GB1517164A - Substituted-phenyl ketones and a process for the manufacture thereof - Google Patents
Substituted-phenyl ketones and a process for the manufacture thereofInfo
- Publication number
- GB1517164A GB1517164A GB36567/74A GB3656774A GB1517164A GB 1517164 A GB1517164 A GB 1517164A GB 36567/74 A GB36567/74 A GB 36567/74A GB 3656774 A GB3656774 A GB 3656774A GB 1517164 A GB1517164 A GB 1517164A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- naturally occurring
- amino acid
- acyl group
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
Abstract
1517164 Dipeptides ROCHE PRODUCTS Ltd 11 Aug 1975 [20 Aug 1974 21 May 1975] 36567/74 and 21821/75 Heading C3H [Also in Division C2] The invention comprises compounds of the formula wherein R is halogen, NO2 or CF3; R<1> is H or C1-C6 alkyl; R<2> is an acyl group derived from a naturally occurring alpha-amino acid (all such groups which contain an asymmetric C atom having the L-configuration); R<3> is phenyl, halophenyl or pyridyl; and R<4> is H, CH3, cyclopropylmethyl, di - (C1-C4 alkyl) aminoethyl, CH3OCH2- or HOCH2CH2-, and acid addition salts thereof. They may be obtained by (1) cleaving off the protecting group(s) present in a group R<20> in a compound of the above formula wherein R<20> is substituted for R<2>, wherein R<20> is an acyl group derived from a naturally occurring amino acid in which the amino group(s) present is (are) in protected form and any other functional group which may be present is in protected form where required, by known methods; (2) resolving a racemate of Formula Ia into its optical isomers and isolating the L-isomer, or (3) when R is NO2 and R<2> is an acyl group derived from a naturally occurring amino acid which is not affected by nitrating agents, nitrating a compound of the formula wherein R<21> is an acyl group derived from a naturally occurring amino acid which is not affected by nitrating agents; and, if desired, converting a free base into an acid addition salt or converting an acid addition salt into a free base or into a different acid addition salt. The products have useful sedative, muscle relaxant and anti-convulsant activity. The starting materials used in method (1) above may be obtained by condensing a compound of the formula with an appropriately protected dipeptide or a reactive derivative thereof by various methods, e.g. by the mixed anhydride, azide, activated ester or acid chloride method.
Priority Applications (37)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB36567/74A GB1517164A (en) | 1974-08-20 | 1974-08-20 | Substituted-phenyl ketones and a process for the manufacture thereof |
GB28087/77A GB1517165A (en) | 1974-08-20 | 1975-05-21 | Substituted-phenyl ketones containing a protected dipeptide residue |
CH1053375A CH620900A5 (en) | 1974-08-20 | 1975-08-13 | Process for the preparation of substituted phenylketones |
ZA00755197A ZA755197B (en) | 1974-08-20 | 1975-08-13 | Phenyl ketones |
US05/605,580 US4007219A (en) | 1974-08-20 | 1975-08-18 | Benzophenone glycinamide derivatives |
IL47936A IL47936A (en) | 1974-08-20 | 1975-08-18 | Dipeptide- triazoly- and imidazolyl derivatives of benzophenone and pyridyl phenyl ketone their preparation and pharmaceutical compositions containing them |
PH17475A PH16616A (en) | 1974-08-20 | 1975-08-18 | Substituted phenyl ketones |
FR7525632A FR2282261A1 (en) | 1974-08-20 | 1975-08-19 | PHENYLIC KETONES |
AU84074/75A AU502104B2 (en) | 1974-08-20 | 1975-08-19 | Heterocyclic peptides |
