ZA200802690B - Thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors - Google Patents
Thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitorsInfo
- Publication number
- ZA200802690B ZA200802690B ZA200802690A ZA200802690A ZA200802690B ZA 200802690 B ZA200802690 B ZA 200802690B ZA 200802690 A ZA200802690 A ZA 200802690A ZA 200802690 A ZA200802690 A ZA 200802690A ZA 200802690 B ZA200802690 B ZA 200802690B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbonitriles
- thieno
- pyridine
- protein kinase
- kinase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72082105P | 2005-09-27 | 2005-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200802690B true ZA200802690B (en) | 2009-08-26 |
Family
ID=37603099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200802690A ZA200802690B (en) | 2005-09-27 | 2008-03-26 | Thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
Country Status (16)
Country | Link |
---|---|
US (1) | US20070082880A1 (xx) |
EP (1) | EP1937690A1 (xx) |
JP (1) | JP2009511439A (xx) |
KR (1) | KR20080059184A (xx) |
CN (1) | CN101273047A (xx) |
AR (1) | AR056200A1 (xx) |
AU (1) | AU2006294726A1 (xx) |
BR (1) | BRPI0616758A2 (xx) |
CA (1) | CA2623228A1 (xx) |
GT (1) | GT200600434A (xx) |
NO (1) | NO20081133L (xx) |
PE (1) | PE20070619A1 (xx) |
RU (1) | RU2008108619A (xx) |
TW (1) | TW200745137A (xx) |
WO (1) | WO2007038519A1 (xx) |
ZA (1) | ZA200802690B (xx) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7276519B2 (en) * | 2002-11-25 | 2007-10-02 | Wyeth | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
TW200821318A (en) * | 2006-09-26 | 2008-05-16 | Wyeth Corp | Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles |
US20090118276A1 (en) * | 2007-11-02 | 2009-05-07 | Wyeth | Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors |
JP5799024B2 (ja) * | 2009-12-18 | 2015-10-21 | グラクソスミスクライン、インテレクチュアル、プロパティー、リミテッドGlaxosmithkline Intellectual Property Limited | 新規化合物 |
EP2611812A1 (en) * | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | Thienopyridine and thienopyrimidine compounds and methods of use thereof |
KR20130056345A (ko) | 2010-09-17 | 2013-05-29 | 퍼듀 퍼머 엘피 | 피리딘 화합물 및 그의 용도 |
WO2012136120A1 (zh) * | 2011-04-02 | 2012-10-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 芳基丙烯酰胺化合物及其用于制备免疫抑制剂的用途 |
ES2647850T3 (es) * | 2012-04-16 | 2017-12-26 | Board Of Regents Of The University Of Texas System | Composiciones y métodos de modulación de la actividad de 15-PGDH |
US9801863B2 (en) | 2012-04-16 | 2017-10-31 | Case Western Reserve University | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis |
CA2927730A1 (en) | 2013-10-15 | 2015-05-07 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
MX2018010693A (es) * | 2016-03-11 | 2019-03-28 | Ac Immune Sa | Compuestos biciclicos para diagnostico y terapia. |
WO2018102552A1 (en) | 2016-11-30 | 2018-06-07 | Case Western Reserve University | Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof |
JP2020514323A (ja) | 2017-02-06 | 2020-05-21 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 |
CN113874015A (zh) | 2018-12-21 | 2021-12-31 | 细胞基因公司 | Ripk2的噻吩并吡啶抑制剂 |
CN114957280A (zh) * | 2021-12-31 | 2022-08-30 | 成都赜灵生物医药科技有限公司 | 噻吩[2,3-d]嘧啶衍生物及其用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA782648B (en) * | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
JP2001522853A (ja) * | 1997-11-11 | 2001-11-20 | ファイザー・プロダクツ・インク | 抗癌剤として有用なチエノピリミジンおよびチエノピリジン誘導体 |
US5948911A (en) * | 1998-11-20 | 1999-09-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives |
GB9906566D0 (en) * | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
ES2292461T3 (es) * | 1999-07-07 | 2008-03-16 | Astrazeneca Uk Limited | Derivados de quinazolina. |
AU2001235804A1 (en) * | 2000-03-06 | 2001-09-17 | Astrazeneca Ab | Therapy |
MXPA02012034A (es) * | 2000-06-06 | 2003-04-25 | Pfizer Prod Inc | Derivados de tiofeno utiles como agentes anticancerosos. |
US20020004511A1 (en) * | 2000-06-28 | 2002-01-10 | Luzzio Michael Joseph | Thiophene derivatives useful as anticancer agents |
