ZA200807382B - Novel Dual Action Receptors Antagonists (DARA) at the ati and eta receptors - Google Patents

Novel Dual Action Receptors Antagonists (DARA) at the ati and eta receptors

Info

Publication number
ZA200807382B
ZA200807382B ZA200807382A ZA200807382A ZA200807382B ZA 200807382 B ZA200807382 B ZA 200807382B ZA 200807382 A ZA200807382 A ZA 200807382A ZA 200807382 A ZA200807382 A ZA 200807382A ZA 200807382 B ZA200807382 B ZA 200807382B
Authority
ZA
South Africa
Prior art keywords
receptors
dara
ati
dual action
novel dual
Prior art date
Application number
ZA200807382A
Other languages
English (en)
Inventor
Gupta Ramesh Chandra
Jagtap Vikrant Vijaykumar
Mandhare Appaji Baburao
Perkins Tim
Westerlund Christer
Original Assignee
Torrent Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrent Pharmaceuticals Ltd filed Critical Torrent Pharmaceuticals Ltd
Publication of ZA200807382B publication Critical patent/ZA200807382B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
ZA200807382A 2006-03-03 2008-08-27 Novel Dual Action Receptors Antagonists (DARA) at the ati and eta receptors ZA200807382B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77885506P 2006-03-03 2006-03-03

Publications (1)

Publication Number Publication Date
ZA200807382B true ZA200807382B (en) 2009-04-29

Family

ID=38459328

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200807382A ZA200807382B (en) 2006-03-03 2008-08-27 Novel Dual Action Receptors Antagonists (DARA) at the ati and eta receptors

Country Status (14)

Country Link
US (1) US20100010035A1 (xx)
EP (1) EP1996588A4 (xx)
JP (1) JP2009529005A (xx)
KR (1) KR20080104052A (xx)
CN (1) CN101437818A (xx)
AR (1) AR059883A1 (xx)
AU (1) AU2007221495B2 (xx)
BR (1) BRPI0708507A2 (xx)
CA (1) CA2644578A1 (xx)
MX (1) MX2008011227A (xx)
RU (1) RU2425833C2 (xx)
TW (1) TW200800975A (xx)
WO (1) WO2007100295A1 (xx)
ZA (1) ZA200807382B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0907650A2 (pt) 2008-01-25 2015-07-21 Torrent Pharmaceuticals Ltd Composições farmacêuticas compreendendo degradadores de produtos finais de glicosilação avançada (ages) e drogas adjuvantes como drogas anti-hipertensivas, antidiabéticas e etc
WO2009096198A1 (ja) * 2008-02-01 2009-08-06 Pharma Ip Limited Liability Intermediary Corporations 新規ビアリール誘導体
WO2010055474A2 (en) * 2008-11-13 2010-05-20 Ariel-University Research And Development Company Ltd. Antimicrobial compounds and compositions
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
CN101891735B (zh) * 2009-11-25 2012-07-18 北京理工大学 联苯磺胺异噁唑类化合物、合成方法及用途
FR2957079B1 (fr) * 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
GB201008134D0 (en) * 2010-05-14 2010-06-30 Medical Res Council Technology Compounds
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
LT3280447T (lt) 2015-04-08 2019-05-27 Torrent Pharmaceuticals Limited Farmacinės kompozicijos
SG11201708140RA (en) 2015-04-08 2017-11-29 Torrent Pharmaceuticals Ltd Novel pyridinium compounds
CN105218388B (zh) * 2015-10-26 2017-07-11 西北农林科技大学 β‑羰基烯胺类化合物及作为制备植物病原菌抗菌剂的应用
US10858342B2 (en) 2016-06-28 2020-12-08 Boehringer Ingelheim International Gmbh Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases
WO2019068613A1 (en) 2017-10-02 2019-04-11 Boehringer Ingelheim International Gmbh NOVEL [1,6] NAPHTHYRIDINE COMPOUNDS AND DERIVATIVES AS CDK8 / CDK19 INHIBITORS
US11958818B2 (en) 2019-05-01 2024-04-16 Boehringer Ingelheim International Gmbh (R)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate
WO2022266370A1 (en) 2021-06-17 2022-12-22 Aria Pharmaceuticals, Inc. Sparsentan for treating idiopathic pulmonary fibrosis
KR20240051999A (ko) * 2021-08-26 2024-04-22 상하이 한서 바이오메디컬 컴퍼니 리미티드 방향족 고리 함유 생물학적 길항제, 이의 제조 방법 및 용도
WO2023085415A1 (ja) * 2021-11-15 2023-05-19 株式会社アークメディスン 化合物、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物
CN116675684B (zh) * 2023-08-02 2023-11-07 上海翰森生物医药科技有限公司 含炔基稠环类衍生物拮抗剂、其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) * 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5411980A (en) * 1989-07-28 1995-05-02 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
UA58494C2 (uk) * 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) * 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
HU227183B1 (en) * 1997-04-28 2010-09-28 Encysive Pharmaceuticals Inc Sulfonamide derivatives and pharmaceutical compositions containing them for the treatment of endothelin-mediated disorders
AU767456B2 (en) * 1998-07-06 2003-11-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
US6638937B2 (en) * 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AU2092601A (en) * 1999-12-15 2001-06-25 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

