ZA200700012B - Compositions for topical treatment - Google Patents
Compositions for topical treatment Download PDFInfo
- Publication number
- ZA200700012B ZA200700012B ZA200700012A ZA200700012A ZA200700012B ZA 200700012 B ZA200700012 B ZA 200700012B ZA 200700012 A ZA200700012 A ZA 200700012A ZA 200700012 A ZA200700012 A ZA 200700012A ZA 200700012 B ZA200700012 B ZA 200700012B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- enzyme based
- psoriasis
- treatment
- topical application
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 67
- 238000011282 treatment Methods 0.000 title claims description 18
- 230000000699 topical effect Effects 0.000 title claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 27
- 102000004190 Enzymes Human genes 0.000 claims description 27
- 229940088598 enzyme Drugs 0.000 claims description 27
- 210000003491 skin Anatomy 0.000 claims description 26
- 230000000844 anti-bacterial effect Effects 0.000 claims description 21
- 201000004681 Psoriasis Diseases 0.000 claims description 18
- 201000004624 Dermatitis Diseases 0.000 claims description 16
- 208000010668 atopic eczema Diseases 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 15
- 239000006071 cream Substances 0.000 claims description 15
- 150000007513 acids Chemical class 0.000 claims description 13
- 239000000839 emulsion Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
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- 238000000034 method Methods 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 9
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 239000003974 emollient agent Substances 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
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- 108010015776 Glucose oxidase Proteins 0.000 claims description 4
- 239000004366 Glucose oxidase Substances 0.000 claims description 4
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- 102000045576 Lactoperoxidases Human genes 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
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- 210000002510 keratinocyte Anatomy 0.000 claims description 4
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- 241000252203 Clupea harengus Species 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 3
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- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 claims description 3
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- 150000002632 lipids Chemical class 0.000 claims description 2
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- 238000004519 manufacturing process Methods 0.000 claims 3
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- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
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- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 14
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- 230000000694 effects Effects 0.000 description 3
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- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
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- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
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- FMMOOAYVCKXGMF-MURFETPASA-N ethyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC FMMOOAYVCKXGMF-MURFETPASA-N 0.000 description 1
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- 230000007062 hydrolysis Effects 0.000 description 1
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- ZCZCOXLLICTZAH-UHFFFAOYSA-N hypothiocyanous acid Chemical compound OSC#N ZCZCOXLLICTZAH-UHFFFAOYSA-N 0.000 description 1
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- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 1
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- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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GBGB0413954.9A GB0413954D0 (en) | 2004-06-22 | 2004-06-22 | Compositions for topical treatment |
Publications (1)
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ZA200700012B true ZA200700012B (en) | 2008-04-30 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200700012A ZA200700012B (en) | 2004-06-22 | 2007-01-02 | Compositions for topical treatment |
Country Status (15)
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---|---|
US (1) | US20070253943A1 (ko) |
EP (1) | EP1776128B1 (ko) |
JP (1) | JP2008503558A (ko) |
KR (1) | KR20070040369A (ko) |
CN (1) | CN1972708A (ko) |
AU (1) | AU2005256908A1 (ko) |
BR (1) | BRPI0511355A (ko) |
CA (1) | CA2571444A1 (ko) |
EA (1) | EA011723B1 (ko) |
GB (5) | GB0413954D0 (ko) |
IL (1) | IL180091A0 (ko) |
IN (1) | IN2006DE07403A (ko) |
MX (1) | MXPA06014787A (ko) |
WO (1) | WO2006000867A1 (ko) |
ZA (1) | ZA200700012B (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITVR20080125A1 (it) * | 2008-11-13 | 2010-05-14 | Phytonature Sas Di Masini Dr Antoni O E C | Nuova forma di preparazione ed utilizzo della boswellia serrata |
WO2010106417A2 (en) * | 2009-03-16 | 2010-09-23 | Himalaya Global Holdings Ltd. | Herbal personal care formulations and method of preparing the same |
CN101721340B (zh) * | 2009-10-23 | 2012-02-15 | 无限极(中国)有限公司 | 一种用于延缓肌肤衰老的化妆品组合物 |
US20130004477A1 (en) * | 2009-10-26 | 2013-01-03 | Zhe Lu | Methods for Treating Inflammation and Oxidative Stress Related Diseases |
PL2366408T3 (pl) * | 2010-03-01 | 2013-01-31 | Salvat Lab Sa | Klarowne roztwory wodne acetonidu fluocinolonu do leczenia zapalenia uszu |
EP2444081B1 (en) * | 2010-10-19 | 2015-04-08 | Parenteral, A.S. | A composition for the treatment of inflammatory diseases comprising boswellic acids and cannabidiol |