AU2002345792A1 (en) * | 2001-06-21 | 2003-01-08 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
CN100386329C (zh) * | 2002-06-06 | 2008-05-07 | 贝林格尔.英格海姆药物公司 | 取代的3-氨基-噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法和用途 |
CL2003002287A1 (es) * | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
US7276519B2 (en) * | 2002-11-25 | 2007-10-02 | Wyeth | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
US7674907B2 (en) * | 2004-07-23 | 2010-03-09 | Amgen Inc. | Furanopyridine derivatives and methods of use |
EP1789055A4 (en) * | 2004-09-15 | 2009-11-11 | Janssen Pharmaceutica Nv | INHIBITORS OF THIAZOLOPYRIDINE KINASE |
US8093264B2 (en) * | 2005-05-20 | 2012-01-10 | Methylgene Inc. | Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling |
-
2006
- 2006-09-25 PE PE2006001155A patent/PE20070619A1/es not_active Application Discontinuation
- 2006-09-25 AR ARP060104166A patent/AR056200A1/es unknown
- 2006-09-26 TW TW095135537A patent/TW200745137A/zh unknown
- 2006-09-27 GT GT200600434A patent/GT200600434A/es unknown
- 2006-09-27 US US11/527,996 patent/US20070082880A1/en not_active Abandoned
- 2006-09-27 JP JP2008533522A patent/JP2009511439A/ja not_active Withdrawn
- 2006-09-27 CA CA002623228A patent/CA2623228A1/en not_active Abandoned
- 2006-09-27 CN CNA2006800357351A patent/CN101273047A/zh active Pending
- 2006-09-27 KR KR1020087008455A patent/KR20080059184A/ko not_active Application Discontinuation
- 2006-09-27 AU AU2006294726A patent/AU2006294726A1/en not_active Abandoned
- 2006-09-27 EP EP06804164A patent/EP1937690A1/en not_active Withdrawn
- 2006-09-27 WO PCT/US2006/037502 patent/WO2007038519A1/en active Application Filing
- 2006-09-27 RU RU2008108619/04A patent/RU2008108619A/ru not_active Application Discontinuation
- 2006-09-27 BR BRPI0616758-6A patent/BRPI0616758A2/pt not_active IP Right Cessation
-
2008
- 2008-03-04 NO NO20081133A patent/NO20081133L/no not_active Application Discontinuation
- 2008-03-26 ZA ZA200802690A patent/ZA200802690B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20070082880A1 (en) | 2007-04-12 |
PE20070619A1 (es) | 2007-07-02 |
JP2009511439A (ja) | 2009-03-19 |
CN101273047A (zh) | 2008-09-24 |
EP1937690A1 (en) | 2008-07-02 |
NO20081133L (no) | 2008-04-25 |
TW200745137A (en) | 2007-12-16 |
BRPI0616758A2 (pt) | 2011-06-28 |
WO2007038519A1 (en) | 2007-04-05 |
KR20080059184A (ko) | 2008-06-26 |
AU2006294726A1 (en) | 2007-04-05 |
CA2623228A1 (en) | 2007-04-05 |
AR056200A1 (es) | 2007-09-26 |
RU2008108619A (ru) | 2009-11-10 |
GT200600434A (es) | 2007-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200802690B (en) | Thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors | |
HK1115879A1 (en) | Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors | |
HRP20180578T1 (hr) | Pirolo[2,3-b]piridin-4-il-amini i pirolo[2m3-b]pirimidin-4-il-amini kao inhibitori janus kinaze | |
ZA201202026B (en) | PYROLO[2,3-b] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | |
SI1966202T1 (sl) | S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze | |
ZA201002318B (en) | Pyrrolo [2,3-d]pyrimidin derivatives as protein kinase b inhibitors | |
ZA201003050B (en) | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or pyridin-2-yle derivatives as protein kinase c-theta | |
IL190598A0 (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
IL173380A0 (en) | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors | |
IL173381A0 (en) | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors | |
IL189667A0 (en) | 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives | |
AP2006003701A0 (en) | 1H-thieno [2,3-c] pyrazole derivatives useful as kinase inhibitors | |
IL187689A0 (en) | Thienopyrimidine and thienopyridine derivatives as flt-3 kinase inhibitors | |
IL189181A0 (en) | Novel 4-amino-thieno[3,2-c]pyridine-7- | |
ZA200709919B (en) | Pyrrol (2,3-B) pyridine derivatives protein kinase inhibitors | |
IL178688A0 (en) | THIENO [3,2-b] PYRIDINE-6-CARBONITRILES AS PROTEIN KINASE INHIBITORS | |
ZA200800273B (en) | Thienopyrimidine and thienopyridine derivatives as FLT3 kinase inhibitors |