ZA200302783B - Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement. - Google Patents

Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement. Download PDF

Info

Publication number: ZA200302783B
Authority: ZA; South Africa
Prior art keywords: cement; tricalcium phosphate; nanoparticles; cement paste; cement powder
Prior art date: 2000-10-16

Application number

ZA200302783A

Other languages

English (en)

Inventor

Brian R Genge

Glenn R Sauer

Ronald Gence

Licia Wu

Roy E Wuthier

Original Assignee

Univ South Carolina

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-16

Filing date

2003-04-09

Publication date

2004-02-27

2003-04-09 Application filed by Univ South Carolina filed Critical Univ South Carolina

2004-02-27 Publication of ZA200302783B publication Critical patent/ZA200302783B/en

Links

239000004568 cement Substances 0.000 title claims description 288
239000001506 calcium phosphate Substances 0.000 title claims description 127
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims description 124
239000002105 nanoparticle Substances 0.000 title claims description 83
238000000034 method Methods 0.000 title claims description 46
235000011010 calcium phosphates Nutrition 0.000 title claims description 12
229910000389 calcium phosphate Inorganic materials 0.000 title claims description 11
229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 115
229940078499 tricalcium phosphate Drugs 0.000 claims description 115
235000019731 tricalcium phosphate Nutrition 0.000 claims description 111
239000000843 powder Substances 0.000 claims description 86
239000000243 solution Substances 0.000 claims description 63
239000000463 material Substances 0.000 claims description 49
239000007788 liquid Substances 0.000 claims description 41
239000004615 ingredient Substances 0.000 claims description 31
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 31
229910052588 hydroxylapatite Inorganic materials 0.000 claims description 30
230000001050 lubricating effect Effects 0.000 claims description 27
229920002125 Sokalan® Polymers 0.000 claims description 25
239000004584 polyacrylic acid Substances 0.000 claims description 25
238000002441 X-ray diffraction Methods 0.000 claims description 23
239000000203 mixture Substances 0.000 claims description 23
229910019142 PO4 Inorganic materials 0.000 claims description 22
239000011575 calcium Substances 0.000 claims description 22
210000000988 bone and bone Anatomy 0.000 claims description 21
239000010452 phosphate Substances 0.000 claims description 19
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 18
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 16
210000001519 tissue Anatomy 0.000 claims description 16
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 15
229910052791 calcium Inorganic materials 0.000 claims description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 14
238000001816 cooling Methods 0.000 claims description 13
150000003839 salts Chemical class 0.000 claims description 13
239000007864 aqueous solution Substances 0.000 claims description 12
ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical group O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 claims description 10
238000001914 filtration Methods 0.000 claims description 9
238000000227 grinding Methods 0.000 claims description 9
238000004519 manufacturing process Methods 0.000 claims description 9
MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 8
229910021529 ammonia Inorganic materials 0.000 claims description 8
229910000019 calcium carbonate Inorganic materials 0.000 claims description 8
ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 8
238000001035 drying Methods 0.000 claims description 8
238000001556 precipitation Methods 0.000 claims description 8
238000005245 sintering Methods 0.000 claims description 8
238000003860 storage Methods 0.000 claims description 8
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 7
150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 7
229920000058 polyacrylate Polymers 0.000 claims description 7
229910052938 sodium sulfate Inorganic materials 0.000 claims description 7
235000011152 sodium sulphate Nutrition 0.000 claims description 7
239000003999 initiator Substances 0.000 claims description 6
229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 5
230000001376 precipitating effect Effects 0.000 claims description 5
NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 5
239000004254 Ammonium phosphate Substances 0.000 claims description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
229910000148 ammonium phosphate Inorganic materials 0.000 claims description 4
235000019289 ammonium phosphates Nutrition 0.000 claims description 4
239000012867 bioactive agent Substances 0.000 claims description 4
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 4
230000009969 flowable effect Effects 0.000 claims description 4
BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims description 4
ROUPZXDBSPQFLE-UHFFFAOYSA-N triazanium;phosphate;hydrate Chemical compound [NH4+].[NH4+].[NH4+].O.[O-]P([O-])([O-])=O ROUPZXDBSPQFLE-UHFFFAOYSA-N 0.000 claims description 4
231100000331 toxic Toxicity 0.000 claims description 3
230000002588 toxic effect Effects 0.000 claims description 3
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 3
229910000406 trisodium phosphate Inorganic materials 0.000 claims description 3
235000019801 trisodium phosphate Nutrition 0.000 claims description 3
238000005406 washing Methods 0.000 claims description 3
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
239000000908 ammonium hydroxide Substances 0.000 claims description 2
150000005323 carbonate salts Chemical class 0.000 claims description 2
239000000945 filler Substances 0.000 claims description 2
239000003102 growth factor Substances 0.000 claims description 2
239000006193 liquid solution Substances 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
238000005549 size reduction Methods 0.000 claims description 2
210000002966 serum Anatomy 0.000 description 16
239000002245 particle Substances 0.000 description 15
230000015572 biosynthetic process Effects 0.000 description 14
210000001612 chondrocyte Anatomy 0.000 description 14
235000021317 phosphate Nutrition 0.000 description 13
229960005069 calcium Drugs 0.000 description 11
239000002639 bone cement Substances 0.000 description 10
238000001000 micrograph Methods 0.000 description 10
229960001714 calcium phosphate Drugs 0.000 description 9
238000002156 mixing Methods 0.000 description 8
238000002360 preparation method Methods 0.000 description 8
241000271566 Aves Species 0.000 description 7
230000006378 damage Effects 0.000 description 7
230000008439 repair process Effects 0.000 description 7
