ZA200801991B - Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds - Google Patents

Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds

Info

Publication number
ZA200801991B
ZA200801991B ZA200801991A ZA200801991A ZA200801991B ZA 200801991 B ZA200801991 B ZA 200801991B ZA 200801991 A ZA200801991 A ZA 200801991A ZA 200801991 A ZA200801991 A ZA 200801991A ZA 200801991 B ZA200801991 B ZA 200801991B
Authority
ZA
South Africa
Prior art keywords
compounds
preparation
pharmaceutical compositions
compositions containing
camptothecin analogues
Prior art date
Application number
ZA200801991A
Other languages
English (en)
Inventor
Lavielle Gilbert
Hautefaye Patrick
Pierre Alain
Hickman John
Leonce Stephane
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ZA200801991B publication Critical patent/ZA200801991B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
ZA200801991A 2005-08-05 2006-08-04 Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds ZA200801991B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0508364A FR2889527A1 (fr) 2005-08-05 2005-08-05 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA200801991B true ZA200801991B (en) 2009-08-26

Family

ID=36216903

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200801991A ZA200801991B (en) 2005-08-05 2006-08-04 Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds

Country Status (19)

Country Link
US (1) US20100168149A1 (fr)
EP (1) EP1910377A2 (fr)
JP (1) JP2009503039A (fr)
KR (1) KR20080032007A (fr)
CN (1) CN101238133A (fr)
AR (1) AR056189A1 (fr)
AU (1) AU2006277863A1 (fr)
BR (1) BRPI0614608A2 (fr)
CA (1) CA2617957C (fr)
EA (1) EA014689B1 (fr)
FR (1) FR2889527A1 (fr)
GE (1) GEP20115243B (fr)
MA (1) MA29653B1 (fr)
MX (1) MX2008001560A (fr)
MY (1) MY150497A (fr)
NO (1) NO20081169L (fr)
UA (1) UA95253C2 (fr)
WO (1) WO2007017585A2 (fr)
ZA (1) ZA200801991B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2014127214A1 (fr) 2013-02-15 2014-08-21 Kala Pharmaceuticals, Inc. Composés thérapeutiques et utilisations de ceux-ci
AU2014219024B2 (en) 2013-02-20 2018-04-05 KALA BIO, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN106188079A (zh) * 2016-07-09 2016-12-07 兰州大学 喜树碱7‑位哌嗪硫脲类化合物、制备方法和用途
CA3036336A1 (fr) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Formes cristallines de composes therapeutiques et leurs utilisations
US10392399B2 (en) 2016-09-08 2019-08-27 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
BR112019004463A2 (pt) 2016-09-08 2019-05-28 Kala Pharmaceuticals Inc formas cristalinas de compostos terapêuticos, seus processos de obtenção e seus métodos de uso
CN110357897A (zh) * 2019-07-26 2019-10-22 上海健康医学院 一种具有抗肿瘤活性的喜树碱衍生物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111107A (en) * 1997-11-20 2000-08-29 Enzon, Inc. High yield method for stereoselective acylation of tertiary alcohols
US6699876B2 (en) * 1999-11-18 2004-03-02 Les Laboratoires Servier Camptothecin analogue compounds
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
AU2003243380A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
CN100443486C (zh) * 2002-09-11 2008-12-17 中国医学科学院药物研究所 7-酯化和7,20-双酯化的喜树碱衍生物及其制法和其药物组合物与用途
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
MY150497A (en) 2014-01-30
EP1910377A2 (fr) 2008-04-16
JP2009503039A (ja) 2009-01-29
AU2006277863A1 (en) 2007-02-15
AR056189A1 (es) 2007-09-26
FR2889527A1 (fr) 2007-02-09
BRPI0614608A2 (pt) 2016-11-16
EA200800393A1 (ru) 2008-08-29
CA2617957C (fr) 2011-09-20
KR20080032007A (ko) 2008-04-11
CN101238133A (zh) 2008-08-06
EA014689B1 (ru) 2010-12-30
MX2008001560A (es) 2008-02-15
GEP20115243B (en) 2011-06-27
WO2007017585A2 (fr) 2007-02-15
UA95253C2 (ru) 2011-07-25
NO20081169L (no) 2008-03-05
CA2617957A1 (fr) 2007-02-15
WO2007017585A3 (fr) 2007-04-12
MA29653B1 (fr) 2008-07-01
US20100168149A1 (en) 2010-07-01

Similar Documents

Publication Publication Date Title
ZA200801991B (en) Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds
GB0403247D0 (en) A pharmaceutical composition
PL1720544T3 (pl) Nowe pochodne azabicykliczne, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne
IL193772A0 (en) 4-oxoquinoline derivatives,methods for the preparation thereof and pharmaceutical compositions containing the same
PL1729739T3 (pl) Sposób wytwarzania stałej kompozycji farmaceutycznej
IL187713A0 (en) 3-aminocarbazole compounds, pharmaceutical composition containing the same and method for the preparation thereof
AP2008004589A0 (en) q,2,4,5- tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them
IL184562A (en) Polymorph ivandront a, a process for its preparation and pharmaceutical preparations containing it
HK1096386A1 (en) Indanyl-piperazine compounds, a process for their preparation and pharmaceutical compositions containing them
HUP0401522A2 (en) New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
IL186862A0 (en) Novel phenyl-pyridinyl-piperazine derivatives, a method for the production thereof and pharmaceutical compositions containing said derivatives
SG121999A1 (en) New benzothiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them
HK1126190A1 (en) Novel pyridinylaminoalkylene- and pyridinyloxyalkylene-cyclopropanamines, process for the preparation thereof and pharmaceutical compositions containing them
HK1096097A1 (en) Phenylpyridylpiperazine compounds, a process for their preparation and pharmaceutical compositions containing them
GB0400452D0 (en) A pharmaceutical composition
HK1079778A1 (en) New fluorinated benzothiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them
HK1123048A1 (en) Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds
ZA200800833B (en) New 1H-indole-pyridinecarboxamide and 1H-indolepiperidinecarboxamide compounds, a process for their preparation and pharmaceutical compositions containing them
ZA200805656B (en) Prodrug ER²-selective substances, methods for the production thereof and pharmaceutical compositions containing said compounds
ZA200606276B (en) Polysubstituted 1,1-pyridylaminocyclopropanamine compounds, a process for their preparation and pharmaceutical compositions containing them
ZA200606277B (en) Polysubstituted 1,1-pyridyloxycyclopropanamine compounds, a process for their preparation and pharmaceutical compositions containing them
ZA200407444B (en) Benzoindoline Compounds, a process for their preparation and pharmaceutical compositions contained them.
ZA200705079B (en) Novel pharmaceutical composition useful for vaccines
SG122000A1 (en) New benzothiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them
GB0409133D0 (en) Methods for preparing pharmaceutical compositions