ES440315A ES440315A1 (en) | 1974-08-20 | 1975-08-19 | Substituted-phenyl ketones and a process for the manufacture thereof |
JP50099885A JPS6018656B2 (en) | 1974-08-20 | 1975-08-19 | Method for producing substituted phenyl ketones |
BE159285A BE832532A (en) | 1974-08-20 | 1975-08-19 | PHENYLIC KETTES |
DD187930A DD123086A5 (en) | 1974-08-20 | 1975-08-19 | |
IE1826/75A IE42154B1 (en) | 1974-08-20 | 1975-08-19 | Substituted-phenyl ketones and a process for the manufacture thereof |
AT642175A AT348985B (en) | 1974-08-20 | 1975-08-19 | PROCESS FOR PRODUCING NEW SUBSTITUTED PHENYLKETONE |
NO752876A NO150199C (en) | 1974-08-20 | 1975-08-19 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PHENYLKETONS |
SE7509268A SE426319B (en) | 1974-08-20 | 1975-08-19 | PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PHENYLKETONS WITH SEDATIVE, MUSCLE RELAXING AND ANTI-CONVULSIVE EFFECTS |
AR260048A AR217041A1 (en) | 1974-08-20 | 1975-08-19 | PROCEDURE FOR THE PREPARATION OF AMINO ACID DERIVATIVES N- (4-HALO-O NITRO-2-BENZOIL-O-MONOHALOBENZOIL OR PICOLINOIL) GLYCINAMIDES AND THE CORRESPONDENTS 2- (3-AMINOMETIL-4H-1,2,4-TRIAZOL-4 -IL) AND 2- (5-AMINOMETIL-1-IMIDAZOLIL) |
LU73219A LU73219A1 (en) | 1974-08-20 | 1975-08-19 | |
CA000233720A CA1177069A (en) | 1974-08-20 | 1975-08-19 | Phenyl ketones |
IE2209/78A IE42155B1 (en) | 1974-08-20 | 1975-08-19 | A substituted-phenyl ketone containing a dipeptide residueand a process for the manufacture thereof |
DK373975A DK149284C (en) | 1974-08-20 | 1975-08-19 | METHOD OF ANALOGY FOR THE PREPARATION OF L-LYSYLGYLINE-N- (2-BENZOYL-4-CHLORPHENYL) -N-METHYLAMIDE OR ACID ADDITION SALTS THEREOF AND USES FOR USE AS EXCEPTIONS USED AS EXCEPTIONS |
IE2210/78A IE42156B1 (en) | 1974-08-20 | 1975-08-19 | Substituted-phenyl ketones containing a protected dipetideresidue |
NL7509884A NL7509884A (en) | 1974-08-20 | 1975-08-20 | METHOD FOR PREPARING PHENYL KETONES. |
DE19752537069 DE2537069A1 (en) | 1974-08-20 | 1975-08-20 | PHENYLKETONE |
FI752350A FI66592C (en) | 1974-08-20 | 1975-08-20 | FOYLKETONER FOYLKETONER FRAMSTAELLNING AV TERAPEUTISKT ANVAENDBARA SUSTITUERADE |
FR7622695A FR2315914A1 (en) | 1974-08-20 | 1976-07-26 | Phenyl ketone derivs. substd. by amino acid residues |
US05/741,001 US4105852A (en) | 1974-08-20 | 1976-11-11 | Substituted phenyl ketones |
US05/741,084 US4046751A (en) | 1974-08-20 | 1976-11-11 | Substituted phenyl ketones |
US05/740,894 US4044017A (en) | 1974-08-20 | 1976-11-11 | Substituted phenyl ketones |
US05/740,917 US4071525A (en) | 1974-08-20 | 1976-11-11 | Substituted phenyl ketones |
US05/740,701 US4069229A (en) | 1974-08-20 | 1976-11-11 | Substituted phenyl ketones |
AT706177A AT345282B (en) | 1974-08-20 | 1977-10-04 | PROCESS FOR PRODUCING NEW DIAZOL OR TRIAZOLE-SUBSTITUTED PHENYLKETONE |
US05/929,383 USRE30473E (en) | 1974-07-20 | 1978-07-31 | Benzophenone glycinamide derivatives |
SE7902522A SE438153B (en) | 1974-08-20 | 1979-03-20 | PROCEDURE FOR PREPARING L-LYSYL-N- (2-BENZOYL-4-CHLORPHENYL) -N-METHYL GYCINAMIDE WITH SEDATIVE, MUSCLE RELAXING AND ANTI-CONVULSIVE EFFECTS |
SE7902521A SE438152B (en) | 1974-08-20 | 1979-03-20 | PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PHENYLKETONS WITH SEDATIVE, MUSCLE RELAXING AND ANTI-CONVULSIVE EFFECTS |
JP58024922A JPS58150549A (en) | 1974-08-20 | 1983-02-18 | Manufacture of substituted phenylketone |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB36567/74A GB1517164A (en) | 1974-08-20 | 1974-08-20 | Substituted-phenyl ketones and a process for the manufacture thereof |
GB2182175 | 1975-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1517164A true GB1517164A (en) | 1978-07-12 |
