ZA200600422B - Indol-5 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators - Google Patents

Indol-5 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators Download PDF

Info

Publication number: ZA200600422B
Authority: ZA; South Africa
Prior art keywords: optionally; mono; compound according; substituted; prophylaxis
Prior art date: 2003-07-30

Application number

ZA200600422A

Other languages

English (en)

Inventor

Merce Vidal Ramon

Codony Soler Xavier

Dordal Zueras Alberto

Original Assignee

Esteve Labor Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-30

Filing date

2004-07-29

Publication date

2007-03-28

2004-07-29 Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr

2007-03-28 Publication of ZA200600422B publication Critical patent/ZA200600422B/en

Links

238000002360 preparation method Methods 0.000 title description 34
VIRVXABSFUGFPJ-UHFFFAOYSA-N 1h-indole-5-sulfonamide Chemical class NS(=O)(=O)C1=CC=C2NC=CC2=C1 VIRVXABSFUGFPJ-UHFFFAOYSA-N 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims description 148
-1 sulfonamide compound Chemical class 0.000 claims description 141
229910052739 hydrogen Inorganic materials 0.000 claims description 112
239000001257 hydrogen Substances 0.000 claims description 112
238000011282 treatment Methods 0.000 claims description 109
238000011321 prophylaxis Methods 0.000 claims description 106
239000003814 drug Substances 0.000 claims description 88
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 82
150000003254 radicals Chemical class 0.000 claims description 76
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 70
229940124530 sulfonamide Drugs 0.000 claims description 66
208000035475 disorder Diseases 0.000 claims description 64
125000005842 heteroatom Chemical group 0.000 claims description 63
238000004519 manufacturing process Methods 0.000 claims description 61
238000000034 method Methods 0.000 claims description 58
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125000000217 alkyl group Chemical group 0.000 claims description 50
150000003839 salts Chemical class 0.000 claims description 40
125000002950 monocyclic group Chemical group 0.000 claims description 39
150000003456 sulfonamides Chemical class 0.000 claims description 38
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
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ZCBIFHNDZBSCEP-UHFFFAOYSA-N 1H-indol-5-amine Chemical compound NC1=CC=C2NC=CC2=C1 ZCBIFHNDZBSCEP-UHFFFAOYSA-N 0.000 claims description 2
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150000008050 dialkyl sulfates Chemical class 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
MXYXPBVGIKNZEZ-UHFFFAOYSA-N n-[1-[2-(diethylamino)ethyl]indol-5-yl]naphthalene-2-sulfonamide Chemical compound C1=CC=CC2=CC(S(=O)(=O)NC=3C=C4C=CN(C4=CC=3)CCN(CC)CC)=CC=C21 MXYXPBVGIKNZEZ-UHFFFAOYSA-N 0.000 claims description 2
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UZMQSZBTFGHLAH-UHFFFAOYSA-N 1-benzothiophene-2-sulfonamide Chemical compound C1=CC=C2SC(S(=O)(=O)N)=CC2=C1 UZMQSZBTFGHLAH-UHFFFAOYSA-N 0.000 claims 1
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XAJKDSPZNRKHSD-UHFFFAOYSA-N 3,5-dichloro-n-[1-(3-piperidin-1-ylpropyl)indol-5-yl]benzenesulfonamide Chemical compound ClC1=CC(Cl)=CC(S(=O)(=O)NC=2C=C3C=CN(CCCN4CCCCC4)C3=CC=2)=C1 XAJKDSPZNRKHSD-UHFFFAOYSA-N 0.000 claims 1
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239000003981 vehicle Substances 0.000 description 1
CZPRKINNVBONSF-UHFFFAOYSA-M zinc;dioxido(oxo)phosphanium Chemical compound [Zn+2].[O-][P+]([O-])=O CZPRKINNVBONSF-UHFFFAOYSA-M 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Ceramic Engineering (AREA)
Manufacturing & Machinery (AREA)
Psychiatry (AREA)
Hematology (AREA)
Materials Engineering (AREA)
Inorganic Chemistry (AREA)
Structural Engineering (AREA)
Endocrinology (AREA)
Obesity (AREA)
Psychology (AREA)
Epidemiology (AREA)
Nutrition Science (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA200600422A 2003-07-30 2004-07-29 Indol-5 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators ZA200600422B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES200301805A ES2222827B1 (es)	2003-07-30	2003-07-30	Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.

