IL53692A - 17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation - Google Patents

17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation

Info

Publication number: IL53692A
Authority: IL; Israel
Prior art keywords: pregn; ene; hydroxy; preparation; carboxylic acids
Prior art date: 1976-12-27

Application number

IL53692A

Other languages

English (en)

Other versions

IL53692A0 (en

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-12-27

Filing date

1977-12-26

Publication date

1982-07-30

1977-12-26 Application filed by Searle & Co filed Critical Searle & Co

1978-03-10 Publication of IL53692A0 publication Critical patent/IL53692A0/xx

1982-07-30 Publication of IL53692A publication Critical patent/IL53692A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

IL53692A 1976-12-27 1977-12-26 17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation IL53692A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/754,136 US4069219A (en)	1976-12-27	1976-12-27	7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (2)

Publication Number	Publication Date
IL53692A0 IL53692A0 (en)	1978-03-10
IL53692A true IL53692A (en)	1982-07-30

Family

ID=25033598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL53692A IL53692A (en)	1976-12-27	1977-12-26	17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation

Country Status (19)

Country	Link
US (1)	US4069219A (xx)
JP (1)	JPS5382767A (xx)
AU (1)	AU518862B2 (xx)
BE (1)	BE862365A (xx)
CA (1)	CA1099702A (xx)
CH (6)	CH637403A5 (xx)
DE (1)	DE2758279A1 (xx)
DK (1)	DK577377A (xx)
FI (1)	FI773936A (xx)
FR (1)	FR2375253A1 (xx)
GB (1)	GB1575986A (xx)
IE (1)	IE46128B1 (xx)
IL (1)	IL53692A (xx)
NL (1)	NL7714428A (xx)
NO (2)	NO774464L (xx)
NZ (1)	NZ186119A (xx)
PT (1)	PT67455B (xx)
SE (1)	SE7714764L (xx)
ZA (1)	ZA777684B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3111951A1 (de) *	1981-03-23	1982-09-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) *	1982-07-22	1984-02-03	シエ−リング・アクチエンゲゼルシヤフト	１７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) *	1983-08-17	1985-03-07	Schering AG, 1000 Berlin und 4709 Bergkamen	7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK0973791T3 (da)	1995-12-11	2007-09-17	Searle Llc	Fremgangsmåde til fremstilling af en epoxyforbindelse
US8389687B2 (en) *	2000-10-23	2013-03-05	Shanbrom Technologies, Llc	Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7297716B2 (en) *	2000-10-23	2007-11-20	Shanbrom Technologies, Llc	Enhanced production of blood components, blood cells and plasma without freezing
US7411006B2 (en) *	2000-10-23	2008-08-12	Shanbrom Technologies, Llc	Enhanced production of blood clotting factors and fibrin fabric
JP2005523306A (ja) *	2002-03-22	2005-08-04	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	エプレレノンの製法
AU2003213807A1 (en) *	2002-11-06	2004-06-03	Pharmacia & Upjohn Company Llc	Processes for preparing 7-carboxy substituted steroids
CA2500580A1 (en) *	2002-11-07	2004-05-27	Pharmacia & Upjohn Company Llc	Processes for preparing c-7 substituted 5-androstenes
AU2006271885B8 (en)	2005-07-21	2012-03-08	Bayer Pharma Aktiengsellshaft	Process for the production of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes
ES2311927T5 (es)	2005-07-21	2014-09-08	Bayer Pharma Aktiengesellschaft	Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE787940A (fr) *	1971-08-25	1973-02-26	Searle & Co	Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) *	1972-08-24	1974-09-25	Searle & Co	4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) *	1975-09-22	1976-08-03	G. D. Searle & Co.	6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

