ZA200504043B - N-arylsulfony; 3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them - Google Patents

N-arylsulfony; 3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them Download PDF

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Publication number
ZA200504043B
ZA200504043B ZA200504043A ZA200504043A ZA200504043B ZA 200504043 B ZA200504043 B ZA 200504043B ZA 200504043 A ZA200504043 A ZA 200504043A ZA 200504043 A ZA200504043 A ZA 200504043A ZA 200504043 B ZA200504043 B ZA 200504043B
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indole
methylpiperazin
yimethyl
bromo
indol
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ZA200504043A
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English (en)
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Venkata S N Ramakrishna
Vikas S Shirsath
Rama S Kambhampati
Venkata S V V Rao
Venkateswarlu Jasti
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Suven Life Sciences Ltd
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Publication of ZA200504043B publication Critical patent/ZA200504043B/en

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    • C07D209/04Indoles; Hydrogenated indoles
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
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    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200504043A 2002-11-28 2005-05-19 N-arylsulfony; 3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them ZA200504043B (en)

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IN884MA2002 2002-11-28

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US (1) US7875605B2 (xx)
EP (1) EP1581492B1 (xx)
JP (1) JP4559230B2 (xx)
KR (1) KR100818508B1 (xx)
CN (2) CN1720225B (xx)
AT (1) ATE401307T1 (xx)
AU (1) AU2003237599B2 (xx)
BR (2) BRPI0318799B8 (xx)
CA (1) CA2509982C (xx)
CY (1) CY1108786T1 (xx)
DE (1) DE60322266D1 (xx)
DK (1) DK1581492T3 (xx)
EA (1) EA011320B1 (xx)
ES (1) ES2310243T3 (xx)
HK (2) HK1083217A1 (xx)
MX (1) MXPA05005701A (xx)
NO (2) NO330341B1 (xx)
NZ (2) NZ540840A (xx)
PT (1) PT1581492E (xx)
SI (1) SI1581492T1 (xx)
WO (1) WO2004048330A1 (xx)
ZA (1) ZA200504043B (xx)

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CN101258144B (zh) 2005-08-12 2012-05-30 苏文生命科学有限公司 作为功能性5-ht6配体的氨基芳基磺酰胺衍生物
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MX2012007783A (es) 2010-01-05 2012-10-03 Suven Life Sciences Ltd Compuestos sulfona que actuan como ligandos del receptor 5-ht6.
CN102093149A (zh) * 2010-12-08 2011-06-15 天津理工大学 一种促进氰基快速水解制备羧酸类化合物的方法
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CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
KR101534136B1 (ko) * 2013-06-11 2015-07-07 이화여자대학교 산학협력단 인돌 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 5-ht6 수용체 관련 질환의 예방 또는 치료용 약학적 조성물
CA2929309C (en) * 2013-12-02 2018-07-03 Suven Life Sciences Limited Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. 芳香族複素環式化合物及び医薬におけるその応用
AU2015286049B2 (en) 2014-07-08 2018-03-01 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof
JP6629322B2 (ja) 2014-08-16 2020-01-15 スヴェン・ライフ・サイエンシズ・リミテッド 1−[(2−ブロモフェニル)スルフォニル]−5−メトキシ−3−[(4−メチル−1−ピペラジニル)メチル]−1h−インドールジメシレート一水和物の活性代謝産物及びその活性代謝産物のジメシレート二水和物の塩
KR102015484B1 (ko) * 2016-05-18 2019-08-28 수벤 라이프 사이언시스 리미티드 순수한 5-ht6 수용체 길항제와 아세틸콜린에스테라제 저해제의 조합물
CA3023828C (en) * 2016-05-18 2019-08-27 Suven Life Sciences Limited Combination of pure 5-ht6 receptor antagonists with nmda receptor antagonist
CA3023836C (en) * 2016-05-18 2019-08-27 Suven Life Sciences Limited Triple combination of pure 5-ht6 receptor antagonists, acetylcholinesterase inhibitors and nmda receptor antagonist
JP6669937B2 (ja) * 2016-10-03 2020-03-18 スヴェン・ライフ・サイエンシズ・リミテッド 5−ht6拮抗薬の医薬組成物
CN107174586B (zh) * 2017-02-21 2020-08-11 中国科学院昆明植物研究所 以芦竹碱衍生物为活性成分的药物组合物及其应用
US20210338661A1 (en) * 2017-07-03 2021-11-04 Suven Life Sciences Limited New uses of a pure 5-ht 6 receptor antagonist
JP2023506724A (ja) 2019-12-02 2023-02-20 スヴェン・ライフ・サイエンシーズ・リミテッド 認知症患者の行動心理学的症状の治療
CA3162938A1 (en) 2019-12-02 2021-06-10 Suven Life Sciences Limited Methods for treating behavioral and psychological symptoms in patients with dementia
CN111233737B (zh) * 2020-03-16 2021-05-11 东莞市东阳光新药研发有限公司 芳杂环类衍生物的盐及其用途
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