Publications (1)

Publication Number	Publication Date
ZA200600422B true ZA200600422B (en)	2007-03-28

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ID=34130539

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200600422A ZA200600422B (en)	2003-07-30	2004-07-29	Indol-5 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators

Country Status (22)

Country	Link
US (1)	US20070032520A1 (es)
EP (1)	EP1648445B1 (es)
JP (1)	JP2007500165A (es)
KR (1)	KR20060066710A (es)
CN (1)	CN100558355C (es)
AR (1)	AR045156A1 (es)
AT (1)	ATE432699T1 (es)
AU (1)	AU2004262485A1 (es)
BR (1)	BRPI0413110A (es)
CA (1)	CA2533976A1 (es)
DE (1)	DE602004021384D1 (es)
EC (1)	ECSP066325A (es)
ES (2)	ES2222827B1 (es)
IL (1)	IL172891A0 (es)
MX (1)	MXPA06001159A (es)
NO (1)	NO20060865L (es)
PE (1)	PE20050725A1 (es)
PT (1)	PT1648445E (es)
RU (1)	RU2006105779A (es)
TW (1)	TW200504014A (es)
WO (1)	WO2005013977A1 (es)
ZA (1)	ZA200600422B (es)

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US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
ES2246721B1 (es) *	2004-08-10	2007-03-16	Laboratorios Del Dr. Esteve, S.A.	Compuestos indolicos sustituidos, su preparacion y su uso como medicamentos.
EP1632491A1 (en) *	2004-08-30	2006-03-08	Laboratorios Del Dr. Esteve, S.A.	Substituted indole compounds and their use as 5-HT6 receptor modulators
EP1856075A1 (en)	2005-01-25	2007-11-21	Epix Delaware, Inc.	Substituted arylamine compounds and their use as 5-ht6 modulators
EP1953153A1 (en) *	2007-01-31	2008-08-06	Laboratorios del Dr. Esteve S.A.	Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
DE102007007751A1 (de) *	2007-02-16	2008-08-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007012284A1 (de)	2007-03-16	2008-09-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
EP2018861A1 (en) *	2007-07-26	2009-01-28	Laboratorios del Dr. Esteve S.A.	5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain
DE102007035333A1 (de)	2007-07-27	2009-01-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007035334A1 (de) *	2007-07-27	2009-01-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
ATE495737T1 (de)	2007-08-01	2011-02-15	Esteve Labor Dr	Kombination von mindestens zwei 5-ht6-liganden
DE102007042154A1 (de)	2007-09-05	2009-03-12	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
EP2053052A1 (en)	2007-10-23	2009-04-29	Laboratorios del Dr. Esteve S.A.	Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide
IN2012DN00471A (es)	2009-06-29	2015-06-05	Agios Pharmaceuticals Inc
KR101593099B1 (ko) *	2009-10-27	2016-02-11	엘지디스플레이 주식회사	액정표시장치용 어레이 기판 및 그 제조방법
US20190336585A1 (en) *	2018-05-03	2019-11-07	John Lawrence Mee	Method for sustainable human cognitive enhancement
US20190390193A1 (en) *	2018-06-23	2019-12-26	John Lawrence Mee	Reversible method for sustainable human cognitive enhancement