229910001220 stainless steel Inorganic materials 0.000 description 7
239000010935 stainless steel Substances 0.000 description 7
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 6
230000008901 benefit Effects 0.000 description 5
238000001878 scanning electron micrograph Methods 0.000 description 5
208000010392 Bone Fractures Diseases 0.000 description 4
VSWDORGPIHIGNW-UHFFFAOYSA-N Pyrrolidine dithiocarbamic acid Chemical compound SC(=S)N1CCCC1 VSWDORGPIHIGNW-UHFFFAOYSA-N 0.000 description 4
239000000292 calcium oxide Substances 0.000 description 4
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 4
230000029087 digestion Effects 0.000 description 4
239000007943 implant Substances 0.000 description 4
210000003789 metatarsus Anatomy 0.000 description 4
239000000047 product Substances 0.000 description 4
239000002253 acid Substances 0.000 description 3
230000009471 action Effects 0.000 description 3
239000000316 bone substitute Substances 0.000 description 3
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
238000011161 development Methods 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
238000011081 inoculation Methods 0.000 description 3
231100000252 nontoxic Toxicity 0.000 description 3
230000003000 nontoxic effect Effects 0.000 description 3
230000000399 orthopedic effect Effects 0.000 description 3
238000001356 surgical procedure Methods 0.000 description 3
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
230000002411 adverse Effects 0.000 description 2
239000012620 biological material Substances 0.000 description 2
230000036760 body temperature Effects 0.000 description 2
239000003054 catalyst Substances 0.000 description 2
230000010261 cell growth Effects 0.000 description 2
238000010276 construction Methods 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000011049 filling Methods 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
238000011534 incubation Methods 0.000 description 2
208000014674 injury Diseases 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
210000001872 metatarsal bone Anatomy 0.000 description 2
239000004570 mortar (masonry) Substances 0.000 description 2
-1 polypropylene Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
239000011148 porous material Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000005297 pyrex Substances 0.000 description 2
239000000376 reactant Substances 0.000 description 2
238000007634 remodeling Methods 0.000 description 2
238000011160 research Methods 0.000 description 2
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000010257 thawing Methods 0.000 description 2
101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
206010017076 Fracture Diseases 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
229910019093 NaOCl Inorganic materials 0.000 description 1
239000005708 Sodium hypochlorite Substances 0.000 description 1
206010048049 Wrist fracture Diseases 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
239000013060 biological fluid Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
210000001431 cementocyte Anatomy 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000004567 concrete Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000007123 defense Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
230000001815 facial effect Effects 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000003517 fume Substances 0.000 description 1
210000004349 growth plate Anatomy 0.000 description 1
230000035876 healing Effects 0.000 description 1
238000002513 implantation Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229910010272 inorganic material Inorganic materials 0.000 description 1
239000011147 inorganic material Substances 0.000 description 1
229910052816 inorganic phosphate Inorganic materials 0.000 description 1
230000005865 ionizing radiation Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000002085 irritant Substances 0.000 description 1
231100000021 irritant Toxicity 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
239000002159 nanocrystal Substances 0.000 description 1
235000020030 perry Nutrition 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
238000002278 reconstructive surgery Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
239000012465 retentate Substances 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
231100001055 skeletal defect Toxicity 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
238000012360 testing method Methods 0.000 description 1
GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
238000010792 warming Methods 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
- A61L24/0063—Phosphorus containing materials, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C01B25/324—Preparation from a reaction solution obtained by acidifying with an acid other than orthophosphoric acid
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B12/00—Cements not provided for in groups C04B7/00 - C04B11/00
- C04B12/02—Phosphate cements
- C04B12/025—Phosphates of ammonium or of the alkali or alkaline earth metals
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B20/00—Use of materials as fillers for mortars, concrete or artificial stone according to more than one of groups C04B14/00 - C04B18/00 and characterised by shape or grain distribution; Treatment of materials according to more than one of the groups C04B14/00 - C04B18/00 specially adapted to enhance their filling properties in mortars, concrete or artificial stone; Expanding or defibrillating materials
- C04B20/0016—Granular materials, e.g. microballoons
- C04B20/002—Hollow or porous granular materials
- C04B20/0036—Microsized or nanosized
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/346—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition as a mixture of free acid and one or more phosphates
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/02—Homopolymers or copolymers of acids; Metal or ammonium salts thereof
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00034—Physico-chemical characteristics of the mixtures
- C04B2111/00189—Compositions or ingredients of the compositions characterised by analysis-spectra, e.g. NMR
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00637—Uses not provided for elsewhere in C04B2111/00 as glue or binder for uniting building or structural materials
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Ceramic Engineering (AREA)
Inorganic Chemistry (AREA)
Materials Engineering (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Structural Engineering (AREA)
Oral & Maxillofacial Surgery (AREA)
Surgery (AREA)
Plastic & Reconstructive Surgery (AREA)
Composite Materials (AREA)
Nanotechnology (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Materials For Medical Uses (AREA)