Also Published As

Publication number Publication date
RU2008139321A (ru) 2010-04-10
RU2425833C2 (ru) 2011-08-10
WO2007100295A1 (en) 2007-09-07
CA2644578A1 (en) 2007-09-07
KR20080104052A (ko) 2008-11-28
AU2007221495A1 (en) 2007-09-07
MX2008011227A (es) 2009-02-10
AR059883A1 (es) 2008-05-07
JP2009529005A (ja) 2009-08-13
EP1996588A1 (en) 2008-12-03
AU2007221495B2 (en) 2011-09-15
CN101437818A (zh) 2009-05-20
US20100010035A1 (en) 2010-01-14
EP1996588A4 (en) 2011-10-05
BRPI0708507A2 (pt) 2011-05-31
TW200800975A (en) 2008-01-01

Similar Documents

Publication Publication Date Title
ZA200807382B (en) Novel Dual Action Receptors Antagonists (DARA) at the ati and eta receptors
ZA200803811B (en) Neuropolin antagonists
IL225521A0 (en) 1trpv antagonists and their uses
IL192309A0 (en) Phenoxypiperidines and analogs thereof useful as histamine h3 antagonists
GB0819947D0 (en) Kinase antagonists
HK1143994A1 (en) Glucagon antagonists
IL192426A0 (en) Prokineticin 2 receptor antagonists
IL192424A0 (en) Prokineticin 1 receptor antagonists
ZA200906812B (en) Crig antagonists
HK1131140A1 (en) Substituted prolinamides, and the use thereof
EP1959959A4 (en) MORPHOLIN-CARBOXAMIDE PROKINETICIN RECEPTOR ANTAGONISTS
EP2054434A4 (en) ANTAGONISTS AGAINST MYOSTATIN
PL1984466T3 (pl) Reaktywne cząstki powlekane
IL199430A0 (en) Crth2 antagonists
IL204928A0 (en) Cgrp antagonists
IL192693A0 (en) Urotensin ii receptor antagonists
GB2436840B (en) Railings
HK1137353A1 (en) Urotensin ii receptor antagonists ii
GB2443193B (en) Railing
GB201000798D0 (en) Poly-TLR antagonists
EP2097446A4 (en) RESISTANT ANTAGONISTS AND ITS USE
HK1146065A1 (en) Nlrr-1 antagonists and uses thereof nlrr-1
IL198618A0 (en) Novel amides acting on the adenosine receptors
ZA200906996B (en) TRPV1 Antagonists and uses thereof
GB0611768D0 (en) Corcost new set 1