WO2012177825A1 (en) | 2011-06-21 | 2012-12-27 | Bvw Holding Ag | Medical device comprising boswellic acid |
ITUA20162425A1 (it) * | 2016-04-08 | 2017-10-08 | Medivis S R L | Composizione oftalmica che comprende PVP-I |
US9975917B1 (en) | 2017-09-20 | 2018-05-22 | King Saud University | Pentacyclic triterpenoidal derivatives |
GB2584647A (en) * | 2019-06-06 | 2020-12-16 | Boston Healthcare Ltd | Skin treatment composition |
BE1028576B1 (fr) * | 2021-12-30 | 2023-08-17 | Dyna S A R L | Composition comprenant au moins un acide boswellique et/ou au moins un extrait végétal comprenant au moins un acide boswellique pour utilisation topique dans le traitement des maladies inflammatoires de la peau |
WO2023187598A1 (en) * | 2022-03-27 | 2023-10-05 | Biblical Lands Ltd | Compositions and methods |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9002422D0 (en) | 1990-02-03 | 1990-04-04 | Boots Co Plc | Anti-microbial compositions |
GB9127062D0 (en) * | 1991-12-20 | 1992-02-19 | Unilever Plc | Lip treatment composition |
FR2685202B1 (fr) * | 1991-12-24 | 1995-03-24 | Sederma Sa | Nouvelle methode de traitement pharmaceutique et cosmetique pour la regulation de la seborrhee, de l'acne et de la flore cutanee. |
DE4201903B4 (de) | 1992-01-24 | 2004-04-15 | Hermann P.T. Prof. Dr.Med. Ammon | Pharmazeutische Verwendung von Boswelliasäuren |
JP3746081B2 (ja) | 1994-02-24 | 2006-02-15 | 森永乳業株式会社 | 動物皮膚病治療剤 |
JP3888707B2 (ja) * | 1996-01-22 | 2007-03-07 | 森永乳業株式会社 | 血管新生病治療剤 |
NO301635B1 (no) * | 1996-07-29 | 1997-11-24 | Bjoern Gunnar Risa | Oppspolingsanordning, særlig for oppspoling av lastestropper |
US5972355A (en) * | 1997-09-30 | 1999-10-26 | E-L Management Corp. | Stable compositions containing biologically active components |
EP1121021A1 (en) | 1998-10-15 | 2001-08-08 | Dsm N.V. | Antimicrobial enzymes in animal feed |
GB9906914D0 (en) * | 1999-03-26 | 1999-05-19 | Quest Int | Compositions containing boswellia extracts |
EP1173162A1 (en) * | 1999-04-30 | 2002-01-23 | Sabinsa Corporation | Compositions of boswellic acids derived from boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions |
US6214339B1 (en) * | 2000-01-12 | 2001-04-10 | Michael A. Pellico | Di-enzymatic treatment of outer ear infection in dogs and cats |
WO2001074327A1 (en) * | 2000-04-04 | 2001-10-11 | Color Access, Inc. | Composition for improving skin lipid barrier function |
GB0100643D0 (en) * | 2001-01-10 | 2001-02-21 | Basf Ag | Liquid antimicrobial compositions |
WO2002085921A2 (de) * | 2001-03-01 | 2002-10-31 | Johann Jauch | Einfaches verfahren zur synthese von boswelliasäuren und derivaten davon |
NL1018421C1 (nl) * | 2001-06-29 | 2003-01-07 | Sara Lee De Nv | Mondverzorgingsmiddel. |
JP2003089629A (ja) * | 2001-09-18 | 2003-03-28 | Kakunai Juyotai Kenkyusho:Kk | 新規化粧品、新規外用剤及び新規浴剤の製造方法 |
US20030211995A1 (en) | 2001-12-21 | 2003-11-13 | Kokai-Kun John Fitzgerald | Methods and formulations for eradicating or alleviating staphylococcal nasal colonization using lysostaphin |
US20040082504A1 (en) * | 2002-05-10 | 2004-04-29 | Atul Varadhachary | Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
US20040214750A1 (en) * | 2003-04-28 | 2004-10-28 | Georgiades Izolda M. | Medicaments for healing skin conditions in humans |
US20070264222A1 (en) * | 2006-05-10 | 2007-11-15 | Biohealth Advance, Llc | Enhanced protection against skin injury in humans |
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2004
- 2004-06-22 GB GBGB0413954.9A patent/GB0413954D0/en not_active Ceased
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2005
- 2005-06-16 WO PCT/IB2005/001692 patent/WO2006000867A1/en active Application Filing
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- 2005-06-16 AU AU2005256908A patent/AU2005256908A1/en not_active Abandoned
- 2005-06-16 EA EA200700044A patent/EA011723B1/ru not_active IP Right Cessation
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- 2005-06-16 KR KR1020077000578A patent/KR20070040369A/ko not_active Application Discontinuation
- 2005-06-16 US US11/570,806 patent/US20070253943A1/en not_active Abandoned
- 2005-06-16 MX MXPA06014787A patent/MXPA06014787A/es not_active Application Discontinuation
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- 2005-06-16 BR BRPI0511355-5A patent/BRPI0511355A/pt not_active IP Right Cessation
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2006
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2007
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2008
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Also Published As
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GB2430884A (en) | 2007-04-11 |
KR20070040369A (ko) | 2007-04-16 |
GB2451597B (en) | 2009-03-25 |
WO2006000867B1 (en) | 2006-05-18 |
GB0413954D0 (en) | 2004-07-28 |
IN2006DE07403A (ko) | 2007-08-31 |
GB0820552D0 (en) | 2008-12-17 |
AU2005256908A1 (en) | 2006-01-05 |
CN1972708A (zh) | 2007-05-30 |
US20070253943A1 (en) | 2007-11-01 |
BRPI0511355A (pt) | 2007-12-04 |
CA2571444A1 (en) | 2006-01-05 |
WO2006000867A1 (en) | 2006-01-05 |
EP1776128A1 (en) | 2007-04-25 |
EP1776128B1 (en) | 2018-02-14 |
GB0625339D0 (en) | 2007-02-07 |
MXPA06014787A (es) | 2007-03-12 |
GB0800351D0 (en) | 2008-02-20 |
GB2445674B (en) | 2009-02-18 |
GB2445674A (en) | 2008-07-16 |
JP2008503558A (ja) | 2008-02-07 |
EA011723B1 (ru) | 2009-04-28 |
IL180091A0 (en) | 2007-07-04 |
GB0817929D0 (en) | 2008-11-05 |
GB2451597A (en) | 2009-02-04 |
EA200700044A1 (ru) | 2007-08-31 |
GB2430884B (en) | 2008-03-19 |
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