ZA777684B - 7 e-(alkoxycarbonyl)-6e-alkyl/halo-17-hydroxy-3-oxo-17a-pregn-4-ene-21-carboxylic acid gamma-lactones and corresponding 21-carboxylic acids,their salts and esters - Google Patents

7 e-(alkoxycarbonyl)-6e-alkyl/halo-17-hydroxy-3-oxo-17a-pregn-4-ene-21-carboxylic acid gamma-lactones and corresponding 21-carboxylic acids,their salts and esters

Info

Publication number
ZA777684B
ZA777684B ZA00777684A ZA777684A ZA777684B ZA 777684 B ZA777684 B ZA 777684B ZA 00777684 A ZA00777684 A ZA 00777684A ZA 777684 A ZA777684 A ZA 777684A ZA 777684 B ZA777684 B ZA 777684B
Authority
ZA
South Africa
Prior art keywords
pregn
lactones
ene
alkoxycarbonyl
halo
Prior art date
Application number
ZA00777684A
Other languages
English (en)
Inventor
R Weier
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA777684B publication Critical patent/ZA777684B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
ZA00777684A 1976-12-27 1977-12-28 7 e-(alkoxycarbonyl)-6e-alkyl/halo-17-hydroxy-3-oxo-17a-pregn-4-ene-21-carboxylic acid gamma-lactones and corresponding 21-carboxylic acids,their salts and esters ZA777684B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (1)

Publication Number Publication Date
ZA777684B true ZA777684B (en) 1979-08-29

Family

ID=25033598

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00777684A ZA777684B (en) 1976-12-27 1977-12-28 7 e-(alkoxycarbonyl)-6e-alkyl/halo-17-hydroxy-3-oxo-17a-pregn-4-ene-21-carboxylic acid gamma-lactones and corresponding 21-carboxylic acids,their salts and esters

Country Status (19)

Country Link
US (1) US4069219A (xx)
JP (1) JPS5382767A (xx)
AU (1) AU518862B2 (xx)
BE (1) BE862365A (xx)
CA (1) CA1099702A (xx)
CH (6) CH637403A5 (xx)
DE (1) DE2758279A1 (xx)
DK (1) DK577377A (xx)
FI (1) FI773936A (xx)
FR (1) FR2375253A1 (xx)
GB (1) GB1575986A (xx)
IE (1) IE46128B1 (xx)
IL (1) IL53692A (xx)
NL (1) NL7714428A (xx)
NO (2) NO774464L (xx)
NZ (1) NZ186119A (xx)
PT (1) PT67455B (xx)
SE (1) SE7714764L (xx)
ZA (1) ZA777684B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト １７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK0973791T3 (da) 1995-12-11 2007-09-17 Searle Llc Fremgangsmåde til fremstilling af en epoxyforbindelse
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
JP2005523306A (ja) * 2002-03-22 2005-08-04 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー エプレレノンの製法
AU2003213807A1 (en) * 2002-11-06 2004-06-03 Pharmacia & Upjohn Company Llc Processes for preparing 7-carboxy substituted steroids
CA2500580A1 (en) * 2002-11-07 2004-05-27 Pharmacia & Upjohn Company Llc Processes for preparing c-7 substituted 5-androstenes
AU2006271885B8 (en) 2005-07-21 2012-03-08 Bayer Pharma Aktiengsellshaft Process for the production of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes
ES2311927T5 (es) 2005-07-21 2014-09-08 Bayer Pharma Aktiengesellschaft Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787940A (fr) * 1971-08-25 1973-02-26 Searle & Co Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
IE46128B1 (en) 1983-02-23
PT67455B (en) 1979-05-25
CH637405A5 (de) 1983-07-29
AU518862B2 (en) 1981-10-22
FI773936A (fi) 1978-06-28
NO774464L (no) 1978-06-28
IL53692A0 (en) 1978-03-10
FR2375253A1 (fr) 1978-07-21
IE46128L (en) 1978-06-27
FR2375253B1 (xx) 1981-04-30
US4069219A (en) 1978-01-17
DK577377A (da) 1978-06-28
CH638536A5 (de) 1983-09-30
DE2758279A1 (de) 1978-06-29
NZ186119A (en) 1979-08-31
CH635595A5 (de) 1983-04-15
PT67455A (en) 1978-01-01
NL7714428A (nl) 1978-06-29
SE7714764L (sv) 1978-06-28
JPS5382767A (en) 1978-07-21
AU3201277A (en) 1979-06-28
IL53692A (en) 1982-07-30
CH637408A5 (de) 1983-07-29
CH637403A5 (de) 1983-07-29
BE862365A (fr) 1978-06-27
CH637404A5 (de) 1983-07-29
GB1575986A (en) 1980-10-01
CA1099702A (en) 1981-04-21
NO820059L (no) 1978-06-28

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