Family
ID=26255542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB36567/74A Expired GB1517164A (en) | 1974-07-20 | 1974-08-20 | Substituted-phenyl ketones and a process for the manufacture thereof |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS6018656B2 (en) |
AR (1) | AR217041A1 (en) |
AT (1) | AT348985B (en) |
AU (1) | AU502104B2 (en) |
CA (1) | CA1177069A (en) |
CH (1) | CH620900A5 (en) |
DD (1) | DD123086A5 (en) |
DE (1) | DE2537069A1 (en) |
DK (1) | DK149284C (en) |
ES (1) | ES440315A1 (en) |
FI (1) | FI66592C (en) |
FR (1) | FR2282261A1 (en) |
GB (1) | GB1517164A (en) |
IL (1) | IL47936A (en) |
LU (1) | LU73219A1 (en) |
NL (1) | NL7509884A (en) |
NO (1) | NO150199C (en) |
PH (1) | PH16616A (en) |
SE (1) | SE426319B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5484586A (en) * | 1977-12-05 | 1979-07-05 | Kali Chemie Pharma Gmbh | 1*44benzodiazepin derivatives*their manufacture and medical drug active to center control*antispasm*muscle relaxation*anxiety mollification and tranquilization |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN184976B (en) * | 1996-06-13 | 2000-10-14 | Ranbaxy Lab Ltd |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3709898A (en) * | 1971-02-09 | 1973-01-09 | Upjohn Co | Process for the production of triazolobenzodiazepines and intermediates |
JPS526861B2 (en) * | 1972-05-27 | 1977-02-25 | ||
ZA735932B (en) * | 1972-09-21 | 1974-07-31 | Hoffmann La Roche | Benzodiazepine derivatives |
-
1974
- 1974-08-20 GB GB36567/74A patent/GB1517164A/en not_active Expired
-
1975
- 1975-08-13 CH CH1053375A patent/CH620900A5/en not_active IP Right Cessation
- 1975-08-18 PH PH17475A patent/PH16616A/en unknown
- 1975-08-18 IL IL47936A patent/IL47936A/en unknown
- 1975-08-19 SE SE7509268A patent/SE426319B/en not_active IP Right Cessation
- 1975-08-19 AR AR260048A patent/AR217041A1/en active
- 1975-08-19 AU AU84074/75A patent/AU502104B2/en not_active Expired
- 1975-08-19 JP JP50099885A patent/JPS6018656B2/en not_active Expired
- 1975-08-19 LU LU73219A patent/LU73219A1/xx unknown
- 1975-08-19 DK DK373975A patent/DK149284C/en active
- 1975-08-19 ES ES440315A patent/ES440315A1/en not_active Expired
- 1975-08-19 NO NO752876A patent/NO150199C/en unknown
- 1975-08-19 DD DD187930A patent/DD123086A5/xx unknown
- 1975-08-19 AT AT642175A patent/AT348985B/en not_active IP Right Cessation
- 1975-08-19 CA CA000233720A patent/CA1177069A/en not_active Expired
- 1975-08-19 FR FR7525632A patent/FR2282261A1/en active Granted
- 1975-08-20 DE DE19752537069 patent/DE2537069A1/en active Granted
- 1975-08-20 FI FI752350A patent/FI66592C/en not_active IP Right Cessation
- 1975-08-20 NL NL7509884A patent/NL7509884A/en not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5484586A (en) * | 1977-12-05 | 1979-07-05 | Kali Chemie Pharma Gmbh | 1*44benzodiazepin derivatives*their manufacture and medical drug active to center control*antispasm*muscle relaxation*anxiety mollification and tranquilization |
EP0024272A1 (en) * | 1977-12-05 | 1981-03-04 | Kali-Chemie Pharma GmbH | 1,4-Benzodiazepines and their salts, process for their preparation and pharmaceutical compositions containing them |
JPS6310698B2 (en) * | 1977-12-05 | 1988-03-08 | Kali Chemie Pharma Gmbh |
Also Published As
Publication number | Publication date |
---|---|
NO150199C (en) | 1984-09-05 |
CH620900A5 (en) | 1980-12-31 |
AR217041A1 (en) | 1980-02-29 |
NL7509884A (en) | 1976-02-24 |
DE2537069C2 (en) | 1988-09-08 |
DK149284B (en) | 1986-04-21 |
ATA642175A (en) | 1978-08-15 |