ZA200302783A 2000-10-16 2003-04-09 Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement. ZA200302783B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23998000P	2000-10-16	2000-10-16

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ZA200302783B true ZA200302783B (en)	2004-02-27

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Application Number	Title	Priority Date	Filing Date
ZA200302783A ZA200302783B (en)	2000-10-16	2003-04-09	Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement.

Country Status (9)

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US (3)	US6808561B2 (ko)
EP (1)	EP1335887A4 (ko)
JP (1)	JP2004511320A (ko)
KR (1)	KR20030084891A (ko)
CN (1)	CN1481343A (ko)
AU (2)	AU1331302A (ko)
CA (1)	CA2425612A1 (ko)
WO (1)	WO2002032827A1 (ko)
ZA (1)	ZA200302783B (ko)

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2001
- 2001-10-16 KR KR10-2003-7005237A patent/KR20030084891A/ko not_active Application Discontinuation
- 2001-10-16 AU AU1331302A patent/AU1331302A/xx active Pending
- 2001-10-16 AU AU2002213313A patent/AU2002213313B2/en not_active Ceased
- 2001-10-16 WO PCT/US2001/032377 patent/WO2002032827A1/en active Application Filing
- 2001-10-16 CN CNA018206379A patent/CN1481343A/zh active Pending
- 2001-10-16 US US09/978,601 patent/US6808561B2/en not_active Expired - Lifetime
- 2001-10-16 JP JP2002536018A patent/JP2004511320A/ja active Pending
- 2001-10-16 CA CA002425612A patent/CA2425612A1/en not_active Abandoned
- 2001-10-16 EP EP01981683A patent/EP1335887A4/en not_active Withdrawn
2003
- 2003-04-09 ZA ZA200302783A patent/ZA200302783B/en unknown
2004
- 2004-05-07 US US10/841,885 patent/US7081161B2/en not_active Expired - Fee Related
2006
- 2006-06-12 US US11/451,527 patent/US7527687B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2002213313B2 (en)	2006-08-17
US7527687B2 (en)	2009-05-05
JP2004511320A (ja)	2004-04-15
AU1331302A (en)	2002-04-29
CN1481343A (zh)	2004-03-10
US20060260511A1 (en)	2006-11-23
US20020073894A1 (en)	2002-06-20
EP1335887A4 (en)	2004-06-23
US20060118007A1 (en)	2006-06-08
EP1335887A1 (en)	2003-08-20
US7081161B2 (en)	2006-07-25
US6808561B2 (en)	2004-10-26
WO2002032827A1 (en)	2002-04-25
CA2425612A1 (en)	2002-04-25
KR20030084891A (ko)	2003-11-01

Publication	Publication Date	Title
US7081161B2 (en)	2006-07-25	Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using cement
AU2002213313A1 (en)	2002-07-04	Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement
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EP2533818A1 (en)	2012-12-19	Preparation of bone cement compositions
Kucko et al.	2019	Calcium phosphate bioceramics and cements
US20190192725A1 (en)	2019-06-27	Magnesium phosphate biomaterials
El-Maghraby et al.	2020	Preparation, structural characterization, and biomedical applications of gypsum-based nanocomposite bone cements
CN115400272B (zh)	2023-07-11	一种硫酸钙-磷酸钙-二氧化硅三元骨水泥及其制备方法