011993A1 (en) 1999-07-23
YU9891A (sh) 1994-06-24
AU631957B2 (en) 1992-12-10
PH30059A (en) 1996-11-08
IL97002A0 (en) 1992-03-29
EP0438796A3 (en) 1992-03-18
HRP930321A2 (en) 1996-08-31
RU2072354C1 (ru) 1997-01-27
NZ236837A (en) 1993-03-26
PT96534B (pt) 1998-07-31
ATE170173T1 (de) 1998-09-15
JPH04342566A (ja) 1992-11-30
KR0175933B1 (ko) 1999-03-20
DK0438796T3 (da) 1999-05-25
PT96534A (pt) 1991-10-15
CS9100123A2 (en) 1991-09-15

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