ZA200207766B - Synergistic methods and compositions for treating cancer. - Google Patents
Synergistic methods and compositions for treating cancer. Download PDFInfo
- Publication number
- ZA200207766B ZA200207766B ZA200207766A ZA200207766A ZA200207766B ZA 200207766 B ZA200207766 B ZA 200207766B ZA 200207766 A ZA200207766 A ZA 200207766A ZA 200207766 A ZA200207766 A ZA 200207766A ZA 200207766 B ZA200207766 B ZA 200207766B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- tetrahydro
- benzodiazepine
- imidazol
- optionally substituted
- Prior art date
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
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US19227800P | 2000-03-27 | 2000-03-27 |
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EP (1) | EP1272193B1 (pt) |
JP (1) | JP5110756B2 (pt) |
KR (1) | KR20020084254A (pt) |
CN (1) | CN100384424C (pt) |
AR (1) | AR028296A1 (pt) |
AT (1) | ATE430570T1 (pt) |
AU (2) | AU4768301A (pt) |
BR (1) | BR0109517A (pt) |
CA (1) | CA2404712A1 (pt) |
CZ (1) | CZ20023220A3 (pt) |
DE (1) | DE60138611D1 (pt) |
ES (1) | ES2325055T3 (pt) |
HU (1) | HUP0301690A3 (pt) |
IL (1) | IL151373A0 (pt) |
MX (1) | MXPA02009463A (pt) |
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NO (1) | NO20024610L (pt) |
PE (1) | PE20011291A1 (pt) |
RU (1) | RU2264217C2 (pt) |
TW (1) | TWI310684B (pt) |
UY (1) | UY26635A1 (pt) |
WO (1) | WO2001072721A2 (pt) |
ZA (1) | ZA200207766B (pt) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ335383A (en) | 1996-11-18 | 2000-10-27 | Biotechnolog Forschung Gmbh | Epothilone C,D,E and F for plant protection and cytostatic effects shown in kidney cells |
DE69734362T2 (de) | 1996-12-03 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon |
US6867305B2 (en) * | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
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WO2001072721A2 (en) | 2001-10-04 |
MY127082A (en) | 2006-11-30 |
US20020002162A1 (en) | 2002-01-03 |
CN100384424C (zh) | 2008-04-30 |
AR028296A1 (es) | 2003-04-30 |
RU2002129000A (ru) | 2004-03-27 |
PE20011291A1 (es) | 2002-01-13 |
US6537988B2 (en) | 2003-03-25 |
BR0109517A (pt) | 2006-08-29 |
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AU4768301A (en) | 2001-10-08 |
ES2325055T3 (es) | 2009-08-25 |
DE60138611D1 (de) | 2009-06-18 |
CZ20023220A3 (cs) | 2003-11-12 |
KR20020084254A (ko) | 2002-11-04 |
HUP0301690A3 (en) | 2005-05-30 |
TWI310684B (en) | 2009-06-11 |
HUP0301690A2 (hu) | 2003-08-28 |
UY26635A1 (es) | 2001-10-25 |
JP2003528864A (ja) | 2003-09-30 |
EP1272193B1 (en) | 2009-05-06 |
RU2264217C2 (ru) | 2005-11-20 |
JP5110756B2 (ja) | 2012-12-26 |
ATE430570T1 (de) | 2009-05-15 |
EP1272193A2 (en) | 2003-01-08 |
WO2001072721A3 (en) | 2002-06-13 |
NO20024610L (no) | 2002-11-25 |
AU2001247683B2 (en) | 2006-01-12 |
MXPA02009463A (es) | 2003-04-10 |
IL151373A0 (en) | 2003-04-10 |
CA2404712A1 (en) | 2001-10-04 |
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