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FR2665444B1 (fr) *	1990-08-06	1992-11-27	Sanofi Sa	Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
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2003
- 2003-07-30 ES ES200301805A patent/ES2222827B1/es not_active Expired - Fee Related
2004
- 2004-07-29 PT PT04763610T patent/PT1648445E/pt unknown
- 2004-07-29 WO PCT/EP2004/008511 patent/WO2005013977A1/en active Application Filing
- 2004-07-29 TW TW093122669A patent/TW200504014A/zh unknown
- 2004-07-29 RU RU2006105779/04A patent/RU2006105779A/ru unknown
- 2004-07-29 AR ARP040102698A patent/AR045156A1/es unknown
- 2004-07-29 BR BRPI0413110-0A patent/BRPI0413110A/pt not_active Application Discontinuation
- 2004-07-29 AT AT04763610T patent/ATE432699T1/de not_active IP Right Cessation
- 2004-07-29 JP JP2006521529A patent/JP2007500165A/ja active Pending
- 2004-07-29 ES ES04763610T patent/ES2327847T3/es active Active
- 2004-07-29 ZA ZA200600422A patent/ZA200600422B/en unknown
- 2004-07-29 KR KR1020067001392A patent/KR20060066710A/ko not_active Application Discontinuation
- 2004-07-29 AU AU2004262485A patent/AU2004262485A1/en not_active Abandoned
- 2004-07-29 US US10/566,094 patent/US20070032520A1/en not_active Abandoned
- 2004-07-29 CA CA002533976A patent/CA2533976A1/en not_active Abandoned
- 2004-07-29 DE DE602004021384T patent/DE602004021384D1/de active Active
- 2004-07-29 MX MXPA06001159A patent/MXPA06001159A/es active IP Right Grant
- 2004-07-29 EP EP04763610A patent/EP1648445B1/en active Active
- 2004-07-29 CN CNB2004800224721A patent/CN100558355C/zh not_active Expired - Fee Related
- 2004-08-02 PE PE2004000736A patent/PE20050725A1/es not_active Application Discontinuation
2005
- 2005-12-29 IL IL172891A patent/IL172891A0/en unknown
2006
- 2006-01-26 EC EC2006006325A patent/ECSP066325A/es unknown
- 2006-02-22 NO NO20060865A patent/NO20060865L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2222827B1 (es)	2006-03-01
EP1648445B1 (en)	2009-06-03
IL172891A0 (en)	2006-06-11
BRPI0413110A (pt)	2006-10-03
TW200504014A (en)	2005-02-01
ATE432699T1 (de)	2009-06-15
PT1648445E (pt)	2009-09-03
AU2004262485A1 (en)	2005-02-17
CA2533976A1 (en)	2005-02-17
DE602004021384D1 (de)	2009-07-16
ES2222827A1 (es)	2005-02-01
MXPA06001159A (es)	2006-04-24
KR20060066710A (ko)	2006-06-16
JP2007500165A (ja)	2007-01-11
NO20060865L (no)	2006-02-22
US20070032520A1 (en)	2007-02-08
RU2006105779A (ru)	2007-09-20
PE20050725A1 (es)	2005-11-16
AR045156A1 (es)	2005-10-19
CN100558355C (zh)	2009-11-11
EP1648445A1 (en)	2006-04-26
ECSP066325A (es)	2006-08-30
WO2005013977A1 (en)	2005-02-17
ES2327847T3 (es)	2009-11-04
CN1832740A (zh)	2006-09-13

Publication	Publication Date	Title
ZA200600422B (en)	2007-03-28	Indol-5 sulfonamide derivatives, their preparation and their use as 5-HT-6 modulators
US20070213326A1 (en)	2007-09-13	Substituted indole compounds and their use as 5-ht6 receptor modulators
EP1660077B1 (en)	2009-06-03	Indol-6 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators
WO2005013974A1 (en)	2005-02-17	1-sulfonylindole derivatives, their preparation and their use as 5-ht6 ligands
US8097643B2 (en)	2012-01-17	Indol-4 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators
EP1648444B1 (en)	2009-06-03	Indol-7 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators
MXPA05012052A (es)	2006-10-17	Uso de derivados de sulfonamida para la fabricacion de un medicamento para la profilaxis y/o tratamiento de transtornos de la ingesta de alimentos