ZA200503756B - Positional isomers of PEG IFN alpha 2a - Google Patents

Positional isomers of PEG IFN alpha 2a

Info

Publication number
ZA200503756B
ZA200503756B ZA200503756A ZA200503756A ZA200503756B ZA 200503756 B ZA200503756 B ZA 200503756B ZA 200503756 A ZA200503756 A ZA 200503756A ZA 200503756 A ZA200503756 A ZA 200503756A ZA 200503756 B ZA200503756 B ZA 200503756B
Authority
ZA
South Africa
Prior art keywords
positional isomers
ifn alpha
peg ifn
peg
alpha
Prior art date
Application number
ZA200503756A
Other languages
English (en)
Inventor
Brugger Doris
Schacher Alfred
Foser Stefan
Weyer Karl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200503756B publication Critical patent/ZA200503756B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200503756A 2002-11-15 2005-05-10 Positional isomers of PEG IFN alpha 2a ZA200503756B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02025585 2002-11-15

Publications (1)

Publication Number Publication Date
ZA200503756B true ZA200503756B (en) 2008-02-27

Family

ID=32319537

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200503756A ZA200503756B (en) 2002-11-15 2005-05-10 Positional isomers of PEG IFN alpha 2a

Country Status (23)

Country Link
US (1) US20040223950A1 (no)
EP (1) EP1562634B1 (no)
JP (1) JP4279258B2 (no)
KR (1) KR20050065677A (no)
CN (1) CN1323722C (no)
AR (1) AR042039A1 (no)
AT (1) ATE337017T1 (no)
AU (1) AU2003293668A1 (no)
BR (1) BR0316227A (no)
CA (1) CA2503594C (no)
DE (1) DE60307881T2 (no)
ES (1) ES2270152T3 (no)
GT (1) GT200300244A (no)
MX (1) MXPA05005178A (no)
NO (1) NO20052310L (no)
PA (1) PA8587801A1 (no)
PE (1) PE20040834A1 (no)
PL (1) PL376883A1 (no)
RU (1) RU2005118752A (no)
TW (1) TW200413404A (no)
UY (1) UY28080A1 (no)
WO (1) WO2004045648A1 (no)
ZA (1) ZA200503756B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0316324A (pt) * 2002-11-18 2005-09-27 Maxygen Inc Polipeptìdeos e conjugados de interferon-alfa
US7314613B2 (en) 2002-11-18 2008-01-01 Maxygen, Inc. Interferon-alpha polypeptides and conjugates
AU2008201682B2 (en) * 2004-02-02 2011-02-24 Ambrx, Inc. Modified human interferon polypeptides and their uses
KR20070007086A (ko) 2004-02-02 2007-01-12 암브룩스, 인코포레이티드 변형된 인간의 4 개의 나선형 다발 폴리펩티드 및 이의용도
CN101115769A (zh) 2004-05-19 2008-01-30 马克西根公司 干扰素-α多肽和偶联物
MX2007014524A (es) 2005-05-18 2008-02-07 Maxygen Inc Polipeptidos desarrollados de interferon-alfa.
US7695710B2 (en) 2005-06-20 2010-04-13 Pepgen Corporation Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
WO2007002233A2 (en) * 2005-06-20 2007-01-04 Pepgen Corporation Low-toxicity, long-circulating chimeras of human interferon- alpha analogs and interferon tau
CN101002944B (zh) * 2006-01-17 2012-07-25 中国科学院过程工程研究所 支链聚乙二醇-干扰素结合物及其制备方法
AR078117A1 (es) * 2006-06-20 2011-10-19 Protech Pharma S A Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina
BRPI0721988B1 (pt) * 2007-09-04 2021-07-27 Biosteed Gene Expression Tech. Co., Ltd Interferon alfa 2a modificado por polietileno glicol, método para preparação e uso do mesmo, e composição.
RU2485134C2 (ru) * 2007-09-04 2013-06-20 Биостид Джене Експрешен Тек. Ко., Лтд. Интерферон альфа 2в, модифицированный полиэтиленгликолем, получение препарата и его применение
AU2008353850B2 (en) * 2008-04-03 2014-08-21 Biosteed Gene Expression Tech. Co., Ltd. Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
EP2113256A1 (en) 2008-04-29 2009-11-04 Ascendis Pharma AS PEGylated rhGH compounds
CA2915677C (en) 2008-04-29 2018-06-26 Ascendis Pharma Growth Disorders Division A/S Pegylated recombinant human growth hormone compounds
DE102009009344B4 (de) * 2009-02-05 2018-01-04 Helmholtz-Zentrum Dresden - Rossendorf E.V. Verfahren und Anordnung zur Reinigung des Reaktionsgemisches bei der Herstellung von Radiopharmaka
WO2010110503A1 (ko) * 2009-03-27 2010-09-30 주식회사 중외제약 인터페론-알파 및 세포질 잔류성 세포막 투과 펩타이드를 포함하는 IFN-α 융합 단백질
CN101514229B (zh) * 2009-04-03 2012-05-09 海南四环心脑血管药物研究院有限公司 人干扰素α衍生物及其聚乙二醇化修饰物
PT3220892T (pt) 2014-11-21 2021-11-05 Ascendis Pharma Endocrinology Div A/S Formas de dosagem de hormona do crescimento de longa ação
CN106749608B (zh) * 2015-11-18 2021-10-15 石药集团中奇制药技术（石家庄）有限公司 干扰素α缀合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
CA2497777A1 (en) * 2002-09-05 2004-03-18 The General Hospital Corporation Modified asialo-interferons and uses thereof

Also Published As

Publication number Publication date
ES2270152T3 (es) 2007-04-01
EP1562634A1 (en) 2005-08-17
DE60307881T2 (de) 2007-03-08
JP2006515571A (ja) 2006-06-01
UY28080A1 (es) 2004-05-31
PL376883A1 (pl) 2006-01-09
AU2003293668A1 (en) 2004-06-15
RU2005118752A (ru) 2006-02-10
EP1562634B1 (en) 2006-08-23
AR042039A1 (es) 2005-06-08
KR20050065677A (ko) 2005-06-29
PE20040834A1 (es) 2004-11-17
GT200300244A (es) 2004-06-03
CA2503594A1 (en) 2004-06-03
NO20052310L (no) 2005-08-09
CA2503594C (en) 2011-05-10
BR0316227A (pt) 2005-10-04
CN1323722C (zh) 2007-07-04
ATE337017T1 (de) 2006-09-15
MXPA05005178A (es) 2005-07-22
TW200413404A (en) 2004-08-01
CN1711109A (zh) 2005-12-21
DE60307881D1 (de) 2006-10-05
NO20052310D0 (no) 2005-05-11
WO2004045648A1 (en) 2004-06-03
US20040223950A1 (en) 2004-11-11
JP4279258B2 (ja) 2009-06-17
PA8587801A1 (es) 2004-09-16

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