ZA7251B - Process for the production of triazolobenzodiazepines and intermediates - Google Patents

Process for the production of triazolobenzodiazepines and intermediates

Info

Publication number
ZA7251B
ZA7251B ZA720051A ZA7251A ZA7251B ZA 7251 B ZA7251 B ZA 7251B ZA 720051 A ZA720051 A ZA 720051A ZA 7251 A ZA7251 A ZA 7251A ZA 7251 B ZA7251 B ZA 7251B
Authority
ZA
South Africa
Prior art keywords
triazolobenzodiazepines
intermediates
production
Prior art date
Application number
ZA720051A
Other languages
English (en)
Inventor
J Hester
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA7251B publication Critical patent/ZA7251B/xx
Priority claimed from US00372313A external-priority patent/US3856792A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA720051A 1971-02-09 1972-01-04 Process for the production of triazolobenzodiazepines and intermediates ZA7251B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11404971A 1971-02-09 1971-02-09
US24075672A 1972-04-03 1972-04-03
US00372313A US3856792A (en) 1971-02-09 1973-06-21 2-{8 2-(substituted aminomethyl)-4h-1,2,4-triazol-4-yl{9 benzophenones

Publications (1)

Publication Number Publication Date
ZA7251B true ZA7251B (en) 1972-09-27

Family

ID=27381433

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA720051A ZA7251B (en) 1971-02-09 1972-01-04 Process for the production of triazolobenzodiazepines and intermediates

Country Status (14)

Country Link
US (1) US3709898A (da)
JP (1) JPS4966679A (da)
BE (1) BE779144A (da)
BR (1) BR7200590D0 (da)
CA (1) CA966123A (da)
CH (2) CH569736A5 (da)
DE (2) DE2265617C3 (da)
DK (1) DK513578A (da)
FR (1) FR2124559B1 (da)
GB (4) GB1374825A (da)
HK (1) HK2580A (da)
NL (1) NL151709B (da)
SE (1) SE414928B (da)
ZA (1) ZA7251B (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA995214A (en) * 1971-06-05 1976-08-17 Kanji Meguro Benzodiazepines
US3904641A (en) * 1971-06-18 1975-09-09 Yoshitomi Pharmaceutical Triazolothienodiazepine compounds
BE790838A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles 1-aminophenyl-6-phenyl-s-triazolo (4,3-a) (1,4)- benzodiazepines, leur procede de preparation et medicament les contenant
US3879413A (en) * 1973-02-14 1975-04-22 Upjohn Co Process for the production of 6-phenyl-4-H-s-triazolo {8 4,3-a{9 {8 1,4{9 benzodiazepines
US3842090A (en) * 1973-02-14 1974-10-15 Upjohn Co Certain 1-aminomethyl-6-phenyl 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
CA999000A (en) * 1973-02-14 1976-10-26 Jackson B. Hester (Jr.) Process for new benzodiazepines and intermediates
US4263310A (en) * 1974-03-02 1981-04-21 Boehringer Ingelheim Gmbh 8-Bromo-6-(o-chloro-phenyl)-4H-S-triazolo-[3,4,-c]-thieno-[2,3-e]-1,4-diazepines and salts thereof
GB1517164A (en) * 1974-08-20 1978-07-12 Roche Products Ltd Substituted-phenyl ketones and a process for the manufacture thereof
US4000151A (en) * 1974-09-11 1976-12-28 The Upjohn Company Triazolyl benzophenone compounds
US4000153A (en) * 1974-09-26 1976-12-28 The Upjohn Company Triazolobenzodiazepine intermediates
JPS6015633B2 (ja) * 1974-11-06 1985-04-20 パーク・デービス・アンド・コンパニー 新規なジアゼピン化合物の製法
CH601267A5 (da) * 1975-12-12 1978-06-30 Ciba Geigy Ag
US4105851A (en) * 1975-09-08 1978-08-08 Parke, Davis & Company 1,3,8-Trimethylimidazopyrazolodiazepine compounds
US4009175A (en) * 1976-03-15 1977-02-22 The Upjohn Company 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines
US4405518A (en) * 1981-07-23 1983-09-20 Hoffmann-La Roche Inc. Pyrrolo[3,4-d] [2] benzazepines
US4409390A (en) * 1981-07-23 1983-10-11 Hoffmann-La Roche Inc. Pyrrolo[3,4-D][2]Benzazepines
US4375473A (en) * 1982-01-04 1983-03-01 The Upjohn Company Method
US4501698A (en) * 1983-03-31 1985-02-26 The Upjohn Company Preparing 1-(hydroxymethyl)-triazolobenzodiazepines and 1-(aminomethyl)-triazolobenzodiazepines
EP2569434B1 (en) 2010-05-14 2019-09-04 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia and related disorders
AU2015201727B2 (en) * 2010-05-14 2018-03-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
HUE031073T2 (en) * 2010-05-14 2017-06-28 Dana Farber Cancer Inst Inc Thieno triazolo-diazepine compounds for the treatment of neoplasia
US9301962B2 (en) 2010-05-14 2016-04-05 Baylor College Of Medicine Male contraceptive compositions and methods of use
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2864336B1 (en) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
KR20160034379A (ko) 2013-07-25 2016-03-29 다나-파버 캔서 인스티튜트 인크. 전사 인자의 억제제 및 그의 용도
WO2015070020A2 (en) 2013-11-08 2015-05-14 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors
EP3099693A4 (en) 2014-01-31 2017-08-16 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
CA2936865A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
AU2015222805B2 (en) 2014-02-28 2020-05-21 Tensha Therapeutics, Inc. Treatment of conditions associated with hyperinsulinaemia
EP3157928B1 (en) 2014-06-20 2019-02-13 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
CA2955077A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Dihydropteridinone derivatives and uses thereof
CN106715437A (zh) 2014-08-08 2017-05-24 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
BR112017008714A2 (pt) 2014-10-27 2017-12-19 Tensha Therapeutics Inc inibidores de bromodomínio
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
WO2017044849A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
PE20181086A1 (es) 2015-09-11 2018-07-05 Dana Farber Cancer Inst Inc Acetamida tienotrizolodiazepinas y usos de las mismas
SG10201913450PA (en) 2015-11-25 2020-03-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3413346A (en) * 1966-01-19 1968-11-26 Hoffmann La Roche 2-(2-haloethylamino)-5-halo-benzophenones
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
DE1955349C2 (de) * 1969-11-04 1982-01-28 Takeda Chemical Industries, Ltd., Osaka s-Triazolo [4,3-a] [1,4] benzodiazepine
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives

Also Published As

Publication number Publication date
GB1374824A (en) 1974-11-20
DE2265617C3 (de) 1982-05-06
DE2203782C2 (de) 1982-05-13
FR2124559B1 (da) 1975-08-01
JPS4966679A (da) 1974-06-27
CH569736A5 (da) 1975-11-28
US3709898A (en) 1973-01-09
GB1374825A (en) 1974-11-20
FR2124559A1 (da) 1972-09-22
GB1374822A (en) 1974-11-20
NL7201692A (da) 1972-08-11
DE2203782A1 (de) 1972-08-24
HK2580A (en) 1980-01-25
BR7200590D0 (pt) 1973-07-17
AU3772572A (en) 1973-07-12
CA966123A (en) 1975-04-15
DK513578A (da) 1978-11-17
DE2265617B2 (de) 1981-07-16
NL151709B (nl) 1976-12-15
GB1374823A (en) 1974-11-20
SE414928B (sv) 1980-08-25
BE779144A (fr) 1972-08-09
CH570404A5 (da) 1975-12-15

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