ZA904524B - Dibenzo(1,5)dioxocin-5-one derivatives,their use in medicaments and processes for their preparation - Google Patents

Dibenzo(1,5)dioxocin-5-one derivatives,their use in medicaments and processes for their preparation

Info

Publication number
ZA904524B
ZA904524B ZA904524A ZA904524A ZA904524B ZA 904524 B ZA904524 B ZA 904524B ZA 904524 A ZA904524 A ZA 904524A ZA 904524 A ZA904524 A ZA 904524A ZA 904524 B ZA904524 B ZA 904524B
Authority
ZA
South Africa
Prior art keywords
medicaments
dioxocin
dibenzo
processes
preparation
Prior art date
Application number
ZA904524A
Other languages
English (en)
Inventor
Klaus Frobel
Jan-Bernd Lenfers
Peter Fey
Andreas Knorr
Johannes-Peter Stasch
Hartwig Mueller
Erwin Bischoff
Hans-Georg Dellweg
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA904524B publication Critical patent/ZA904524B/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D321/00Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/12Eight-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/08Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
    • C12R2001/80Penicillium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA904524A 1989-06-13 1990-06-12 Dibenzo(1,5)dioxocin-5-one derivatives,their use in medicaments and processes for their preparation ZA904524B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3919255A DE3919255A1 (de) 1989-06-13 1989-06-13 Dibenzo/1,5/dioxocin-5-one-derivate, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ZA904524B true ZA904524B (en) 1991-04-24

Family

ID=6382649

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA904524A ZA904524B (en) 1989-06-13 1990-06-12 Dibenzo(1,5)dioxocin-5-one derivatives,their use in medicaments and processes for their preparation

Country Status (20)

Country Link
US (1) US5089487A (pt)
EP (1) EP0411268B1 (pt)
JP (1) JPH0324073A (pt)
KR (1) KR910000698A (pt)
CN (1) CN1048041A (pt)
AT (1) ATE121396T1 (pt)
AU (1) AU632578B2 (pt)
CA (1) CA2018659A1 (pt)
DD (1) DD298423A5 (pt)
DE (2) DE3919255A1 (pt)
DK (1) DK0411268T3 (pt)
ES (1) ES2072332T3 (pt)
FI (1) FI902901A0 (pt)
HU (2) HUT54136A (pt)
IE (1) IE902114A1 (pt)
IL (1) IL94693A0 (pt)
NO (1) NO175745C (pt)
NZ (1) NZ233989A (pt)
PT (1) PT94338A (pt)
ZA (1) ZA904524B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4039860A1 (de) * 1990-12-13 1992-06-17 Bayer Ag Substituierte dibenz-oxa-thiocinone verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5198463A (en) * 1992-03-30 1993-03-30 Merck & Co., Inc. Oxytocin antagonists
JPH05280682A (ja) * 1992-04-01 1993-10-26 Kazuo Yano 屈曲自在なプラグイン・ワンタッチ接続型管継手装置
KR20010049586A (ko) * 1999-11-24 2001-06-15 윤종용 흡입마취용 식도내기관튜브
DE10250687A1 (de) * 2002-10-31 2004-05-13 Bayer Ag 7H-Dibenzo(b,g)(1,5)dioxocin-5-on-Derivate und ihre Verwendung
DE10250710A1 (de) * 2002-10-31 2004-05-19 Bayer Ag Neue Verwendung von Dioxocin-5-on-Derivaten
CN103044383B (zh) * 2011-10-17 2015-01-07 复旦大学 一种制备天然产物Penicillide消旋体的方法
CN103087040B (zh) * 2011-11-01 2015-10-28 复旦大学 Penicillide衍生物、其制备方法及其在药用用途
CN104370849A (zh) * 2014-11-13 2015-02-25 中科院广州化学有限公司 一种n-芳基二苯并氧氮杂环辛酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639612A (en) * 1969-05-16 1972-02-01 Lilly Co Eli Chalcogen containing heterocyclics as an in vitro anti-viral agent
US4751238A (en) * 1983-03-10 1988-06-14 Hoechst-Roussel Pharmaceuticals, Inc. Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins
FR2580280B1 (fr) * 1985-04-11 1987-05-22 Synthelabo Derives d'acide dibenzo(be)oxepinne-acetique, leur preparation et leur application en therapeutique
JPH0560831B1 (pt) * 1986-06-17 1993-09-03 Dainippon Pharmaceutical Co
US4940726A (en) * 1989-04-26 1990-07-10 Arizona Board Of Regents Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2
WO1991000009A1 (en) * 1989-06-29 1991-01-10 Fermenta Asc Corporation Novel glyoxylates and herbicidal and plant growth regulant activity of glyoxylates

Also Published As

Publication number Publication date
NO175745B (no) 1994-08-22
DE3919255A1 (de) 1990-12-20
PT94338A (pt) 1991-02-08
EP0411268B1 (de) 1995-04-19
DE59008921D1 (de) 1995-05-24
NO175745C (no) 1994-11-30
NO902400L (no) 1990-12-14
NO902400D0 (no) 1990-05-30
CN1048041A (zh) 1990-12-26
KR910000698A (ko) 1991-01-30
NZ233989A (en) 1993-03-26
HU903811D0 (en) 1990-11-28
ATE121396T1 (de) 1995-05-15
DD298423A5 (de) 1992-02-20
DK0411268T3 (da) 1995-08-14
EP0411268A3 (en) 1991-07-03
IE902114L (en) 1990-12-13
FI902901A0 (fi) 1990-06-11
US5089487A (en) 1992-02-18
AU5600890A (en) 1990-12-20
CA2018659A1 (en) 1990-12-13
JPH0324073A (ja) 1991-02-01
EP0411268A2 (de) 1991-02-06
AU632578B2 (en) 1993-01-07
HUT54136A (en) 1991-01-28
IE902114A1 (en) 1991-01-02
HU211554A9 (en) 1995-12-28
IL94693A0 (en) 1991-04-15
ES2072332T3 (es) 1995-07-16

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