1976
- 1976-12-27 US US05/754,136 patent/US4069219A/en not_active Expired - Lifetime
1977
- 1977-12-22 NZ NZ186119A patent/NZ186119A/xx unknown
- 1977-12-23 AU AU32012/77A patent/AU518862B2/en not_active Expired
- 1977-12-23 DK DK577377A patent/DK577377A/da unknown
- 1977-12-23 CA CA293,844A patent/CA1099702A/en not_active Expired
- 1977-12-23 GB GB53717/77A patent/GB1575986A/en not_active Expired
- 1977-12-26 IL IL53692A patent/IL53692A/xx unknown
- 1977-12-26 FR FR7739218A patent/FR2375253A1/fr active Granted
- 1977-12-26 PT PT67455A patent/PT67455B/pt unknown
- 1977-12-27 NL NL7714428A patent/NL7714428A/xx not_active Application Discontinuation
- 1977-12-27 DE DE19772758279 patent/DE2758279A1/de not_active Withdrawn
- 1977-12-27 JP JP15852277A patent/JPS5382767A/ja active Pending
- 1977-12-27 SE SE7714764A patent/SE7714764L/xx unknown
- 1977-12-27 BE BE183884A patent/BE862365A/xx not_active IP Right Cessation
- 1977-12-27 CH CH1607777A patent/CH637403A5/de not_active IP Right Cessation
- 1977-12-27 NO NO774464A patent/NO774464L/no unknown
- 1977-12-27 FI FI773936A patent/FI773936A/fi not_active Application Discontinuation
- 1977-12-28 ZA ZA00777684A patent/ZA777684B/xx unknown
- 1977-12-29 IE IE2635/77A patent/IE46128B1/en unknown
1982
- 1982-01-11 NO NO820059A patent/NO820059L/no unknown
- 1982-05-18 CH CH310682A patent/CH637404A5/de not_active IP Right Cessation
- 1982-06-03 CH CH343682A patent/CH637408A5/de not_active IP Right Cessation
- 1982-06-03 CH CH343582A patent/CH635595A5/de not_active IP Right Cessation
- 1982-06-03 CH CH343482A patent/CH637405A5/de not_active IP Right Cessation
- 1982-11-15 CH CH665682A patent/CH638536A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE46128B1 (en)	1983-02-23
PT67455B (en)	1979-05-25
CH637405A5 (de)	1983-07-29
AU518862B2 (en)	1981-10-22
FI773936A (fi)	1978-06-28
ZA777684B (en)	1979-08-29
NO774464L (no)	1978-06-28
IL53692A0 (en)	1978-03-10
FR2375253A1 (fr)	1978-07-21
IE46128L (en)	1978-06-27
FR2375253B1 (xx)	1981-04-30
US4069219A (en)	1978-01-17
DK577377A (da)	1978-06-28
CH638536A5 (de)	1983-09-30
DE2758279A1 (de)	1978-06-29
NZ186119A (en)	1979-08-31
CH635595A5 (de)	1983-04-15
PT67455A (en)	1978-01-01
NL7714428A (nl)	1978-06-29
SE7714764L (sv)	1978-06-28
JPS5382767A (en)	1978-07-21
AU3201277A (en)	1979-06-28
CH637408A5 (de)	1983-07-29
CH637403A5 (de)	1983-07-29
BE862365A (fr)	1978-06-27
CH637404A5 (de)	1983-07-29
GB1575986A (en)	1980-10-01
CA1099702A (en)	1981-04-21
NO820059L (no)	1978-06-28

Publication	Publication Date	Title
ZA77564B (en)	1977-12-28	Carboxyalkylacylamino acids
HK57483A (en)	1983-11-25	Androstadiene-17-carboxylic acids and their esters
IL51705A (en)	1982-09-30	Acetohydroxamic acids and their preparation
JPS52105131A (en)	1977-09-03	Substituted phenylamidines and preparation thereof
IL60155A0 (en)	1980-07-31	Substituted phenoxybenzylalcohols and their preparation
IL53650A0 (en)	1978-03-10	Cyclopentan-1-amines and the preparation thereof
GB1542938A (en)	1979-03-28	Aminophosphonous acids and processes for their preparation
AU512557B2 (en)	1980-10-16	Azolyl-carboxylic acids
ZA773055B (en)	1979-01-31	12-azaprostanoic acids
JPS5291814A (en)	1977-08-02	Polyfluoroalkylthioalcohol and ester * their preparation and use
IL53692A (en)	1982-07-30	17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation
AU510758B2 (en)	1980-07-10	P-benzylaminobenzoic acids
AU514389B2 (en)	1981-02-05	Polyvinylbenzenesulphonic acids
GB2040287B (en)	1982-12-08	6-alkyl-1,2-dihydro-2-oxonicotinic acids and esters
ZA777629B (en)	1978-10-25	Sulphamoylbenzoic acids
IL52668A (en)	1981-03-31	7 -amino-1-oxa-1-dethiacephalosporins and their preparation
AU2266077A (en)	1978-08-31	15, 16-dioxy prostenoic acids and esters
IL52019A (en)	1980-09-16	5-phenylcarbamoyl-barbituric acids and their use as insecticides
ZA775350B (en)	1978-07-26	Substituted 5-amino-2-pyridinecarboxylic acids
JPS52100480A (en)	1977-08-23	Substituted ppaminophenyllasstriazinedione and its preparation
JPS5346977A (en)	1978-04-27	55secondary alkylidenehydantoin and its preparation
IL49823A (en)	1979-09-30	1-acyl-1,2,3,4-tetrahydro-6-quinolinols, their esters and preparation thereof
JPS5470222A (en)	1979-06-05	Nncarboxyalkaneephosphoric acids and manufacture
DE2862411D1 (en)	1984-06-28	3-thienylmalonic acids, the corresponding diesters and their preparation
JPS5346960A (en)	1978-04-27	Biss22furanizylether and its preparation