FI752350A (en) | 1976-02-21 |
FI66592B (en) | 1984-07-31 |
PH16616A (en) | 1983-11-28 |
FR2282261A1 (en) | 1976-03-19 |
LU73219A1 (en) | 1977-04-15 |
NO752876L (en) | 1976-02-23 |
DD123086A5 (en) | 1976-11-20 |
NO150199B (en) | 1984-05-28 |
DK149284C (en) | 1986-10-13 |
AT348985B (en) | 1979-03-12 |
SE7509268L (en) | 1976-02-23 |
JPS6018656B2 (en) | 1985-05-11 |
AU8407475A (en) | 1977-02-24 |
ES440315A1 (en) | 1977-09-16 |
DK373975A (en) | 1976-02-21 |
DE2537069A1 (en) | 1976-03-04 |
AU502104B2 (en) | 1979-07-12 |
IL47936A (en) | 1980-01-31 |
CA1177069A (en) | 1984-10-30 |
SE426319B (en) | 1982-12-27 |
FI66592C (en) | 1984-11-12 |
JPS51125048A (en) | 1976-11-01 |
IL47936A0 (en) | 1975-11-25 |
FR2282261B1 (en) | 1978-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE127801T1 (en) | PYRAZOLOPYRIDINE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF. | |
ATE20469T1 (en) | CARBOXYALKYL DIPEPTIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM. | |
DK0659174T3 (en) | Derivatives of valproic acid and 2-valproic acid amides as well as their use as anticonvulsants | |
SE9203825D0 (en) | DUAL INHIBITORS OF NO SYNTHASE AND CYCLOOXYGENASE, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL COMPOSITIONS CONTAINING THEM | |
MY101359A (en) | 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation | |
ES2197160T3 (en) | BICYCLING FIBRONOGEN ANTAGONISTS. | |
DK623586D0 (en) | PIPERIDE INGREDIENTS OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS | |
ES2137998T3 (en) | NEW AMINO ACID DERIVATIVES, PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINED IN THESE COMPOUNDS. | |
KR900009598A (en) | Compound having vascular smooth muscle relaxation and preparation method thereof | |
ES8306160A1 (en) | New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds. | |
HUP9903459A2 (en) | Oxa- and tiabicyclo[3.1.0]hexane-carboxylic acids,compositions of the same | |
HUP9900040A2 (en) | Tetrahydroquinolines as nmda antagonists, process for producing them and pharmaceutical compositions containing them | |
ATE48001T1 (en) | CEPHEM COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS. | |
IE812888L (en) | Phenylalkylamines. | |
ATE19773T1 (en) | NITROALIPHATIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE. | |
ES8300774A1 (en) | New cephem compounds and processes for preparation thereof. | |
GB1517164A (en) | Substituted-phenyl ketones and a process for the manufacture thereof | |
BG88028A (en) | AMIDES OF CYCLOMETHYLENE-1,2-DICARBOXYLIC ACIDS WITH THERAPEUTIC ACTIVITY, METHODS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
ES8700241A1 (en) | 1-Phenyl-imidazole-5-carboxylic acid derivatives, process for their preparation and their use as growth regulators. | |
KR910007912A (en) | Novel derivatives of pyridones, methods for their preparation, novel intermediates, their use as medicaments and compositions containing them | |
HUT49613A (en) | Process for producing new 8-aza-1,4-dioxaspiro/4,5/decan-2-ylmethyl ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids and pharmaceutical compositions comprising same | |
ATE15375T1 (en) | ANTHRACYCLINE GLYCOSIDES, INTERMEDIATE PRODUCTS, PROCESSES FOR BOTH MANUFACTURE AND PHARMACEUTICALS. | |
GB1517165A (en) | Substituted-phenyl ketones containing a protected dipeptide residue | |
HUP0004177A2 (en) | 4,5-diaryloxazole derivatives, pharmaceutical compositions containing them and process for producing them | |
KR930017874A (en) | Derivatives of saturated nitrogen heterocycles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |